| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriella Aviello, Barbara Romano, Francesca Borrelli, Raffaele Capasso, Laura Gallo, Fabiana Piscitelli, Vincenzo Di Marzo, Angelo A Izz. Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. Journal of molecular medicine (Berlin, Germany). vol 90. issue 8. 2012-11-16. PMID:22231745. |
in colorectal carcinoma cell lines, cannabidiol protected dna from oxidative damage, increased endocannabinoid levels and reduced cell proliferation in a cb(1)-, trpv1- and pparγ-antagonists sensitive manner. |
2012-11-16 |
2023-08-12 |
mouse |
| C Molly, O Mory, T Basset, H Patura. [Acute cannabis poisoning in a 10-month-old infant]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. vol 19. issue 7. 2012-11-13. PMID:22652516. |
questioning the parents led to suspecting accidental ingestion of a piece of cannabis, which was confirmed by the detection of high blood and urine levels of cannabinoid derivatives. |
2012-11-13 |
2023-08-12 |
Not clear |
| J Hirvonen, R S Goodwin, C-T Li, G E Terry, S S Zoghbi, C Morse, V W Pike, N D Volkow, M A Huestis, R B Inni. Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers. Molecular psychiatry. vol 17. issue 6. 2012-11-07. PMID:21747398. |
reversible and regionally selective downregulation of brain cannabinoid cb1 receptors in chronic daily cannabis smokers. |
2012-11-07 |
2023-08-12 |
human |
| J Hirvonen, R S Goodwin, C-T Li, G E Terry, S S Zoghbi, C Morse, V W Pike, N D Volkow, M A Huestis, R B Inni. Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers. Molecular psychiatry. vol 17. issue 6. 2012-11-07. PMID:21747398. |
rodent studies show reversible downregulation of brain cannabinoid cb(1) (cannabinoid receptor type 1) receptors after chronic exposure to cannabis. |
2012-11-07 |
2023-08-12 |
human |
| J Hirvonen, R S Goodwin, C-T Li, G E Terry, S S Zoghbi, C Morse, V W Pike, N D Volkow, M A Huestis, R B Inni. Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers. Molecular psychiatry. vol 17. issue 6. 2012-11-07. PMID:21747398. |
here we show, using positron emission tomography imaging, reversible and regionally selective downregulation of brain cannabinoid cb(1) receptors in human subjects who chronically smoke cannabis. |
2012-11-07 |
2023-08-12 |
human |
| J Hirvonen, R S Goodwin, C-T Li, G E Terry, S S Zoghbi, C Morse, V W Pike, N D Volkow, M A Huestis, R B Inni. Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers. Molecular psychiatry. vol 17. issue 6. 2012-11-07. PMID:21747398. |
this is the first direct demonstration of cortical cannabinoid cb(1) receptor downregulation as a neuroadaptation that may promote cannabis dependence in human brain. |
2012-11-07 |
2023-08-12 |
human |
| Stefan Kneisel, Volker Auwärte. Analysis of 30 synthetic cannabinoids in serum by liquid chromatography-electrospray ionization tandem mass spectrometry after liquid-liquid extraction. Journal of mass spectrometry : JMS. vol 47. issue 7. 2012-11-05. PMID:22791249. |
the analysis of synthetic cannabinoids in human matrices is of particular importance in the fields of forensic and clinical toxicology since cannabis users partly shift to the consumption of 'herbal mixtures' as a legal alternative to cannabis products in order to circumvent drug testing. |
2012-11-05 |
2023-08-12 |
human |
| María M Caffarel, Clara Andradas, Eduardo Pérez-Gómez, Manuel Guzmán, Cristina Sánche. Cannabinoids: a new hope for breast cancer therapy? Cancer treatment reviews. vol 38. issue 7. 2012-10-26. PMID:22776349. |
experimental evidence accumulated during the last decade supports that cannabinoids, the active components of cannabis sativa and their derivatives, possess anticancer activity. |
2012-10-26 |
2023-08-12 |
mouse |
| Steve J Gagne, Jake M Stout, Enwu Liu, Zakia Boubakir, Shawn M Clark, Jonathan E Pag. Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 31. 2012-10-26. PMID:22802619. |
Δ(9)-tetrahydrocannabinol (thc) and other cannabinoids are responsible for the psychoactive and medicinal properties of cannabis sativa l. (marijuana). |
2012-10-26 |
2023-08-12 |
Not clear |
| Steve J Gagne, Jake M Stout, Enwu Liu, Zakia Boubakir, Shawn M Clark, Jonathan E Pag. Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 31. 2012-10-26. PMID:22802619. |
we analyzed the transcriptome of glandular trichomes from female cannabis flowers, which are the primary site of cannabinoid biosynthesis, and searched for polyketide cyclase-like enzymes that could assist in oa cyclization. |
2012-10-26 |
2023-08-12 |
Not clear |
| Nicholas T Van Dam, Gillinder Bedi, Mitch Earleywin. Characteristics of clinically anxious versus non-anxious regular, heavy marijuana users. Addictive behaviors. vol 37. issue 11. 2012-10-24. PMID:22727786. |
both the key mechanism of action for marijuana (the endocannabinoid system) and the symptoms associated with marijuana withdrawal suggest an important link to anxiety. |
2012-10-24 |
2023-08-12 |
human |
| Giuseppe Calvaruso, Ornella Pellerito, Antonietta Notaro, Michela Giulian. Cannabinoid-associated cell death mechanisms in tumor models (review). International journal of oncology. vol 41. issue 2. 2012-10-19. PMID:22614735. |
in recent years, cannabinoids (the active components of cannabis sativa) and their derivatives have received considerable interest due to findings that they can affect the viability and invasiveness of a variety of different cancer cells. |
2012-10-19 |
2023-08-12 |
Not clear |
| Sandeep Singla, Rajesh Sachdeva, Jawahar L Meht. Cannabinoids and atherosclerotic coronary heart disease. Clinical cardiology. vol 35. issue 6. 2012-10-11. PMID:22278660. |
cannabinoids, the active ingredients of marijuana, affect multiple organ systems in the human body. |
2012-10-11 |
2023-08-12 |
human |
| Sandeep Singla, Rajesh Sachdeva, Jawahar L Meht. Cannabinoids and atherosclerotic coronary heart disease. Clinical cardiology. vol 35. issue 6. 2012-10-11. PMID:22278660. |
the pharmacologic effects of marijuana, based on stimulation of cannabinoid receptors cb1 and cb2, which are widely distributed in the cardiovascular system, have been well described. |
2012-10-11 |
2023-08-12 |
human |
| Sandeep Singla, Rajesh Sachdeva, Jawahar L Meht. Cannabinoids and atherosclerotic coronary heart disease. Clinical cardiology. vol 35. issue 6. 2012-10-11. PMID:22278660. |
we also propose a marijuana paradox, which implies that inhalation of marijuana may be linked to precipitation of acute coronary syndromes, but modulation of the endocannabinoid system by a noninhalation route may have a salutary effect on the development of atherosclerosis. |
2012-10-11 |
2023-08-12 |
human |
| Javier Fernández-Rui. [Cannabinoid drugs for neurological diseases: what is behind?]. Revista de neurologia. vol 54. issue 10. 2012-10-10. PMID:22573509. |
in any case, this incipient clinical use of cannabinoid drugs is not backed just by the anecdote of the medicinal use of cannabis since ancient times, but instead the boost it has been given by scientific research, which has made it possible to identify the target molecules that are activated or inhibited by these substances. |
2012-10-10 |
2023-08-12 |
Not clear |
| Angelo A Izzo, Raffaele Capasso, Gabriella Aviello, Francesca Borrelli, Barbara Romano, Fabiana Piscitelli, Laura Gallo, Francesco Capasso, Pierangelo Orlando, Vincenzo Di Marz. Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. British journal of pharmacology. vol 166. issue 4. 2012-10-09. PMID:22300105. |
inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from cannabis sativa, on inflammation-induced hypermotility in mice. |
2012-10-09 |
2023-08-12 |
mouse |
| Daniel W Bowles, Cindy L O'Bryant, D Ross Camidge, Antonio Jimen. The intersection between cannabis and cancer in the United States. Critical reviews in oncology/hematology. vol 83. issue 1. 2012-10-05. PMID:22019199. |
corresponding with this change there has been escalating interest in the role that cannabis, commonly referred to as marijuana, and cannabinoids play in the care of patients with cancer. |
2012-10-05 |
2023-08-12 |
human |
| Daniel W Bowles, Cindy L O'Bryant, D Ross Camidge, Antonio Jimen. The intersection between cannabis and cancer in the United States. Critical reviews in oncology/hematology. vol 83. issue 1. 2012-10-05. PMID:22019199. |
this review will examine cannabis' and cannabinoids' current and potential roles in cancer care. |
2012-10-05 |
2023-08-12 |
human |
| Daniel W Bowles, Cindy L O'Bryant, D Ross Camidge, Antonio Jimen. The intersection between cannabis and cancer in the United States. Critical reviews in oncology/hematology. vol 83. issue 1. 2012-10-05. PMID:22019199. |
specifically, we will examine five areas of cannabis medicine: (1) pharmacologic properties of cannabis; (2) its potential role in the development of human cancers, particularly smoking-related malignancies; (3) cannabinoids' potential as anti-cancer therapies; (4) cannabis and cannabinoids in the palliation of common cancer-associated symptoms; (5) current legal status of cannabis for medical purposes in the united states. |
2012-10-05 |
2023-08-12 |
human |