| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Moos, D Trinder, E H Morga. Cellular distribution of ferric iron, ferritin, transferrin and divalent metal transporter 1 (DMT1) in substantia nigra and basal ganglia of normal and beta2-microglobulin deficient mouse brain. Cellular and molecular biology (Noisy-le-Grand, France). vol 46. issue 3. 2000-11-07. PMID:10872742. |
in particular, we focussed on the substantia nigra and basal ganglia as several papers have indicated that iron may accumulate here and cause death of dopaminergic neurons. |
2000-11-07 |
2023-08-12 |
mouse |
| P Svenningsson, L Gunne, P E Andre. L-DOPA produces strong induction of c-fos messenger RNA in dopamine-denervated cortical and striatal areas of the common marmoset. Neuroscience. vol 99. issue 3. 2000-11-07. PMID:11029538. |
the effects of l-dopa probably depend both on a direct activation of supersensitized dopamine receptors by dopamine produced in the few remaining, but hyperactive, dopaminergic nerve terminals and in serotonergic nerve terminals, as well as on indirect actions of l-dopa related to activation of circuitries connecting cerebral cortex and basal ganglia structures. |
2000-11-07 |
2023-08-12 |
marmoset |
| E Bezard, M Jaber, F Gonon, A Boireau, B Bloch, C E Gros. Adaptive changes in the nigrostriatal pathway in response to increased 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration in the mouse. The European journal of neuroscience. vol 12. issue 8. 2000-10-19. PMID:10971632. |
in order to examine: (i) the nature of the dopaminergic adaptive mechanisms that come into action; (ii) their sequential activation in relation to the severity of degeneration; and (iii) their efficacy with regard to the maintenance of a normal level of basal ganglia activity, we analysed the brains of mice treated daily with 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (mptp, 4 mg/kg, i.p.) |
2000-10-19 |
2023-08-12 |
mouse |
| D W Smith, T Friedman. Characterization of the dopamine defect in primary cultures of dopaminergic neurons from hypoxanthine phosphoribosyltransferase knockout mice. Molecular therapy : the journal of the American Society of Gene Therapy. vol 1. issue 5 Pt 1. 2000-09-07. PMID:10933970. |
nevertheless, the demonstration that gdnf trophic support promotes the survival of these dopaminergic neurons will facilitate gaining a better understanding of the neuropathological mechanisms of lnd by allowing a more extensive analysis of the cells central to the lesch-nyhan phenotype, the dopaminergic neurons of the basal ganglia. |
2000-09-07 |
2023-08-12 |
mouse |
| R H Mach, M A Nader, R L Ehrenkaufer, H D Gage, S R Childers, L M Hodges, M M Hodges, H M Davie. Fluorine-18-labeled tropane analogs for PET imaging studies of the dopamine transporter. Synapse (New York, N.Y.). vol 37. issue 2. 2000-08-24. PMID:10881032. |
both compounds possessed a high affinity and selectivity for the dopamine transporter and had a higher accumulation in the basal ganglia, a brain region having a high density of the dopamine transporter (dat) than the cerebellum, a reference region devoid of dopaminergic terminals. |
2000-08-24 |
2023-08-12 |
Not clear |
| F Blandini, G Nappi, C Tassorelli, E Martignon. Functional changes of the basal ganglia circuitry in Parkinson's disease. Progress in neurobiology. vol 62. issue 1. 2000-08-15. PMID:10821982. |
in parkinson's disease, the degeneration of dopaminergic neurons of the substantia nigra pars compacta triggers a cascade of functional changes affecting the whole basal ganglia network. |
2000-08-15 |
2023-08-12 |
Not clear |
| S S Emami-Avedon, M Ichise, A E Lan. The use of SPECT in the diagnosis of Parkinson's disease. Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes. vol 51. issue 3. 2000-08-11. PMID:10914086. |
spect radiotracers target either the pre- or postsynaptic component of the dopaminergic system in the basal ganglia. |
2000-08-11 |
2023-08-12 |
Not clear |
| J M Henderson, K Carpenter, H Cartwright, G M Hallida. Loss of thalamic intralaminar nuclei in progressive supranuclear palsy and Parkinson's disease: clinical and therapeutic implications. Brain : a journal of neurology. vol 123 ( Pt 7). 2000-08-07. PMID:10869053. |
both the dopaminergic nigra and the glutamatergic caudal intralaminar thalamus are the major regulators of basal ganglia function via the caudate nucleus and putamen. |
2000-08-07 |
2023-08-12 |
Not clear |
| P De Deurwaèrdere, M F Chessele. Nigrostriatal lesions alter oral dyskinesia and c-Fos expression induced by the serotonin agonist 1-(m-chlorophenyl)piperazine in adult rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 13. 2000-07-26. PMID:10864974. |
the loss of dopaminergic innervation of the basal ganglia, a group of subcortical regions involved in motor control, is the hallmark of parkinson's disease. |
2000-07-26 |
2023-08-12 |
rat |
| G Orieux, C Francois, J Féger, J Yelnik, M Vila, M Ruberg, Y Agid, E C Hirsc. Metabolic activity of excitatory parafascicular and pedunculopontine inputs to the subthalamic nucleus in a rat model of Parkinson's disease. Neuroscience. vol 97. issue 1. 2000-06-23. PMID:10771341. |
in parkinson's disease, the loss of dopaminergic neurons induces a cascade of functional changes in the basal ganglia circuitry including a hyperactivity of the subthalamic nucleus. |
2000-06-23 |
2023-08-12 |
rat |
| S Z Meng, J Ohyu, M Itoh, S Takashim. Dopamine transporter and nitric oxide synthase in hypoxic-ischemic brain. Pediatric neurology. vol 22. issue 2. 2000-05-11. PMID:10738916. |
we speculate that glutamate excitotoxicity mediated by glutamate receptors 1, 2/3, and 4 and excessive dopaminergic excitatory activity may play important roles in hypoxic-ischemic basal ganglia necrosis and that nnos does not contribute to that condition. |
2000-05-11 |
2023-08-12 |
human |
| D Joel, I Weine. The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatum. Neuroscience. vol 96. issue 3. 2000-04-27. PMID:10717427. |
the topography of other basal ganglia projections to the dopaminergic system with respect to their tripartite functional subdivision is also reviewed. |
2000-04-27 |
2023-08-12 |
rat |
| J Radulovic, T Blank, I Nijholt, J Kammermeier, J Spies. In vivo NMDA/dopamine interaction resulting in Fos production in the limbic system and basal ganglia of the mouse brain. Brain research. Molecular brain research. vol 75. issue 2. 2000-04-21. PMID:10686348. |
glutamatergic and dopaminergic effects on molecular processes have been extensively investigated in the basal ganglia. |
2000-04-21 |
2023-08-12 |
mouse |
| M Filio. Physiologic basis of dyskinesia. Annals of neurology. vol 47. issue 4 Suppl 1. 2000-04-21. PMID:10762130. |
thus, levodopa in parkinsonism is likely to exaggerate imbalance between regions of the basal ganglia more or less deprived of dopaminergic terminals. |
2000-04-21 |
2023-08-12 |
Not clear |
| B J Morris, A Newman-Tancredi, V Audinot, C S Simpson, M J Milla. Activation of dopamine D(3) receptors induces c-fos expression in primary cultures of rat striatal neurons. Journal of neuroscience research. vol 59. issue 6. 2000-04-13. PMID:10700011. |
a modulation of the expression of immediate-early genes (iegs) such as c-fos is likely involved in the long-term influence of dopaminergic ligands on the activity of basal ganglia neurons. |
2000-04-13 |
2023-08-12 |
rat |
| R Betarbet, R H Porter, J T Greenamyr. GluR1 glutamate receptor subunit is regulated differentially in the primate basal ganglia following nigrostriatal dopamine denervation. Journal of neurochemistry. vol 74. issue 3. 2000-03-09. PMID:10693949. |
nigrostriatal dopaminergic denervation is associated with complex changes in the functional and neurochemical anatomy of the basal ganglia. |
2000-03-09 |
2023-08-12 |
Not clear |
| E Masliah, E Rockenstein, I Veinbergs, M Mallory, M Hashimoto, A Takeda, Y Sagara, A Sisk, L Muck. Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science (New York, N.Y.). vol 287. issue 5456. 2000-03-06. PMID:10678833. |
these alterations were associated with loss of dopaminergic terminals in the basal ganglia and with motor impairments. |
2000-03-06 |
2023-08-12 |
mouse |
| M Madhusudana. Dystonia : emerging concepts in pathophysiology. Neurology India. vol 47. issue 4. 2000-02-08. PMID:10625895. |
this may again be due to a dopaminergic dysfunction of basal ganglia. |
2000-02-08 |
2023-08-12 |
Not clear |
| I N Krasnova, E R Bychkov, V I Lioudyno, O E Zubareva, S A Dambinov. Intracerebroventricular administration of substance P increases dopamine content in the brain of 6-hydroxydopamine-lesioned rats. Neuroscience. vol 95. issue 1. 2000-01-31. PMID:10619467. |
the interactions existing between substance p- and dopamine-positive neurons, notably in the basal ganglia, suggest that substance p may have therapeutic use in treatment of parkinson's disease characterized by impaired dopaminergic transmission. |
2000-01-31 |
2023-08-12 |
rat |
| H Salim, S Ferré, A Dalal, R A Peterfreund, K Fuxe, J D Vincent, P M Lled. Activation of adenosine A1 and A2A receptors modulates dopamine D2 receptor-induced responses in stably transfected human neuroblastoma cells. Journal of neurochemistry. vol 74. issue 1. 2000-01-18. PMID:10617149. |
adenosine can influence dopaminergic neurotransmission in the basal ganglia via postsynaptic interaction between adenosine a2a and dopamine d2 receptors. |
2000-01-18 |
2023-08-12 |
human |