| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Abdelmalik, H G Ruhé, K Barwari, E-J van den Dool, J C M Meijers, S Middeldorp, H R Büller, A H Schene, P W Kamphuise. Effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a SLC6A4 serotonin transporter polymorphism. Journal of thrombosis and haemostasis : JTH. vol 6. issue 12. 2009-02-09. PMID:18983505. |
effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a slc6a4 serotonin transporter polymorphism. |
2009-02-09 |
2023-08-12 |
Not clear |
| David M Marks, Min-Hyeon Park, Byung-Joo Ham, Changsu Han, Ashwin A Patkar, Prakash S Masand, Chi-Un Pa. Paroxetine: safety and tolerability issues. Expert opinion on drug safety. vol 7. issue 6. 2009-01-21. PMID:18983224. |
paroxetine is a selective serotonin re-uptake inhibitor (ssri) available in immediate release and controlled release (cr) formulations. |
2009-01-21 |
2023-08-12 |
Not clear |
| David M Marks, Min-Hyeon Park, Byung-Joo Ham, Changsu Han, Ashwin A Patkar, Prakash S Masand, Chi-Un Pa. Paroxetine: safety and tolerability issues. Expert opinion on drug safety. vol 7. issue 6. 2009-01-21. PMID:18983224. |
paroxetine is the most potent inhibitor of serotonin re-uptake among the now available ssris. |
2009-01-21 |
2023-08-12 |
Not clear |
| Nada Bozina, Alma Mihaljevic Peles, Marina Sagud, Hrvoje Bilusic, Miro Jakovljevi. Association study of paroxetine therapeutic response with SERT gene polymorphisms in patients with major depressive disorder. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 9. issue 3. 2009-01-14. PMID:17853254. |
we investigated the relationships between ls promoter (sertpr) and ls intron2 (sertin2) genetic variants of serotonin transporter (sert) polymorphisms with treatment response in 130 patients with major depressive disorder (mdd) treated with paroxetine (20 mg/day) for 6 weeks. |
2009-01-14 |
2023-08-12 |
human |
| Elke Weisshaa. Intractable chronic pruritus in a 67-year-old man. Acta dermato-venereologica. vol 88. issue 5. 2009-01-08. PMID:18779888. |
therapy with the selective serotonin reuptake inhibitor paroxetine significantly relieved pruritus, but was less effective when external therapy was discontinued. |
2009-01-08 |
2023-08-12 |
Not clear |
| Subbu Apparsundaram, Daniel J Stockdale, Robert A Henningsen, Marcos E Milla, Renee S Marti. Antidepressants targeting the serotonin reuptake transporter act via a competitive mechanism. The Journal of pharmacology and experimental therapeutics. vol 327. issue 3. 2009-01-05. PMID:18801947. |
in accordance with the cheng-prusoff relationship for a competitive interaction, we observed that test compound concentrations associated with 50% maximal inhibition of radiotracer binding (ic(50)) increased linearly with increasing radioligand concentration for all ligands: 5-ht, s-citalopram, r-citalopram, paroxetine, clomipramine, fluvoxamine, imipramine venlafaxine, duloxetine, indatraline, cocaine, and 2-beta-carboxy-3-beta-(4-iodophenyl)tropane. |
2009-01-05 |
2023-08-12 |
human |
| Wei-Chuan Chen, Chorng-Chih Huang, Chun-Jen Huang, Jau-Min Chien, Ko-Long Lin, Yih-Chau Lu, I-Shu Chen, Shiuh-Inn Liu, Shu-Shong Hsu, Hong-Tai Chang, Chiang-Ting Chou, Chung-Ren Ja. Mechanism of paroxetine-induced cell death in renal tubular cells. Basic & clinical pharmacology & toxicology. vol 103. issue 5. 2008-12-16. PMID:18801027. |
paroxetine belongs to the family of selective serotonin reuptake inhibitors. |
2008-12-16 |
2023-08-12 |
Not clear |
| Thomas C Rosenthal, Barbara A Majeroni, Richard Pretorius, Khalid Mali. Fatigue: an overview. American family physician. vol 78. issue 10. 2008-12-16. PMID:19035066. |
selective serotonin reuptake inhibitors, such as fluoxetine, paroxetine, or sertraline, may improve energy in patients with depression. |
2008-12-16 |
2023-08-12 |
Not clear |
| Aroldo Cupello, Daniela Audenino, Simona Scarrone, Michele Fornaro, Elena Gatta, Pantaleo Fornaro, Claudio Alban. Epileptic seizures but not pseudoseizures are associated with decreased density of the serotonin transporter in blood platelet membranes. Neurochemical research. vol 33. issue 11. 2008-12-12. PMID:18427983. |
the density of the serotonin transporter in the plasma membranes of blood platelets was evaluated by labelled paroxetine binding in three different groups. |
2008-12-12 |
2023-08-12 |
Not clear |
| Subhash M Nadgir, Manish Malviy. In vivo effect of antidepressants on [3H]paroxetine binding to serotonin transporters in rat brain. Neurochemical research. vol 33. issue 11. 2008-12-12. PMID:18437564. |
in vivo effect of antidepressants on [3h]paroxetine binding to serotonin transporters in rat brain. |
2008-12-12 |
2023-08-12 |
rat |
| Ludmila A Vataeva, Vladimir S Kudrin, Elena A Vershinina, Vjacheslav M Mosin, Ekaterina I Tiul'kova, Vladimir A Otelli. Maternal para-chlorophenylalanine exposure modifies central monoamines and behaviors in the adult offspring. Brain research. vol 1234. 2008-12-08. PMID:18718452. |
in the present study we have shown that the selective 5ht reuptake inhibitor (ssri) paroxetine decreases locomotor activity in the prenatally pcpa-treated offspring. |
2008-12-08 |
2023-08-12 |
rat |
| Ryuji Sakakibara, Takashi Ito, Tomoyuki Uchiyama, Yusuke Awa, Chiharu Yamaguchi, Takamichi Hattor. Effects of milnacipran and paroxetine on overactive bladder due to neurologic diseases: a urodynamic assessment. Urologia internationalis. vol 81. issue 3. 2008-12-04. PMID:18931554. |
to determine the effects of milnacipran hydrochloride, a serotonin-norepinephrine reuptake inhibitor (snri), or paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on overactive bladder (oab) in neurologic diseases, given by objective measures of urodynamic studies. |
2008-12-04 |
2023-08-12 |
Not clear |
| V M Hargrove, J R McCutcheo. Comparison of drug concentrations taken from clamped and unclamped femoral vessels. Journal of analytical toxicology. vol 32. issue 8. 2008-12-04. PMID:19007512. |
drug concentrations of three selective serotonin reuptake inhibitors, or ssris (sertraline, paroxetine, citalopram), two benzodiazepines (diazepam and alprazolam), two antihistamines (diphenhydramine and promethazine), and one opiate (hydrocodone) were evaluated in clamped femoral blood, blind stick femoral blood, and heart blood and compared using concentration ratios and linear regression analysis. |
2008-12-04 |
2023-08-12 |
Not clear |
| Simon T Rang, Jennifer Field, Colm Irvin. Serotonin toxicity caused by an interaction between fentanyl and paroxetine. Canadian journal of anaesthesia = Journal canadien d'anesthesie. vol 55. issue 8. 2008-12-02. PMID:18676387. |
serotonin toxicity caused by an interaction between fentanyl and paroxetine. |
2008-12-02 |
2023-08-12 |
Not clear |
| Simon T Rang, Jennifer Field, Colm Irvin. Serotonin toxicity caused by an interaction between fentanyl and paroxetine. Canadian journal of anaesthesia = Journal canadien d'anesthesie. vol 55. issue 8. 2008-12-02. PMID:18676387. |
to report a case of serotonin toxicity, presenting in the postoperative period, caused by an interaction between paroxetine (a selective serotonin reuptake inhibitor, ssri) and fentanyl (a phenylpiperidine opioid). |
2008-12-02 |
2023-08-12 |
Not clear |
| Sara Guzzetti, Eleonora Calcagno, Alessandro Canetta, Giuseppina Sacchetti, Claudia Fracasso, Silvio Caccia, Luigi Cervo, Roberto W Invernizz. Strain differences in paroxetine-induced reduction of immobility time in the forced swimming test in mice: role of serotonin. European journal of pharmacology. vol 594. issue 1-3. 2008-11-25. PMID:18691569. |
we studied the antidepressant-like effect of paroxetine in strains of mice carrying different isoforms of tryptophan hydroxylase-2 (tph-2), the enzyme responsible for the synthesis of brain serotonin (5-ht). |
2008-11-25 |
2023-08-12 |
mouse |
| Sara Guzzetti, Eleonora Calcagno, Alessandro Canetta, Giuseppina Sacchetti, Claudia Fracasso, Silvio Caccia, Luigi Cervo, Roberto W Invernizz. Strain differences in paroxetine-induced reduction of immobility time in the forced swimming test in mice: role of serotonin. European journal of pharmacology. vol 594. issue 1-3. 2008-11-25. PMID:18691569. |
the effect of paroxetine alone and in combination with pharmacological treatments enhancing or lowering 5-ht synthesis or melatonin was assessed in the forced swimming test in mice carrying allelic variants of tph-2 (1473c in c57bl/6 and 1473g in dba/2 and balb/c). |
2008-11-25 |
2023-08-12 |
mouse |
| Sara Guzzetti, Eleonora Calcagno, Alessandro Canetta, Giuseppina Sacchetti, Claudia Fracasso, Silvio Caccia, Luigi Cervo, Roberto W Invernizz. Strain differences in paroxetine-induced reduction of immobility time in the forced swimming test in mice: role of serotonin. European journal of pharmacology. vol 594. issue 1-3. 2008-11-25. PMID:18691569. |
enhancing 5-ht synthesis with tryptophan reinstated the antidepressant-like effect of paroxetine in dba/2j, dba/2n and balb/c mice whereas inhibition of 5-ht synthesis prevented the effect of paroxetine in c57bl/6n mice. |
2008-11-25 |
2023-08-12 |
mouse |
| Sara Guzzetti, Eleonora Calcagno, Alessandro Canetta, Giuseppina Sacchetti, Claudia Fracasso, Silvio Caccia, Luigi Cervo, Roberto W Invernizz. Strain differences in paroxetine-induced reduction of immobility time in the forced swimming test in mice: role of serotonin. European journal of pharmacology. vol 594. issue 1-3. 2008-11-25. PMID:18691569. |
these results support the importance of 5-ht synthesis in the response to ssris and suggest that melatonin does not contribute to the ability of tryptophan to rescue the antidepressant-like effect of paroxetine. |
2008-11-25 |
2023-08-12 |
mouse |
| Wen Wang, Yu Liu, Hong Zheng, Hua Ning Wang, Xiang Jin, Yun Chun Chen, Li Na Zheng, Xiao Xing Luo, Qing Rong Ta. A modified single-prolonged stress model for post-traumatic stress disorder. Neuroscience letters. vol 441. issue 2. 2008-11-05. PMID:18577419. |
additionally, paroxetine, a selective serotonin reuptake inhibitor (ssri) was administered after sps&s for 14 days to test its potential preventive effect on ptsd-like symptoms. |
2008-11-05 |
2023-08-12 |
rat |