| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Matsuda, T Kato, Y Yamamoto, H Miichi, S Ogaw. [Pharmacological studies on basic ethers (R111 and R97) with antispasmodic activity]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 72. issue 4. 1976-12-30. PMID:987972. |
(2) r111 and r97 antagonized acetylcholine, barium chloride, nicotine and serotonine-induced spasm, but not that of histamine and bradykinin. |
1976-12-30 |
2023-08-11 |
mouse |
| T B Paiva, G B Mendes, J Aboulafia, A C Paiv. Evidence against cholinergic mediation of the effect of angiotensin II on the guinea pig ileum. Pflugers Archiv : European journal of physiology. vol 365. issue 2-3. 1976-12-30. PMID:988550. |
depolarization by high doses of nicotine, and inhibition of acetylcholine synthesis by hemicholinium, did not affect the response to angiotensin. |
1976-12-30 |
2023-08-11 |
Not clear |
| R E Gibso. Ligand interactions with the acetylcholine receptor from Torpedo californica. Extensions of the allosteric model for cooperativity to half-of-site activity. Biochemistry. vol 15. issue 17. 1976-11-01. PMID:952883. |
the solubilized acetylcholine receptor from torpedo californica showed positive cooperativity in acetylcholine binding with a dissociation constant of 1.2 x 10(-8) m. blockade of acetylcholine binding by nicotine was competitive; blockade by d-tubocurarine appeared to result from an allosteric interaction that altered half of the acetylcholine binding sites to a lower affinity form; decamethonium blockade displayed properties of competitive and allosteric inhibition suggesting less specificity for decamethonium binding than seen with either nicotine or d-tubocurarine. |
1976-11-01 |
2023-08-11 |
Not clear |
| F K Okwuasaba, J T Hamilto. The effect of metoclopramide on intestinal muscle responses and the peristaltic reflex in vitro. Canadian journal of physiology and pharmacology. vol 54. issue 3. 1976-11-01. PMID:953868. |
on the guinea pig ileum, taenia coli, rabbit ileum and rat duodenum, mcp increased the tone and responses to acetylcholine, carbachol and nicotine; had no effect on responses to histamine, potassium chloride and prostaglandin e1; decreased responses to 5-hydroxytryptamine (5-ht). |
1976-11-01 |
2023-08-11 |
rat |
| P O Heiwall, A Dahlström, P A Larsso. The effect of nicotine on intra-axonal transport in cholinergic motor neurons of the rat; influence of acutely administered, non-toxic doses. Acta physiologica Scandinavica. vol 97. issue 3. 1976-11-01. PMID:961441. |
the intra-axonal transport of acetylcholine (ach) and ach-metabolizing enzymes in rat sciatic nerves was studied following nicotine treatment. |
1976-11-01 |
2023-08-11 |
rat |
| U Otten, H Thoene. Mechanisms of tyrosine hydroxylase and dopamine beta-hydroxylase induction in organ cultures of rat sympathetic ganglia by potassium depolarization and cholinomimetics. Naunyn-Schmiedeberg's archives of pharmacology. vol 292. issue 2. 1976-09-25. PMID:7752. |
carbamylcholine, acetylcholine and nicotine at concentrations of 10(-4) m elicited a selective induction of th and dbh both in intact and decentralized ganglia via nicotinic receptor stimulation. |
1976-09-25 |
2023-08-11 |
rat |
| b' A S Mirkin, V S Eremeev, V F Mashanski\\xc3\\xa. [The effect of cholinergic substances on individual mechanoreceptors--Pacinian corpuscles]. Biulleten\' eksperimental\'noi biologii i meditsiny. vol 79. issue 5. 1976-09-02. PMID:1227584.' |
acetylcholine and nicotine application to the intact pacinian corpuscle failed to stimulate the spike activity, but changed the sensitivity to the mechanical stimulation: low concentration (1.10(-6) g/ml) increased the sensitivity and high concentration (1.10(-4) g/ml) decreased it. |
1976-09-02 |
2023-08-11 |
Not clear |
| A J Pappan. Onset of chronotropic effects of nicotinic drugs and tyramine on the sinoatrial pacemaker in chick embryo heart: relationship to the development of autonomic neuroeffector transmission. The Journal of pharmacology and experimental therapeutics. vol 196. issue 3. 1976-07-06. PMID:177754. |
blockade of the inhibitory effects of nicotine hexamethonium, tetroditoxin and atropine supported the conclusion that nicotine initiated propagated impulses in postganglionic cholinergic nerves and released acetylcholine to act on atropine-sensitive receptors on pacemaker cells. |
1976-07-06 |
2023-08-11 |
chicken |
| J A Bevan, G Haeusle. Electrical events associated with the action of nicotine at the adrenergic nerve terminal. Archives internationales de pharmacodynamie et de therapie. vol 218. issue 1. 1976-03-24. PMID:2124. |
during the nicotine infusion and immediately afterwards, the antidromic response to acetylcholine and the effector responses associated with the adrenergic transmitter release by acetylcholine and sympathetic nerve stimulation were blocked. |
1976-03-24 |
2023-08-11 |
cat |
| J P Famaey, J Fontaine, J Reus. Inhibiting effects of morphine, chloroquine, nonsteroidal and steroidal anti-inflammatory drugs on electrically-induced contractions of guinea-pig ileum and the reversing effect of prostaglandins. Agents and actions. vol 5. issue 4. 1976-03-20. PMID:1211309. |
the reversing action of nicotine could be related to a release of acetylcholine while a sensitization of guinea-pig ileum smooth muscle to acetylcholine could explain the reversing properties of prostaglandins. |
1976-03-20 |
2023-08-11 |
Not clear |
| P Mitznegg, E Schubert, W Domschke, U Strunz, S Domschke, K Schwemmle, L Demling, F Hei. [Mode of action of bisacodyl (dulcolax) on isolated muscles of human colon (author's transl)]. Klinische Wochenschrift. vol 53. issue 10. 1976-02-09. PMID:1195655. |
maximal contractions achieved by 10 mug/ml of bisacodyl were quite comparable to those due to 1 mug/ml of acetylcholine, 1 mug/ml of histamine and 0.5 mug/ml of nicotine, respectively. |
1976-02-09 |
2023-08-11 |
human |
| O S Steinsland, R F Furchgot. Vasoconstriction of the isolated rabbit ear artery caused by nicotinic agonists acting on adrenergic neurons. The Journal of pharmacology and experimental therapeutics. vol 193. issue 1. 1975-08-22. PMID:237110. |
in the perfused isolated central ear artery of the rabbit, nicotine, acetylcholine (ach), tetramethylammonium (tma) and carbachol (cch) at high concentrations (greater than 1 mug/ml) produced transient vasoconstriction. |
1975-08-22 |
2023-08-11 |
rabbit |
| O S Steinsland, R F Furchgot. Desensitization of the adrenergic neurons of the isolated rabbit ear artery to nicotinic agonists. The Journal of pharmacology and experimental therapeutics. vol 193. issue 1. 1975-08-22. PMID:1133760. |
at 37 degrees c the vasoconstrictor response of the isolated, perfused rabbit ear artery to an infusion of nicotine or acetylcholine (ach) was transient--rising rapidly to a peak and then fading completely within a minute or two. |
1975-08-22 |
2023-08-11 |
rabbit |
| K Kar, V N Puri, G K Patnaik, R N Sur, B N Dhawan, D K Kulshrestha, R P Rastog. Spasmolytic constituents of Cedrus deodara (Roxb.) Loud: pharmacological evaluation of himachalol. Journal of pharmaceutical sciences. vol 64. issue 2. 1975-08-04. PMID:47907. |
the pharmacological studies of himachalol on various isolated smooth muscles (guinea pig ileum, rabbit jejunum, rat uterus, and guinea pig seminal vesicle) and against different agonists (acetylcholine, histamine, serotonin, nicotine, and barium chloride) indicated spasmolytic activity similar to that of papaverine. |
1975-08-04 |
2023-08-11 |
rabbit |
| N Ambache, S W Killick, M A Za. The rabbit rectococcygeus: a ganglion-free parasympathetically innervated preparation. British journal of pharmacology. vol 52. issue 2. 1975-06-12. PMID:4155988. |
single-pulse twitches were greatly potentiated in amplitude and duration only when both cholinesterases were inhibited.4 the preparations could not be made to contract by nicotine (2.1-21 mum) even after cholinesterase inhibition, suggesting an absence of ganglion-cells; with nicotine (105-210 mum) small, atropine-susceptible responses were elicited, which were non-ganglionic because they were not reduced by tetrodotoxin.5 rectococcygeus preparations that had been treated with physostigmine released acetylcholine into the bath fluid on electrical stimulation.6 the motor transmission was paralyzed by botulinum toxin (type a) and abolished by atropine; the block of muscarinic receptors by atropine was effective against both endogenous and exogenous acetylcholine.7 inhibitory adrenoceptors and scanty motor alpha-adrenoceptors were detected in the smooth muscle.8 strong inhibitions of motor transmission and of rhythmic activity were produced by noradrenaline (but not by tyramine), by isoprenaline, and, after phentolamine, also by adrenaline and phenylephrine. |
1975-06-12 |
2023-08-11 |
rabbit |
| b' K Lederis, M Medakovi\\xc4\\x8. Pharmacological observations on the hypotensive action of extracts of teleost fish Urophyses (urotensin I) in the rat. British journal of pharmacology. vol 51. issue 3. 1975-06-12. PMID:4375526.' |
nicotine, acetylcholine, noradrenaline, isoprenaline and histamine were inhibited.5 in conscious rats, pressor effects of adrenaline, noradrenaline, nicotine and angiotensin ii, and depressor effects of acetylcholine and bradykinin, were decreased or inhibited, whereas the hypotensive effect of phenoxybenzamine was potentiated by previous administration of urotensin i. carotid occlusion reflex was partially inhibited by lower doses of urotensin and abolished by higher doses in rats lightly anaesthetized with chloralose. |
1975-06-12 |
2023-08-11 |
rat |
| M H Fran. Cardiovascular chemoreflexes from the perfused innervated ileum of the cat. The American journal of physiology. vol 228. issue 3. 1975-05-19. PMID:1115258. |
addition of acetylcholine or nicotine to the perfusion inflow was followed by increases of systemic arterial pressure. |
1975-05-19 |
2023-08-11 |
cat |
| M H Fran. Cardiovascular chemoreflexes from the perfused innervated ileum of the cat. The American journal of physiology. vol 228. issue 3. 1975-05-19. PMID:1115258. |
calculated mean concentrations of 32 mug/ml acetylcholine or 35 mug/ml nicotine in the perfusion fluid induced mean pressor responses of 19 and 23 mmhg. |
1975-05-19 |
2023-08-11 |
cat |
| L G Magazanik, N N Potap'ev. [The blocking action of snake venom polypeptides on the cholinergic mechanisms of leech dorsal muscle]. Biulleten' eksperimental'noi biologii i meditsiny. vol 79. issue 1. 1975-05-10. PMID:1111642. |
it was shown that these neurotoxins failed to inhibit the responses to mononitrogen cholinomimetics (acetylcholine, nicotine, carbamylcholine, etc.). |
1975-05-10 |
2023-08-11 |
Not clear |
| S D Jaanus, R P Rubi. Analysis of the role of cyclic adenosine 3',5'-monophosphate in catecholamine release. The Journal of physiology. vol 237. issue 2. 1974-06-26. PMID:4363455. |
perfusion with acetylcholine (ach) or nicotine increased cyclic amp both in the intact adrenal and in the perfusate. |
1974-06-26 |
2023-08-11 |
cat |