| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gaia Rocchitta, Ottavio Secchi, Maria Domenica Alvau, Rossana Migheli, Giammario Calia, Gianfranco Bazzu, Donatella Farina, Maria Speranza Desole, Robert D O'Neill, Pier Andrea Serr. Development and characterization of an implantable biosensor for telemetric monitoring of ethanol in the brain of freely moving rats. Analytical chemistry. vol 84. issue 16. 2012-12-20. PMID:22823474. |
while its psychoactive effects are mainly associated with gabaergic and glutamatergic systems, the positive reinforcing properties of ethanol are related to activation of mesolimbic dopaminergic pathways resulting in a release of dopamine in the nucleus accumbens. |
2012-12-20 |
2023-08-12 |
rat |
| Bo Söderpalm, Mia Ericso. Neurocircuitry involved in the development of alcohol addiction: the dopamine system and its access points. Current topics in behavioral neurosciences. vol 13. 2012-11-13. PMID:22094880. |
whereas the mechanisms of actions for central stimulants, opioids and nicotine in their dopamine activating effects are fairly well established, the corresponding mechanisms with respect to ethanol have been elusive. |
2012-11-13 |
2023-08-12 |
Not clear |
| Amine Bahi, Jean-Luc Dreye. Involvement of nucleus accumbens dopamine D1 receptors in ethanol drinking, ethanol-induced conditioned place preference, and ethanol-induced psychomotor sensitization in mice. Psychopharmacology. vol 222. issue 1. 2012-10-22. PMID:22222864. |
involvement of nucleus accumbens dopamine d1 receptors in ethanol drinking, ethanol-induced conditioned place preference, and ethanol-induced psychomotor sensitization in mice. |
2012-10-22 |
2023-08-12 |
mouse |
| Amine Bahi, Jean-Luc Dreye. Involvement of nucleus accumbens dopamine D1 receptors in ethanol drinking, ethanol-induced conditioned place preference, and ethanol-induced psychomotor sensitization in mice. Psychopharmacology. vol 222. issue 1. 2012-10-22. PMID:22222864. |
dopamine d1 receptor (d1r) signaling has been associated to ethanol consumption and reward in laboratory animals. |
2012-10-22 |
2023-08-12 |
mouse |
| J Liu, C F Wu, W Liu, H L Zhang, C L L. Involvement of the corticostriatal glutamatergic pathway in ethanol-induced ascorbic acid release in rat striatum. Addiction biology. vol 4. issue 3. 2012-10-02. PMID:20575794. |
this effect of ethanol could be partially antagonized by amantadine, a non-selective nmda receptor antagonist and dopamine releaser, at a dose of 200 mg/kg i.p. |
2012-10-02 |
2023-08-12 |
rat |
| H Furuya, H Aikawa, T Yoshida, I Okazak. Effects of ethyl alcohol administration to rat dams during the gestation period on learning behavior and on levels of monoamines and metabolites in rat pup brain after birth. Environmental health and preventive medicine. vol 1. issue 2. 2012-10-02. PMID:21432428. |
learning ability (sidman avoidance behavior), the amounts of monoamines (noradrenalin, dopamine, serotonin) and metabolites (3,4-dihydroxyphenyl acetic acid [dopac], homovanillic acid [hva] and 5-hydroxyindole acetic acid [5-hiaa])in whole brain were examined for neurobehavioral and neurochemical effects.there was no effect on sidman avoidance behavior in 56-day-old offspring, but alterations of the amounts of monoamines and their metabolites were observed even in 66-day-old offspring as a result of the dams' exposure to ethanol during pregnancy. |
2012-10-02 |
2023-08-12 |
rat |
| Guiqin Xie, Jiang-Hong Y. Salsolinol facilitates glutamatergic transmission to dopamine neurons in the posterior ventral tegmental area of rats. PloS one. vol 7. issue 5. 2012-09-19. PMID:22590592. |
we have reported previously that salsolinol stimulates dopamine neurons in the posterior ventral tegmental area (p-vta) partly by reducing inhibitory gabaergic transmission, and that ethanol increases glutamatergic transmission to vta-dopamine neurons via the activation of dopamine d(1) receptors (d(1)rs). |
2012-09-19 |
2023-08-12 |
rat |
| Paul J Fitzgeral. Neurodrinking: is alcohol a substrate in a novel, endogenous synthetic pathway for norepinephrine? Medical hypotheses. vol 78. issue 6. 2012-08-22. PMID:22425177. |
for example, ethanol interacts with dopamine beta-hydroxylase (dbh), an enzyme that plays an essential role in the only well-established endogenous synthetic pathway for ne, whereby dopamine is hydroxylated to form ne. |
2012-08-22 |
2023-08-12 |
mouse |
| Zheng-Ming Ding, Simon N Katner, Zachary A Rodd, William Truitt, Sheketha R Hauser, Gerald A Deehan, Eric A Engleman, William J McBrid. Repeated exposure of the posterior ventral tegmental area to nicotine increases the sensitivity of local dopamine neurons to the stimulating effects of ethanol. Alcohol (Fayetteville, N.Y.). vol 46. issue 3. 2012-07-30. PMID:22449786. |
repeated exposure of the posterior ventral tegmental area to nicotine increases the sensitivity of local dopamine neurons to the stimulating effects of ethanol. |
2012-07-30 |
2023-08-12 |
rat |
| Zheng-Ming Ding, Simon N Katner, Zachary A Rodd, William Truitt, Sheketha R Hauser, Gerald A Deehan, Eric A Engleman, William J McBrid. Repeated exposure of the posterior ventral tegmental area to nicotine increases the sensitivity of local dopamine neurons to the stimulating effects of ethanol. Alcohol (Fayetteville, N.Y.). vol 46. issue 3. 2012-07-30. PMID:22449786. |
on the 8th day, rats received microinjections of either vehicle or ethanol (100 or 200 mg%) into the pvta while extracellular dopamine samples were collected from the ipsilateral nucleus accumbens shell (nacsh) with microdialysis. |
2012-07-30 |
2023-08-12 |
rat |
| Zheng-Ming Ding, Simon N Katner, Zachary A Rodd, William Truitt, Sheketha R Hauser, Gerald A Deehan, Eric A Engleman, William J McBrid. Repeated exposure of the posterior ventral tegmental area to nicotine increases the sensitivity of local dopamine neurons to the stimulating effects of ethanol. Alcohol (Fayetteville, N.Y.). vol 46. issue 3. 2012-07-30. PMID:22449786. |
another experiment tested the effects of challenge microinjections of 200 μm nicotine in the pvta on extracellular dopamine levels in the nacsh following 7 daily pretreatments with 200 mg% ethanol in the pvta. |
2012-07-30 |
2023-08-12 |
rat |
| Zheng-Ming Ding, Simon N Katner, Zachary A Rodd, William Truitt, Sheketha R Hauser, Gerald A Deehan, Eric A Engleman, William J McBrid. Repeated exposure of the posterior ventral tegmental area to nicotine increases the sensitivity of local dopamine neurons to the stimulating effects of ethanol. Alcohol (Fayetteville, N.Y.). vol 46. issue 3. 2012-07-30. PMID:22449786. |
the results suggest that repeated exposure of the pvta to nicotine increased the response of local dopamine neurons to the stimulating effects of ethanol, whereas repeated exposure of the pvta to ethanol did not alter the responses of pvta dopamine neurons to nicotine. |
2012-07-30 |
2023-08-12 |
rat |
| Karina Possa Abrahao, Isabel Marian Hartmann Quadros, Andre Luiz Monezi Andrade, Maria Lucia Oliveira Souza-Formigon. Accumbal dopamine D2 receptor function is associated with individual variability in ethanol behavioral sensitization. Neuropharmacology. vol 62. issue 2. 2012-07-27. PMID:21964435. |
accumbal dopamine d2 receptor function is associated with individual variability in ethanol behavioral sensitization. |
2012-07-27 |
2023-08-12 |
mouse |
| A M Smith, K A Wellmann, T M Lundblad, M L Carter, S Barron, L P Dwoski. Lobeline attenuates neonatal ethanol-mediated changes in hyperactivity and dopamine transporter function in the prefrontal cortex in rats. Neuroscience. vol 206. 2012-07-18. PMID:22119644. |
developmental exposure to ethanol produces changes in dopamine (da) systems, and da has also been implicated in adhd pathology. |
2012-07-18 |
2023-08-12 |
rat |
| María de Los Ángeles Juricic, Pablo A Berríos-Cárcamo, Mónica L Acevedo, Yedy Israel, Iriux Almodóvar, Bruce K Cassel. Salsolinol and isosalsolinol: condensation products of acetaldehyde and dopamine. Separation of their enantiomers in the presence of a large excess of dopamine. Journal of pharmaceutical and biomedical analysis. vol 63. 2012-06-25. PMID:22370127. |
dopamine (da) condenses, at least in vitro, with acetaldehyde, the primary metabolite of ethanol, to form the regioisomers salsolinol (sal) and isosalsolinol (isosal). |
2012-06-25 |
2023-08-12 |
Not clear |
| Teresa Femenía, Jorge Manzanare. Increased ethanol intake in prodynorphin knockout mice is associated to changes in opioid receptor function and dopamine transmission. Addiction biology. vol 17. issue 2. 2012-05-08. PMID:21966993. |
increased ethanol intake in prodynorphin knockout mice is associated to changes in opioid receptor function and dopamine transmission. |
2012-05-08 |
2023-08-12 |
mouse |
| Teresa Femenía, Jorge Manzanare. Increased ethanol intake in prodynorphin knockout mice is associated to changes in opioid receptor function and dopamine transmission. Addiction biology. vol 17. issue 2. 2012-05-08. PMID:21966993. |
handling-induced convulsion (hic) associated to alcohol, alcohol-induced loss of righting reflex (lorr), hypothermic effects in response to acute ethanol challenge, blood ethanol levels (bels), conditioned place preference, voluntary ethanol consumption and preference, tyrosine hydroxylase (th), dopamine transporter (dat) and proenkephalin (penk) gene expression, and µ-, δ- and κ-opioid agonist-stimulated [s(35) ]- guanosine 5'-triphosphate-binding autoradiography were studied in prodynorphin knockout (pdyn ko) and wild-type (wt) mice. |
2012-05-08 |
2023-08-12 |
mouse |
| Hsien-yang Lee, Junko Nakayama, Ying Xu, Xueliang Fan, Maha Karouani, Yiguo Shen, Emmanuel N Pothos, Ellen J Hess, Ying-Hui Fu, Robert H Edwards, Louis J Ptáce. Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia. The Journal of clinical investigation. vol 122. issue 2. 2012-04-20. PMID:22214848. |
they also showed nigrostriatal neurotransmission deficits that were manifested by reduced extracellular dopamine levels in the striatum and a proportional increase of dopamine release in response to caffeine and ethanol treatment. |
2012-04-20 |
2023-08-12 |
mouse |
| Lucía Hipólito, María José Sánchez-Catalán, Lucía Martí-Prats, Luis Granero, Ana Polach. Revisiting the controversial role of salsolinol in the neurobiological effects of ethanol: old and new vistas. Neuroscience and biobehavioral reviews. vol 36. issue 1. 2012-04-19. PMID:21802444. |
the possible involvement of salsolinol (sal), an endogenous condensation product of acd (the first metabolite of ethanol) and dopamine, in the neurochemical basis underlying ethanol action has been repeatedly suggested although it has not been unequivocally established, still being a controversial matter of debate. |
2012-04-19 |
2023-08-12 |
Not clear |
| Tomislav Jukić, Bojan Rojc, Darja Boben-Bardutzky, Mateja Hafner, Alojz Iha. The use of a food supplementation with D-phenylalanine, L-glutamine and L-5-hydroxytriptophan in the alleviation of alcohol withdrawal symptoms. Collegium antropologicum. vol 35. issue 4. 2012-03-29. PMID:22397264. |
since abstinence from ethanol causes a hypodopaminergic and a hypoopioidergic environment in the reword system circuits, manifesting with withdrawal symptoms, food supplements that contains d-phenylalanine a peptidase inhibitor (of opioide inactivation) and l-amino-acids (for dopamine synthesis) were used to replenish a lack in neurotransmitters and alleviate the symptoms of alcohol withdrawal. |
2012-03-29 |
2023-08-12 |
Not clear |