| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Louise Adermark, Bo Söderpalm, John M Burkhard. Brain region specific modulation of ethanol-induced depression of GABAergic neurons in the brain reward system by the nicotine receptor antagonist mecamylamine. Alcohol (Fayetteville, N.Y.). vol 48. issue 5. 2015-02-23. PMID:24961541. |
this finding, taken together with previous microdialysis studies, supports an involvement of gabaergic neurons and nachrs in ethanol's interaction with the mesolimbic dopamine system. |
2015-02-23 |
2023-08-13 |
mouse |
| Jamie H Rose, Erin S Calipari, Tiffany A Mathews, Sara R Jone. Greater ethanol-induced locomotor activation in DBA/2J versus C57BL/6J mice is not predicted by presynaptic striatal dopamine dynamics. PloS one. vol 8. issue 12. 2014-09-29. PMID:24349553. |
because of the role of the dopamine system in reinforcement and reward learning, differences in dopamine signaling between the strains could have implications for addiction-related behaviors that extend beyond ethanol effects in the striatum. |
2014-09-29 |
2023-08-12 |
mouse |
| Angela Renee Ozburn, Edgardo Falcon, Shibani Mukherjee, Andrea Gillman, Rachel Arey, Sade Spencer, Colleen A McClun. The role of clock in ethanol-related behaviors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 12. 2014-06-03. PMID:23722243. |
taken together, we have identified a significant role for clock in the vta as a negative regulator of ethanol intake and implicate the vta dopamine system in this response. |
2014-06-03 |
2023-08-12 |
mouse |
| L Adermark, S Jonsson, B Söderpalm, M Ericso. Region-specific depression of striatal activity in Wistar rat by modest ethanol consumption over a ten-month period. Alcohol (Fayetteville, N.Y.). vol 47. issue 4. 2013-10-21. PMID:23601928. |
the nucleus accumbens (nac) is the primary target for the mesolimbic dopamine system and a key brain region for the reinforcing effects displayed by drugs of abuse, including ethanol. |
2013-10-21 |
2023-08-12 |
rat |
| Ravi Kiran Sajja, Shafiqur Rahma. Cytisine modulates chronic voluntary ethanol consumption and ethanol-induced striatal up-regulation of ΔFosB in mice. Alcohol (Fayetteville, N.Y.). vol 47. issue 4. 2013-10-21. PMID:23601929. |
chronic administration of ethanol induces persistent accumulation of Δfosb, an important transcription factor, in the midbrain dopamine system. |
2013-10-21 |
2023-08-12 |
mouse |
| Ravi K Sajja, Shafiqur Rahma. Neuronal nicotinic receptor ligands modulate chronic nicotine-induced ethanol consumption in C57BL/6J mice. Pharmacology, biochemistry, and behavior. vol 102. issue 1. 2013-03-14. PMID:22741175. |
alcohol and nicotine are commonly abused drugs in humans and evidence suggests that neuronal nicotinic acetylcholine receptors (nachrs) in the midbrain dopamine system are common targets for the neurobehavioral interactions between alcohol (ethanol) and nicotine. |
2013-03-14 |
2023-08-12 |
mouse |
| Bo Söderpalm, Mia Ericso. Neurocircuitry involved in the development of alcohol addiction: the dopamine system and its access points. Current topics in behavioral neurosciences. vol 13. 2012-11-13. PMID:22094880. |
all major drugs of abuse, including ethanol, acutely activate the mesolimbic dopamine system. |
2012-11-13 |
2023-08-12 |
Not clear |
| Bo Söderpalm, Mia Ericso. Neurocircuitry involved in the development of alcohol addiction: the dopamine system and its access points. Current topics in behavioral neurosciences. vol 13. 2012-11-13. PMID:22094880. |
here we review the actions of ethanol in the mesolimbic dopamine system, focusing on ethanol's interaction with ligand-gated ion-channel receptors, opiate receptors, the ghrelin system and the possible involvement of acetaldehyde. |
2012-11-13 |
2023-08-12 |
Not clear |
| Jennifer Carrillo, Rueben A Gonzale. A single exposure to voluntary ethanol self-administration produces adaptations in ethanol consumption and accumbal dopamine signaling. Alcohol (Fayetteville, N.Y.). vol 45. issue 6. 2011-12-05. PMID:21827930. |
furthermore, we speculate that the dopamine response during ethanol consumption likely reflects the reward-prediction role of the mesolimbic dopamine system. |
2011-12-05 |
2023-08-12 |
rat |
| T K Newman, C C Parker, S J Suomi, D Goldman, C S Barr, J Dee Higle. DRD1 5'UTR variation, sex and early infant stress influence ethanol consumption in rhesus macaques. Genes, brain, and behavior. vol 8. issue 6. 2011-01-10. PMID:19563515. |
the mesolimbic dopamine system plays an important role in mediating a variety of behaviors and is involved in mediating the reinforcing effects of ethanol. |
2011-01-10 |
2023-08-12 |
human |
| Peipei Chau, Helga Höifödt-Lidö, Elin Löf, Bo Söderpalm, Mia Ericso. Glycine receptors in the nucleus accumbens involved in the ethanol intake-reducing effect of acamprosate. Alcoholism, clinical and experimental research. vol 34. issue 1. 2010-08-10. PMID:19860809. |
we have previously demonstrated that strychnine-sensitive glycine receptors (glyrs) in the nucleus accumbens (nac) and nicotinic acetylcholine receptors (nachrs) in the ventral tegmental area are involved in mediating ethanol (etoh)-induced elevation of dopamine in the rat mesolimbic dopamine system. |
2010-08-10 |
2023-08-12 |
rat |
| Heidi Kemppainen, Noora Raivio, Harri Nurmi, Kalervo Kiianma. GABA and glutamate overflow in the VTA and ventral pallidum of alcohol-preferring AA and alcohol-avoiding ANA rats after ethanol. Alcohol and alcoholism (Oxford, Oxfordshire). vol 45. issue 2. 2010-04-30. PMID:20075026. |
the purpose of the present study was, therefore, to clarify the role of gabaergic and glutamatergic afferents and efferents with the mesolimbic dopamine system in the control of ethanol intake as well as in differential intake of ethanol by aa and ana rats. |
2010-04-30 |
2023-08-12 |
rat |
| B Söderpalm, E Löf, M Ericso. Mechanistic studies of ethanol's interaction with the mesolimbic dopamine reward system. Pharmacopsychiatry. vol 42 Suppl 1. 2009-07-01. PMID:19434560. |
available data suggests that the mesolimbic dopamine system is involved both in the positive and negative reinforcing effects of ethanol. |
2009-07-01 |
2023-08-12 |
Not clear |
| B Söderpalm, E Löf, M Ericso. Mechanistic studies of ethanol's interaction with the mesolimbic dopamine reward system. Pharmacopsychiatry. vol 42 Suppl 1. 2009-07-01. PMID:19434560. |
the proposed neurocircuitry, has implications for understanding ethanol conditioned dopamine activation, chronic effects of ethanol on the mesolimbic dopamine system and the overall role/importance of dopamine and the nucleus accumbens for the reinforcing effects of ethanol. |
2009-07-01 |
2023-08-12 |
Not clear |
| María E Quintanilla, Elizabeth Perez, Lutske Tampie. Baclofen reduces ethanol intake in high-alcohol-drinking University of Chile bibulous rats. Addiction biology. vol 13. issue 3-4. 2009-03-05. PMID:18422834. |
baclofen dose-dependently suppressed the motor activity stimulated by ethanol administration, a phenomenon mediated by activation of the mesolimbic dopamine system. |
2009-03-05 |
2023-08-12 |
rat |
| b' Hanna Malinen, Petri Hyyti\\xc3\\xa. Ethanol self-administration is regulated by CB1 receptors in the nucleus accumbens and ventral tegmental area in alcohol-preferring AA rats. Alcoholism, clinical and experimental research. vol 32. issue 11. 2009-02-09. PMID:18782338.' |
in the present study, we assessed the role of cb1 receptors within the key regions of the mesolimbic dopamine pathway, the nucleus accumbens (nacc) and ventral tegmental area (vta), in regulation of ethanol self-administration. |
2009-02-09 |
2023-08-12 |
rat |
| Thomas L Kash, Robert T Matthews, Danny G Winde. Alcohol inhibits NR2B-containing NMDA receptors in the ventral bed nucleus of the stria terminalis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 6. 2008-08-07. PMID:17625498. |
components of the mesolimbic dopamine system, in particular dopaminergic cells in the ventral tegmental area (vta), have been implicated in the acute reinforcing actions of ethanol. |
2008-08-07 |
2023-08-12 |
Not clear |
| Mia Ericson, Elin Löf, Rosita Stomberg, PeiPei Chau, Bo Söderpal. Nicotinic acetylcholine receptors in the anterior, but not posterior, ventral tegmental area mediate ethanol-induced elevation of accumbal dopamine levels. The Journal of pharmacology and experimental therapeutics. vol 326. issue 1. 2008-07-30. PMID:18369179. |
however, it has not yet been demonstrated where the primary point of action of ethanol is in the mesolimbic dopamine system, and there appear to be conflicting findings depending on methodology (electrophysiology, microdialysis, or intracranial self-administration). |
2008-07-30 |
2023-08-12 |
Not clear |
| Maria Izco, Ivanny Marchant, Isabel Escobedo, Ines Peraile, Mercedes Delgado, Alejandro Higuera-Matas, Oscar Olias, Emilio Ambrosio, Esther O'Shea, M Isabel Colad. Mice with decreased cerebral dopamine function following a neurotoxic dose of MDMA (3,4-methylenedioxymethamphetamine, "Ecstasy") exhibit increased ethanol consumption and preference. The Journal of pharmacology and experimental therapeutics. vol 322. issue 3. 2007-10-19. PMID:17526809. |
there is strong evidence indicating that the dopamine system plays a key role in the rewarding effects of ethanol and modulates ethanol intake. |
2007-10-19 |
2023-08-12 |
mouse |
| Yuichiro Inoue, Lina Yao, F Woodward Hopf, Peidong Fan, Zhan Jiang, Antonello Bonci, Ivan Diamon. Nicotine and ethanol activate protein kinase A synergistically via G(i) betagamma subunits in nucleus accumbens/ventral tegmental cocultures: the role of dopamine D(1)/D(2) and adenosine A(2A) receptors. The Journal of pharmacology and experimental therapeutics. vol 322. issue 1. 2007-08-30. PMID:17468300. |
the mesolimbic dopamine system contributes significantly to nicotine and ethanol reinforcement, but the underlying cellular signaling mechanisms are poorly understood. |
2007-08-30 |
2023-08-12 |
Not clear |