| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bhagawati Saxena, Sairam Krishnamurthy, Sanjay Sing. Gastroprotective potential of risperidone, an atypical antipsychotic, against stress and pyloric ligation induced gastric lesions. Chemico-biological interactions. vol 190. issue 2-3. 2011-07-26. PMID:21315700. |
thus, the aim of the present study is to investigate, whether risperidone, a d(2) receptor and 5-ht(2a) receptor antagonist, would be able to result in gastroprotective effect in stress-induced lesions and also explore the possible mechanism of action behind its gastroprotective activity. |
2011-07-26 |
2023-08-12 |
Not clear |
| H Y Meltzer, B W Masse. The role of serotonin receptors in the action of atypical antipsychotic drugs. Current opinion in pharmacology. vol 11. issue 1. 2011-07-25. PMID:21420906. |
there is considerable preclinical and some clinical evidence that effects on 5-ht receptors contribute to the low risk of producing extrapyramidal side effects, which is the defining characteristic of an atypical apd, the lack of elevation in plasma prolactin levels (with risperidone and 9-hydroxyrisperidone being exceptions), antipsychotic action, and ability to improve some domains of cognition in patients with schizophrenia. |
2011-07-25 |
2023-08-12 |
Not clear |
| N Khorana, S Maphanta, O Lohitnavy, A Srichaiya, J Sayasathi. Comparative pharmacokinetics and bioequivalence of two tablet formulations of 2 mg risperidone in healthy Thai male volunteers. International journal of clinical pharmacology and therapeutics. vol 49. issue 6. 2011-07-19. PMID:21612749. |
risperidone is an atypical antipsychotic drug with potent serotonin and moderate dopamine antagonistic properties. |
2011-07-19 |
2023-08-12 |
human |
| Jeong-Min Kim, Soon-Tae Lee, Eun-Cheol Song, Keun-Hwa Jung, Dong-In Sinn, Hakjae Chung, Kon Chu, Manho Ki. Neurotoxic syndrome developed after taking sertraline and risperidone. Journal of clinical neurology (Seoul, Korea). vol 3. issue 3. 2011-07-14. PMID:19513287. |
here we present a case of 19-year-old man who experienced serotonin syndrome caused by sertraline intake, and consecutive neuroleptic malignant syndrome by risperidone. |
2011-07-14 |
2023-08-12 |
Not clear |
| Atsushi Tsutsumi, Tetsufumi Kanazawa, Hiroki Kikuyama, Gaku Okugawa, Hiroyuki Uenishi, Toshio Miyamoto, Naoki Matsumoto, Jun Koh, Kazuhiro Shinosaki, Toshifumi Kishimoto, Hiroshi Yoneda, Toshihiko Kinoshit. Genetic polymorphisms in dopamine- and serotonin-related genes and treatment responses to risperidone and perospirone. Psychiatry investigation. vol 6. issue 3. 2011-07-14. PMID:20046399. |
we investigated the possible association between genetic polymorphisms in the dopamine receptor and serotonin transporter genes and the responses of schizophrenic patients treated with either risperidone or perospirone. |
2011-07-14 |
2023-08-12 |
human |
| O V Vasudevan, Denzil A Pinto, P S Gopinat. Risperidone induced tardive dyskinesia - a case report. Indian journal of psychiatry. vol 44. issue 4. 2011-07-14. PMID:21206608. |
risperidone is a serotonin - dopamine antagonist which has got less propensity to cause tardive dyskinesia than conventional antipsychotics. |
2011-07-14 |
2023-08-12 |
Not clear |
| A K Agarwal, V S Bashyam, S M Channabasavanna, H S Dhavale, M A Khan, S Khanna, P V Pradhan, M Katiyar, R Rajkumar, F R Niazi, R K Jalali, R Gowrishankar, S K Mishra, O P Soo. Risperidone in Indian patients with schizophrenia. Indian journal of psychiatry. vol 40. issue 3. 2011-07-14. PMID:21494480. |
risperidone is a noval antipsychotic agent whose dual antagonism of dopamine and serotonin receptors is believed to underlie its efficacy against negative symptoms and the low incidence of extrapyramidal side effects. |
2011-07-14 |
2023-08-12 |
Not clear |
| Kota Nakaya, Osamu Nakagawasai, Yuichiro Arai, Hiroshi Onogi, Atsushi Sato, Fukie Niijima, Koichi Tan-No, Takeshi Tadan. Pharmacological characterizations of memantine-induced disruption of prepulse inhibition of the acoustic startle response in mice: involvement of dopamine D2 and 5-HT2A receptors. Behavioural brain research. vol 218. issue 1. 2011-05-25. PMID:21130810. |
this effect of memantine on ppi was attenuated by pretreatment with the antipsychotics clozapine (3 and 6 mg/kg), risperidone (0.3mg/kg) and haloperidol (0.5mg/kg), the selective d(2) antagonist sulpiride (40 mg/kg) and 5-ht(2a/2c) antagonist ketanserin (2 and 4 mg/kg) but not with the selective d(1) antagonist sch23390 (0.05 and 0.1mg/kg). |
2011-05-25 |
2023-08-12 |
mouse |
| Martha Sajatovic, Madhusoodanan Subramoniam, Matthew A Fulle. Risperidone in the treatment of bipolar mania. Neuropsychiatric disease and treatment. vol 2. issue 2. 2011-05-17. PMID:19412457. |
the receptor-binding profile of risperidone, which includes potent antagonism of the serotonin 5-ht2(a), dopamine d(2), and alpha-adrenergic receptors, is believed to be related to positive effects on mood. |
2011-05-17 |
2023-08-12 |
Not clear |
| Keiko Ohoyama, Satoshi Yamamura, Tatsuya Hamaguchi, Masanori Nakagawa, Eishi Motomura, Takashi Shiroyama, Hisashi Tanii, Motohiro Okad. Effect of novel atypical antipsychotic, blonanserin, on extracellular neurotransmitter level in rat prefrontal cortex. European journal of pharmacology. vol 653. issue 1-3. 2011-05-02. PMID:21147094. |
to clarify the mechanisms of action of blonanserin, an atypical antipsychotic drug, we studied the effects of systemic administration of blonanserin and risperidone on extracellular levels of norepinephrine, dopamine, serotonin, gaba and glutamate in the medial prefrontal cortex using microdialysis, and neuronal firing in the ventral tegmental area, locus coeruleus, dorsal raphe nucleus and mediodorsal thalamic nucleus using radiotelemetry. |
2011-05-02 |
2023-08-12 |
rat |
| Keiko Ohoyama, Satoshi Yamamura, Tatsuya Hamaguchi, Masanori Nakagawa, Eishi Motomura, Takashi Shiroyama, Hisashi Tanii, Motohiro Okad. Effect of novel atypical antipsychotic, blonanserin, on extracellular neurotransmitter level in rat prefrontal cortex. European journal of pharmacology. vol 653. issue 1-3. 2011-05-02. PMID:21147094. |
blonanserin persistently increased frontal extracellular levels of norepinephrine and dopamine but not serotonin, gaba or glutamate, whereas risperidone persistently increased those of norepinephrine, dopamine and serotonin but not gaba or glutamate. |
2011-05-02 |
2023-08-12 |
rat |
| Delia Bishar. Once-monthly paliperidone injection for the treatment of schizophrenia. Neuropsychiatric disease and treatment. vol 6. 2011-04-28. PMID:20856919. |
paliperidone (9-hydroxyrisperidone) is the major active metabolite of risperidone and acts at dopamine d(2) and serotonin 5ht(2a) receptors. |
2011-04-28 |
2023-08-12 |
Not clear |
| Marilyn A Davies, Yvette Conley, Bryan L Rot. Functional SNPs in genes encoding the 5-HT2A receptor modify the affinity and potency of several atypical antipsychotic drugs. Biological research for nursing. vol 13. issue 1. 2011-04-25. PMID:20097665. |
this in vitro pharmacogenetic study examined whether allelic variants in the 5-hydroxytryptamine (ht)(2a) receptor alter the in vitro pharmacology of six aads (clozapine, olanzapine, risperidone, quetiapine, ziprasidone, and aripiprazole). |
2011-04-25 |
2023-08-12 |
human |
| Pieter J Hoekstra, Pieter W Troost, Bertine E Lahuis, Hans Mulder, Erik J Mulder, Barbara Franke, Jan K Buitelaar, George M Anderson, Lawrence Scahill, Ruud B Mindera. Risperidone-induced weight gain in referred children with autism spectrum disorders is associated with a common polymorphism in the 5-hydroxytryptamine 2C receptor gene. Journal of child and adolescent psychopharmacology. vol 20. issue 6. 2011-04-11. PMID:21186965. |
here, we investigated differences between age- and gender-normed body mass index-standardized z scores at baseline and after 8 weeks of open-label, flexible-dose risperidone treatment (mean dose: 1.70 mg/day) in 32 youths with pervasive developmental disorder (mean age = 8.74, range = 5-16 years) in relation to -759c/t 5-hydroxytryptamine 2c receptor (htr2c) promoter and rs1414334 htr2c intragenic c/g alleles, along with gender, age, and risperidone dose, using repeated measures analyses of variance. |
2011-04-11 |
2023-08-12 |
Not clear |
| Analía Bortolozzi, Mercè Masana, Llorenç Díaz-Mataix, Roser Cortés, María Cecilia Scorza, Jay A Gingrich, Miklos Toth, Francesc Artiga. Dopamine release induced by atypical antipsychotics in prefrontal cortex requires 5-HT(1A) receptors but not 5-HT(2A) receptors. The international journal of neuropsychopharmacology. vol 13. issue 10. 2011-03-18. PMID:20158933. |
local apds (clozapine, olanzapine, risperidone) administered by reverse dialysis induced a dose-dependent increase in mpfc da output equally in wt and 5-ht(2a)r ko mice whereas the da increase was absent in 5-ht(1a)r ko mice. |
2011-03-18 |
2023-08-12 |
mouse |
| Melik Seyrek, Serdar Kahraman, Mehmet Salih Deveci, Ozgur Yesilyurt, Ahmet Dogru. Systemic cannabinoids produce CB₁-mediated antinociception by activation of descending serotonergic pathways that act upon spinal 5-HT(7) and 5-HT(2A) receptors. European journal of pharmacology. vol 649. issue 1-3. 2011-03-03. PMID:20868676. |
risperidone, an atypical antipsychotic displaying 5-ht(2a) antagonism, also irreversibly binds to and inactivates the 5-ht₇ receptors. |
2011-03-03 |
2023-08-12 |
mouse |
| Farhat Batool, Ambreen Hasnat, Muhammad Abdul Haleem, Darakhshan Jabeen Halee. Dose-related effects of clozapine and risperidone on the pattern of brain regional serotonin and dopamine metabolism and on tests related to extrapyramidal functions in rats. Acta pharmaceutica (Zagreb, Croatia). vol 60. issue 2. 2011-03-03. PMID:21134850. |
dose-related effects of clozapine and risperidone on the pattern of brain regional serotonin and dopamine metabolism and on tests related to extrapyramidal functions in rats. |
2011-03-03 |
2023-08-12 |
rat |
| Farhat Batool, Ambreen Hasnat, Muhammad Abdul Haleem, Darakhshan Jabeen Halee. Dose-related effects of clozapine and risperidone on the pattern of brain regional serotonin and dopamine metabolism and on tests related to extrapyramidal functions in rats. Acta pharmaceutica (Zagreb, Croatia). vol 60. issue 2. 2011-03-03. PMID:21134850. |
5-hydroxytryptamine (5-ht) was significantly (p < 0.01) increased by risperidone and decreased by clozapine in the rest of the brain. |
2011-03-03 |
2023-08-12 |
rat |
| Michihiko Iijima, Akie Ito, Shinsuke Kurosu, Shigeyuki Chak. Pharmacological characterization of repeated corticosterone injection-induced depression model in rats. Brain research. vol 1359. 2011-01-25. PMID:20813098. |
in contrast, an acute treatment with a selective serotonin reuptake inhibitor (ssri), fluvoxamine, and a tricyclic antidepressant (tca), imipramine, did not have any effect on this condition, while a combination of fluvoxamine and risperidone exerted an antidepressant-like effect. |
2011-01-25 |
2023-08-12 |
rat |
| Henry A Nasrallah, Tracy Hopkins, Sarah K Pixle. Differential effects of antipsychotic and antidepressant drugs on neurogenic regions in rats. Brain research. vol 1354. 2011-01-03. PMID:20682307. |
young adult male rats were treated with risperidone and paliperidone, atypical antipsychotic medications; fluoxetine, a selective serotonin reuptake inhibitor (ssri) antidepressant; and diluent control for 28days via drinking water. |
2011-01-03 |
2023-08-12 |
human |