| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J L Waddington, A J Cros. Baclofen and muscimol: behavioural and neurochemical sequelae of unilateral intranigral administration and effects on 3H-GABA receptor binding. Naunyn-Schmiedeberg's archives of pharmacology. vol 306. issue 3. 1979-10-24. PMID:471079. |
the behavioural effects of both drugs were only weakly antagonised by haloperidol and were not antagonised by 6-hydroxydopamine lesions of ipsilateral dopamine (da) neurons, indicating that these responses were independent of daergic mechanisms. |
1979-10-24 |
2023-08-11 |
rat |
| P C Waldmeier, A A Delini-Stul. Serotonin--dopamine interactions in the nigrostriatal system. European journal of pharmacology. vol 55. issue 4. 1979-10-17. PMID:572774. |
in contrast, the serotonin antagonists methysergide, mianserin and cinanserin antagonized the acceleration of dopamine turnover induced by haloperidol. |
1979-10-17 |
2023-08-11 |
rat |
| R Horowski, K J Grä. Neuroendocrine effects of neuropsychotropic drugs and their possible influence on toxic reactions in animals and man -- the role of the dopamine-prolactin system. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement. issue 2. 1979-09-25. PMID:288372. |
in rats, all functional dopamine antagonists (reserpine alone or combined with alpha-methyl-p-tyrosine or benserazide, haloperidol, spiroperidol, sulpiride) increased serum prl levels. |
1979-09-25 |
2023-08-11 |
rat |
| Z Hochber. Abnormal excretion of phenolic acids in rheumatic chorea. Israel journal of medical sciences. vol 15. issue 3. 1979-09-25. PMID:457373. |
sydenham's chorea can be successfully treated with haloperidol, an agent that is known to interfere with the binding of dopamine to its receptors. |
1979-09-25 |
2023-08-11 |
Not clear |
| B Angrist, M Ain, J Rotrosen, S Gershon, F S Halpern, E J Sacha. Behavioral and neuroendocrine effects of low dose ET-495: antagonism by haloperidol. Journal of neural transmission. vol 44. issue 4. 1979-09-17. PMID:458429. |
low doses of the dopamine agonist et-495 were administered to nonpsychotic volunteer subjects by slow intravenous infusion, followed by a bolus of 1.5--2.5 mg haloperidol. |
1979-09-17 |
2023-08-11 |
human |
| J M Loeb, M Vassall. Adrenergic mechanisms in postvagal tachycardia. The Journal of pharmacology and experimental therapeutics. vol 210. issue 1. 1979-09-01. PMID:448648. |
postvagal tachycardia: 1) is not affected by ventricular or atrial drive; 2) is enhanced by the application of either norepinephrine or dopamine on the sinus node area; 3) is increased in magnitude and duration by the catecholamine uptake blockers desipramine and phenoxybenzamine; 4) is significantly reduced by beta blockade with propranolol; 5) is not affected by alpha blockade with phentolamine or dopaminergic blockade with haloperidol; 6) is not affected by disulfiram, a drug which inhibits dopamine beta-hydroxylase and thereby increases endogenous dopamine; 7) rises more slowly to a smaller peak after bretylium; and 8) is enhanced by phenoxybenzamine, but not by desipramine, after destruction of sympathetic nerves by 6-hydroxydopamine. |
1979-09-01 |
2023-08-11 |
dog |
| J C Cheronis, L Erinoff, A Heller, P C Hoffman. Pharmacological analysis of the functional ontogeny of the nigrostriatal dopaminergic neurons. Brain research. vol 169. issue 3. 1979-08-16. PMID:36209. |
nevertheless, despite the absence of neuronal activity at 4 days of age, these neurons are capable of generating and conducting impulse traffic since both 4- and 10-day-old rats showed increased striatal dihydroxyphenylacetic acid (dopac) levels when treated with haloperidol indicating increased dopamine release; such increase in dopac being dependent on an intact pathway. |
1979-08-16 |
2023-08-11 |
rat |
| R Horowsk. Hypothermic action of lisuride in rats and differences to bromocriptine in the antagonistic effect of neuroleptics. Naunyn-Schmiedeberg's archives of pharmacology. vol 306. issue 2. 1979-08-16. PMID:36572. |
the effect of both drugs could be reduced by pretreatment with the dopamine antagonist haloperidol, which indicated a dopaminergic action of both drugs. |
1979-08-16 |
2023-08-11 |
rat |
| G Di Chiara, M L Porceddu, M Morelli, M L Mulas, G L Gess. Substantia nigra as an out-put station for striatal dopaminergic responses: role of a GABA-mediated inhibition of pars reticulata neurons. Naunyn-Schmiedeberg's archives of pharmacology. vol 306. issue 2. 1979-08-16. PMID:571967. |
unilateral nigral lesions with kainic acid result in an ipsilateral turning upon administration of apomorphine, a dopamine (da)-receptor agonist and in contralateral turning upon administration of haloperidol, a da-receptor blocker. |
1979-08-16 |
2023-08-11 |
Not clear |
| M P Fernandez-Tome, P Sanchez-Blazquez, J del Ri. Impairment by apomorphine of one-trial passive avoidance learning in mice: the opposing roles of the dopamine and noradrenaline systems. Psychopharmacology. vol 61. issue 1. 1979-07-28. PMID:35807. |
of the dopamine receptor-blocking agents used, haloperidol (0.125--1 mg/kg), but not chlorpromazine or clozapine (0.25--4 mg/kg), prevented the apomorphine effect. |
1979-07-28 |
2023-08-11 |
mouse |
| P Zandberg, W De Jong, D De Wie. Effect of catecholamine-receptor stimulating agents on blood pressure after local application in the nucleus tractus solitarii of the medulla oblongata. European journal of pharmacology. vol 55. issue 1. 1979-07-28. PMID:374097. |
prior application of haloperidol, yohimbine and phentolamine antagonized the hypotensive response to dopamine and alpha-methylnoradrenaline. |
1979-07-28 |
2023-08-11 |
rat |
| P Bevan, C M Bradshaw, R Y Pun, N T Slater, E Szabad. The action of microelectrophoretically applied (3,4-dihydroxy-phenylamino)-2-imidazoline (DPI) on single cortical neurones. British journal of pharmacology. vol 65. issue 4. 1979-07-25. PMID:435693. |
the dopamine antagonist, haloperidol, could discriminate between excitatory responses to dpi and dopamine: responses to dopamine were abolished, whereas responses to dpi, and to a control agonist, acetylcholine, were unaffected. |
1979-07-25 |
2023-08-11 |
rat |
| J C Miller, A J Friedhof. Effects of haloperidol and apomorphine on the K+-depolarized overflow of [3H] dopamine from rat striatal slices. Biochemical pharmacology. vol 28. issue 5. 1979-07-25. PMID:444255. |
effects of haloperidol and apomorphine on the k+-depolarized overflow of [3h] dopamine from rat striatal slices. |
1979-07-25 |
2023-08-11 |
rat |
| E Creso, V De Marino, L Donatelli, G Pagnin. [Neuropsychopharmacological effects of TCDD]. Bollettino della Societa italiana di biologia sperimentale. vol 54. issue 17. 1979-07-25. PMID:749917. |
haloperidol (dopamine antagonist) inhibits the stimulation produced by tcdd. |
1979-07-25 |
2023-08-11 |
rat |
| D M Jackson, R Dunstan, A Perringto. The hyperkinetic syndrome following long-term haloperidol treatment: involvement of dopamine and noradrenaline. Journal of neural transmission. vol 44. issue 3. 1979-07-16. PMID:571456. |
the hyperkinetic syndrome following long-term haloperidol treatment: involvement of dopamine and noradrenaline. |
1979-07-16 |
2023-08-11 |
mouse |
| G Kapatos, M J Zigmon. Effect of haloperidol on dopamine synthesis and tyrosine hydroxylase in striatal synaptosomes. The Journal of pharmacology and experimental therapeutics. vol 208. issue 3. 1979-06-29. PMID:34711. |
effect of haloperidol on dopamine synthesis and tyrosine hydroxylase in striatal synaptosomes. |
1979-06-29 |
2023-08-11 |
Not clear |
| N Vaysse, J P Esteve, B Brenac, J P Moatti, J P Pasca. Action of dopamine on cyclic AMP-tissue level in the rat pancreas. Interaction with secretin. Biomedicine / [publiee pour l'A.A.I.C.I.G.]. vol 28. issue 6. 1979-06-11. PMID:218644. |
haloperidol 10(-4)m, a dopamine blocking agent almost completely inhibited the response to dopamine but had no effect on the response to secretin. |
1979-06-11 |
2023-08-11 |
rat |
| D A Brown, M P Caulfiel. Hyperpolarizing 'alpha 2'-adrenoceptors in rat sympathetic ganglia. British journal of pharmacology. vol 65. issue 3. 1979-06-11. PMID:218668. |
hyperpolarization was unaffected by changing the temperature from 25 degrees to 37 degrees c.3 hyperpolarization was also produced by the following agonists (potencies relative to (-)-noradrenaline): (-)-noradrenaline 1; (+/-)-isoprenaline 0.41; (-)-phenylephrine 0.40; (+)-noradrenaline 0.13; 2-amino-6,7-dihydroxy tetrahydronaphthalene (adtn) 0.25; dopamine 0.1; methoxamine 0.012; amidephrine 0.0015.4 responses were antagonized by phentolamine (1 mum) but not by (+/-)-propranolol (1 mum), haloperidol (10 mum) or alpha-flupenthixol (1 mum). |
1979-06-11 |
2023-08-11 |
rat |
| T Muraki, Y Tokunag. Effects of morphine on the serum prolactin levels of morphine-tolerant and nontolerant male rats and of the in vitro release of pituitary prolactin. Japanese journal of pharmacology. vol 28. issue 6. 1979-05-26. PMID:745306. |
although neither haloperidol nor morphine increased the release of prl from the isolated anterior pituitary, haloperidol, but not morphine, reversed the inhibition by dopamine of the in vitro release of pituitary prl. |
1979-05-26 |
2023-08-11 |
rat |
| T Muraki, Y Tokunag. Effects of morphine on the serum prolactin levels of morphine-tolerant and nontolerant male rats and of the in vitro release of pituitary prolactin. Japanese journal of pharmacology. vol 28. issue 6. 1979-05-26. PMID:745306. |
these results indicate that tolerance develops regarding the effect of morphine with a resulting increase in the serum prl levels, abstinence precipitated by naloxone has no effect on the serum prl levels, the mechanism of morphine involved in increase in the serum prl is different from that of haloperidol as the effect of haloperidol is not antagonized by naloxone and morphine does not antagonize the effect of dopamine which inhibits the release of prl from the anterior pituitary in vitro. |
1979-05-26 |
2023-08-11 |
rat |