| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicole Toohey, Michael T Klein, Jessica Knight, Carol Smith, Milt Teitle. Human 5-HT7 receptor-induced inactivation of forskolin-stimulated adenylate cyclase by risperidone, 9-OH-risperidone and other "inactivating antagonists". Molecular pharmacology. vol 76. issue 3. 2009-09-09. PMID:19509219. |
we have previously reported on the unusual human 5-hydroxytryptamine(7) (h5-ht(7)) receptor-inactivating properties of risperidone, 9-oh-risperidone, bromocriptine, methiothepin, metergoline, and lisuride. |
2009-09-09 |
2023-08-12 |
human |
| Francesco Angelucci, Sergio Bernardini, Paolo Gravina, Lorenza Bellincampi, Alberto Trequattrini, Fulvia Di Iulio, Diego Vanni, Giorgio Federici, Carlo Caltagirone, Paola Bossù, Gianfranco Spallett. Delusion symptoms and response to antipsychotic treatment are associated with the 5-HT2A receptor polymorphism (102T/C) in Alzheimer's disease: a 3-year follow-up longitudinal study. Journal of Alzheimer's disease : JAD. vol 17. issue 1. 2009-08-12. PMID:19494443. |
in a 3-year follow-up study, we evaluated the association of serotonin (5-ht) receptor 5-ht2a 102t/c polymorphism (allelic variants cc, ct and tt) with psychotic symptom severity and response to treatment with atypical antipsychotics (risperidone, olanzapine and quietapine) in 80 patients with a diagnosis of probable alzheimer's disease. |
2009-08-12 |
2023-08-12 |
Not clear |
| Hitoshi Hashimoto, Ryota Hashimoto, Norihito Shintani, Kazuhiro Tanaka, Akiko Yamamoto, Michiyoshi Hatanaka, Xiaohong Guo, Yoshiko Morita, Mamoru Tanida, Katsuya Nagai, Masatoshi Takeda, Akemichi Bab. Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone. Journal of neurochemistry. vol 110. issue 2. 2009-07-31. PMID:19457081. |
the atypical antipsychotic risperidone and the selective serotonin (5-ht)(2) antagonist ritanserin normalized the depression-like behavior in pacap-/- mice. |
2009-07-31 |
2023-08-12 |
mouse |
| Yoshihiro Tadori, Robert A Forbes, Robert D McQuade, Tetsuro Kikuch. Receptor reserve-dependent properties of antipsychotics at human dopamine D2 receptors. European journal of pharmacology. vol 607. issue 1-3. 2009-07-07. PMID:19217900. |
in an effort to elucidate aripiprazole's pharmacological activity in relation to clinically relevant fluctuation of dopamine d(2) receptor reserves, we compared the properties of aripiprazole to other antipsychotics, quetiapine, clozapine, olanzapine, ziprasidone, risperidone and haloperidol, a dopamine d(2) receptor partial agonist, bifeprunox, dopamine d(3) receptor modulators, bp897 (n-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]naphthalene-2-carboxamide) and gr103691 (4'-acetyl-n-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]biphenyl-4-carboxamide), and a 5-ht(1a) partial agonist, buspirone using forskolin-stimulated camp accumulation in clonal chinese hamster ovary cell lines expressing low and high densities of human dopamine d(2s) receptors (hd(2s)-low and hd(2s)-high, respectively). |
2009-07-07 |
2023-08-12 |
human |
| Zhiyun Wei, Lei Wang, Jiekun Xuan, Ronglin Che, Jing Du, Shengying Qin, Yi Xing, Bo Gu, Lun Yang, Huafang Li, Jun Li, Guoyin Feng, Lin He, Qinghe Xin. Association analysis of serotonin receptor 7 gene (HTR7) and risperidone response in Chinese schizophrenia patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 3. 2009-06-16. PMID:19233240. |
several lines of evidence suggest that the human 5-ht(7) receptor may be involved in the pharmacodynamics of risperidone and may influence clinical response of the drug. |
2009-06-16 |
2023-08-12 |
human |
| José Brea, Marián Castro, Jesús Giraldo, Juan F López-Giménez, Juan Fernando Padín, Fátima Quintián, Maria Isabel Cadavid, Maria Teresa Vilaró, Guadalupe Mengod, Kelly A Berg, William P Clarke, Jean-Pierre Vilardaga, Graeme Milligan, Maria Isabel Loz. Evidence for distinct antagonist-revealed functional states of 5-hydroxytryptamine(2A) receptor homodimers. Molecular pharmacology. vol 75. issue 6. 2009-06-15. PMID:19279328. |
some antagonists, like the atypical antipsychotics clozapine and risperidone, differentiate themselves from others, like the typical antipsychotic haloperidol, antagonizing these 5-ht(2a) receptor-mediated functions in a pathway-specific manner, explained here by a new model of multiple active interconvertible conformations at dimeric receptors. |
2009-06-15 |
2023-08-12 |
Not clear |
| Ashish Dhir, S K Kulkarn. Risperidone, an atypical antipsychotic enhances the antidepressant-like effect of venlafaxine or fluoxetine: possible involvement of alpha-2 adrenergic receptors. Neuroscience letters. vol 445. issue 1. 2009-04-14. PMID:18778754. |
clinical studies have reported the beneficial outcome of addition of lower doses of risperidone to antidepressant therapy specifically with selective serotonin reuptake inhibitors (ssris) in the treatment of major depression. |
2009-04-14 |
2023-08-12 |
mouse |
| Ashish Dhir, S K Kulkarn. Risperidone, an atypical antipsychotic enhances the antidepressant-like effect of venlafaxine or fluoxetine: possible involvement of alpha-2 adrenergic receptors. Neuroscience letters. vol 445. issue 1. 2009-04-14. PMID:18778754. |
the present study, therefore, examined the beneficial effect, if any, of addition of risperidone (an atypical antipsychotic) to the antidepressant-like effect of venlafaxine (dual reuptake inhibitors of both serotonin and norepinephrine, snri) or fluoxetine (ssri) in porsolt's forced swim test (fst) using male laca mice. |
2009-04-14 |
2023-08-12 |
mouse |
| Katsutoshi Shioda, Koichi Nisijima, Tatsuki Yoshino, Kyoko Kuboshima, Tatsunori Iwamura, Kunio Yui, Satoshi Kat. Risperidone attenuates and reverses hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats. Neurotoxicology. vol 29. issue 6. 2009-03-26. PMID:18722468. |
these results demonstrate that the mechanism underlying the suppression of mdma-induced hyperthermia by risperidone is primarily based on the drug's potent 5-ht(2a) receptor blocking effect, and to a lesser extent, on its d(1) receptor blocking effect. |
2009-03-26 |
2023-08-12 |
rat |
| Katsutoshi Shioda, Koichi Nisijima, Tatsuki Yoshino, Kyoko Kuboshima, Tatsunori Iwamura, Kunio Yui, Satoshi Kat. Risperidone attenuates and reverses hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats. Neurotoxicology. vol 29. issue 6. 2009-03-26. PMID:18722468. |
these increases in the da and 5-ht levels after mdma injection were significantly suppressed by pretreatment with risperidone (0.5mg/kg). |
2009-03-26 |
2023-08-12 |
rat |
| Moti L Chapagain, Laarni Sumibcay, Ulziijargal Gurjav, Pakieli H Kaufusi, Richard E Kast, Vivek R Nerurka. Serotonin receptor 2A blocker (risperidone) has no effect on human polyomavirus JC infection of primary human fetal glial cells. Journal of neurovirology. vol 14. issue 5. 2009-03-12. PMID:18989819. |
to assess the ability of a potent 5ht(2a)r blocker, risperidone, to inhibit jcv infection, the authors treated primary human fetal glial (phfg) cells in vitro with risperidone for 24 h and inoculated with jcv(mad1). |
2009-03-12 |
2023-08-12 |
human |
| Moti L Chapagain, Laarni Sumibcay, Ulziijargal Gurjav, Pakieli H Kaufusi, Richard E Kast, Vivek R Nerurka. Serotonin receptor 2A blocker (risperidone) has no effect on human polyomavirus JC infection of primary human fetal glial cells. Journal of neurovirology. vol 14. issue 5. 2009-03-12. PMID:18989819. |
these data indicate that risperidone does not inhibit jcv(mad1) attachment, internalisation, and replication in phfg cells, and 5ht(2a)r blockers may not be effective in treating progressive multifocal leukoencephalopathy (pml). |
2009-03-12 |
2023-08-12 |
human |
| Jessica A Knight, Carol Smith, Nicole Toohey, Michael T Klein, Milt Teitle. Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists. Molecular pharmacology. vol 75. issue 2. 2009-02-23. PMID:18996971. |
in a previous publication, using human 5-hydroxytryptamine(7) (h5-ht(7)) receptor-expressing human embryonic kidney (hek) 293 cells, we reported the rapid, potent inactivation of the h5-ht(7) receptor stimulation of camp production by three antagonists: risperidone, 9-oh-risperidone, and methiothepin (smith et al., 2006). |
2009-02-23 |
2023-08-12 |
human |
| Jessica A Knight, Carol Smith, Nicole Toohey, Michael T Klein, Milt Teitle. Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists. Molecular pharmacology. vol 75. issue 2. 2009-02-23. PMID:18996971. |
pretreatment of 5-ht(7)-expressing hek cells with increasing concentrations of the inactivating drugs risperidone, 9-oh-risperidone, methiothepin, lisuride, bromocriptine, and metergoline potently inhibited radiolabeling of the h5-ht(7) receptor, with ic(50) values of 9, 5.5, 152, 3, 73, and 10 nm, respectively. |
2009-02-23 |
2023-08-12 |
human |
| Jessica A Knight, Carol Smith, Nicole Toohey, Michael T Klein, Milt Teitle. Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists. Molecular pharmacology. vol 75. issue 2. 2009-02-23. PMID:18996971. |
these results indicate that risperidone and 9-oh risperidone may be producing 5-ht(7) receptor inactivation by different mechanisms than lisuride, bromocryptine, metergoline, and methiothepin. |
2009-02-23 |
2023-08-12 |
human |
| Masashi Ikeda, Yoshio Yamanouchi, Yoko Kinoshita, Tsuyoshi Kitajima, Reiji Yoshimura, Shuji Hashimoto, Michael C O'Donovan, Jun Nakamura, Norio Ozaki, Nakao Iwat. Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia. Pharmacogenomics. vol 9. issue 10. 2009-02-13. PMID:18855532. |
variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia. |
2009-02-13 |
2023-08-12 |
Not clear |
| Atheir Abbas, Bryan L Rot. Pimavanserin tartrate: a 5-HT2A inverse agonist with potential for treating various neuropsychiatric disorders. Expert opinion on pharmacotherapy. vol 9. issue 18. 2009-02-06. PMID:19040345. |
pimavanserin tartrate is the first 5-ht(2a) inverse agonist to enter clinical trials as a treatment for l-dopa-induced psychosis in parkinson's disease and for augmentation of low-dose risperidone treatment in schizophrenia. |
2009-02-06 |
2023-08-12 |
Not clear |
| Isamu Yamaguchi, Kentaro Hamada, Masanori Yoshida, Hiroyuki Isayama, Shuichi Kanazashi, Koji Takeuch. Risperidone attenuates local and systemic inflammatory responses to ameliorate diet-induced severe necrotic pancreatitis in mice: it may provide a new therapy for acute pancreatitis. The Journal of pharmacology and experimental therapeutics. vol 328. issue 1. 2009-02-03. PMID:18832108. |
in a previous article, we showed that a potent serotonin-, 5-hydroxytryptamine-2a (5-ht(2a)) antagonist, risperidone, ameliorated cerulein-induced edematous pancreatitis in mice. |
2009-02-03 |
2023-08-12 |
mouse |
| Delia Bishara, David Taylo. Upcoming agents for the treatment of schizophrenia: mechanism of action, efficacy and tolerability. Drugs. vol 68. issue 16. 2009-01-23. PMID:18973393. |
its pharmacology is comparable to risperidone, having d2 and 5-ht(2a) receptor antagonist activity. |
2009-01-23 |
2023-08-12 |
Not clear |
| L Wang, C Fang, A Zhang, J Du, L Yu, J Ma, G Feng, Q Xing, L H. The --1019 C/G polymorphism of the 5-HT(1)A receptor gene is associated with negative symptom response to risperidone treatment in schizophrenia patients. Journal of psychopharmacology (Oxford, England). vol 22. issue 8. 2009-01-13. PMID:18308786. |
the --1019 c/g polymorphism of the 5-ht(1)a receptor gene is associated with negative symptom response to risperidone treatment in schizophrenia patients. |
2009-01-13 |
2023-08-12 |
Not clear |