| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomotaka Murotani, Tomoko Ishizuka, Yuka Isogawa, Michitaka Karashima, Atsushi Yamatodan. Possible involvement of serotonin 5-HT2 receptor in the regulation of feeding behavior through the histaminergic system. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21514311. |
some atypical antipsychotics like risperidone and aripiprazole are known to affect feeding behavior and to antagonize the serotonin (5-ht) receptor subtypes. |
2012-04-17 |
2023-08-12 |
mouse |
| Hisato Matsunaga, Kazuhisa Hayashida, Kensei Maebayashi, Hironori Mito, Nobuo Kiriik. A case series of aripiprazole augmentation of selective serotonin reuptake inhibitors in treatment-refractory obsessive compulsive disorder. International journal of psychiatry in clinical practice. vol 15. issue 4. 2012-04-17. PMID:22121999. |
for the obsessive compulsive disorder (ocd) patients refractory to selective serotonin reuptake inhibitors (ssris), atypical antipsychotics, such as risperidone, or olanzapine have been found effective in the augmentation of ssris. |
2012-04-17 |
2023-08-12 |
Not clear |
| Alma Bravo-Mehmedbasi. Risperidone in the treatment of schizophrenia. Medicinski arhiv. vol 65. issue 6. 2012-02-22. PMID:22299296. |
risperidone is a second generation antipsychotic agent, with potent serotonin 5-ht2a and dopamine d2 receptor blocking effects. |
2012-02-22 |
2023-08-12 |
Not clear |
| Alma Bravo-Mehmedbasi. Risperidone in the treatment of schizophrenia. Medicinski arhiv. vol 65. issue 6. 2012-02-22. PMID:22299296. |
specifically, risperidone possesses a unique balance of serotonin and dopamine antagonism, namely that its affinity for 5-ht2a receptors is significantly greater than its affinity for d2 receptors. |
2012-02-22 |
2023-08-12 |
Not clear |
| Miguel Fribourg, José L Moreno, Terrell Holloway, Davide Provasi, Lia Baki, Rahul Mahajan, Gyu Park, Scott K Adney, Candice Hatcher, José M Eltit, Jeffrey D Ruta, Laura Albizu, Zheng Li, Adrienne Umali, Jihyun Shim, Alexandre Fabiato, Alexander D MacKerell, Vladimir Brezina, Stuart C Sealfon, Marta Filizola, Javier González-Maeso, Diomedes E Logotheti. Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell. vol 147. issue 5. 2012-01-23. PMID:22118459. |
atypical antipsychotic drugs, such as clozapine and risperidone, have a high affinity for the serotonin 5-ht(2a) g protein-coupled receptor (gpcr), the 2ar, which signals via a g(q) heterotrimeric g protein. |
2012-01-23 |
2023-08-12 |
Not clear |
| Kondapalli Venkata Gowri Chandra Sekhar, Vajja Samabasiva Rao, Winnie Deuther-Conrad, Aravalli Satish Reddy, Peter Brust, Mutyala Murali Krishna Kuma. Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 2-{4-[4-(2,5-disubstituted thiazol-4-yl)phenylethyl]piperazin-1-yl}-1,8-naphthyridine-3-carbonitriles as atypical antipsychotic agents. Journal of enzyme inhibition and medicinal chemistry. vol 26. issue 4. 2011-12-30. PMID:21171898. |
it was observed that none of the new chemical entities exhibited catalepsy and 10f is the most active among the synthesized compounds with 5-ht(2a)/d(2) ratio of 1.1286 although the standard drug risperidone exhibited 5-ht(2a)/d(2) ratio of 1.0989. |
2011-12-30 |
2023-08-12 |
mouse |
| Lily P H Yan. Oral paliperidone: a review of its use in the management of schizoaffective disorder. CNS drugs. vol 25. issue 6. 2011-12-30. PMID:21649452. |
paliperidone (or 9-hydroxyrisperidone) is the major active metabolite of the well known atypical antipsychotic risperidone, and its mechanism of action is thought to be the antagonism of dopamine d(2) and serotonin 5-ht(2a) receptors. |
2011-12-30 |
2023-08-12 |
Not clear |
| Logan K Wink, Craig A Erickson, Christopher J McDougl. Pharmacologic treatment of behavioral symptoms associated with autism and other pervasive developmental disorders. Current treatment options in neurology. vol 12. issue 6. 2011-11-10. PMID:20848330. |
serotonin reuptake inhibitors are of limited efficacy in children and adolescents, but risperidone and aripiprazole have been shown to reduce these symptoms. |
2011-11-10 |
2023-08-12 |
Not clear |
| Wendy Adams, Maarten van den Buus. Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21477601. |
hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-ht(2c) receptors in the dorsal hippocampus. |
2011-10-14 |
2023-08-12 |
rat |
| Wendy Adams, Maarten van den Buus. Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21477601. |
in contrast, risperidone treatment increased ppi to a significantly greater extent in rats with hippocampal serotonin depletion, an effect which was most prominent at low prepulse intensities. |
2011-10-14 |
2023-08-12 |
rat |
| Wendy Adams, Maarten van den Buus. Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21477601. |
partial serotonin depletion in the ventral hippocampus did not alter ppi modulation by risperidone. |
2011-10-14 |
2023-08-12 |
rat |
| Wendy Adams, Maarten van den Buus. Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21477601. |
therefore, despite intact baseline ppi, abnormal ppi regulation in rats with >70% serotonin depletion in the hippocampus was unmasked by acute risperidone treatment. |
2011-10-14 |
2023-08-12 |
rat |
| Marieke Liem-Moolenaar, Mandana Rad, Stefano Zamuner, Adam F Cohen, Francesca Lemme, Kari L Franson, Joop M A van Gerven, Emilio Merlo Pic. Central nervous system effects of the interaction between risperidone (single dose) and the 5-HT6 antagonist SB742457 (repeated doses) in healthy men. British journal of clinical pharmacology. vol 71. issue 6. 2011-09-14. PMID:21223356. |
risperidone, commonly used to control agitation and psychotic features in both schizophrenia and alzheimer's disease, is a d(2)/5-ht(2a ) antagonist with low affinity for 5-ht(6) receptors and limited effects on cognitive parameters. |
2011-09-14 |
2023-08-12 |
Not clear |
| Katsutoshi Shioda, Koichi Nisijima, Tatsuki Yoshino, Satoshi Kat. Effect of risperidone on acute methamphetamine-induced hyperthermia in rats. Drug and alcohol dependence. vol 111. issue 3. 2011-08-11. PMID:20541333. |
the same effect was produced by dopamine-1 (da(1)) and serotonin-2a (5-ht(2a)) receptor blockers, but not by d₂, 5-ht(1a), 5-ht(2b/2c), or 5-ht(2c) receptor blockers, demonstrating that risperidone suppressed meth-induced hyperthermia by blocking the d(1) and 5-ht(2a) receptors. |
2011-08-11 |
2023-08-12 |
rat |
| Katsutoshi Shioda, Koichi Nisijima, Tatsuki Yoshino, Satoshi Kat. Effect of risperidone on acute methamphetamine-induced hyperthermia in rats. Drug and alcohol dependence. vol 111. issue 3. 2011-08-11. PMID:20541333. |
risperidone pretreatment significantly attenuated increases in the levels of da, 5-ht, glutamate, and nox. |
2011-08-11 |
2023-08-12 |
rat |
| Katsutoshi Shioda, Koichi Nisijima, Tatsuki Yoshino, Satoshi Kat. Effect of risperidone on acute methamphetamine-induced hyperthermia in rats. Drug and alcohol dependence. vol 111. issue 3. 2011-08-11. PMID:20541333. |
the present study indicates that risperidone may be an effective drug for treating meth-induced hyperthermia in humans and that meth influences the da and 5-ht neuron systems as well as other neuron systems, including the glutamate and no systems. |
2011-08-11 |
2023-08-12 |
rat |
| b' Zofia Rog\\xc3\\xb3\\xc5\\xb. Effects of co-treatment with mirtazapine and low doses of risperidone on immobility time in the forced swimming test in mice. Pharmacological reports : PR. vol 62. issue 6. 2011-08-10. PMID:21273677.' |
way100636 (a 5-ht(1a) receptor antagonist) inhibited, while yohimbine (an α(2)-adrenergic receptor antagonist) potentiated the antidepressant-like effect induced by co-administration of mir and risperidone. |
2011-08-10 |
2023-08-12 |
mouse |
| b' Zofia Rog\\xc3\\xb3\\xc5\\xb. Effects of co-treatment with mirtazapine and low doses of risperidone on immobility time in the forced swimming test in mice. Pharmacological reports : PR. vol 62. issue 6. 2011-08-10. PMID:21273677.' |
the obtained results indicate that risperidone applied in a low dose enhances the antidepressant-like activity of mir and that, among other mechanisms, 5-ht(1a)-, and α(2)-adrenergic receptors may play a role in this effect. |
2011-08-10 |
2023-08-12 |
mouse |
| Antonio Ortega-Alvaro, Auxiliadora Aracil-Fernández, María S García-Gutiérrez, Francisco Navarrete, Jorge Manzanare. Deletion of CB2 cannabinoid receptor induces schizophrenia-related behaviors in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 7. 2011-08-10. PMID:21430651. |
chronic risperidone treatment in wt mice left α(2c)r gene expression unchanged, decreased d(2)r gene expression (15 μg/kg), and decreased 5-ht(2c)r and 5-ht(2a)r in pfc and dr. |
2011-08-10 |
2023-08-12 |
mouse |
| Antonio Ortega-Alvaro, Auxiliadora Aracil-Fernández, María S García-Gutiérrez, Francisco Navarrete, Jorge Manzanare. Deletion of CB2 cannabinoid receptor induces schizophrenia-related behaviors in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 7. 2011-08-10. PMID:21430651. |
in cb(2)ko, the gene expression of d(2)r in the pfc, of α(2c)r in the lc, and of 5-ht(2c)r and 5-ht(2a)r in pfc was reduced; 5-ht(2c)r and 5-ht(2a)r gene expressions in dr were increased after treatment with risperidone. |
2011-08-10 |
2023-08-12 |
mouse |