| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer S Isaacs, Yun-Jin Jung, Edward G Mimnaugh, Alfredo Martinez, Frank Cuttitta, Leonard M Necker. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. The Journal of biological chemistry. vol 277. issue 33. 2002-09-20. PMID:12052835. |
to examine the role of hsp90 in hif-1 alpha function, we used renal carcinoma cell (rcc) lines that lack functional vhl and express stable hif-1 alpha protein under normoxia. |
2002-09-20 |
2023-08-12 |
Not clear |
| Jennifer S Isaacs, Yun-Jin Jung, Edward G Mimnaugh, Alfredo Martinez, Frank Cuttitta, Leonard M Necker. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. The Journal of biological chemistry. vol 277. issue 33. 2002-09-20. PMID:12052835. |
furthermore, hif-1 alpha point mutations that block vhl association did not protect hif-1 alpha from ga-induced destabilization. |
2002-09-20 |
2023-08-12 |
Not clear |
| Isabelle Groulx, Stephen Le. Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein. Molecular and cellular biology. vol 22. issue 15. 2002-08-05. PMID:12101228. |
here, we show that nuclear-cytoplasmic trafficking of the von hippel-lindau tumor suppressor protein (vhl) is required for oxygen-dependent ubiquitination and degradation of the alpha subunits of hypoxia-inducible factor (hif-alpha). |
2002-08-05 |
2023-08-12 |
Not clear |
| Jodi K Maranchie, James R Vasselli, Joseph Riss, Juan S Bonifacino, W Marston Linehan, Richard D Klausne. The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer cell. vol 1. issue 3. 2002-08-01. PMID:12086861. |
vhl is the substrate recognition subunit of an e3 ligase, known to target the alpha subunits of the hif heterodimeric transcription factor for ubiquitin-mediated degradation under normoxic conditions. |
2002-08-01 |
2023-08-12 |
Not clear |
| Wai-Ching Hon, Michael I Wilson, Karl Harlos, Timothy D W Claridge, Christopher J Schofield, Christopher W Pugh, Patrick H Maxwell, Peter J Ratcliffe, David I Stuart, E Yvonne Jone. Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature. vol 417. issue 6892. 2002-07-19. PMID:12050673. |
hif-1 alpha is stable in hypoxia, but in the presence of oxygen it is targeted for proteasomal degradation by the ubiquitination complex pvhl, the protein of the von hippel lindau (vhl) tumour suppressor gene and a component of an e3 ubiquitin ligase complex. |
2002-07-19 |
2023-08-12 |
Not clear |
| Zaibo Li, Dakun Wang, Xi Na, Susan R Schoen, Edward M Messing, Guan W. Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor. Biochemical and biophysical research communications. vol 294. issue 3. 2002-07-16. PMID:12056827. |
the vhl protein (pvhl) is a component of an e3 ubiquitin ligase complex which is involved in the ubiquitination and degradation of the alpha subunits of hif (hypoxia-inducible factor) in the presence of oxygen. |
2002-07-16 |
2023-08-12 |
mouse |
| Nianli Sang, Jie Fang, Vickram Srinivas, Irene Leshchinsky, Jaime Car. Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP. Molecular and cellular biology. vol 22. issue 9. 2002-05-16. PMID:11940656. |
hydroxylation of at least two prolyl residues in the oxygen-dependent degradation domain of hif-1 alpha regulates its interaction with the von hippel-lindau protein (vhl) that targets hif-1 alpha for ubiquitination and proteasomal degradation. |
2002-05-16 |
2023-08-12 |
Not clear |
| Nianli Sang, Jie Fang, Vickram Srinivas, Irene Leshchinsky, Jaime Car. Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP. Molecular and cellular biology. vol 22. issue 9. 2002-05-16. PMID:11940656. |
in this report, we investigated possible roles of vhl and hydroxylases in the regulation of the transactivation activity of the c-terminal activating domain (cad) of hif-1 alpha. |
2002-05-16 |
2023-08-12 |
Not clear |
| Nianli Sang, Jie Fang, Vickram Srinivas, Irene Leshchinsky, Jaime Car. Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP. Molecular and cellular biology. vol 22. issue 9. 2002-05-16. PMID:11940656. |
we demonstrate that regulation of the transactivation activity of hif-1 alpha cad also involves hydroxylase activity but does not require functional vhl. |
2002-05-16 |
2023-08-12 |
Not clear |
| Alexander Minchenko, Irene Leshchinsky, Irina Opentanova, Nianli Sang, Vickram Srinivas, Valerie Armstead, Jaime Car. Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. The Journal of biological chemistry. vol 277. issue 8. 2002-04-24. PMID:11744734. |
this induction could be replicated by the use of an inhibitor of the prolyl hydroxylase enzymes responsible for the von hippel lindau (vhl)-dependent destabilization and tagging of hif-1 alpha. |
2002-04-24 |
2023-08-12 |
mouse |
| X Ma, K Yang, P Lindblad, L Egevad, K Hemmink. VHL gene alterations in renal cell carcinoma patients: novel hotspot or founder mutations and linkage disequilibrium. Oncogene. vol 20. issue 38. 2001-09-27. PMID:11536052. |
three novel hotspot or founder mutations were detected in our study: four ccrccs carried a missense mutation (glutamic acid to lysine) at codon 160 which is critical in the stabilization of the h1 helix of the alpha domain and the alpha-beta domain interface in the vhl protein. |
2001-09-27 |
2023-08-12 |
human |
| K Kondo, W G Kaeli. The von Hippel-Lindau tumor suppressor gene. Experimental cell research. vol 264. issue 1. 2001-04-12. PMID:11237528. |
the vhl gene product, pvhl, is a component of an e3 ubiquitin ligase that targets the alpha subunits of the hif (hypoxia-inducible factor) transcription factor for destruction in the presence of oxygen. |
2001-04-12 |
2023-08-12 |
Not clear |
| C C Wykoff, C W Pugh, P H Maxwell, A L Harris, P J Ratcliff. Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling. Oncogene. vol 19. issue 54. 2001-03-22. PMID:11175344. |
genes newly defined as targets of the vhl/hypoxia pathway (conditionally downregulated by vhl in normoxic cells) include aminopeptidase a, collagen type v, alpha 1, cyclin g2, dec1/stra13, endothelin 1, low density lipoprotein receptor-related protein 1, mic2/cd99, and transglutaminase 2. |
2001-03-22 |
2023-08-12 |
Not clear |
| K Tanimoto, Y Makino, T Pereira, L Poellinge. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. The EMBO journal. vol 19. issue 16. 2000-10-25. PMID:10944113. |
here we show that the product of the von hippel-lindau (vhl) tumor suppressor gene mediated ubiquitylation and proteasomal degradation of hif-1 alpha under normoxic conditions via interaction with the core of the oxygen-dependent degradation domain of hif-1 alpha. |
2000-10-25 |
2023-08-12 |
Not clear |
| K Tanimoto, Y Makino, T Pereira, L Poellinge. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. The EMBO journal. vol 19. issue 16. 2000-10-25. PMID:10944113. |
the region of vhl mediating interaction with hif-1 alpha overlapped with a putative macromolecular binding site observed within the crystal structure of vhl. |
2000-10-25 |
2023-08-12 |
Not clear |
| K Tanimoto, Y Makino, T Pereira, L Poellinge. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. The EMBO journal. vol 19. issue 16. 2000-10-25. PMID:10944113. |
this motif of vhl also represents a mutational hotspot in tumors, and one of these mutations impaired interaction with hif-1 alpha and subsequent degradation. |
2000-10-25 |
2023-08-12 |
Not clear |
| K Tanimoto, Y Makino, T Pereira, L Poellinge. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. The EMBO journal. vol 19. issue 16. 2000-10-25. PMID:10944113. |
interestingly, the vhl binding site within hif-1 alpha overlapped with one of the minimal transactivation domains. |
2000-10-25 |
2023-08-12 |
Not clear |
| K Tanimoto, Y Makino, T Pereira, L Poellinge. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. The EMBO journal. vol 19. issue 16. 2000-10-25. PMID:10944113. |
protection of hif-1 alpha against degradation by vhl was a multistep mechanism, including hypoxia-induced nuclear translocation of hif-1 alpha and an intranuclear hypoxia-dependent signal. |
2000-10-25 |
2023-08-12 |
Not clear |
| K Tanimoto, Y Makino, T Pereira, L Poellinge. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. The EMBO journal. vol 19. issue 16. 2000-10-25. PMID:10944113. |
vhl was not released from hif-1 alpha during this process. |
2000-10-25 |
2023-08-12 |
Not clear |
| H Okuda, S Hirai, Y Takaki, M Kamada, M Baba, N Sakai, T Kishida, S Kaneko, M Yao, S Ohno, T Shui. Direct interaction of the beta-domain of VHL tumor suppressor protein with the regulatory domain of atypical PKC isotypes. Biochemical and biophysical research communications. vol 263. issue 2. 1999-10-21. PMID:10491320. |
vhl tumor suppressor protein contains two domains, alpha and beta. |
1999-10-21 |
2023-08-12 |
Not clear |