| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sergey Sikora, Adam Godzi. Combination of multiple alignment analysis and surface mapping paves a way for a detailed pathway reconstruction--the case of VHL (von Hippel-Lindau) protein and angiogenesis regulatory pathway. Protein science : a publication of the Protein Society. vol 13. issue 3. 2004-10-26. PMID:14767077. |
to aid in an analysis of the vhl protein regulation of hif-1 alpha degradation, an important and only partially understood process that directly influences angiogenesis, we performed a comprehensive search for the orthologs of the vhl as well as for vhl-interacting proteins in all the available eukaryotic genomes. |
2004-10-26 |
2023-08-12 |
Not clear |
| Sergey Sikora, Adam Godzi. Combination of multiple alignment analysis and surface mapping paves a way for a detailed pathway reconstruction--the case of VHL (von Hippel-Lindau) protein and angiogenesis regulatory pathway. Protein science : a publication of the Protein Society. vol 13. issue 3. 2004-10-26. PMID:14767077. |
we have also shown that relation trees derived from the multiple sequence alignment, functional surface-mapping, and hif-1 alpha degradation pathway structure are in complete agreement, linking the functional and structural evolution of the vhl protein and vhl-dependent hif-1 alpha degradation complex. |
2004-10-26 |
2023-08-12 |
Not clear |
| Heng Qi, Michelle L Gervais, Wei Li, James A DeCaprio, John R G Challis, Michael Oh. Molecular cloning and characterization of the von Hippel-Lindau-like protein. Molecular cancer research : MCR. vol 2. issue 1. 2004-09-03. PMID:14757845. |
von hippel-lindau (vhl) tumor suppressor protein-inactivated in vhl disease and sporadic kidney cancer-is a component of an e3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (hif) transcription factor for subsequent destruction by the 26s proteasome. |
2004-09-03 |
2023-08-12 |
human |
| Heng Qi, Michelle L Gervais, Wei Li, James A DeCaprio, John R G Challis, Michael Oh. Molecular cloning and characterization of the von Hippel-Lindau-like protein. Molecular cancer research : MCR. vol 2. issue 1. 2004-09-03. PMID:14757845. |
however, unlike vhl, it does not contain a recognizable alpha domain, which is required for nucleating the multiprotein e3 ubiquitin ligase complex. |
2004-09-03 |
2023-08-12 |
human |
| M R Morris, E Maina, N V Morgan, D Gentle, D Astuti, H Moch, T Kishida, M Yao, P Schraml, F M Richards, F Latif, E R Mahe. Molecular genetic analysis of FIH-1, FH, and SDHB candidate tumour suppressor genes in renal cell carcinoma. Journal of clinical pathology. vol 57. issue 7. 2004-08-09. PMID:15220362. |
thus, the vhl (von hippel-lindau) tumour suppressor gene (tsg) regulates hif-1 and hif-2 expression in normoxia by targeting the alpha subunits for ubiquitination and proteolysis. |
2004-08-09 |
2023-08-12 |
human |
| Mindy A Maynard, Michael Oh. Von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer. American journal of nephrology. vol 24. issue 1. 2004-06-03. PMID:14654728. |
the product of the vhl gene, pvhl, in association with elongins b and c, cullin 2, and rbx1 form an e3 ubiquitin-ligase complex vec that targets the alpha subunits of hypoxia-inducible factor (hif) for ubiquitination. |
2004-06-03 |
2023-08-12 |
Not clear |
| Mina I Zhou, Hongmei Wang, Rebecca L Foy, Jonathan J Ross, Herbert T Cohe. Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent. Cancer research. vol 64. issue 4. 2004-04-02. PMID:14973063. |
vhl loss increases expression of the hypoxia-inducible factor alpha transcription factors. |
2004-04-02 |
2023-08-12 |
Not clear |
| Mina I Zhou, Hongmei Wang, Rebecca L Foy, Jonathan J Ross, Herbert T Cohe. Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent. Cancer research. vol 64. issue 4. 2004-04-02. PMID:14973063. |
although the vhl beta domain was sufficient for jade-1 binding, both the alpha and beta domains were required for jade-1 stabilization. |
2004-04-02 |
2023-08-12 |
Not clear |
| Yves Pastore, Katerina Jedlickova, Yongli Guan, Enli Liu, James Fahner, Henrik Hasle, Jaroslav F Prchal, Josef T Prcha. Mutations of von Hippel-Lindau tumor-suppressor gene and congenital polycythemia. American journal of human genetics. vol 73. issue 2. 2003-09-24. PMID:12844285. |
in hypoxia or secondary to a mutated vhl gene, the nondegraded hif-1 alpha forms a heterodimer with hif-beta and leads to increased transcription of hypoxia-inducible genes, including erythropoietin (epo). |
2003-09-24 |
2023-08-12 |
human |
| Xi Na, Guan Wu, Charlotte K Ryan, Susan R Schoen, P Anthony di'Santagnese, Edward M Messin. Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas. The Journal of urology. vol 170. issue 2 Pt 1. 2003-07-30. PMID:12853836. |
the vhl protein targets hypoxia-inducible factor-1 alpha (hif-1 alpha), a transcription factor that can induce vascular endothelial growth factor (vegf) expression, for ubiquitination and degradation. |
2003-07-30 |
2023-08-12 |
Not clear |
| Xi Na, Guan Wu, Charlotte K Ryan, Susan R Schoen, P Anthony di'Santagnese, Edward M Messin. Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas. The Journal of urology. vol 170. issue 2 Pt 1. 2003-07-30. PMID:12853836. |
accumulation of hif-1 alpha caused by mutant vhl protein in tumor cells may result in vegf over expression, which has been used to explain the increased vascularity of rcc. |
2003-07-30 |
2023-08-12 |
Not clear |
| Xi Na, Guan Wu, Charlotte K Ryan, Susan R Schoen, P Anthony di'Santagnese, Edward M Messin. Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas. The Journal of urology. vol 170. issue 2 Pt 1. 2003-07-30. PMID:12853836. |
however, quantitative analyses of vegf production and its correlation with vhl mutations and hif-1 alpha expression in authentic tissues from patients with rcc are lacking. |
2003-07-30 |
2023-08-12 |
Not clear |
| Matt Yu Liu, Lorenz Poellinger, Cheryl L Walke. Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Cancer research. vol 63. issue 10. 2003-06-23. PMID:12750296. |
by analogy to human rcc in which mutations in the von hippel-lindau (vhl) tumor suppressor gene result in accumulation of hypoxia-inducible factor alpha (hifalpha) and up-regulation of vascular endothelial growth factor (vegf), we investigated the regulation of hif and its target gene vegf in rat rcc resulting from tsc-2 defects. |
2003-06-23 |
2023-08-12 |
human |
| Sonny O Ang, Hua Chen, Victor R Gordeuk, Adelina I Sergueeva, Lydia A Polyakova, Galina Y Miasnikova, Robert Kralovics, David W Stockton, Josef T Prcha. Endemic polycythemia in Russia: mutation in the VHL gene. Blood cells, molecules & diseases. vol 28. issue 1. 2003-06-18. PMID:11987242. |
the vhl protein (pvhl) downregulates the alpha subunit of hypoxia-inducible factor 1 (hif-1 alpha), the main regulator of hypoxia adaptation, by targeting the protein for degradation. |
2003-06-18 |
2023-08-12 |
Not clear |
| Mindy A Maynard, Heng Qi, Jacky Chung, Eric H L Lee, Yukihiro Kondo, Shuntaro Hara, Ronald C Conaway, Joan W Conaway, Michael Oh. Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex. The Journal of biological chemistry. vol 278. issue 13. 2003-05-02. PMID:12538644. |
the vhl gene product (pvhl) is a component of an e3 ubiquitin ligase complex that targets the hypoxia-inducible factor (hif) 1 and 2 alpha subunits for polyubiquitylation. |
2003-05-02 |
2023-08-12 |
human |
| YunJin Jung, Jennifer S Isaacs, Sunmin Lee, Jane Trepel, Zheng-Gang Liu, Len Necker. Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation. The Biochemical journal. vol 370. issue Pt 3. 2003-04-23. PMID:12479793. |
finally, tnf failed to induce both hif-1 alpha, made resistant to von hippel-lindau (vhl), and wild-type hif-1 alpha transfected into vhl(-/-) cells. |
2003-04-23 |
2023-08-12 |
mouse |
| Sonny O Ang, Hua Chen, Kiichi Hirota, Victor R Gordeuk, Jaroslav Jelinek, Yongli Guan, Enli Liu, Adelina I Sergueeva, Galina Y Miasnikova, David Mole, Patrick H Maxwell, David W Stockton, Gregg L Semenza, Josef T Prcha. Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia. Nature genetics. vol 32. issue 4. 2003-01-17. PMID:12415268. |
the protein vhl modulates the ubiquitination and subsequent destruction of hypoxia-inducible factor 1, subunit alpha (hif1alpha). |
2003-01-17 |
2023-08-12 |
Not clear |
| Jianhe Huang, Quan Zhao, Sharon M Mooney, Frank S Le. Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3. The Journal of biological chemistry. vol 277. issue 42. 2002-12-19. PMID:12181324. |
under normoxic conditions, site-specific proline hydroxylation of the alpha subunits of hif allows recognition by the von hippel-lindau tumor suppressor protein (vhl), a component of an e3 ubiquitin ligase complex that targets these subunits for degradation by the ubiquitin-proteasome pathway. |
2002-12-19 |
2023-08-12 |
Not clear |
| Patrick H Maxwell, Peter J Ratcliff. Oxygen sensors and angiogenesis. Seminars in cell & developmental biology. vol 13. issue 1. 2002-11-27. PMID:11969369. |
following modification hif- alpha chains are captured by a ubiquitin ligase e3 complex containing the von hippel-lindau (vhl) tumour suppressor protein. |
2002-11-27 |
2023-08-12 |
Not clear |
| Jennifer S Isaacs, Yun-Jin Jung, Edward G Mimnaugh, Alfredo Martinez, Frank Cuttitta, Leonard M Necker. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. The Journal of biological chemistry. vol 277. issue 33. 2002-09-20. PMID:12052835. |
although the von hippel lindau (vhl) gene product, the ubiquitin ligase responsible for regulating hif-1 alpha protein levels, efficiently targets hif-1 alpha for rapid proteasome-dependent degradation under normoxia, hif-1 alpha is resistant to the destabilizing effects of vhl under hypoxia. |
2002-09-20 |
2023-08-12 |
Not clear |