| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Rassnick, L Stinus, G F Koo. The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat. Brain research. vol 623. issue 1. 1993-12-21. PMID:8221085. |
the effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat. |
1993-12-21 |
2023-08-12 |
rat |
| S Rassnick, L Stinus, G F Koo. The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat. Brain research. vol 623. issue 1. 1993-12-21. PMID:8221085. |
previous studies using this self-administration model have shown that dopamine receptor antagonists injected systemically or directly into the terminal regions of the mesolimbic dopamine system decrease lever pressing for ethanol, suggesting an important role for dopamine in ethanol reinforcement. |
1993-12-21 |
2023-08-12 |
rat |
| S Rassnick, L Stinus, G F Koo. The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat. Brain research. vol 623. issue 1. 1993-12-21. PMID:8221085. |
the purpose of the present study was to test the hypothesis that the mesolimbic dopamine system is a critical substrate for ethanol reinforcement. |
1993-12-21 |
2023-08-12 |
rat |
| S Rassnick, L Stinus, G F Koo. The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat. Brain research. vol 623. issue 1. 1993-12-21. PMID:8221085. |
results of this study show that 6-hydroxydopamine (6-ohda)-induced lesions of the mesolimbic dopamine system, sufficient to produce a 93% depletion of dopamine in the nucleus accumbens, an 85% depletion in the olfactory tubercle, an 82% depletion in the frontal cortex and a 78% depletion in the amygdala, failed to alter ethanol self-administration as measured by the total lever presses. |
1993-12-21 |
2023-08-12 |
rat |
| S Rassnick, L Stinus, G F Koo. The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat. Brain research. vol 623. issue 1. 1993-12-21. PMID:8221085. |
the results of this study indicate that while the mesolimbic dopamine system may contribute to the reinforcing actions of ethanol, it is not critical for maintaining ethanol reinforcement. |
1993-12-21 |
2023-08-12 |
rat |
| Z L Rossetti, Y Hmaidan, M Diana, G L Gess. Lack of tolerance to ethanol-induced dopamine release in the rat ventral striatum. European journal of pharmacology. vol 231. issue 2. 1993-04-20. PMID:8453975. |
these results indicate that tolerance does not develop to the ethanol-induced stimulation of dopamine release and support the hypothesis that activation of the mesolimbic dopamine system contributes to the reinforcing properties of ethanol. |
1993-04-20 |
2023-08-12 |
rat |
| T Suzuki, Y Shiozaki, T Moriizumi, M Misaw. Establishment of the ethanol-induced place preference in rats. Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence. vol 27. issue 1. 1992-06-26. PMID:1596241. |
these results suggest that a blockade of ethanol metabolism is very important for development of the ethanol-induced place preference in rats, and that the ethanol-induced place preference may be mediated by the mesolimbic dopamine system through 5-ht3 receptors. |
1992-06-26 |
2023-08-11 |
rat |
| S M Pellegrino, M J Drus. The effects of chronic ethanol consumption on the mesolimbic and nigrostriatal dopamine systems. Alcoholism, clinical and experimental research. vol 16. issue 2. 1992-06-22. PMID:1534209. |
both the mesolimbic dopamine system, which is involved with the rewarding properties of several drugs of abuse, and the nigrostriatal dopamine system, which is involved with motor function, appear to be sensitive to the effects of ethanol. |
1992-06-22 |
2023-08-11 |
rat |
| P L Hoffman, B Tabakof. Adaptive changes in the dopamine system produced by chronic ethanol feeding. Drug and alcohol dependence. vol 4. issue 3-4. 1980-04-17. PMID:43240. |
adaptive changes in the dopamine system produced by chronic ethanol feeding. |
1980-04-17 |
2023-08-11 |
mouse |