| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mani Erfanian Abdoust, Monja Isabel Froböse, Alfons Schnitzler, Elisabeth Schreivogel, Gerhard Jocha. Dopamine and acetylcholine have distinct roles in delay- and effort-based decision-making in humans. PLoS biology. vol 22. issue 7. 2024-07-12. PMID:38995982. |
we found opposing effects of dopamine d2 (haloperidol) and acetylcholine m1 receptor (biperiden) antagonism on specific components of effort-based decision-making in healthy humans: haloperidol decreased, whereas biperiden increased the willingness to exert physical effort. |
2024-07-12 |
2024-07-15 |
Not clear |
| Chuyu Chen, Meghan Masotti, Nathaniel Shepard, Vanessa Promes, Giulia Tombesi, Daniel Arango, Claudia Manzoni, Elisa Greggio, Sabine Hilfiker, Yevgenia Kozorovitskiy, Loukia Parisiado. LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons. bioRxiv : the preprint server for biology. 2024-06-19. PMID:38895420. |
haloperidol is used to manage psychotic symptoms in several neurological disorders through mechanisms that involve antagonism of dopamine d2 receptors that are highly expressed in the striatum. |
2024-06-19 |
2024-06-21 |
mouse |
| Chuyu Chen, Meghan Masotti, Nathaniel Shepard, Vanessa Promes, Giulia Tombesi, Daniel Arango, Claudia Manzoni, Elisa Greggio, Sabine Hilfiker, Yevgenia Kozorovitskiy, Loukia Parisiado. LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons. bioRxiv : the preprint server for biology. 2024-06-19. PMID:38895420. |
our study suggests that lrrk2 kinase plays a key role in striatal dopamine d2 receptor signaling underlying the undesirable motor side effects of haloperidol. |
2024-06-19 |
2024-06-21 |
mouse |
| Andreea O Diaconescu, Povilas Karvelis, Daniel J Hauk. Rethinking interpersonal judgments: dopamine antagonists impact attributional dynamics. Trends in cognitive sciences. 2024-05-26. PMID:38797602. |
investigated the effects of haloperidol, a d2/d3 dopamine antagonist, on social attributions. |
2024-05-26 |
2024-05-31 |
Not clear |
| Takumi Yamasaki, Yasushi Kiyokawa, Arisa Munetomo, Yukari Takeuch. Naloxone increases conditioned fear responses during social buffering in male rats. The European journal of neuroscience. 2024-04-22. PMID:38644789. |
given that opioids, dopamine, oxytocin and vasopressin play an important role in affiliative behaviour, here, we assessed the effects of the most well-known antagonists, naloxone (opioid receptor antagonist), haloperidol (dopamine d2 receptor antagonist), atosiban (oxytocin receptor antagonist) and sr49059 (vasopressin v1a receptor antagonist), on social buffering. |
2024-04-22 |
2024-04-24 |
human |
| Chang Hyeon Kong, Kyungnam Cho, Ji Won Min, Jae Youn Kim, Keontae Park, Do Yeon Kim, Mijin Jeon, Woo Chang Kang, Seo Yun Jung, Jae Yeol Lee, Jong Hoon Ry. Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-10-09. PMID:37812895. |
also, oa normalised the levels of dopamine and acetylcholine in the striatum which were increased by haloperidol. |
2023-10-09 |
2023-10-15 |
mouse |
| Cátia Santa, Diana Rodrigues, Joana F Coelho, Sandra I Anjo, Vera M Mendes, Diogo Bessa-Neto, Michael J Dunn, David Cotter, Graça Baltazar, Patrícia Monteiro, Bruno Manada. Chronic treatment with D2-antagonist haloperidol leads to inhibitory/excitatory imbalance in striatal D1-neurons. Translational psychiatry. vol 13. issue 1. 2023-10-06. PMID:37803004. |
haloperidol is a typical antipsychotic medication used in the treatment of schizophrenia that is known to antagonize dopamine d2 receptors, which are abundantly expressed in the striatum. |
2023-10-06 |
2023-10-15 |
mouse |
| Cátia Santa, Diana Rodrigues, Joana F Coelho, Sandra I Anjo, Vera M Mendes, Diogo Bessa-Neto, Michael J Dunn, David Cotter, Graça Baltazar, Patrícia Monteiro, Bruno Manada. Chronic treatment with D2-antagonist haloperidol leads to inhibitory/excitatory imbalance in striatal D1-neurons. Translational psychiatry. vol 13. issue 1. 2023-10-06. PMID:37803004. |
cell-type specific electrophysiological recordings further revealed that haloperidol not only reduces the excitability of striatal medium spiny neurons expressing dopamine d2 receptors (d2-msns) but also affects d1-msns by increasing the ratio of inhibitory/excitatory synaptic transmission (i/e ratio) specifically onto d1-msns but not d2-msns. |
2023-10-06 |
2023-10-15 |
mouse |
| Toshiro Niwa, Yuka Yamamot. Stimulatory and inhibitory effect of antipsychotic agents including dopaminergic neuro-depressants on dopamine formation from p-tyramine mediated by cytochrome P450 2D6. Drug metabolism and bioanalysis letters. 2023-09-15. PMID:37711131. |
the effects of antipsychotic agents, including dopamine d2 receptor blocking agents such as haloperidol, chlorpromazine, and sulpiride, and related compounds such as mirtazapine and sertraline, on dopamine formation from p-tyramine catalyzed by cytochrome p450 (cyp) 2d6.2 (arg296cys;ser486thr), cyp2d6.10 (pro34ser;ser486thr), and cyp2d6.39 (ser486thr) were compared with those of cyp2d6.1. |
2023-09-15 |
2023-10-07 |
Not clear |
| Karima Chakroun, Antonius Wiehler, Ben Wagner, David Mathar, Florian Ganzer, Thilo van Eimeren, Tobias Sommer, Jan Peter. Dopamine regulates decision thresholds in human reinforcement learning in males. Nature communications. vol 14. issue 1. 2023-09-04. PMID:37666865. |
here, we examine dopaminergic mechanisms underlying human reinforcement learning and action selection via a combined pharmacological neuroimaging approach in male human volunteers (n = 31, within-subjects; placebo, 150 mg of the dopamine precursor l-dopa, 2 mg of the d2 receptor antagonist haloperidol). |
2023-09-04 |
2023-09-07 |
human |
| Nannan Gao, Zhipeng Liu, Hongsheng Wang, Chen Shen, Zhaoqi Dong, Wanpeng Cui, Wen-Cheng Xiong, Lin Me. Deficiency of Cullin 3, a protein encoded by a schizophrenia and autism risk gene, impairs behaviors by enhancing the excitability of ventral tegmental area (VTA) DA neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-08-09. PMID:37558490. |
behavioral impairments were attenuated by dopamine d2 receptor antagonist haloperidol and chemogenetic inhibition of da neurons. |
2023-08-09 |
2023-08-16 |
mouse |
| Shobhit Kumar, Satish Kumar Gupta, Rakesh Pahw. Designing lisuride intranasal nanocarrier system for reduction of oxidative damage with enhanced dopamine level in brain for Parkinsonism. Journal of psychiatric research. vol 165. 2023-07-30. PMID:37517241. |
when lisuride ne was administered intranasally resulted in considerably higher dopamine concentrations (17.48 ± 0.05 ng/ml) in comparison to rats receiving haloperidol (7.28 ± 0.02 ng/ml). |
2023-07-30 |
2023-08-14 |
rat |
| Sanja Strbe, Ivan Maria Smoday, Ivan Krezic, Luka Kalogjera, Vlasta Vukovic, Helena Zizek, Slaven Gojkovic, Hrvoje Vranes, Ivan Barisic, Suncana Sikiric, Marijan Tepes, Katarina Oroz, Filip Brkic, Martin Drinkovic, Lidija Beketic Oreskovic, Jelena Popic, Alenka Boban Blagaic, Anita Skrtic, Mario Staresinic, Sven Seiwerth, Predrag Sikiri. Innate Vascular Failure by Application of Neuroleptics, Amphetamine, and Domperidone Rapidly Induced Severe Occlusion/Occlusion-like Syndromes in Rats and Stable Gastric Pentadecapeptide BPC 157 as Therapy. Pharmaceuticals (Basel, Switzerland). vol 16. issue 6. 2023-06-28. PMID:37375736. |
in rats with complete calvariectomy, medication (bpc 157 10 µg/kg, 10 ng/kg ip or ig) was given 5 min after distinctive dopamine agents (mg/kg ip) (haloperidol (5), fluphenazine (5), clozapine (10), risperidone (5), olanzapine (10), quetiapine (10), or aripiprazole (10), domperidone (25), amphetamine (10), and combined amphetamine and haloperidol) and assessed at 15 min thereafter. |
2023-06-28 |
2023-08-14 |
rat |
| Luis Felipe Sarmiento, Jorge Alexander Ríos-Flórez, Hector Andres Paez-Ardila, Pêssi Socorro Lima de Sousa, Antonio Olivera-La Rosa, Anderson Manoel Herculano Oliveira da Silva, Amauri Gouvei. Pharmacological Modulation of Temporal Discounting: A Systematic Review. Healthcare (Basel, Switzerland). vol 11. issue 7. 2023-04-13. PMID:37046974. |
the most important findings were the involvement of dopamine modulation in a u-shape for choosing the delayed outcome (metoclopradime, haloperidol, and amisulpride). |
2023-04-13 |
2023-08-14 |
Not clear |
| Maciej M Jankowski, Bogna M Ignatowska-Jankowska, Wojciech Glac, Marek Wiergowski, Paulina Kazmierska-Grebowska, Artur H Swiergie. Intravenous haloperidol and cocaine alter the distribution of T CD3 Clinical and experimental pharmacology & physiology. 2023-02-21. PMID:36802086. |
intravenous haloperidol and cocaine alter the distribution of t cd3 the modulation of dopamine transmission evokes strong behavioral effects that can be achieved by commonly used psychoactive drugs such as haloperidol or cocaine. |
2023-02-21 |
2023-08-14 |
rat |
| Maciej M Jankowski, Bogna M Ignatowska-Jankowska, Wojciech Glac, Marek Wiergowski, Paulina Kazmierska-Grebowska, Artur H Swiergie. Intravenous haloperidol and cocaine alter the distribution of T CD3 Clinical and experimental pharmacology & physiology. 2023-02-21. PMID:36802086. |
cocaine non-specifically increases dopamine transmission by blocking dopamine active transporter (dat) and evokes behavioral arousal, while haloperidol is a non-specific d2-like dopamine receptor antagonist with sedative effects. |
2023-02-21 |
2023-08-14 |
rat |
| Hamna Rafiq, Muhammad Farhan, Hira Rafi, Sadia Rehman, Maria Arshad, Sarah Shakee. Inhibition of drug induced Parkinsonism by chronic supplementation of quercetin in haloperidol-treated wistars. Pakistan journal of pharmaceutical sciences. vol 35. issue 6. 2023-02-15. PMID:36789825. |
haloperidol causes drug-induced parkinsonism (dip) by blocking central dopamine receptors and causing extrapyramidal symptoms during long-term treatment. |
2023-02-15 |
2023-08-14 |
rat |
| Jingheng Zhou, Jicheng Li, Amy B Papaneri, Guohong Cu. AJ76 and UH232 as potential agents for diagnosing early-stage Parkinson's disease. Neuropharmacology. 2023-01-09. PMID:36623805. |
the use of haloperidol in the original dnc test to challenge dopamine neurons was less than ideal, as it may cause extrapyramidal motor symptoms. |
2023-01-09 |
2023-08-14 |
mouse |
| Jingheng Zhou, Jicheng Li, Amy B Papaneri, Guohong Cu. AJ76 and UH232 as potential agents for diagnosing early-stage Parkinson's disease. Neuropharmacology. 2023-01-09. PMID:36623805. |
here we report an improved dnc test, in which the original challenging agents, haloperidol and methylphenidate, are replaced by a single challenging agent, a dopamine autoreceptor preferring antagonist aj76 or uh232. |
2023-01-09 |
2023-08-14 |
mouse |
| Kota Yamada, Koji Tod. Pupillary dynamics of mice performing a Pavlovian delay conditioning task reflect reward-predictive signals. Frontiers in systems neuroscience. vol 16. 2022-12-26. PMID:36567756. |
furthermore, we clarified that pupil size is still modulated by reward prediction even after the disruption of body movements by intraperitoneal injection of haloperidol, a dopamine d2 receptor antagonist. |
2022-12-26 |
2023-08-14 |
mouse |