| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M R Sakina, P C Dandiya, M E Hamdard, A Hamee. Preliminary psychopharmacological evaluation of Ocimum sanctum leaf extract. Journal of ethnopharmacology. vol 28. issue 2. 1990-05-29. PMID:2329804. |
this action was blocked by haloperidol and sulpiride, indicating a possible action involving dopaminergic neurones. |
1990-05-29 |
2023-08-11 |
mouse |
| J H Meador-Woodruff, B Pellerito, D Bronstein, H L Lin, N Ling, H Aki. Differential effects of haloperidol on the rat pituitary: decreased biosynthesis, processing and release of anterior lobe pro-opiomelanocortin. Neuroendocrinology. vol 51. issue 3. 1990-05-24. PMID:2109273. |
these results suggest that pituitary pomc biosynthesis, processing and release are under at least partial dopaminergic control in both the il and the al of the pituitary, but by different mechanisms; chronic haloperidol treatment upregulates the pomc system in il, but downregulates it in al, despite similarities of the responses of both lobes to acute haloperidol challenge. |
1990-05-24 |
2023-08-11 |
rat |
| R K Agarwal, U S Pandey, K S Dixit, N Shukla, S K Sing. Role of dopaminergic system in opioid-induced cardiovascular responses in dogs. Indian journal of medical sciences. vol 43. issue 12. 1990-05-16. PMID:2632409. |
partial blockade of the parenterally induced hypotensive response of morphine by haloperidol given centrally induced hypotensive responses of morphine by haloperidol given centrally in doses, which are too low to be effective by the peripheral route, strongly favours the involvement of central dopaminergic system in the morphine-induced hypotensive responses. |
1990-05-16 |
2023-08-11 |
Not clear |
| W D Bowen, E L Moses, P J Tolentino, J M Walke. Metabolites of haloperidol display preferential activity at sigma receptors compared to dopamine D-2 receptors. European journal of pharmacology. vol 177. issue 3. 1990-04-26. PMID:2155804. |
these findings suggest that administration of haloperidol results initially in effects mediated through both dopamine and sigma receptors, but as metabolism proceeds the sigma actions would be expected to decline at a significantly slower rate than the dopaminergic actions. |
1990-04-26 |
2023-08-11 |
rat |
| J Lappalainen, J Hietala, M Koulu, T Seppälä, B Sjöholm, E Syvälaht. Chronic treatment with SCH 23390 and haloperidol: effects on dopaminergic and serotonergic mechanisms in rat brain. The Journal of pharmacology and experimental therapeutics. vol 252. issue 2. 1990-04-16. PMID:2179533. |
chronic treatment with sch 23390 and haloperidol: effects on dopaminergic and serotonergic mechanisms in rat brain. |
1990-04-16 |
2023-08-11 |
rat |
| J Lappalainen, J Hietala, M Koulu, T Seppälä, B Sjöholm, E Syvälaht. Chronic treatment with SCH 23390 and haloperidol: effects on dopaminergic and serotonergic mechanisms in rat brain. The Journal of pharmacology and experimental therapeutics. vol 252. issue 2. 1990-04-16. PMID:2179533. |
effects of chronic administration (18 days) with sch 23390 (0.1 or 0.5 mg/kg/day s.c.) and haloperidol (1 mg/kg/day s.c.) on dopamine and serotonin synthesis and metabolism in discrete dopaminergic and serotonergic nuclei of rat brain were studied. |
1990-04-16 |
2023-08-11 |
rat |
| J Lappalainen, J Hietala, M Koulu, T Seppälä, B Sjöholm, E Syvälaht. Chronic treatment with SCH 23390 and haloperidol: effects on dopaminergic and serotonergic mechanisms in rat brain. The Journal of pharmacology and experimental therapeutics. vol 252. issue 2. 1990-04-16. PMID:2179533. |
sch 23390 and haloperidol had no significant effects on serotonin synthesis and metabolism in serotonergic and dopaminergic areas. |
1990-04-16 |
2023-08-11 |
rat |
| J Lappalainen, J Hietala, M Koulu, T Seppälä, B Sjöholm, E Syvälaht. Chronic treatment with SCH 23390 and haloperidol: effects on dopaminergic and serotonergic mechanisms in rat brain. The Journal of pharmacology and experimental therapeutics. vol 252. issue 2. 1990-04-16. PMID:2179533. |
in conclusion, the classical antipsychotic drug, haloperidol, clearly decreases dopamine turnover in nigrostriatal and mesolimbic dopaminergic systems. |
1990-04-16 |
2023-08-11 |
rat |
| R Miranda, T Ceckler, R Guillet, C Kellog. Early developmental exposure to benzodiazepine ligands alters brain 31P-NMR spectra in young adult rats. Brain research. vol 506. issue 1. 1990-03-27. PMID:2154280. |
the dopaminergic antagonist haloperidol did not alter intracellular ph or any index of phosphate metabolism indicating a selective receptor mediated role for bdz ligands in influences on the long term organization of intracellular phosphate metabolism. |
1990-03-27 |
2023-08-11 |
rat |
| G Debonnel, P Gaudreau, R Quirion, C de Montign. Effects of long-term haloperidol treatment on the responsiveness of accumbens neurons to cholecystokinin and dopamine: electrophysiological and radioligand binding studies in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 10. issue 2. 1990-03-21. PMID:2137531. |
since long-term haloperidol treatment results in a depolarization inactivation of a10 dopaminergic neurons, these results suggest that, despite the reduced firing activity of mesolimbic dopaminergic neurons induced by the long-term haloperidol treatment, dopamine is still released in an amount sufficient to maintain a normal neuronal responsiveness of postsynaptic accumbens neurons to da, whereas the release of cck is possibly decreased to a greater extent, resulting in an enhanced responsiveness of the neurons to this peptide. |
1990-03-21 |
2023-08-11 |
rat |
| S R McGurk, E D Levin, L L Butche. Radial-arm maze performance in rats is impaired by a combination of nicotinic-cholinergic and D2 dopaminergic antagonist drugs. Psychopharmacology. vol 99. issue 3. 1990-01-25. PMID:2687921. |
co-administration of the dopaminergic antagonist, haloperidol, ameliorated the performance deficit caused by scopolamine but exacerbated the deficit caused by mecamylamine. |
1990-01-25 |
2023-08-11 |
rat |
| M Clagett-Dame, R Schoenleber, C Chung, J F McKelv. Preparation of an affinity chromatography matrix for the selective purification of the dopamine D2 receptor from bovine striatal membranes. Biochimica et biophysica acta. vol 986. issue 2. 1990-01-24. PMID:2531613. |
dopamine d2 receptor was eluted from the affinity resin using a competing dopaminergic antagonist molecule, haloperidol. |
1990-01-24 |
2023-08-11 |
cattle |
| S V Ramana, T Desiraj. Investigation of influence of diazepam, valproate, cyproheptadine and cortisol on the rewarding ventral tegmental self-stimulation behaviour. Indian journal of physiology and pharmacology. vol 33. issue 3. 1990-01-23. PMID:2512254. |
the modulators are the wellknown drugs: diazepam which is a facilitator of some of the gaba receptors, and used clinically for its tranquilizing, anxiolytic, sedative-hypnotic and anti-convulsant properties; sodium valproate which is known to enhance the gaba synapse function, and used clinically for its anti-convulsant property; haloperidol which is a dopaminergic receptor (d2) blocker, and clinically used for its anti-psychotic property; cyproheptadine which is both anti-histaminic and anti-serotonergic (blocks 5-ht2 receptor), used clinically for its antihistaminic and other beneficial properties; and hydrocortisone which is the stress-resisting glucocorticoid having direct effects on both brain and body cells, used clinically for the wide-ranging glucocorticoid therapeutic effects. |
1990-01-23 |
2023-08-11 |
rat |
| b' I Gacs\\xc3\\xa1lyi, L Pet\\xc3\\xb6cz, M I Fekete, B B\\xc3\\xbckkf\\xc3\\xa1lvi, F G\\xc3\\xb6rgenyi, M Arat\\xc3\\xb. EGYT-2509 a novel neuroleptic agent without extrapyramidal and endocrine side effects. Polish journal of pharmacology and pharmacy. vol 40. issue 6. 1990-01-03. PMID:2908364.' |
it interacted with dopaminergic compounds similarly to chlorpromazine and haloperidol, but in certain tests it showed different activity. |
1990-01-03 |
2023-08-11 |
mouse |
| J E Rubinstein, R J Hitzemann, C R Ashby, R Y Wan. Long-term treatment with antipsychotics does not alter the phosphoinositide response to muscarinic or D2 dopaminergic agonists in rat striatum. Brain research. vol 496. issue 1-2. 1989-12-21. PMID:2572294. |
the effects of the muscarinic agonist carbachol and the d2 dopaminergic agonist quinpirole on phosphoinositide hydrolysis were studied in the corpus striatum of rats which had been treated for one year with either haloperidol or clozapine. |
1989-12-21 |
2023-08-11 |
rat |
| J Y Sovilla, P Magistretti, M Schordere. Potentiation of apomorphine-induced climbing behaviour in mice by d-LSD. Progress in neuro-psychopharmacology. vol 3. issue 5-6. 1989-12-07. PMID:401002. |
subsequent experiments performed with a neuroleptic (haloperidol) or a serotonin precursor (5-oh-tryptophan) compared to those of d-lsd with and without apomorphine would indicate that d-lsd alone displays typical serotoninergic syndrome (including inhibition of the climbing), whereas in the presence of apomorphine, an interaction at presynaptic receptors may possibly modulate dopaminergic activity. |
1989-12-07 |
2023-08-11 |
mouse |
| E S Prosser, R Pruthi, J G Csernansk. Differences in the time course of dopaminergic supersensitivity following chronic administration of haloperidol, molindone, or sulpiride. Psychopharmacology. vol 99. issue 1. 1989-10-25. PMID:2506596. |
differences in the time course of dopaminergic supersensitivity following chronic administration of haloperidol, molindone, or sulpiride. |
1989-10-25 |
2023-08-11 |
rat |
| O Mrabet, C Messier, C Destrad. [Circling behavior produced by the unilateral intra-accumbens injection of dopaminergic agonist and two dopaminergic antagonists in mice]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 309. issue 3. 1989-10-10. PMID:2504444. |
unilateral intra-accumbens injection of haloperidol and metoclopramide, two dopaminergic antagonists, produced ipsilateral circling. |
1989-10-10 |
2023-08-11 |
mouse |
| P F Vonvoigtlander, R A Lewi. Evidence for the combined involvement of serotonergic and alpha 2 adrenergic mechanisms in the analgesic activity of tazadolene succinate. Drug design and delivery. vol 2. issue 2. 1989-09-28. PMID:2855569. |
however, yohimbine, sch 23390 and haloperidol, antagonists of alpha 2 adrenergic, d1 dopaminergic and d2 dopaminergic receptors respectively, did not block tazadolene, nor did the serotonin depletor, p-chlorophenylalanine. |
1989-09-28 |
2023-08-11 |
mouse |
| M Morelli, S Fenu, G Di Chiar. Substantia nigra as a site of origin of dopamine-dependent motor syndromes induced by stimulation of mu and delta opioid receptors. Brain research. vol 487. issue 1. 1989-08-31. PMID:2546645. |
sch 23390 and haloperidol, two antagonists of dopaminergic d1 and d2 receptors, respectively, blocked the effects of plo 17 and dpdpe. |
1989-08-31 |
2023-08-11 |
rat |