| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gian Marco Leggio, Vincenzo Micale, Filippo Drag. Increased sensitivity to antidepressants of D3 dopamine receptor-deficient mice in the forced swim test (FST). European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 4. 2008-04-23. PMID:17804207. |
different groups of mice received one injection of the tricyclic compound, clomipramine (1, 5 and 10 mg/kg) or of one the selective serotonin reuptake inhibitors (ssris), paroxetine, sertraline or citalopram (1, 4 and 16 mg/kg), 30 min prior the behavioral test. |
2008-04-23 |
2023-08-12 |
mouse |
| Hidetaka Ota, Yasuhiro Yamaguchi, Kiyoshi Yamaguchi, Masato Eto, Masahiro Akishita, Yasuyoshi Ouch. [Paroxetine-induced hyponatremia in an elderly man due to the syndrome of inappropriate secretion of antidiuretic hormone]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. vol 45. issue 1. 2008-04-22. PMID:18332578. |
therefore sulpiride was changed to selective serotonin reuptake inhibitor, paroxetine 10mg daily. |
2008-04-22 |
2023-08-12 |
Not clear |
| Bruno P Guiard, Denis J P David, Thierry Deltheil, Franck Chenu, Erwan Le Maître, Thibault Renoir, Isabelle Leroux-Nicollet, Pierre Sokoloff, Laurence Lanfumey, Michel Hamon, Anne M Andrews, René Hen, Alain M Gardie. Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype. The international journal of neuropsychopharmacology. vol 11. issue 1. 2008-04-15. PMID:17559709. |
in keeping with these results, the selective serotonin reuptake inhibitor paroxetine failed to increase hippocampal extracellular 5-ht levels in bdnf +/- mice while it produced robust effects in wild-type littermates. |
2008-04-15 |
2023-08-12 |
mouse |
| Munehiko Ikeda, Takashi Egawa, Atsushi Yamauchi, Yoshio Sohda, Ayako Koga, Kohji Tominaga, Hideki Shuto, Yasufumi Kataok. Selective serotonin reuptake inhibitors fluvoxamine and paroxetine restore forced exercise-induced temperature dysregulation in ovariectomized mice. European journal of pharmacology. vol 579. issue 1-3. 2008-04-15. PMID:18155696. |
selective serotonin reuptake inhibitors fluvoxamine and paroxetine restore forced exercise-induced temperature dysregulation in ovariectomized mice. |
2008-04-15 |
2023-08-12 |
mouse |
| Kimberly R Tyeryar, Habiba O U Vongtau, Ashiwel S Undie. Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain. BMC neuroscience. vol 9. 2008-04-03. PMID:18218113. |
for this, drug effects on [3h]cytidine-labeled cdp-diacylglycerol and [3h]inositol-labeled phosphatidylinositides were measured in response to the tricyclics desipramine and imipramine, the selective serotonin reuptake inhibitors fluoxetine and paroxetine, the atypical antidepressants maprotiline and nomifensine, and several monoamine oxidase inhibitors. |
2008-04-03 |
2023-08-12 |
rat |
| Patrice Péran, Jean-François Démonet, Dominique Cardeba. Paroxetine-induced modulation of cortical activity supporting language representations of action. Psychopharmacology. vol 195. issue 4. 2008-03-31. PMID:17874333. |
previous studies have shown that paroxetine, a selective serotonin reuptake inhibitor, affects brain motor pathway activity in healthy subjects using simple motor tasks. |
2008-03-31 |
2023-08-12 |
human |
| Seth D Norrholm, David B Horton, Linda P Dwoski. The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes. Neuropharmacology. vol 53. issue 8. 2008-03-21. PMID:18022203. |
nonspecific [(3)h]serotonin uptake was defined as the amount of uptake remaining in the presence of fluoxetine (10microm) or paroxetine (0.05microm). |
2008-03-21 |
2023-08-12 |
rat |
| Seth D Norrholm, David B Horton, Linda P Dwoski. The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes. Neuropharmacology. vol 53. issue 8. 2008-03-21. PMID:18022203. |
in hippocampal synaptosomes, k(m) and v(max) values for [(3)h]serotonin uptake did not differ whether fluoxetine or paroxetine was used to define nonspecific uptake. |
2008-03-21 |
2023-08-12 |
rat |
| Seth D Norrholm, David B Horton, Linda P Dwoski. The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes. Neuropharmacology. vol 53. issue 8. 2008-03-21. PMID:18022203. |
however, in striatal synaptosomes, both k(m) and v(max) values for [(3)h]serotonin uptake were greater when fluoxetine, rather than paroxetine, was used to define nonspecific uptake. |
2008-03-21 |
2023-08-12 |
rat |
| Seth D Norrholm, David B Horton, Linda P Dwoski. The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes. Neuropharmacology. vol 53. issue 8. 2008-03-21. PMID:18022203. |
these data suggest that, at the concentrations employed, fluoxetine inhibits serotonin uptake at both dat and sert, whereas paroxetine only inhibits serotonin uptake at sert. |
2008-03-21 |
2023-08-12 |
rat |
| Charles B Nemeroff, Richard Entsuah, Isma Benattia, Mark Demitrack, Diane M Sloan, Michael E Thas. Comprehensive analysis of remission (COMPARE) with venlafaxine versus SSRIs. Biological psychiatry. vol 63. issue 4. 2008-02-29. PMID:17888885. |
to compare venlafaxine and selective serotonin reuptake inhibitors (ssris; fluoxetine, sertraline, paroxetine, fluvoxamine, and citalopram) in the treatment of depression. |
2008-02-29 |
2023-08-12 |
Not clear |
| Marcel D Waldinge. Premature ejaculation: state of the art. The Urologic clinics of North America. vol 34. issue 4. 2008-01-29. PMID:17983899. |
a meta-analysis of all selective serotonin reuptake inhibitors (ssris) and clomipramine studies, which were performed according to current standards of evidence-based medicine, demonstrated a similar efficacy for the daily treatment with the serotonergic antidepressants paroxetine hemihydrate, clomipramine, sertraline, and fluoxetine, with paroxetine hemihydrate exerting the strongest effect on ejaculation. |
2008-01-29 |
2023-08-12 |
Not clear |
| T Ushiroyama, A Ikeda, M Uek. Evaluation of double-blind comparison of fluvoxamine and paroxetine in the treatment of depressed outpatients in menopause transition. Journal of medicine. vol 35. issue 1-6. 2008-01-29. PMID:18084873. |
to evaluate the efficacy of the selective serotonin reuptake inhibitors (ssris) fluvoxamine and paroxetine in treating depression in the menopausal transition and to compare their efficacy, safety, side-effect profiles and drug compliance. |
2008-01-29 |
2023-08-12 |
Not clear |
| Daniël L A Van den Hove, Carlos E Blanco, Arjan Scheepens, Lieve Desbonnet, Aye-Mu Myint, Brian E Leonard, Jos Prickaerts, Harry W M Steinbusc. Prenatal maternal paroxetine treatment and neonatal mortality in the rat: a preliminary study. Neonatology. vol 93. issue 1. 2008-01-23. PMID:17652957. |
our aim was to examine the efficacy of using the selective serotonin reuptake inhibitor, paroxetine, to alleviate the symptoms of prenatal maternal stress in fisher 344 rats. |
2008-01-23 |
2023-08-12 |
rat |
| Mark J Millan, Anne Dekeyn. Discriminative stimulus properties of the selective norepinephrine reuptake inhibitor, reboxetine, in rats: a characterization with alpha/beta-adrenoceptor subtype selective ligands, antidepressants, and antagonists at neuropeptide receptors. The international journal of neuropsychopharmacology. vol 10. issue 5. 2008-01-17. PMID:17076935. |
in contrast, the 5-ht reuptake inhibitors, citalopram, sertraline and paroxetine (all >2.5), and the 5-ht reuptake inhibitors/5-ht2 receptor antagonists, nefazodone and trazodone (both >10.0), did not substitute for reboxetine. |
2008-01-17 |
2023-08-12 |
rat |
| Sabrina X Zhao, Deepak K Dalvie, Joan M Kelly, John R Soglia, Kosea S Frederick, Evan B Smith, R Scott Obach, Amit S Kalgutka. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine. Chemical research in toxicology. vol 20. issue 11. 2008-01-16. PMID:17907785. |
the primary pathway of clearance of the methylenedioxyphenyl-containing compound and selective serotonin reuptake inhibitor paroxetine in humans involves p450 2d6-mediated demethylenation to a catechol intermediate. |
2008-01-16 |
2023-08-12 |
human |
| C U Pae, P S Masand, N Ajwani, C Lee, A A Patka. Irritable bowel syndrome in psychiatric perspectives: a comprehensive review. International journal of clinical practice. vol 61. issue 10. 2007-12-19. PMID:17877658. |
english language papers cited in medline and pychinfo from january 2000 to july 2006 were searched with a combination of the following key words: irritable bowel syndrome, 5-ht, pathogenesis, comorbid, psychiatry, treatment, psychotropic drugs, antidepressant, selective serotonin reuptake inhibitors (fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram and sertraline), tricyclic antidepressants, review, meta-analysis and placebo. |
2007-12-19 |
2023-08-12 |
Not clear |
| Magí Farré, Sergio Abanades, Pere N Roset, Ana M Peiró, Marta Torrens, Bryan O'Mathúna, Mireia Segura, Rafael de la Torr. Pharmacological interaction between 3,4-methylenedioxymethamphetamine (ecstasy) and paroxetine: pharmacological effects and pharmacokinetics. The Journal of pharmacology and experimental therapeutics. vol 323. issue 3. 2007-12-17. PMID:17890444. |
a clinical trial was designed where subjects pretreated with paroxetine, one of the most potent inhibitors of both 5-hydroxytryptamine reuptake and cyp2d6 activity, were challenged with a single dose of mdma. |
2007-12-17 |
2023-08-12 |
human |
| Magí Farré, Sergio Abanades, Pere N Roset, Ana M Peiró, Marta Torrens, Bryan O'Mathúna, Mireia Segura, Rafael de la Torr. Pharmacological interaction between 3,4-methylenedioxymethamphetamine (ecstasy) and paroxetine: pharmacological effects and pharmacokinetics. The Journal of pharmacology and experimental therapeutics. vol 323. issue 3. 2007-12-17. PMID:17890444. |
it seems that paroxetine could interact with mdma at pharmacodynamic (serotonin transporter) and pharmacokinetic (cyp2d6 metabolism) levels. |
2007-12-17 |
2023-08-12 |
human |
| Malcolm W Greave. Recent advances in pathophysiology and current management of itch. Annals of the Academy of Medicine, Singapore. vol 36. issue 9. 2007-12-11. PMID:17925991. |
a stepwise approach to management of generalised itch is recommended, including broadband or narrow band ultraviolet (uv), tricyclics such as doxepin, opioid antagonists including naltrexone and selective serotonin reuptake inhibitors (ssris) such as paroxetine. |
2007-12-11 |
2023-08-12 |
Not clear |