| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Sällström Baum, R Hill, K Kiianmaa, H Rommelspache. Effect of ethanol on (R)- and (S)-salsolinol, salsoline, and THP in the nucleus accumbens of AA and ANA rats. Alcohol (Fayetteville, N.Y.). vol 18. issue 2-3. 1999-10-07. PMID:10456568. |
in case of changes following ethanol application (dopamine, salsoline, thp), the aa rats were less sensitive. |
1999-10-07 |
2023-08-12 |
rat |
| M S Gevaerd, R N Takahash. Involvement of dopamine receptors on locomotor stimulation and sensitization elicited by the interaction of ethanol and mazindol in mice. Pharmacology, biochemistry, and behavior. vol 63. issue 3. 1999-09-14. PMID:10418779. |
involvement of dopamine receptors on locomotor stimulation and sensitization elicited by the interaction of ethanol and mazindol in mice. |
1999-09-14 |
2023-08-12 |
mouse |
| J Tiihonen, T Hallikainen, H Lachman, T Saito, J Volavka, J Kauhanen, J T Salonen, O P Ryynänen, M Koulu, M K Karvonen, T Pohjalainen, E Syvälahti, J Hietal. Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism. Molecular psychiatry. vol 4. issue 3. 1999-09-13. PMID:10395222. |
since ethanol-induced euphoria is associated with the rapid release of dopamine in limbic areas, it is conceivable that subjects who inherit the allele encoding the low activity comt variant would have a relatively low dopamine inactivation rate, and therefore would be more vulnerable to the development of ethanol dependence. |
1999-09-13 |
2023-08-12 |
human |
| Y Yamamoto, H Nakanishi, N Takai, T Shimazoe, S Watanabe, H Kit. Expression of N-methyl-D-aspartate receptor-dependent long-term potentiation in the neostriatal neurons in an in vitro slice after ethanol withdrawal of the rat. Neuroscience. vol 91. issue 1. 1999-08-02. PMID:10336060. |
dopamine also significantly depressed the induction of long-term potentiation in ethanol withdrawal rat neostriatum and this depressant effect was antagonized by the d2 antagonist l-sulpiride but not by the d1 antagonist sch23390. |
1999-08-02 |
2023-08-12 |
rat |
| M S Brodie, M A McElvain, E B Bunney, S B Appe. Pharmacological reduction of small conductance calcium-activated potassium current (SK) potentiates the excitatory effect of ethanol on ventral tegmental area dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 290. issue 1. 1999-07-26. PMID:10381795. |
pharmacological reduction of small conductance calcium-activated potassium current (sk) potentiates the excitatory effect of ethanol on ventral tegmental area dopamine neurons. |
1999-07-26 |
2023-08-12 |
rat |
| H H Samson, A M Chappel. Effects of microinjection of the D2 dopamine antagonist raclopride into the ventral tegmental area on ethanol and sucrose self-administration. Alcoholism, clinical and experimental research. vol 23. issue 3. 1999-06-25. PMID:10195813. |
effects of microinjection of the d2 dopamine antagonist raclopride into the ventral tegmental area on ethanol and sucrose self-administration. |
1999-06-25 |
2023-08-12 |
rat |
| H H Samson, A M Chappel. Effects of microinjection of the D2 dopamine antagonist raclopride into the ventral tegmental area on ethanol and sucrose self-administration. Alcoholism, clinical and experimental research. vol 23. issue 3. 1999-06-25. PMID:10195813. |
in these studies, the effects of self administration of ethanol or sucrose solutions on maintained responding were similar when a dopamine antagonist was injected in the nucleus accumbens or a dopamine agonist was injected into the vta. |
1999-06-25 |
2023-08-12 |
rat |
| M Ufer, M Dadmarz, W H Voge. Voluntary consumption of amphetamine, cocaine, ethanol and morphine by rats as influenced by a preceding period of forced drug intake and clozapine. Pharmacology. vol 58. issue 6. 1999-06-22. PMID:10325573. |
cl, a dopamine d4 antagonist, increased the voluntary consumption of amphetamine and morphine with no effects on ethanol or cocaine intake. |
1999-06-22 |
2023-08-12 |
rat |
| C P Bailey, S J Manley, W P Watson, S Wonnacott, A Molleman, H J Littl. Chronic ethanol administration alters activity in ventral tegmental area neurons after cessation of withdrawal hyperexcitability. Brain research. vol 803. issue 1-2. 1999-05-26. PMID:9729345. |
no changes were seen in release of tritiated dopamine, in response to applied kcl or amphetamine, from slices of striatum or cerebral cortex, prepared 24 h after cessation of the chronic ethanol consumption, compared with control values. |
1999-05-26 |
2023-08-12 |
mouse |
| C Cohen, G Perrault, D J Sange. Effects of D1 dopamine receptor agonists on oral ethanol self-administration in rats: comparison with their efficacy to produce grooming and hyperactivity. Psychopharmacology. vol 142. issue 1. 1999-05-26. PMID:10102789. |
in order to study the potential efficacy of dopamine receptor agonists in the treatment of alcohol abuse, the present study investigated the effects of several dopamine d1 receptor agonists with different intrinsic activities on ethanol self-administration in rats. |
1999-05-26 |
2023-08-12 |
rat |
| C Cohen, G Perrault, D J Sange. Effects of D1 dopamine receptor agonists on oral ethanol self-administration in rats: comparison with their efficacy to produce grooming and hyperactivity. Psychopharmacology. vol 142. issue 1. 1999-05-26. PMID:10102789. |
pretreatment with full (r-6br-apb, skf 82958 and skf 81297) and partial (skf 38393 and skf 77434) dopamine d1 receptor agonists dose-dependently decreased responding for ethanol. |
1999-05-26 |
2023-08-12 |
rat |
| G Y Sun, J Xia, B Draczynska-Lusiak, A Simonyi, A Y Su. Grape polyphenols protect neurodegenerative changes induced by chronic ethanol administration. Neuroreport. vol 10. issue 1. 1999-05-25. PMID:10094140. |
chronic ethanol caused significant decreases in synaptosomal na,k-atpase (20.5%) and dopamine uptake (22.8%) activities compared with pair-fed controls. |
1999-05-25 |
2023-08-12 |
rat |
| W J McBride, T K L. Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. Critical reviews in neurobiology. vol 12. issue 4. 1999-05-24. PMID:10348615. |
systemic administration of agents that (1) increase synaptic levels of serotonin (5-ht) or dopamine (da); (2) activate 5-ht1a, 5-ht2, d2, d3, or gaba(a) receptors; or (3) block opioid and 5-ht3 receptors decrease ethanol intake in most animal models. |
1999-05-24 |
2023-08-12 |
rat |
| P Nestby, L J Vanderschuren, T J De Vries, A H Mulder, G Wardeh, F Hogenboom, A N Schoffelmee. Unrestricted free-choice ethanol self-administration in rats causes long-term neuroadaptations in the nucleus accumbens and caudate putamen. Psychopharmacology. vol 141. issue 3. 1999-05-07. PMID:10027512. |
in the present study, the reactivity of striatal dopamine and dopamine-sensitive neurons in super-fused striatal slices of ethanol-experienced rats was compared to that of ethanol-naive rats, 3 weeks after oral ethanol self-administration. |
1999-05-07 |
2023-08-12 |
rat |
| D M Nielsen, K J Crosley, R W Keller, S D Glick, J N Carlso. Left and right 6-hydroxydopamine lesions of the medial prefrontal cortex differentially affect voluntary ethanol consumption. Brain research. vol 823. issue 1-2. 1999-05-07. PMID:10095012. |
dopaminergic projections to the medial prefrontal cortex (mpfc) were unilaterally lesioned with 6-hydroxydopamine (6-ohda) to examine how dopamine (da) asymmetry in the mpfc influences voluntary ethanol consumption. |
1999-05-07 |
2023-08-12 |
rat |
| D M Nielsen, K J Crosley, R W Keller, S D Glick, J N Carlso. Ethanol induced differences in medial prefrontal cortex dopamine asymmetry and in nucleus accumbens dopamine metabolism in left- and right-turning rats. Brain research. vol 823. issue 1-2. 1999-05-07. PMID:10095029. |
ethanol induced differences in medial prefrontal cortex dopamine asymmetry and in nucleus accumbens dopamine metabolism in left- and right-turning rats. |
1999-05-07 |
2023-08-12 |
rat |
| D M Nielsen, K J Crosley, R W Keller, S D Glick, J N Carlso. Ethanol induced differences in medial prefrontal cortex dopamine asymmetry and in nucleus accumbens dopamine metabolism in left- and right-turning rats. Brain research. vol 823. issue 1-2. 1999-05-07. PMID:10095029. |
in the nucleus accumbens (nas), ethanol decreased dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac), and hva levels in rats that exhibited low levels of locomotor activity but not in rats that exhibited high levels of locomotor activity. |
1999-05-07 |
2023-08-12 |
rat |
| Y Itzhak, J L Marti. Effects of cocaine, nicotine, dizocipline and alcohol on mice locomotor activity: cocaine-alcohol cross-sensitization involves upregulation of striatal dopamine transporter binding sites. Brain research. vol 818. issue 2. 1999-05-06. PMID:10082805. |
assessment of the densities of striatal dopamine transporter (dat) sites (by [3h]mazindol binding) 11 days after the extinction of repeated treatment with either cocaine or ethanol revealed a significant increase (71-108%) in the number of dat binding sites. |
1999-05-06 |
2023-08-12 |
mouse |
| T J Phillips, K J Brown, S Burkhart-Kasch, C D Wenger, M A Kelly, M Rubinstein, D K Grandy, M J Lo. Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors. Nature neuroscience. vol 1. issue 7. 1999-04-29. PMID:10196569. |
we studied the ethanol preference and sensitivity of d2-receptor-deficient mice to directly evaluate whether dopamine d2 receptors contribute to alcohol (ethanol) consumption. |
1999-04-29 |
2023-08-12 |
mouse |
| T J Phillips, K J Brown, S Burkhart-Kasch, C D Wenger, M A Kelly, M Rubinstein, D K Grandy, M J Lo. Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors. Nature neuroscience. vol 1. issue 7. 1999-04-29. PMID:10196569. |
these data demonstrate that dopamine signaling via d2 receptors is an essential component of the molecular pathway determining ethanol self-administration and sensitivity. |
1999-04-29 |
2023-08-12 |
mouse |