| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J P Grierson, M D James, J R Pearson, C A Wilso. The effect of selective D1 and D2 dopaminergic agents on sexual receptivity in the female rat. Neuropharmacology. vol 27. issue 2. 1988-05-06. PMID:2965316. |
the results of administration of mixed dopaminergic agents (dopa, 10-50 mg/kg with benserazide or 100-200 mg/kg alone and haloperidol 0.01-1.0 mg/kg) and selective d2 dopaminergic agents (ly 171555 2.5-800 micrograms/kg, bht 920 0.01-1.0 mg/kg and sulpiride 5-80 mg/kg) indicate that a central dopaminergic system has an inhibitory control on female sexual activity exerted through d2 receptors. |
1988-05-06 |
2023-08-11 |
rat |
| M A Sherman, R J Deans, M B Bolge. Haloperidol binding to monoclonal antibodies. Hypervariable region amino acid sequence determination. The Journal of biological chemistry. vol 263. issue 9. 1988-04-21. PMID:3267217. |
the primary sequences of five monoclonal antibodies (mabs a-e) which bind with various affinities (kd = 4-810 nm) to the d-2 dopaminergic antagonist, haloperidol, have been determined. |
1988-04-21 |
2023-08-11 |
Not clear |
| M A Sherman, M B Bolge. Haloperidol binding to monoclonal antibodies. Predictions of three-dimensional combining site structure via computer modeling. The Journal of biological chemistry. vol 263. issue 9. 1988-04-21. PMID:3346235. |
the amino acid sequences of five monoclonal antibodies (designated mabs a-e) which bind to the dopaminergic d-2 antagonist, haloperidol, with a variety of affinities (kd = 4-810 nm), have been used to build theoretical, three-dimensional, computer models of the variable region combining sites. |
1988-04-21 |
2023-08-11 |
Not clear |
| H A Tilson, G J Harry, K Nanry, P M Hudson, J S Hon. Ganglioside interactions with the dopaminergic system of rats. Journal of neuroscience research. vol 19. issue 1. 1988-03-25. PMID:3125345. |
the effects of ganglioside treatment on changes in dopaminergic function following 6-hydroxydopamine (6-ohda) or repeated exposure to haloperidol were studied in male fischer-344 rats. |
1988-03-25 |
2023-08-11 |
rat |
| B Costall, A M Domeney, R J Naylor, M B Tyer. Effects of the 5-HT3 receptor antagonist, GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain. British journal of pharmacology. vol 92. issue 4. 1988-03-22. PMID:2962686. |
it is concluded that the 5-ht3 receptor antagonist gr38032f, and the neuroleptic agents fluphenazine, sulpiride and haloperidol, can reduce raised mesolimbic dopaminergic activity in the rat and marmoset. |
1988-03-22 |
2023-08-11 |
rat |
| R Kuczenski, D S Segal, N J Leith, C D Applegat. Effects of amphetamine, methylphenidate, and apomorphine on regional brain serotonin and 5-hydroxyindole acetic acid. Psychopharmacology. vol 93. issue 3. 1988-03-03. PMID:2448842. |
pretreatment of animals with alpha-methyltyrosine at a dose sufficient to prevent the locomotor stimulation and stereotypy promoted by amphetamine, or by haloperidol, failed to prevent the amphetamine-induced increase in 5hiaa, indicating that these serotonergic effects are not secondary to the amphetamine facilitation of dopaminergic transmission. |
1988-03-03 |
2023-08-11 |
Not clear |
| P M Beardsley, R L Balste. Evaluation of antagonists of the discriminative stimulus and response rate effects of phencyclidine. The Journal of pharmacology and experimental therapeutics. vol 244. issue 1. 1988-02-24. PMID:3336008. |
drugs combined with pcp to test for antagonism included an alpha-1 (prazosin) and an alpha-2 (yohimbine) adrenergic antagonist, the adenosine receptor agonist, i-phenylisopropyl adenosine, the gamma-aminobutyric acid agonist, imidazole acetic acid, the dopaminergic antagonist, haloperidol, the acylating agent of the pcp receptor, metaphit, and the dopaminergic drugs (+)- and (-)-3-(3-hydroxyphenyl)-n-(1-propyl)piperidine. |
1988-02-24 |
2023-08-11 |
rat |
| J A Joseph, R E Berger, B T Engel, G S Rot. Age-related changes in the nigrostriatum: a behavioral and biochemical analysis. Journal of gerontology. vol 33. issue 5. 1988-02-04. PMID:299552. |
direct dopaminergic stimulation under apomorphine or dopaminergic receptor blockade with haloperidol produced no such age related deficits. |
1988-02-04 |
2023-08-11 |
rat |
| F Chaouloff, B Jeanrenau. 5-HT1A and alpha-2 adrenergic receptors mediate the hyperglycemic and hypoinsulinemic effects of 8-hydroxy-2-(di-n-propylamino)tetralin in the conscious rat. The Journal of pharmacology and experimental therapeutics. vol 243. issue 3. 1988-02-02. PMID:2826757. |
pretreatments with the dopaminergic blocker haloperidol, the alpha-1 adrenoceptor antagonist prazosin or the 5-ht2 blocker ketanserin were ineffective. |
1988-02-02 |
2023-08-11 |
rat |
| O B Kuz'min, P V Mikhaĭlenk. [Role of kidney prostaglandins, kinins and dopamine receptors in the natriuretic effect of ethacrynic acid]. Farmakologiia i toksikologiia. vol 50. issue 5. 1988-01-25. PMID:2446916. |
a blocker of dopaminergic receptors haloperidol (3 mg/kg subcutaneously) caused no changes in the rat kidney response to ethacrynic acid. |
1988-01-25 |
2023-08-11 |
rat |
| T P Jerussi, J F Capacchione, M J Benveng. Reversal of opioid-induced muscular rigidity in rats: evidence for alpha-2 adrenergic involvement. Pharmacology, biochemistry, and behavior. vol 28. issue 2. 1988-01-13. PMID:2891145. |
however, dopaminergic antagonists with adrenolytic activity (i.e., chlorpromazine, haloperidol) reversed rigidity, whereas sulpiride did not. |
1988-01-13 |
2023-08-11 |
rat |
| A Smiałowski, M Bija. Excitatory and inhibitory action of dopamine on hippocampal neurons in vitro. Involvement of D2 and D1 receptors. Neuroscience. vol 23. issue 1. 1988-01-11. PMID:2960914. |
having used selective dopaminergic agonists (pergolide and 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1h-3-benzazepines) and selective antagonists (haloperidol, spiperone, sulpiride and (r)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1h-3- benzazepine-7-ol), it was concluded that the excitation evoked by dopamine was due to activation of d2 dopamine receptors, while the inhibition was the result of d1 receptor activation. |
1988-01-11 |
2023-08-11 |
rat |
| C Delbende, S Jégou, D Tranchand-Bunel, G Pelletier, H Vaudr. Hypothalamic alpha-melanocyte-stimulating hormone (alpha-MSH) is not under dopaminergic control. Brain research. vol 423. issue 1-2. 1987-12-22. PMID:2960424. |
acute or 3-weeks chronic in vivo treatments with the dopaminergic agonists apomorphine (1 mg/kg: s.c.) and 2-br-alpha-ergocriptine (2.5 mg/kg; s.c.) or the dopaminergic antagonist haloperidol (0.15-3 mg/kg; i.p.) |
1987-12-22 |
2023-08-11 |
rat |
| T Sato, T Yoneyama, H K Kim, T A Suzuk. Effect of dopamine and haloperidol on the c-wave and light peak of light-induced retinal responses in chick eye. Documenta ophthalmologica. Advances in ophthalmology. vol 65. issue 1. 1987-12-15. PMID:2822368. |
the relation between dopaminergic cells (and centrifugal fibers), the electroretinogram (erg) c-wave, and the light peak were electrophysiologically investigated by observing the effects of a retrobulbar conduction block and intravitreal injection of either dopamine or haloperidol on these retinal responses. |
1987-12-15 |
2023-08-11 |
chicken |
| G F Steinfels, S W Tam, L Coo. Discriminative stimulus properties of a sigma receptor agonist in the rat: role of monoamine systems. European journal of pharmacology. vol 141. issue 1. 1987-12-14. PMID:2822445. |
activation of the dopaminergic system by apomorphine did not produce (+)-nanm ds however, haloperidol, which binds to the sigma receptor with high affinity, antagonized (+)-nanm ds. |
1987-12-14 |
2023-08-11 |
rat |
| A Iu Klintsova, N A Uranova, H Schenk, U Hasselhors. [Action of haloperidol on the ultrastructure of areas of the dopaminergic system of the brain]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). vol 87. issue 7. 1987-12-08. PMID:3673382. |
[action of haloperidol on the ultrastructure of areas of the dopaminergic system of the brain]. |
1987-12-08 |
2023-08-11 |
Not clear |
| C Castellano, F Pavon. Effects of the selective kappa-opioid receptor agonist U-50,488 on locomotor activity and passive avoidance behaviour in DBA/2 and C57BL/6 mice. Archives internationales de pharmacodynamie et de therapie. vol 288. issue 2. 1987-12-04. PMID:2823735. |
moreover, this activity depression was enhanced in both strains by the administration of haloperidol and muscimol, showing the involvement of dopaminergic and gabaergic mechanisms. |
1987-12-04 |
2023-08-11 |
mouse |
| K Kashihara, K Fukuda, M Sato, S Otsuk. Haloperidol prevents the methamphetamine-induced apomorphine subsensitivity of dopamine metabolism in rat striatum. Neuroscience research. vol 4. issue 5. 1987-12-01. PMID:3670749. |
since gamma-butyrolactone was administered in combination with apomorphine so as to remove complications which might arise from the modification of impulse flow through the striatonigral feedback loop, it is possible that the observed effect of apomorphine upon striatal dopaminergic metabolism and its antagonism with haloperidol may be mediated by autoreceptors of dopaminergic axon terminals in rat striatum. |
1987-12-01 |
2023-08-11 |
rat |
| V Huang, H Figge, R Demlin. Haloperidol complications in burn patients. The Journal of burn care & rehabilitation. vol 8. issue 4. 1987-11-20. PMID:3654715. |
haloperidol causes a relative imbalance of dopaminergic and cholinergic neuronal activity in the basal ganglia with a relative increase in cholinergic activity being responsible for eps. |
1987-11-20 |
2023-08-11 |
Not clear |
| M W Emmett-Oglesby, A Her. Opioid modulation of the discriminative stimulus produced by pentylenetetrazol. Psychopharmacology. vol 92. issue 3. 1987-10-16. PMID:2819916. |
the observation that haloperidol blocked the ptz-like stimulus of mu agonists suggests the possible involvement of dopaminergic mechanisms in the mediation of the effect. |
1987-10-16 |
2023-08-11 |
rat |