| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dahye Yoon, Seon Min Oh, Hyeon Seon Na, Bo-Ram Choi, Kwan-Woo Kim, Young-Seob Lee, Dong-Ryung Lee, Dae Young Le. Metabolomics study to reveal cognitive improvement with treatment of Scrophularia buergeriana. Scientific reports. vol 14. issue 1. 2024-07-23. PMID:39043762. |
niacinamide, tyrosine, uridine, and valine in the cortex and gaba, choline, creatine, formate, fumarate, hypoxanthine, leucine, myo-inositol, pyroglutamate, and taurine in the hippocampus were identified as biomarker candidates for recovering cognitive impairment. |
2024-07-23 |
2024-07-26 |
mouse |
| Shirelle X Liu, Aarthi Ramakrishnan, Li Shen, Jonathan C Gewirtz, Michael K Georgieff, Phu V Tra. Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus. BMC genomics. vol 25. issue 1. 2024-03-22. PMID:38515015. |
prenatal choline supplementation partially normalizes these effects, suggesting an interaction between iron and choline in hippocampal transcriptome regulation. |
2024-03-22 |
2024-03-24 |
rat |
| Yao Wu, Josepheen De Asis-Cruz, Catherine Limperopoulo. Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy. Molecular psychiatry. 2024-02-28. PMID:38418579. |
elevated maternal psychological distress is associated with changes in fetal brain structure and function, including reduced hippocampal and cerebellar volumes, increased cerebral cortical gyrification and sulcal depth, decreased brain metabolites (e.g., choline and creatine levels), and disrupted functional connectivity. |
2024-02-28 |
2024-03-02 |
Not clear |
| Shirelle X Liu, Natalia Calixto Mancipe, Tate Gisslen, Michael K Georgieff, Phu V Tra. Identification of Genes Responding to Iron or Choline Treatment for Early-Life Iron Deficiency in the Male Rat Hippocampal Transcriptomes. The Journal of nutrition. 2024-02-26. PMID:38408730. |
identification of genes responding to iron or choline treatment for early-life iron deficiency in the male rat hippocampal transcriptomes. |
2024-02-26 |
2024-03-02 |
rat |
| Siamak Sheikhi, Razieh Aghazadeh, Hojjat Sayyadi, Bagher Pourheydar, Ehsan Saboory, Morteza Bagheri, Leila Derafshpou. The effects of choline supplementation in mothers with hypothyroidism on the alteration of cognitive-behavioral, long-term potentiation, morphology, and apoptosis in the hippocampus of pre-pubertal offspring rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2024-02-08. PMID:38311365. |
the effects of choline supplementation in mothers with hypothyroidism on the alteration of cognitive-behavioral, long-term potentiation, morphology, and apoptosis in the hippocampus of pre-pubertal offspring rats. |
2024-02-08 |
2024-02-11 |
rat |
| Thomas A Bellio, Jessenia Y Laguna-Torres, Mary S Campion, Jay Chou, Sheila Yee, Jan K Blusztajn, Tiffany J Mellot. Perinatal choline supplementation prevents learning and memory deficits and reduces brain amyloid Aβ42 deposition in AppNL-G-F Alzheimer's disease model mice. PloS one. vol 19. issue 2. 2024-02-06. PMID:38315685. |
perinatal choline supplementation reduced aβ42 deposition in the amygdala, cortex, and hippocampus of appnl-g-f mice. |
2024-02-06 |
2024-02-09 |
mouse |
| Abigail J Myers, Callum Potts, Jenna A Makarewicz, Elizabeth McGee, Julie A Duma. Choline kinase alpha genotype is related to hippocampal brain volume and cognition in postmenopausal women. Heliyon. vol 10. issue 1. 2024-01-16. PMID:38226229. |
choline kinase alpha genotype is related to hippocampal brain volume and cognition in postmenopausal women. |
2024-01-16 |
2024-01-18 |
Not clear |
| Abigail J Myers, Callum Potts, Jenna A Makarewicz, Elizabeth McGee, Julie A Duma. Choline kinase alpha genotype is related to hippocampal brain volume and cognition in postmenopausal women. Heliyon. vol 10. issue 1. 2024-01-16. PMID:38226229. |
this study examined how single nucleotide polymorphisms (snps) related to choline synthesis and metabolism, processes largely regulated by estrogen, influenced hippocampal volume and neuropsychological function following menopause. |
2024-01-16 |
2024-01-18 |
Not clear |
| Zhen Zeng, Jing He, Tao Ya. Characteristic early changes of Glu and Cho in brain regions affected by different types of subjective cognitive decline and their clinical significance. Medicine. vol 102. issue 49. 2023-12-08. PMID:38065860. |
using the bilateral hippocampus, left posterior cingulate gyrus (pcg), and frontal lobe as regions of interest, the scope under the peak of n-acetylaspartate (naa), choline complex (cho), glutamate (glu), metabolic images (mi), and creatine (cr) was tested. |
2023-12-08 |
2023-12-17 |
human |
| Yinli Huang, Junli Chen, Jiahui Lu, Hanqi Luo, Na Ying, Wei Dong, Minjie Lin, Hong Zhen. Transient neonatal hyperglycemia induces metabolic shifts in the rat hippocampus: a Metabolic brain disease. 2023-06-26. PMID:37358727. |
the results show that tnh rats had significantly increased levels of n-acetyl aspartate, glutamine, aspartate and choline in the hippocampus relative to ctrl rats at p7. |
2023-06-26 |
2023-08-14 |
rat |
| Yinli Huang, Junli Chen, Jiahui Lu, Hanqi Luo, Na Ying, Wei Dong, Minjie Lin, Hong Zhen. Transient neonatal hyperglycemia induces metabolic shifts in the rat hippocampus: a Metabolic brain disease. 2023-06-26. PMID:37358727. |
therefore, our results suggest that tnh may have a long-term effect on hippocampal metabolic changes mainly involving neurotransmitter metabolism and choline metabolism. |
2023-06-26 |
2023-08-14 |
rat |
| Shirelle X Liu, Tenille K Fredrickson, Natalia Calixto Mancipe, Michael K Georgieff, Phu V Tra. Sex-Specific Effects of Early-Life Iron Deficiency and Prenatal Choline Treatment on Adult Rat Hippocampal Transcriptome. Nutrients. vol 15. issue 6. 2023-03-29. PMID:36986048. |
sex-specific effects of early-life iron deficiency and prenatal choline treatment on adult rat hippocampal transcriptome. |
2023-03-29 |
2023-08-14 |
rat |
| Shihan Zhou, Jing Liu, Yan Sun, Ping Xu, Jin Ling Liu, Suping Sun, Boran Zhu, Haoxin W. Dietary choline metabolite TMAO impairs cognitive function and induces hippocampal synaptic plasticity declining through the mTOR/P70S6K/4EBP1 pathway. Food & function. 2023-03-08. PMID:36883968. |
dietary choline metabolite tmao impairs cognitive function and induces hippocampal synaptic plasticity declining through the mtor/p70s6k/4ebp1 pathway. |
2023-03-08 |
2023-08-14 |
Not clear |
| Jessica A Baker, Tamara S Bodnar, Kristen R Breit, Joanne Weinberg, Jennifer D Thoma. Choline Supplementation Alters Hippocampal Cytokine Levels in Adolescence and Adulthood in an Animal Model of Fetal Alcohol Spectrum Disorders. Cells. vol 12. issue 4. 2023-02-25. PMID:36831213. |
choline supplementation alters hippocampal cytokine levels in adolescence and adulthood in an animal model of fetal alcohol spectrum disorders. |
2023-02-25 |
2023-08-14 |
rat |
| Jessica A Baker, Tamara S Bodnar, Kristen R Breit, Joanne Weinberg, Jennifer D Thoma. Choline Supplementation Alters Hippocampal Cytokine Levels in Adolescence and Adulthood in an Animal Model of Fetal Alcohol Spectrum Disorders. Cells. vol 12. issue 4. 2023-02-25. PMID:36831213. |
thus, we examined the effects of choline supplementation on hippocampal cytokine levels in adolescent and adult rats exposed to alcohol early in development. |
2023-02-25 |
2023-08-14 |
rat |
| Jessica A Baker, Tamara S Bodnar, Kristen R Breit, Joanne Weinberg, Jennifer D Thoma. Choline Supplementation Alters Hippocampal Cytokine Levels in Adolescence and Adulthood in an Animal Model of Fetal Alcohol Spectrum Disorders. Cells. vol 12. issue 4. 2023-02-25. PMID:36831213. |
these results suggest that ethanol-induced changes in hippocampal cytokine levels are more evident during adulthood than adolescence, and that choline can mitigate some effects of ethanol exposure on long-lasting inflammatory tone. |
2023-02-25 |
2023-08-14 |
rat |
| Samrat Sheoran, Wouter A J Vints, Kristina Valatkevičienė, Simona Kušleikienė, Rymantė Gleiznienė, Vida J Česnaitienė, Uwe Himmelreich, Oron Levin, Nerijus Masiuli. Strength gains after 12 weeks of resistance training correlate with neurochemical markers of brain health in older adults: a randomized control GeroScience. 2023-01-26. PMID:36701005. |
the study used proton magnetic resonance spectroscopy to quantify the ratio of total n-acetyl aspartate, total choline, glutamate-glutamine complex, and myo-inositol relative to total creatine (tnaa/tcr, tcho/tcr, glx/tcr, and mins/tcr respectively) in the hippocampus (hpc), sensorimotor (sm1), and prefrontal (dlpfc) cortices. |
2023-01-26 |
2023-08-14 |
human |
| Nikhil Dave, Jessica M Judd, Annika Decker, Wendy Winslow, Patrick Sarette, Oscar Villarreal Espinosa, Savannah Tallino, Samantha K Bartholomew, Alina Bilal, Jessica Sandler, Ian McDonough, Joanna K Winstone, Erik A Blackwood, Christopher Glembotski, Timothy Karr, Ramon Velazque. Dietary choline intake is necessary to prevent systems-wide organ pathology and reduce Alzheimer's disease hallmarks. Aging cell. 2023-01-16. PMID:36642814. |
dietary choline deficiency altered hippocampal networks associated with microtubule function and postsynaptic membrane regulation. |
2023-01-16 |
2023-08-14 |
mouse |
| Line S Reitlo, Jelena M Mihailovic, Dorthe Stensvold, Ulrik Wisløff, Fahmeed Hyder, Asta Kristine Håber. Hippocampal neurochemicals are associated with exercise group and intensity, psychological health, and general cognition in older adults. GeroScience. 2023-01-10. PMID:36626020. |
based on the premise that physical activity/exercise impacts hippocampal structure and function, we investigated if hippocampal metabolites for neuronal viability and cell membrane density (i.e., n-acetyl aspartate (naa), choline (cho), creatine (cr)) were higher in older adults performing supervised exercise compared to following national physical activity guidelines. |
2023-01-10 |
2023-08-14 |
human |
| Anja Meissner, Alba M Garcia-Serrano, Lotte Vanherle, Zeinab Rafiee, Nicholas Don-Doncow, Cecilia Skoug, Sara Larsson, Michael Gottschalk, Martin Magnusson, João M N Duart. Alterations to Cerebral Perfusion, Metabolite Profiles, and Neuronal Morphology in the Hippocampus and Cortex of Male and Female Mice during Chronic Exposure to a High-Salt Diet. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36613742. |
compared to nd, hsd increased hippocampal glutamine and phosphocreatine levels and decreased creatine and choline levels. |
2023-01-08 |
2023-08-14 |
mouse |