| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark S Brodi. Increased ethanol excitation of dopaminergic neurons of the ventral tegmental area after chronic ethanol treatment. Alcoholism, clinical and experimental research. vol 26. issue 7. 2003-02-05. PMID:12170113. |
the mesolimbic dopamine pathway, which originates in the ventral tegmental area (vta), is important for the rewarding effects of ethanol. |
2003-02-05 |
2023-08-12 |
mouse |
| Shigeki Matsuzawa, Tsutomu Suzuk. [Psychological stress and rewarding effect of alcohol]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 37. issue 3. 2002-08-02. PMID:12138720. |
it has been hypothesized that activation of the mesolimbic dopamine system mediated by the endogenous opioid system may be particularly important in the rewarding mechanism of ethanol. |
2002-08-02 |
2023-08-12 |
Not clear |
| C L Cunningham, M A Howard, S J Gill, M Rubinstein, M J Low, D K Grand. Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice. Pharmacology, biochemistry, and behavior. vol 67. issue 4. 2001-05-17. PMID:11166059. |
pharmacological blockade studies have supported a role of the dopamine system in ethanol reward for many years, but receptor subtype specificity has been difficult to establish. |
2001-05-17 |
2023-08-12 |
mouse |
| B Söderpalm, M Ericson, P Olausson, O Blomqvist, J A Enge. Nicotinic mechanisms involved in the dopamine activating and reinforcing properties of ethanol. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942035. |
the mechanisms of action of ethanol in its activation of this dopamine system remain, however, to be elucidated. |
2001-01-03 |
2023-08-12 |
mouse |
| M S Brodie, S B Appe. Dopaminergic neurons in the ventral tegmental area of C57BL/6J and DBA/2J mice differ in sensitivity to ethanol excitation. Alcoholism, clinical and experimental research. vol 24. issue 7. 2000-11-28. PMID:10924018. |
the mesolimbic dopamine pathway that originates in the ventral tegmental area (vta) is important for the rewarding effects of ethanol. |
2000-11-28 |
2023-08-12 |
mouse |
| M S Brodie, C Pesold, S B Appe. Ethanol directly excites dopaminergic ventral tegmental area reward neurons. Alcoholism, clinical and experimental research. vol 23. issue 11. 1999-12-30. PMID:10591603. |
the mesolimbic/mesocortical dopamine pathway mediates the rewarding effects of ethanol and other drugs of abuse like cocaine and opiates. |
1999-12-30 |
2023-08-12 |
Not clear |
| M S Cowen, A J Lawrenc. The role of opioid-dopamine interactions in the induction and maintenance of ethanol consumption. Progress in neuro-psychopharmacology & biological psychiatry. vol 23. issue 7. 1999-12-21. PMID:10581642. |
however, studies indicate that there are redundant pathways, and neural pathways 'downstream' of the mesolimbic dopamine system, which also enable the reinforcing properties of ethanol to be mediated. |
1999-12-21 |
2023-08-12 |
human |
| A Amer. The effects of cannabinoids on the brain. Progress in neurobiology. vol 58. issue 4. 1999-07-22. PMID:10368032. |
thus, cannabinoids share a final common neuronal action with other major drugs of abuse such as morphine, ethanol and nicotine in producing facilitation of the mesolimbic dopamine system. |
1999-07-22 |
2023-08-12 |
Not clear |
| C P Bailey, S J Manley, W P Watson, S Wonnacott, A Molleman, H J Littl. Chronic ethanol administration alters activity in ventral tegmental area neurons after cessation of withdrawal hyperexcitability. Brain research. vol 803. issue 1-2. 1999-05-26. PMID:9729345. |
the present study investigated the activity of neurons in the mesolimbic dopamine system after the end of the acute phase of the behavioural signs of ethanol withdrawal in mice. |
1999-05-26 |
2023-08-12 |
mouse |
| M Ericson, O Blomqvist, J A Engel, B Söderpal. Voluntary ethanol intake in the rat and the associated accumbal dopamine overflow are blocked by ventral tegmental mecamylamine. European journal of pharmacology. vol 358. issue 3. 1999-01-13. PMID:9822883. |
the mesocorticolimbic dopamine system is believed to be involved in mediating the positive reinforcing effects of drugs of abuse, including ethanol. |
1999-01-13 |
2023-08-12 |
rat |
| P Olausson, M Ericson, A Petersson, A Kosowski, B Söderpalm, J A Enge. Nefazodone attenuates the behavioral and neurochemical effects of ethanol. Alcohol (Fayetteville, N.Y.). vol 15. issue 1. 1998-02-02. PMID:9426841. |
these results show that nefazodone modulates the mesolimbic dopamine system in a dopamine activity-dependent manner, and influences the neurochemical and behavioral effects of ethanol in the rat. |
1998-02-02 |
2023-08-12 |
rat |
| J Ortiz, L W Fitzgerald, M Charlton, S Lane, L Trevisan, X Guitart, W Shoemaker, R S Duman, E J Nestle. Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. Synapse (New York, N.Y.). vol 21. issue 4. 1997-01-03. PMID:8869159. |
biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. |
1997-01-03 |
2023-08-12 |
Not clear |
| J Ortiz, L W Fitzgerald, M Charlton, S Lane, L Trevisan, X Guitart, W Shoemaker, R S Duman, E J Nestle. Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. Synapse (New York, N.Y.). vol 21. issue 4. 1997-01-03. PMID:8869159. |
these actions of ethanol required long-term exposure to the drug, and were in most cases not seen in the substantia nigra or caudateputamen, components of the nigrostriatal dopamine system studied for comparison. |
1997-01-03 |
2023-08-12 |
Not clear |
| J Ortiz, L W Fitzgerald, M Charlton, S Lane, L Trevisan, X Guitart, W Shoemaker, R S Duman, E J Nestle. Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. Synapse (New York, N.Y.). vol 21. issue 4. 1997-01-03. PMID:8869159. |
these results demonstrate that chronic ethanol exposure results in several biochemical adaptations in the mesolimbic dopamine system, which may underlie prominent changes in the structural and functional properties of this neural pathway related to alcohol abuse and alcoholism. |
1997-01-03 |
2023-08-12 |
Not clear |
| G Di Chiara, E Acquas, G Tand. Ethanol as a neurochemical surrogate of conventional reinforcers: the dopamine-opioid link. Alcohol (Fayetteville, N.Y.). vol 13. issue 1. 1996-12-02. PMID:8837928. |
thus, pharmacological blockade of the endogenous opioid system by mu- or delta-opioid receptor antagonists prevents ethanol's activation of the dopamine system and reduces ethanol consumption. |
1996-12-02 |
2023-08-12 |
Not clear |
| J Ortiz, L W Fitzgerald, S Lane, R Terwilliger, E J Nestle. Biochemical adaptations in the mesolimbic dopamine system in response to repeated stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 6. 1996-11-27. PMID:8726755. |
we have demonstrated previously that chronic administration of morphine, cocaine, or ethanol produces some common biochemical adaptations in the ventral tegmental area (vta) and nucleus accumbens (nac), components of the mesolimbic dopamine system implicated in the reinforcing and locomotor activating properties of these drugs of abuse. |
1996-11-27 |
2023-08-12 |
rat |
| L W Fitzgerald, E J Nestle. Molecular and cellular adaptations in signal transduction pathways following ethanol exposure. Clinical neuroscience (New York, N.Y.). vol 3. issue 3. 1996-06-04. PMID:8612061. |
ethanol, as with other drugs of abuse, also acutely activates the mesolimbic dopamine pathway, an effect which likely accounts, at least in part, for ethanol's acute reinforcing properties. |
1996-06-04 |
2023-08-12 |
Not clear |
| C Fahlke, E Hård, C J Eriksson, J A Engel, S Hanse. Amphetamine-induced hyperactivity: differences between rats with high or low preference for alcohol. Alcohol (Fayetteville, N.Y.). vol 12. issue 4. 1995-11-09. PMID:7546334. |
these data indicate that the same neural substrate (e.g., the mesocorticolimbic dopamine system) may mediate important aspects of both ethanol drinking and amphetamine responsiveness. |
1995-11-09 |
2023-08-12 |
rat |
| H H Samson, C W Hodg. The role of the mesoaccumbens dopamine system in ethanol reinforcement: studies using the techniques of microinjection and voltammetry. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 2. 1995-06-22. PMID:7748341. |
the role of the mesoaccumbens dopamine system in ethanol reinforcement: studies using the techniques of microinjection and voltammetry. |
1995-06-22 |
2023-08-12 |
Not clear |
| B A Blanchard, S Steindorf, S Wang, S D Glic. Sex differences in ethanol-induced dopamine release in nucleus accumbens and in ethanol consumption in rats. Alcoholism, clinical and experimental research. vol 17. issue 5. 1994-02-08. PMID:8279683. |
the pattern of both greater ethanol-induced nucleus accumbens dopamine release and greater ethanol consumption in females supports the hypothesis that ethanol reward is mediated, at least in part, by the mesolimbic dopamine system. |
1994-02-08 |
2023-08-12 |
rat |