| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I S Hoffmann, L X Cubedd. Rate and duration of stimulation determine presynaptic effects of haloperidol on dopaminergic neurons. Journal of neurochemistry. vol 39. issue 2. 1982-08-26. PMID:7086437. |
rate and duration of stimulation determine presynaptic effects of haloperidol on dopaminergic neurons. |
1982-08-26 |
2023-08-12 |
rabbit |
| I S Hoffmann, L X Cubedd. Rate and duration of stimulation determine presynaptic effects of haloperidol on dopaminergic neurons. Journal of neurochemistry. vol 39. issue 2. 1982-08-26. PMID:7086437. |
these results indicate that activation of presynaptic da receptors, and thus facilitation of release by haloperidol was highly dependent on the rate and duration of stimulation of striatal dopaminergic terminals. |
1982-08-26 |
2023-08-12 |
rabbit |
| K Kolasa, R Fusi, S Garattini, S Consolo, H Ladinsk. Neurochemical effects of buspirone, a novel psychotropic drug, on the central cholinergic system. The Journal of pharmacy and pharmacology. vol 34. issue 5. 1982-08-14. PMID:6123570. |
other data indicating that the drug differed from haloperidol both qualitatively and quantitatively on dopaminergic neurochemical parameters, and the fact that it is not cataleptogenic, suggest that buspirone cannot be considered a typical neuroleptic agent. |
1982-08-14 |
2023-08-12 |
rat |
| V Höllt, I Haarmann, B R Seizinger, A Her. Chronic haloperidol treatment increases the level of in vitro translatable messenger ribonucleic acid coding for the beta-endorphin/adrenocorticotropin precursor proopiomelanocortin in the pars intermedia of the rat pituitary. Endocrinology. vol 110. issue 6. 1982-07-22. PMID:6280978. |
these findings suggest that the chronic blockade of dopaminergic receptors by haloperidol causes a reversible increase in the beta-endorphin biosynthesis in the rat intermediate pituitary at the pretranslational level by markedly increasing the level of translatable mrna coding for pomc. |
1982-07-22 |
2023-08-12 |
rat |
| L Grandiso. Suppression of prolactin secretion by benzodiazepines in vivo. Neuroendocrinology. vol 34. issue 5. 1982-07-22. PMID:6979001. |
diazepam administration also blunted the release of prolactin induced by dopaminergic receptor blockade following haloperidol, or by serotonergic receptor activation produced by fluoxetine, a serotonergic reuptake inhibitor plus 5-hydroxytryptophan, a serotonin precursor. |
1982-07-22 |
2023-08-12 |
rat |
| I Ushijima, K Yamada, T Furukaw. Lithium in combination with haloperidol or thyrotropin-releasing hormone induces jumping in mice. Psychopharmacology. vol 76. issue 2. 1982-07-08. PMID:6805023. |
the results indicate that lithium plus haloperidol or trh produces jumping in which dopaminergic and cholinergic inhibition as well as noradrenergic activation may be involved. |
1982-07-08 |
2023-08-12 |
mouse |
| T F Seeger, L Thal, E L Gardne. Behavioral and biochemical aspects of neuroleptic-induced dopaminergic supersensitivity: studies with chronic clozapine and haloperidol. Psychopharmacology. vol 76. issue 2. 1982-07-08. PMID:6805029. |
behavioral and biochemical aspects of neuroleptic-induced dopaminergic supersensitivity: studies with chronic clozapine and haloperidol. |
1982-07-08 |
2023-08-12 |
rat |
| M T Lin, A Chandra, B L Tsay, Y F Cher. Hypothalamic and striatal dopamine receptor activation inhibits heat production in the rat. The American journal of physiology. vol 242. issue 5. 1982-07-08. PMID:7081473. |
direct injection of dopaminergic agonist apomorphine into the lateral cerebral ventricle, the preoptic anterior hypothalamus, the caudate-putamen complex, or the globus pallidus caused hypothermia, decreased metabolism and cutaneous vasoconstriction at ambient temperature (ta) 8 and 22 degrees c, and hyperthermia and cutaneous vasoconstriction in the rat at ta 30 degrees c. on the other hand, local injection of dopaminergic antagonists such as haloperidol and pimozide into the preoptic anterior hypothalamus and the striatal nuclei caused hyperthermia, increased metabolism and cutaneous vasoconstriction at ta 8, 22, and 30 degrees c. however, there was no change in respiratory evaporative heat loss in response to administration of either dopaminergic agonist or antagonists in the rat at all ta studied. |
1982-07-08 |
2023-08-12 |
rat |
| L P Spear, L A Ristin. Suckling behavior in neonatal rats: psychopharmacological investigations. Journal of comparative and physiological psychology. vol 96. issue 2. 1982-06-21. PMID:6121827. |
in contrast, the opiate antagonist naloxone, the dopaminergic antagonist haloperidol, the alpha-noradrenergic antagonist phentolamine, and the beta-noradrenergi antagonist propranolol did not consistently produce any alteration in suckling behavior. |
1982-06-21 |
2023-08-12 |
rat |
| H Lai, M S Kazi, M A Carino, A Horit. Chronic haloperidol treatment potentiates apomorphine- and ethanol-induced hypothermia in the rat. Life sciences. vol 30. issue 10. 1982-06-21. PMID:7200179. |
supersensitivity developed in the central dopaminergic system of the rat after 21 days of chronic haloperidol injection. |
1982-06-21 |
2023-08-12 |
rat |
| U Bucher, H D Fischer, K Andrea. [Effect of ethanol on the behavior of mice treated with haloperidol]. Acta biologica et medica Germanica. vol 40. issue 7-8. 1982-04-20. PMID:7331633. |
three days after haloperidol withdrawal in case of nearly complete haloperidol elimination and development of dopaminergic supersensitivity the decrease was most pronounced. |
1982-04-20 |
2023-08-12 |
mouse |
| G J Augustine, R Fetterer, W H Watso. Amine modulation of the neurogenic Limulus heart. Journal of neurobiology. vol 13. issue 1. 1982-04-12. PMID:6120211. |
(2) the excitatory effects of all these amines are antagonized by the alpha-adrenergic blocker phentolamine and the dopaminergic antagonist haloperidol. |
1982-04-12 |
2023-08-12 |
Not clear |
| A E Snow, S M Tucker, W L Dewe. The role of neurotransmitters in stress-induced antinociception (SIA). Pharmacology, biochemistry, and behavior. vol 16. issue 1. 1982-04-12. PMID:6120525. |
when dopaminergic tone was increased with apomorphine (0.05 mg/kg, sc) the increase of tail-flick latency after stress was markedly attenuated whereas blockage of dopamine receptors with haloperidol (2.5 mg/kg, ip) increased the peak and duration of sia. |
1982-04-12 |
2023-08-12 |
Not clear |
| K H Westermann, J Schmidt, U Buche. Effects of nootropic drugs on dopaminergic systems in the CNS. Polish journal of pharmacology and pharmacy. vol 33. issue 4. 1982-04-12. PMID:6799944. |
whereas mgo-pretreatment increased the dopaminergic supersensitivity following repeated haloperidol in both behavioral tests, the other nootropics were without influence on intensity and duration of supersensitivity. |
1982-04-12 |
2023-08-12 |
rat |
| M D Schechter, J T Concanno. Haloperidol-induced hyperactivity in neonatal rats: effect of lithium and stimulants. Pharmacology, biochemistry, and behavior. vol 16. issue 1. 1982-04-12. PMID:6799967. |
thus, chronic haloperidol administered directly into neonatal rat pups produces hyperactivity possibly by the production of dopaminergic supersensitivity, yet this effect does not model the temporal course seen in hyperkinetic humans. |
1982-04-12 |
2023-08-12 |
human |
| S Gerhardt, J M Liebma. Differential effects of drug treatments on nose-poke and bar-press self-stimulation. Pharmacology, biochemistry, and behavior. vol 15. issue 5. 1982-02-12. PMID:7312912. |
in contrast, clonidine and haloperidol, which disrupt noradrenergic and dopaminergic neurotransmission respectively, had no differential effect on these operants. |
1982-02-12 |
2023-08-12 |
Not clear |
| E J Mikkelsen, J Detlor, D J Cohe. School avoidance and social phobia triggered by haloperidol in patients with Tourette's disorder. The American journal of psychiatry. vol 138. issue 12. 1982-01-28. PMID:6946714. |
haloperidol's effects on dopaminergic functioning support a role for catecholamines in the pathogenesis of phobic syndromes. |
1982-01-28 |
2023-08-12 |
Not clear |
| C Feuerstein, P Demenge, P Caron, G Barrette, B Guerin, P Mouche. Supersensitivity time course of dopamine antagonist binding after nigrostriatal denervation: evidence for early and drastic changes in the rat corpus striatum. Brain research. vol 226. issue 1-2. 1982-01-20. PMID:7296288. |
the sensitivity of the [3h]haloperidol binding technique can be greatly increased by focusing tissue sampling on striatal regions where dopaminergic innervation is the richest. |
1982-01-20 |
2023-08-12 |
rat |
| P R Sanberg, M Pisa, H C Fibige. Kainic acid injections in the striatum alter the cataleptic and locomotor effects of drugs influencing dopaminergic and cholinergic systems. European journal of pharmacology. vol 74. issue 4. 1982-01-09. PMID:7197631. |
the kainic acid-induced lesions potentiated the locomotor response to both the dopaminergic agonist, d-amphetamine, and the cholinergic antagonist, scopolamine, attenuated the cataleptic response to the dopaminergic antagonist, haloperidol, and potentiated the cataleptic acid and convulsive responses to the cholinergic agonist, pilocarpine. |
1982-01-09 |
2023-08-12 |
rat |
| M D Schechte. Haloperidol-induced supersensitivity to the discrimination of apomorphine. European journal of pharmacology. vol 74. issue 4. 1982-01-09. PMID:7297600. |
the results suggest the development of supersensitivity by prolonged pharmacologic blockade of central dopaminergic receptors with haloperidol and indicate the peak and duration of this effect. |
1982-01-09 |
2023-08-12 |
rat |