| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H H Samson, A Chappel. Injected muscimol in pedunculopontine tegmental nucleus alters ethanol self-administration. Alcohol (Fayetteville, N.Y.). vol 23. issue 1. 2001-05-21. PMID:11282451. |
ethanol self-administration was decreased at the 300-ng dose, in a manner similar to the actions of dopamine agonists microinjected in the nucleus accumbens. |
2001-05-21 |
2023-08-12 |
rat |
| C Xu, R Y She. Amphetamine normalizes the electrical activity of dopamine neurons in the ventral tegmental area following prenatal ethanol exposure. The Journal of pharmacology and experimental therapeutics. vol 297. issue 2. 2001-05-21. PMID:11303066. |
amphetamine normalizes the electrical activity of dopamine neurons in the ventral tegmental area following prenatal ethanol exposure. |
2001-05-21 |
2023-08-12 |
rat |
| C Xu, R Y She. Amphetamine normalizes the electrical activity of dopamine neurons in the ventral tegmental area following prenatal ethanol exposure. The Journal of pharmacology and experimental therapeutics. vol 297. issue 2. 2001-05-21. PMID:11303066. |
prenatal ethanol exposure has been shown to produce a persistent reduction in the spontaneous activity of ventral tegmental area (vta) dopamine (da) neurons and in da neurotransmission. |
2001-05-21 |
2023-08-12 |
rat |
| C L Cunningham, M A Howard, S J Gill, M Rubinstein, M J Low, D K Grand. Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice. Pharmacology, biochemistry, and behavior. vol 67. issue 4. 2001-05-17. PMID:11166059. |
recently, genetically engineered mice lacking functional dopamine d2 receptors have been shown to drink less ethanol in a two-bottle choice task. |
2001-05-17 |
2023-08-12 |
mouse |
| C L Cunningham, M A Howard, S J Gill, M Rubinstein, M J Low, D K Grand. Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice. Pharmacology, biochemistry, and behavior. vol 67. issue 4. 2001-05-17. PMID:11166059. |
overall, this study strongly supports the conclusion that dopamine d2 receptors normally influence ethanol reward in mice. |
2001-05-17 |
2023-08-12 |
mouse |
| E A Budygin, P E Phillips, D L Robinson, A P Kennedy, R R Gainetdinov, R M Wightma. Effect of acute ethanol on striatal dopamine neurotransmission in ambulatory rats. The Journal of pharmacology and experimental therapeutics. vol 297. issue 1. 2001-05-03. PMID:11259524. |
effect of acute ethanol on striatal dopamine neurotransmission in ambulatory rats. |
2001-05-03 |
2023-08-12 |
rat |
| E A Budygin, P E Phillips, D L Robinson, A P Kennedy, R R Gainetdinov, R M Wightma. Effect of acute ethanol on striatal dopamine neurotransmission in ambulatory rats. The Journal of pharmacology and experimental therapeutics. vol 297. issue 1. 2001-05-03. PMID:11259524. |
the effect of ethanol on evoked dopamine release in the caudate putamen has been measured in behaving animals with in vivo electrochemistry. |
2001-05-03 |
2023-08-12 |
rat |
| E A Budygin, P E Phillips, D L Robinson, A P Kennedy, R R Gainetdinov, R M Wightma. Effect of acute ethanol on striatal dopamine neurotransmission in ambulatory rats. The Journal of pharmacology and experimental therapeutics. vol 297. issue 1. 2001-05-03. PMID:11259524. |
ethanol dose dependently decreased dopamine efflux compared with saline-treated animals: to 89% of controls with 0.5 g/kg, 70% with 1 g/kg, 34% with 2.5 g/kg, and 18% with 5 g/kg. |
2001-05-03 |
2023-08-12 |
rat |
| E A Budygin, P E Phillips, D L Robinson, A P Kennedy, R R Gainetdinov, R M Wightma. Effect of acute ethanol on striatal dopamine neurotransmission in ambulatory rats. The Journal of pharmacology and experimental therapeutics. vol 297. issue 1. 2001-05-03. PMID:11259524. |
the selective dopamine uptake inhibitor gbr 12909 compensated for the effects of high doses of ethanol on dopamine release. |
2001-05-03 |
2023-08-12 |
rat |
| E A Budygin, P E Phillips, D L Robinson, A P Kennedy, R R Gainetdinov, R M Wightma. Effect of acute ethanol on striatal dopamine neurotransmission in ambulatory rats. The Journal of pharmacology and experimental therapeutics. vol 297. issue 1. 2001-05-03. PMID:11259524. |
in brain slices containing the caudate putamen, ethanol suppressed dopamine release only at the highest dose tested (200 mm). |
2001-05-03 |
2023-08-12 |
rat |
| E A Budygin, P E Phillips, D L Robinson, A P Kennedy, R R Gainetdinov, R M Wightma. Effect of acute ethanol on striatal dopamine neurotransmission in ambulatory rats. The Journal of pharmacology and experimental therapeutics. vol 297. issue 1. 2001-05-03. PMID:11259524. |
the difference in responses between the slice and the intact animal indicates that ethanol exerts its effects in the cell body regions of dopamine neurons as well as in terminals. |
2001-05-03 |
2023-08-12 |
rat |
| E A Budygin, P E Phillips, D L Robinson, A P Kennedy, R R Gainetdinov, R M Wightma. Effect of acute ethanol on striatal dopamine neurotransmission in ambulatory rats. The Journal of pharmacology and experimental therapeutics. vol 297. issue 1. 2001-05-03. PMID:11259524. |
these neurochemical results, combined with published accounts of microdialysis measures of extracellular dopamine and electrophysiological recordings of dopamine neurons, demonstrate that ethanol has a profound effect on dopamine neurons whose net result is a suppression of dopamine neurotransmission at high doses. |
2001-05-03 |
2023-08-12 |
rat |
| L Yu, H Fisher, G C Wagne. Monoaminergic changes associated with audiogenic seizures in ethanol-dependent rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 24. issue 8. 2001-03-01. PMID:11125861. |
however, increased dopamine but decreased serotonin levels in the striatum were observed in rats undergoing one episode of ethanol withdrawal, but not in those experiencing multiple episodes of ethanol withdrawal. |
2001-03-01 |
2023-08-12 |
rat |
| H J Yim, R A Gonzale. Ethanol-induced increases in dopamine extracellular concentration in rat nucleus accumbens are accounted for by increased release and not uptake inhibition. Alcohol (Fayetteville, N.Y.). vol 22. issue 2. 2001-01-25. PMID:11113625. |
we performed a quantitative microdialysis study to determine whether the increase in dialysate dopamine from the nucleus accumbens caused by intraperitoneal administration of ethanol (1 g/kg) was due to enhanced dopamine release or inhibition of dopamine uptake. |
2001-01-25 |
2023-08-12 |
rat |
| H J Yim, R A Gonzale. Ethanol-induced increases in dopamine extracellular concentration in rat nucleus accumbens are accounted for by increased release and not uptake inhibition. Alcohol (Fayetteville, N.Y.). vol 22. issue 2. 2001-01-25. PMID:11113625. |
however, the point of no net flux (true extracellular concentration of dopamine) significantly increased after the ethanol injection from 9.4+/-0.4 nm (mean of six basal samples) to 13.2+/-1.8 nm, at the maximum, but did not change after the saline injection. |
2001-01-25 |
2023-08-12 |
rat |
| H J Yim, R A Gonzale. Ethanol-induced increases in dopamine extracellular concentration in rat nucleus accumbens are accounted for by increased release and not uptake inhibition. Alcohol (Fayetteville, N.Y.). vol 22. issue 2. 2001-01-25. PMID:11113625. |
on the basis of these results, it is suggested that the primary mechanism by which ethanol increases dialysate dopamine levels in the nucleus accumbens after intraperitoneal administration is by increasing dopamine release from the terminals, rather than by inhibiting the dopamine transporter. |
2001-01-25 |
2023-08-12 |
rat |
| A S Gordon, L Yao, Z Jiang, C S Fishburn, S Fuchs, I Diamon. Ethanol acts synergistically with a D2 dopamine agonist to cause translocation of protein kinase C. Molecular pharmacology. vol 59. issue 1. 2001-01-25. PMID:11125036. |
ethanol acts synergistically with a d2 dopamine agonist to cause translocation of protein kinase c. ethanol and other drugs of abuse increase synaptic dopamine levels; however, little is known about how ethanol alters dopaminergic signaling. |
2001-01-25 |
2023-08-12 |
Not clear |
| C Thibault, C Lai, N Wilke, B Duong, M F Olive, S Rahman, H Dong, C W Hodge, D J Lockhart, M F Mile. Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. Molecular pharmacology. vol 58. issue 6. 2001-01-18. PMID:11093800. |
ethanol treatment elevated dopamine beta-hydroxylase (dbh, ec 1.14.17.1) mrna and protein levels and increased releasable norepinephrine in sh-sy5y cultures. |
2001-01-18 |
2023-08-12 |
mouse |
| B Söderpalm, M Ericson, P Olausson, O Blomqvist, J A Enge. Nicotinic mechanisms involved in the dopamine activating and reinforcing properties of ethanol. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942035. |
nicotinic mechanisms involved in the dopamine activating and reinforcing properties of ethanol. |
2001-01-03 |
2023-08-12 |
mouse |
| B Söderpalm, M Ericson, P Olausson, O Blomqvist, J A Enge. Nicotinic mechanisms involved in the dopamine activating and reinforcing properties of ethanol. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942035. |
ethanol shares with all major dependence producing drugs the ability to activate brain mesocorticolimbic dopamine neurons, an important part of the brain reward systems. |
2001-01-03 |
2023-08-12 |
mouse |