| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F S Messih. Genetics, haloperidol and pimozide: a comparative study in two mouse strains. Neurotoxicology. vol 12. issue 1. 1991-05-10. PMID:2014068. |
haloperidol and pimozide are the only medications approved in management of tourette's syndrome, thought due to dopaminergic overactivity with a possible genetic trait. |
1991-05-10 |
2023-08-11 |
mouse |
| P J Fletcher, M Davie. Dorsal raphe microinjection of 5-HT and indirect 5-HT agonists induces feeding in rats. European journal of pharmacology. vol 184. issue 2-3. 1991-04-26. PMID:2150377. |
in addition the effects of 5-ht were blocked by pretreatment with haloperidol, indicating the involvement of a dopaminergic mechanism in mediating the effects of feeding of a suppression in dorsal raphe 5-ht neural activity. |
1991-04-26 |
2023-08-11 |
rat |
| J L Katz, J M Witki. Behavioral effects of cocaine alone and in combination with selective dopamine antagonists in the squirrel monkey. Psychopharmacology. vol 103. issue 1. 1991-04-25. PMID:2006242. |
effects of cocaine, alone and in combination with the dopaminergic antagonists, sch 23390 and haloperidol were studied in squirrel monkeys trained to respond under fixed-interval schedules of electric-shock presentation. |
1991-04-25 |
2023-08-11 |
monkey |
| Y F Cheng, L K Paalzo. A pharmacodynamic model to predict the time dependent adaptation of dopaminergic activity during constant concentrations of haloperidol. The Journal of pharmacy and pharmacology. vol 42. issue 8. 1991-04-15. PMID:1981585. |
a pharmacodynamic model to predict the time dependent adaptation of dopaminergic activity during constant concentrations of haloperidol. |
1991-04-15 |
2023-08-11 |
rat |
| Y F Cheng, L K Paalzo. A pharmacodynamic model to predict the time dependent adaptation of dopaminergic activity during constant concentrations of haloperidol. The Journal of pharmacy and pharmacology. vol 42. issue 8. 1991-04-15. PMID:1981585. |
the dopaminergic activity of the rat brain, as reflected by the hva levels, therefore adapted to a lower activity during the prolonged exposure to haloperidol. |
1991-04-15 |
2023-08-11 |
rat |
| G Volterra, F Borsini, A Lecci, A Mel. Desipramine and nortriptyline antagonize apomorphine and reserpine hypothermia by a different mechanism. The Journal of pharmacy and pharmacology. vol 42. issue 8. 1991-04-15. PMID:1981590. |
in apomorphine-treated animals the effect of both drugs was reversed by the mixed dopaminergic d1- d2-antagonist haloperidol (1 mg kg-1 i.p., 90 min), the d1-receptor blocking drug sch 23390 (0.05 mg kg-1 s.c., 30 min), the alpha 1-adrenoceptor blocking drugs prazosin (3 mg kg-1 s.c., 90 min) and phenoxybenzamine (20 mg kg-1 i.p., 65 min), the beta-adrenoceptor blocking drug (+/-)-propranolol (10 mg kg-1 i.p., 120 min), and the opioid antagonist naloxone (2 mg kg-1 i.p., 15 min). |
1991-04-15 |
2023-08-11 |
mouse |
| P Stanzione, F Fattapposta, M Tagliati, C D'Alessio, M G Marciani, A Foti, G Amabil. Dopaminergic pharmacological manipulations in normal humans confirm the specificity of the visual (PERG-VEP) and cognitive (P300) electrophysiological alterations in Parkinson's disease. Electroencephalography and clinical neurophysiology. Supplement. vol 41. 1991-04-02. PMID:2289431. |
retinal and occipital visual evoked potentials and event-related potentials (p300) have been recorded in normal human subjects before and after the administration of the dopaminergic receptor antagonist, haloperidol, and/or the dopaminergic precursor l-dopa. |
1991-04-02 |
2023-08-11 |
human |
| R Zorrilla, J Simard, E Rhéaume, F Labrie, G Pelletie. Multihormonal control of pre-pro-somatostatin mRNA levels in the periventricular nucleus of the male and female rat hypothalamus. Neuroendocrinology. vol 52. issue 5. 1991-03-11. PMID:1980724. |
a 14-day treatment with the d2 dopamine receptor agonist bromocriptine (bro) increased pre-pross mrna levels by 15 and 28% in intact female and ovx animals, respectively, while the dopaminergic antagonist haloperidol (hal) decreased the value of this parameter by 20 and 30%. |
1991-03-11 |
2023-08-11 |
rat |
| C S Tsai, C Washington, R F Ochill. Cardiovascular effects of doxorubicin. General pharmacology. vol 21. issue 5. 1991-03-01. PMID:2276591. |
haloperidol (10(-6) m), a dopaminergic receptor blocker, and propranolol (10(-8) m), a beta-adrenergic blocker, did not block the positive inotropic effects of doxorubicin. |
1991-03-01 |
2023-08-11 |
Not clear |
| I S Login, S I Kuan, A M Judd, R M MacLeo. Regulation of the intracellular calcium concentration in MMQ pituitary cells by dopamine and protein kinase C. Cell calcium. vol 11. issue 8. 1991-02-08. PMID:1702364. |
dopamine had no detectable independent effect, but significantly inhibited the rise in intracellular calcium mediated by activation of voltage-dependent calcium channels; this dopaminergic action was prevented by haloperidol. |
1991-02-08 |
2023-08-11 |
Not clear |
| H E Shannon, S C Peter. A comparison of the effects of cholinergic and dopaminergic agents on scopolamine-induced hyperactivity in mice. The Journal of pharmacology and experimental therapeutics. vol 255. issue 2. 1990-12-31. PMID:2243341. |
the mixed d1/d2 dopaminergic antagonist haloperidol (0.003-3.0 mg/kg) and the selective d1 antagonist sch 23390 (0.01-0.3 mg/kg) produced dose-related decreases in locomotor activity when administered alone, and also produced dose-related reversals of the hyperactivity produced by scopolamine. |
1990-12-31 |
2023-08-11 |
mouse |
| M Miyake, K Iguchi, H Okamura, K Fukui, T Nakajima, K Chihara, Y Ibata, N Yanaihar. Effect of haloperidol on immunoreactive neuropeptide Y in rat cerebral cortex and basal ganglia. Brain research bulletin. vol 25. issue 2. 1990-12-05. PMID:2224539. |
to clarify the dopaminergic regulation of neuropeptide y (npy) neurons, the effect of haloperidol on npy in basal ganglia and the cerebral cortex of the rat brain was investigated by sensitive radioimmunoassay and immunocytochemistry using antiserum against rat npy. |
1990-12-05 |
2023-08-11 |
rat |
| S E Lindley, K J Lookingland, K E Moor. Dopaminergic and beta-adrenergic receptor control of alpha-melanocyte-stimulating hormone secretion during stress. Neuroendocrinology. vol 52. issue 1. 1990-10-10. PMID:2168526. |
in nonstressed animals the administration of the beta 2-adrenergic agonist metaproterenol increased the plasma levels of alpha-msh, and the effect of this drug was augmented if the inhibitory dopaminergic tone on alpha-msh secretion was blocked by the administration of the da antagonist haloperidol. |
1990-10-10 |
2023-08-11 |
rat |
| T T Soncran. Age-associated functional impairments of specific neurotransmitter systems: detection by pharmacological brain metabolism studies and criteria for design of human investigations. International journal of clinical pharmacology research. vol 10. issue 1-2. 1990-09-24. PMID:1974889. |
in awake, aged fischer-344 rats, cerebral metabolic responses to the dopaminergic agents haloperidol and bromocriptine and to the serotonergic agonist m-chlorophenylpiperazine were reduced when compared to responses in young adult rats, despite similar or greater concentrations of drug in the brains of older animals. |
1990-09-24 |
2023-08-11 |
human |
| J A Angulo, J L Cadet, B S McEwe. Effect of typical and atypical neuroleptic treatment on protachykinin mRNA levels in the striatum of the rat. Neuroscience letters. vol 113. issue 2. 1990-09-05. PMID:1974041. |
since typical and atypical neuroleptic drugs display differential effects on the activity of dopaminergic neurons, we evaluated the effect of typical (haloperidol and prolixin) and atypical (molindone, thioridazine and chlozapine) chronic neuroleptic treatment on protachykinin mrna levels in the medial aspect of the caudate-putamen by in situ hybridization histochemistry. |
1990-09-05 |
2023-08-11 |
rat |
| C Iñiguez, P Tamayo, E Romero, M J Gayoso, J De Jua. Alterations in prolactin secretion during the 1st postnatal month following perinatal dopaminergic blockade with haloperidol. Neuroendocrinology. vol 51. issue 6. 1990-08-08. PMID:2114005. |
alterations in prolactin secretion during the 1st postnatal month following perinatal dopaminergic blockade with haloperidol. |
1990-08-08 |
2023-08-11 |
rat |
| J W Commissiong, C Slimovitch, G Toffan. Regulation of the synthesis and metabolism of striatal dopamine after disruption of nerve conduction in the medial forebrain bundle. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2361171. |
furthermore, haloperidol can act directly on the striatal, dopaminergic nerve terminal, to cause an increase in the synthesis and metabolism of striatal dopamine. |
1990-08-08 |
2023-08-11 |
rat |
| C Hindelang, J M Félix, F M Laurent, M J Klein, M E Stoecke. Ontogenesis of proopiomelanocortin gene expression and regulation in the rat pituitary intermediate lobe. Molecular and cellular endocrinology. vol 70. issue 3. 1990-08-08. PMID:2361568. |
the effects of acute or chronic postnatal treatment with a dopamine antagonist (haloperidol) or a dopamine agonist (bromocriptine) show that the physiological dopaminergic inhibitory control of pomc gene expression operates as early as postnatal day 5. |
1990-08-08 |
2023-08-11 |
rat |
| A Saija, P Princi, R De Pasquale, G Cost. Arecoline, but not haloperidol, induces changes in the permeability of the blood-brain barrier in the rat. The Journal of pharmacy and pharmacology. vol 42. issue 2. 1990-07-20. PMID:1972401. |
injection of the dopaminergic antagonist haloperidol (1 mg kg-1) did not modify the regional bbb permeability. |
1990-07-20 |
2023-08-11 |
rat |
| P J Fletcher, M Davie. The involvement of 5-hydroxytryptaminergic and dopaminergic mechanisms in the eating induced by buspirone, gepirone and ipsapirone. British journal of pharmacology. vol 99. issue 3. 1990-06-06. PMID:2139586. |
pretreatment with haloperidol (0.1 mg kg-1, 30 min) significantly attenuated the effects of equi-effective doses of buspirone, gepirone and ipsapirone, indicating that these drugs interact with dopaminergic systems to increase feeding. |
1990-06-06 |
2023-08-11 |
rat |