| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giancarlo Pepeu, Maria Grazia Giovannini, Laura Bracc. Effect of cholinesterase inhibitors on attention. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23047023. |
since arousal and attention depend on activation of the forebrain cholinergic system, it is to be expected that the loss of cholinergic neurons occurring in ad may lead to impairment of the attentional processes. |
2013-05-28 |
2023-08-12 |
human |
| Giancarlo Pepeu, Maria Grazia Giovannini, Laura Bracc. Effect of cholinesterase inhibitors on attention. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23047023. |
finally, the electrophysiological and neurochemical mechanisms through which the activation of the cholinergic forebrain neurons enhance attention and create the condition for information acquisition are reviewed. |
2013-05-28 |
2023-08-12 |
human |
| Bingbing Song, Jinsuk Song, Shanshan Zhang, Mark A Anderson, Yan Ao, Chu-Ya Yang, Timothy J Deming, Michael V Sofronie. Sustained local delivery of bioactive nerve growth factor in the central nervous system via tunable diblock copolypeptide hydrogel depots. Biomaterials. vol 33. issue 35. 2013-03-22. PMID:22985994. |
to evaluate bioactive protein delivery in vivo, we used nerve growth factor (ngf) and measured the size of mouse forebrain cholinergic neurons, which respond to ngf with cellular hypertrophy. |
2013-03-22 |
2023-08-12 |
mouse |
| Bingbing Song, Jinsuk Song, Shanshan Zhang, Mark A Anderson, Yan Ao, Chu-Ya Yang, Timothy J Deming, Michael V Sofronie. Sustained local delivery of bioactive nerve growth factor in the central nervous system via tunable diblock copolypeptide hydrogel depots. Biomaterials. vol 33. issue 35. 2013-03-22. PMID:22985994. |
in comparison with ngf injected in buffer, depots of ngf dissolved in either k(180)l(20) or e(180)l(20) provided significantly longer delivery of ngf bioactivity, maintaining hypertrophy of local forebrain cholinergic neurons for at least 4 weeks and inducing hypertrophy a further distance away (up to 5 mm) from injection sites. |
2013-03-22 |
2023-08-12 |
mouse |
| Jyoti C Patel, Elsa Rossignol, Margaret E Rice, Robert P Machol. Opposing regulation of dopaminergic activity and exploratory motor behavior by forebrain and brainstem cholinergic circuits. Nature communications. vol 3. 2013-03-22. PMID:23132022. |
opposing regulation of dopaminergic activity and exploratory motor behavior by forebrain and brainstem cholinergic circuits. |
2013-03-22 |
2023-08-12 |
mouse |
| Jyoti C Patel, Elsa Rossignol, Margaret E Rice, Robert P Machol. Opposing regulation of dopaminergic activity and exploratory motor behavior by forebrain and brainstem cholinergic circuits. Nature communications. vol 3. 2013-03-22. PMID:23132022. |
a key regulator is acetylcholine; forebrain acetylcholine regulates striatal dopamine release, whereas brainstem cholinergic inputs regulate the transition of dopamine neurons from tonic to burst firing modes. |
2013-03-22 |
2023-08-12 |
mouse |
| Jyoti C Patel, Elsa Rossignol, Margaret E Rice, Robert P Machol. Opposing regulation of dopaminergic activity and exploratory motor behavior by forebrain and brainstem cholinergic circuits. Nature communications. vol 3. 2013-03-22. PMID:23132022. |
these results support a model in which forebrain and brainstem cholinergic systems act in tandem to regulate striatal dopamine signalling for proper control of motor activity. |
2013-03-22 |
2023-08-12 |
mouse |
| Amanda C Martyn, Xavier De Jaeger, Ana C Magalhães, Rohit Kesarwani, Daniela F Gonçalves, Sanda Raulic, Monica S Guzman, Michael F Jackson, Ivan Izquierdo, John F Macdonald, Marco A M Prado, Vania F Prad. Elimination of the vesicular acetylcholine transporter in the forebrain causes hyperactivity and deficits in spatial memory and long-term potentiation. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 43. 2013-01-07. PMID:23045697. |
moreover, decreased cholinergic tone in the forebrain is linked to hyperactivity, without changes in anxiety or depression-related behavior. |
2013-01-07 |
2023-08-12 |
Not clear |
| Amanda C Martyn, Xavier De Jaeger, Ana C Magalhães, Rohit Kesarwani, Daniela F Gonçalves, Sanda Raulic, Monica S Guzman, Michael F Jackson, Ivan Izquierdo, John F Macdonald, Marco A M Prado, Vania F Prad. Elimination of the vesicular acetylcholine transporter in the forebrain causes hyperactivity and deficits in spatial memory and long-term potentiation. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 43. 2013-01-07. PMID:23045697. |
these data uncover the specific contribution of forebrain cholinergic tone for synaptic plasticity and behavior. |
2013-01-07 |
2023-08-12 |
Not clear |
| J J Turner, H Hodges, J D Sinden, J A Gra. Comparison of radial maze performance of rats after ibotenate and quisqualate lesions of the forebrain cholinergic projection system: effects of pharmacological challenge and changes in training regime. Behavioural pharmacology. vol 3. issue 4. 2012-10-02. PMID:11224138. |
comparison of radial maze performance of rats after ibotenate and quisqualate lesions of the forebrain cholinergic projection system: effects of pharmacological challenge and changes in training regime. |
2012-10-02 |
2023-08-12 |
rat |
| G A Grigoryan, S Peters, J A Gray, H Hodge. Interactions between the effects of propranolol and nicotine on radial maze performance of rats with lesions of the forebrain cholinergic projection system. Behavioural pharmacology. vol 5. issue 3. 2012-10-02. PMID:11224276. |
interactions between the effects of propranolol and nicotine on radial maze performance of rats with lesions of the forebrain cholinergic projection system. |
2012-10-02 |
2023-08-12 |
rat |
| G A Grigoryan, S Peters, J A Gray, H Hodge. Interactions between the effects of propranolol and nicotine on radial maze performance of rats with lesions of the forebrain cholinergic projection system. Behavioural pharmacology. vol 5. issue 3. 2012-10-02. PMID:11224276. |
this experiment investigated the hypothesis that nicotine-induced regional release of noradrenaline contributes to the improvements in radial maze performance following nicotine treatment in rats with lesions to the forebrain cholinergic projection system (fcps), by examining whether pretreatment with the noradrenergic beta-receptor antagonist propranolol abolished the facilitative effects of nicotine. |
2012-10-02 |
2023-08-12 |
rat |
| A Claudio Cuello, E P Pioro, A Ribeiro-da-Silv. Cellular and subcellular localization of nerve growth factor receptor-like immunoreactivity in the rat CNS. Neurochemistry international. vol 17. issue 2. 2012-10-02. PMID:20504621. |
since the relatively recent discovery that ngf exerts neurotrophic effects on cholinergic neurons of the rat basal forebrain, in addition to its previously known actions on sympathetic and sensory neurons of the peripheral nervous system, numerous morphological studies have localized the ngfr to such neurons in the forebrain. |
2012-10-02 |
2023-08-12 |
rat |
| Y J Li, B K Hartman, P L Faris, W C Lo. Specificity of fiber innervation by cholinergic neurons transplanted into the retrosplenial cortex of adult rats as revealed by choline acetyltransferase immunocytochemistry. Restorative neurology and neuroscience. vol 11. issue 1. 2012-10-02. PMID:21551533. |
the retrosplenial cortex (rsc) is a target of the forebrain cholinergic projecting system. |
2012-10-02 |
2023-08-12 |
rat |
| A Claudio Cuell. Gangliosides, NGF, brain aging and disease: a mini-review with personal reflections. Neurochemical research. vol 37. issue 6. 2012-08-31. PMID:22484968. |
furthermore, we have gathered neurochemical evidence for a compromise of this newly discovered ngf metabolic pathway in alzheimer's disease, explaining the vulnerability of ngf-dependent forebrain cholinergic neurons in this disease despite normal ngf synthesis and abundance of ngf precursor. |
2012-08-31 |
2023-08-12 |
Not clear |
| Luigi Manni, M L Rocco, Samuele Barbaro Paparo, Morena Guaragn. Electroacupucture and nerve growth factor: potential clinical applications. Archives italiennes de biologie. vol 149. issue 2. 2012-06-21. PMID:21701996. |
the nerve growth factor (ngf) is a neurotrophin regulating the survival and function peripheral sensory and sympathetic neurons and of forebrain cholinergic neurons. |
2012-06-21 |
2023-08-12 |
Not clear |
| Ana C Takakura, Thiago S Moreira, Thais L Borella, Renata F Paulin, Débora S A Colombari, Laurival A De Luca, Eduardo Colombari, José V Menan. Central mechanisms involved in pilocarpine-induced pressor response. Autonomic neuroscience : basic & clinical. vol 164. issue 1-2. 2012-06-07. PMID:21689994. |
pilocarpine (cholinergic muscarinic agonist) injected peripherally may act centrally to produce pressor responses; in the present study, using c-fos immunoreactive expression, we investigated the forebrain and brainstem areas activated by pressor doses of intravenous (i.v.) |
2012-06-07 |
2023-08-12 |
rat |
| Erik I Hoff, Harry W M Steinbusch, Robert J van Oostenbrugge, Lillian Garrett, Willem M Otte, Kajo van der Marel, Rick M Dijkhuize. Alterations in the cholinergic system after frontal cortical infarction in rat brain: pharmacological magnetic resonance imaging of muscarinic receptor responsiveness and stereological analysis of cholinergic forebrain neurons. Neurobiology of disease. vol 43. issue 3. 2012-05-21. PMID:21640824. |
alterations in the cholinergic system after frontal cortical infarction in rat brain: pharmacological magnetic resonance imaging of muscarinic receptor responsiveness and stereological analysis of cholinergic forebrain neurons. |
2012-05-21 |
2023-08-12 |
rat |
| Efrain Sanchez-Ortiz, Daishi Yui, Dongli Song, Yun Li, John L Rubenstein, Louis F Reichardt, Luis F Parad. TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 12. 2012-05-18. PMID:22442072. |
consistent with a potential link to ad pathogenesis, trka, a ngf receptor, is expressed in cholinergic forebrain neuronal populations including those in bf and striatum, and is markedly reduced in individuals with mild cognitive impairment (mci) without dementia and early-stage ad. |
2012-05-18 |
2023-08-12 |
mouse |
| Stephan Steidl, Anthony D Miller, Charles D Blaha, John S Yeoman. M₅ muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. PloS one. vol 6. issue 11. 2012-05-08. PMID:22102904. |
however, cholinergic inputs from the laterodorsal (ldt) and pedunculopontine (ppt) tegmental nucleus to the vta and substantia nigra (sn) importantly contribute, as either ldt or ppt lesions strongly attenuate morphine-induced forebrain dopamine elevations. |
2012-05-08 |
2023-08-12 |
mouse |