| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M M Murburg, D Paly, C W Wilkinson, R C Veith, K L Malas, D M Dors. Haloperidol increases plasma beta endorphin-like immunoreactivity and cortisol in normal human males. Life sciences. vol 39. issue 4. 1986-09-17. PMID:2942747. |
to investigate possible central dopaminergic regulation of beta-endorphin-like immunoreactivity (beta e-li) and adrenocorticotropin (acth) release in humans, we gave the dopamine antagonist haloperidol or placebo intravenously to twelve normal male subjects and measured beta e-li and cortisol for 120 minutes following injection. |
1986-09-17 |
2023-08-11 |
human |
| P W Kalivas, R Richardson-Carlso. Endogenous enkephalin modulation of dopamine neurons in ventral tegmental area. The American journal of physiology. vol 251. issue 2 Pt 2. 1986-09-17. PMID:3017134. |
thiorphan produced a dose-dependent (0.3-3.33 micrograms) increase in spontaneous motor activity that was blocked by pretreatment with the opioid antagonist naloxone (2.0 mg/kg ip) or the dopamine antagonist haloperidol (0.1 mg/kg ip). |
1986-09-17 |
2023-08-11 |
rat |
| M C González, A R Artalejo, C Montiel, P P Hervás, A G Garcí. Characterization of a dopaminergic receptor that modulates adrenomedullary catecholamine release. Journal of neurochemistry. vol 47. issue 2. 1986-09-17. PMID:3734785. |
whereas spiperone and haloperidol potently displaced such binding, 3,4-dihydroxyphenylethylamine (dopamine) and sulpiride were poorer displacers, and sch23390, prazosin, phenoxybenzamine, propranolol, bay-k-8644, and nitrendipine did not displace [3h]spiperone bound. |
1986-09-17 |
2023-08-11 |
cat |
| E M Pich, R Samani. Disinhibitory effects of buspirone and low doses of sulpiride and haloperidol in two experimental anxiety models in rats: possible role of dopamine. Psychopharmacology. vol 89. issue 1. 1986-09-16. PMID:2874581. |
disinhibitory effects of buspirone and low doses of sulpiride and haloperidol in two experimental anxiety models in rats: possible role of dopamine. |
1986-09-16 |
2023-08-11 |
rat |
| A Crider, L Blockel, P R Solomo. A selective attention deficit in the rat following induced dopamine receptor supersensitivity. Behavioral neuroscience. vol 100. issue 3. 1986-09-16. PMID:3730137. |
in experiment 1, dopamine (da) receptor supersensitivity was induced in rats by prolonged pretreatment with haloperidol. |
1986-09-16 |
2023-08-11 |
rat |
| M Hashimoto, T Hirai, K Oguchi, H Yasuhar. Effect of caerulein with haloperidol on monoamine contents in rat brain regions treated with methamphetamine. Japanese journal of pharmacology. vol 41. issue 1. 1986-09-16. PMID:3735809. |
with a combination of caerulein and haloperidol, dopamine contents in methamphetamine treated-rats were significantly decreased in the striatum. |
1986-09-16 |
2023-08-11 |
rat |
| M J Lavin, V Andrew. Is topical haloperidol a useful glaucoma treatment? The British journal of ophthalmology. vol 70. issue 6. 1986-08-18. PMID:3718908. |
although dopamine blocking agents are effective in reducing intraocular pressure in experimental animals, topical haloperidol appears unlikely to be clinically useful in the treatment of glaucoma. |
1986-08-18 |
2023-08-11 |
human |
| J Ramwani, R K Mishr. Purification of bovine striatal dopamine D-2 receptor by affinity chromatography. The Journal of biological chemistry. vol 261. issue 19. 1986-08-06. PMID:2941422. |
elution of the receptor was also biospecific, as dopaminergic drugs were most effective (spiroperidol greater than haloperidol greater than dopamine) in eluting the bound receptor; whereas other agents, e.g. |
1986-08-06 |
2023-08-11 |
cattle |
| S Ahlenius, V Hillegaar. Involvement of extrapyramidal motor mechanisms in the suppression of locomotor activity by antipsychotic drugs: a comparison between the effects produced by pre- and post-synaptic inhibition of dopaminergic neurotransmission. Pharmacology, biochemistry, and behavior. vol 24. issue 5. 1986-08-04. PMID:2873588. |
the effects of two proposed dopaminergic autoreceptor agonists, (-)3-(3-hydroxyphenyl)-n-n-propylpiperidine (3-ppp) and the azepine derivative b-ht 920, on spontaneous locomotor activity, treadmill locomotion, and catalepsy in the rat have been compared with the effects produced by the postsynaptic dopamine (da) receptor blocking agent haloperidol. |
1986-08-04 |
2023-08-11 |
rat |
| C Saligaut, N Moore, P Chretien, M Daoust, F Boismar. Survival time in hypoxic mice: differentiation between apomorphine-induced hypothermia and antihypoxic properties. Methods and findings in experimental and clinical pharmacology. vol 8. issue 4. 1986-07-30. PMID:3724296. |
both these effects were mediated by cerebral dopamine receptors, however with different affinity for the neuroleptics haloperidol and sulpiride. |
1986-07-30 |
2023-08-11 |
mouse |
| I S Login, A M Judd, R M MacLeo. Dopamine inhibits maitotoxin-stimulated pituitary 45Ca2+ efflux and prolactin release. The American journal of physiology. vol 250. issue 6 Pt 1. 1986-07-23. PMID:3717333. |
haloperidol (0.1 microm) blocked the effects of 0.1 microm dopamine on both parameters. |
1986-07-23 |
2023-08-11 |
rat |
| M A Sherman, D S Linthicum, M B Bolge. Haloperidol binding to monoclonal antibodies: conformational analysis and relationships to D-2 receptor binding. Molecular pharmacology. vol 29. issue 6. 1986-07-18. PMID:2423865. |
in addition, dopamine was able to completely displace 4 nm [3h]haloperidol from mab d at a concentration of 6 mm. |
1986-07-18 |
2023-08-11 |
mouse |
| C P Downes, P E Lewis, M A Ston. A comparison of the binding of sigma opioids and phencyclidine, and the interaction with antipsychotic drugs in rat brain membranes. British journal of pharmacology. vol 88. issue 1. 1986-07-18. PMID:2871882. |
furthermore selective displacement of (+)-[3h]-skf10,047 but not of [3h]-pcp was demonstrated using the non-selective dopamine ligand haloperidol and the dopamine2-selective ligand 3-(3-hydroxyphenyl)n-n-propylpiperidine (3ppp). |
1986-07-18 |
2023-08-11 |
rat |
| K A Strait, R Kuczensk. Dopamine autoreceptor regulation of the kinetic state of striatal tyrosine hydroxylase. Molecular pharmacology. vol 29. issue 6. 1986-07-18. PMID:2872588. |
this effect of dopamine and apomorphine can in turn be blocked by preincubation of the synaptosomes with the dopamine receptor antagonist haloperidol (ic50 30 nm and 4.5 nm, respectively) or chlorpromazine (ic50 50 nm versus apomorphine). |
1986-07-18 |
2023-08-11 |
Not clear |
| K A Strait, R Kuczensk. Dopamine autoreceptor regulation of the kinetic state of striatal tyrosine hydroxylase. Molecular pharmacology. vol 29. issue 6. 1986-07-18. PMID:2872588. |
the observations that dopamine and apomorphine can block forskolin activation of tyrosine hydroxylase, that this blockade can in turn be prevented by preincubation with haloperidol or chlorpromazine, and that the amount of dopamine required for blockade of forskolin activation in synaptosomes has no effect on tyrosine hydroxylase when added to the enzyme assay constitute the first clear evidence of a presynaptic dopamine receptor (autoreceptor). |
1986-07-18 |
2023-08-11 |
Not clear |
| K Kashihara, M Sato, Y Fujiwara, T Harada, T Ogawa, S Otsuk. Effects of intermittent and continuous haloperidol administration on the dopaminergic system in the rat brain. Biological psychiatry. vol 21. issue 7. 1986-07-16. PMID:3011131. |
on the seventh day after cessation of injections or removal of pumps, the changes in dopamine (da) metabolism after a challenge dose of haloperidol (1 mg/kg, intraperitoneally) were noted, and the number of [3h]spiperone binding sites in the striatum were recorded. |
1986-07-16 |
2023-08-11 |
rat |
| L J Thal, K Laing, S G Horowitz, M H Makma. Dopamine stimulates rat cortical somatostatin release. Brain research. vol 372. issue 2. 1986-07-07. PMID:2871899. |
dopamine increased the release of somatostatin from cortex and this effect of dopamine was blocked by haloperidol and other dopaminergic antagonists. |
1986-07-07 |
2023-08-11 |
rat |
| F Weiss, A Ettenber. Comparison of circling induced by unilateral intrastriatal microinjections of haloperidol, clozapine and CCK-8 in rats. Pharmacology, biochemistry, and behavior. vol 24. issue 4. 1986-07-07. PMID:3012602. |
to test this possibility, the present study examined the pharmacological action of cck-8 by comparing its effects on da-mediated circling behavior with those of a typical (haloperidol; hal) and an atypical (clozapine; clz) dopamine antagonist neuroleptic drug. |
1986-07-07 |
2023-08-11 |
rat |
| J Vayssette, N Vaysse, A Ribe. Dopamine receptors in pancreatic acinar cells from dog. European journal of pharmacology. vol 122. issue 3. 1986-07-03. PMID:2872068. |
the effect of dopamine was potently blocked by dopamine receptor antagonists such as cis-(z)-flupenthixol, haloperidol, fluphenazine, whereas spiperone, sulpiride and domperidone were weakly active. |
1986-07-03 |
2023-08-11 |
dog |
| V Georgiev, L György, D Getova, V Markovsk. Some central effects of angiotensin II. Interactions with dopaminergic transmission. Acta physiologica et pharmacologica Bulgarica. vol 11. issue 4. 1986-06-27. PMID:3012944. |
this effect was potentiated by nomifensine (a dopamine uptake blocker) and was blocked by haloperidol. |
1986-06-27 |
2023-08-11 |
mouse |