| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brenda L Petrella, Constance E Brinckerhof. Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase. Molecular cancer. vol 5. 2007-02-12. PMID:17140440. |
successful rcc tumor suppression by vhl requires the negative regulation of hypoxia inducible factor alpha (hif alpha) protein and its downstream targets. |
2007-02-12 |
2023-08-12 |
Not clear |
| Andrew J Evans, Ryan C Russell, Olga Roche, T Nadine Burry, Jason E Fish, Vinca W K Chow, William Y Kim, Arthy Saravanan, Mindy A Maynard, Michelle L Gervais, Roxana I Sufan, Andrew M Roberts, Leigh A Wilson, Mark Betten, Cindy Vandewalle, Geert Berx, Philip A Marsden, Meredith S Irwin, Bin T Teh, Michael A S Jewett, Michael Oh. VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Molecular and cellular biology. vol 27. issue 1. 2007-01-18. PMID:17060462. |
the product of the von hippel-lindau gene (vhl) acts as the substrate-recognition component of an e3 ubiquitin ligase complex that ubiquitylates the catalytic alpha subunit of hypoxia-inducible factor (hif) for oxygen-dependent destruction. |
2007-01-18 |
2023-08-12 |
Not clear |
| Roxana I Sufan, Michael Oh. Role of the NEDD8 modification of Cul2 in the sequential activation of ECV complex. Neoplasia (New York, N.Y.). vol 8. issue 11. 2007-01-11. PMID:17132228. |
ecv is an e3 ubiquitin ligase complex, which is composed of elongins b and c, rbx1, cul2, and the substrate-conferring von hippel-lindau (vhl) tumor-suppressor protein that targets the catalytic alpha subunit of hypoxia-inducible factor (hif) for oxygen-dependent ubiquitin-mediated destruction. |
2007-01-11 |
2023-08-12 |
Not clear |
| William Y Kim, Michal Safran, Marshall R M Buckley, Benjamin L Ebert, Jonathan Glickman, Marcus Bosenberg, Meredith Regan, William G Kaeli. Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo. The EMBO journal. vol 25. issue 19. 2006-11-13. PMID:16977322. |
failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies vhl inactivation in vivo. |
2006-11-13 |
2023-08-12 |
Not clear |
| Michael Oh. pVHL's kryptonite: E2-EPF UCP. Cancer cell. vol 10. issue 2. 2006-09-29. PMID:16904608. |
identified von hippel-lindau (vhl) tumor suppressor protein, which targets the alpha subunit of hypoxia-inducible factor (hif) for ubiquitin-mediated destruction, as a bona fide substrate of ucp and demonstrated a potential pvhl-hif pathway-dependent role for ucp in cancer development. |
2006-09-29 |
2023-08-12 |
human |
| Mallory S Lutz, Robert D Bur. Primary cilium formation requires von hippel-lindau gene function in renal-derived cells. Cancer research. vol 66. issue 14. 2006-09-19. PMID:16849532. |
vhl's function, regulating the degradation of hypoxia-inducible factor alpha (hifalpha) subunits, explains the angiogenic nature of these tumors, but not tumor initiation. |
2006-09-19 |
2023-08-12 |
Not clear |
| Jasmien Hoebeeck, Jo Vandesompele, Helén Nilsson, Katleen De Preter, Nadine Van Roy, Els De Smet, Nurten Yigit, Anne De Paepe, Geneviève Laureys, Sven Påhlman, Frank Spelema. The von Hippel-Lindau tumor suppressor gene expression level has prognostic value in neuroblastoma. International journal of cancer. vol 119. issue 3. 2006-07-28. PMID:16506218. |
the significance of the reduced vhl expression levels in relation to nb tumor biology remains unexplained, as functional analysis demonstrated no clear effect of the reduction in vhl mrna expression on protein stability of its downstream target hypoxia-inducible factor alpha. |
2006-07-28 |
2023-08-12 |
Not clear |
| J Chung, A M Roberts, J Chow, N Coady-Osberg, M Oh. Homotypic association between tumour-associated VHL proteins leads to the restoration of HIF pathway. Oncogene. vol 25. issue 21. 2006-07-07. PMID:16407835. |
the von hippel-lindau (vhl) tumour suppressor gene encodes a substrate-specifying component of an e3 ubiquitin ligase that targets hypoxia-inducible factor (hif) alpha subunits for degradation under normoxia. |
2006-07-07 |
2023-08-12 |
Not clear |
| J Chung, A M Roberts, J Chow, N Coady-Osberg, M Oh. Homotypic association between tumour-associated VHL proteins leads to the restoration of HIF pathway. Oncogene. vol 25. issue 21. 2006-07-07. PMID:16407835. |
the vhl protein is composed of an n-terminal hifalpha-binding beta domain and a c-terminal alpha domain, which is necessary and sufficient for the formation of the e3 multiprotein enzyme. |
2006-07-07 |
2023-08-12 |
Not clear |
| J Chung, A M Roberts, J Chow, N Coady-Osberg, M Oh. Homotypic association between tumour-associated VHL proteins leads to the restoration of HIF pathway. Oncogene. vol 25. issue 21. 2006-07-07. PMID:16407835. |
here, we show that vhl forms a self-associated complex in vivo, but not in vitro, and demonstrate that coexpression of two different vhl missense mutants -- one in the alpha domain and the other in the beta domain -- restores hif-mediated gene expression profile. |
2006-07-07 |
2023-08-12 |
Not clear |
| Tammie Bishop, Kah Weng Lau, Andrew C R Epstein, Stuart K Kim, Min Jiang, Delia O'Rourke, Christopher W Pugh, Jonathan M Gleadle, Martin S Taylor, Jonathan Hodgkin, Peter J Ratcliff. Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans. PLoS biology. vol 2. issue 10. 2006-05-23. PMID:15361934. |
the von hippel-lindau (vhl) tumor suppressor functions as a ubiquitin ligase that mediates proteolytic inactivation of hydroxylated alpha subunits of hypoxia-inducible factor (hif). |
2006-05-23 |
2023-08-12 |
caenorhabditis_elegans |
| Nathalie Arquier, Paul Vigne, Eric Duplan, Tien Hsu, Pascal P Therond, Christian Frelin, Gisela D'Angel. Analysis of the hypoxia-sensing pathway in Drosophila melanogaster. The Biochemical journal. vol 393. issue Pt 2. 2006-03-24. PMID:16176182. |
the mechanism by which hypoxia induces gene transcription involves the inhibition of hif-1alpha (hypoxia-inducible factor-1 alpha subunit) phd (prolyl hydroxylase) activity, which prevents the vhl (von hippel-lindau)-dependent targeting of hif-1alpha to the ubiquitin/proteasome pathway. |
2006-03-24 |
2023-08-12 |
human |
| Eijiro Nakamura, Paula Abreu-e-Lima, Yasuo Awakura, Takahiro Inoue, Toshiyuki Kamoto, Osamu Ogawa, Hirokazu Kotani, Toshiaki Manabe, Guo-Jun Zhang, Keiichi Kondo, Vānia Nosé, William G Kaeli. Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von Hippel-Lindau tumor suppressor protein. The American journal of pathology. vol 168. issue 2. 2006-03-21. PMID:16436671. |
the best documented function of the vhl gene product (pvhl) relates to its ability to polyubiquitinate, and hence target for destruction, the alpha subunits of the heterodimeric transcription factor hypoxia-inducible factor (hif). |
2006-03-21 |
2023-08-12 |
Not clear |
| Keiichi Kondo, William Y Kim, Mirna Lechpammer, William G Kaeli. Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth. PLoS biology. vol 1. issue 3. 2006-01-13. PMID:14691554. |
the vhl gene product, pvhl, is part of an e3 ubiquitin ligase complex that targets the alpha subunits of the heterodimeric transcription factor hif (hypoxia-inducible factor) for degradation in the presence of oxygen. |
2006-01-13 |
2023-08-12 |
Not clear |
| Jiabin An, Matthew B Retti. Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity. Molecular and cellular biology. vol 25. issue 17. 2005-09-22. PMID:16107702. |
biallelic vhl loss results in accumulation of hypoxia-inducible factor alpha (hifalpha). |
2005-09-22 |
2023-08-12 |
Not clear |
| Karlene Smith, Lakshman Gunaratnam, Melissa Morley, Aleksandra Franovic, Karim Mekhail, Stephen Le. Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer. Cancer research. vol 65. issue 12. 2005-08-08. PMID:15958567. |
the vhl protein targets the alpha subunits of hypoxia-inducible factor (hif) transcription factor for ubiquitination and degradation. |
2005-08-08 |
2023-08-12 |
human |
| Raju R Raval, Kah Weng Lau, Maxine G B Tran, Heidi M Sowter, Stefano J Mandriota, Ji-Liang Li, Christopher W Pugh, Patrick H Maxwell, Adrian L Harris, Peter J Ratcliff. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Molecular and cellular biology. vol 25. issue 13. 2005-08-02. PMID:15964822. |
defective function of the von hippel-lindau (vhl) tumor suppressor ablates proteolytic regulation of hypoxia-inducible factor alpha subunits (hif-1alpha and hif-2alpha), leading to constitutive activation of hypoxia pathways in renal cell carcinoma (rcc). |
2005-08-02 |
2023-08-12 |
Not clear |
| Masakazu Ogura, Toru Shibata, Junlin Yi, Junye Liu, Runjiang Qu, Hiroshi Harada, Masahiro Hiraok. A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas. Cancer science. vol 96. issue 5. 2005-07-28. PMID:15904470. |
the vhl protein binds to the alpha subunit of (hif-alpha) for its oxygen-dependent degradation. |
2005-07-28 |
2023-08-12 |
mouse |
| Felicia Miller, Alex Kentsis, Roman Osman, Zhen-Qiang Pa. Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex. The Journal of biological chemistry. vol 280. issue 9. 2005-04-07. PMID:15611064. |
the von hippel-lindau (vhl) gene product, pvhl, targets the alpha subunit of the hypoxia-inducible transcription factor (hif-alpha) for ubiquitin-dependent degradation. |
2005-04-07 |
2023-08-12 |
Not clear |
| Brenda L Petrella, Jouko Lohi, Constance E Brinckerhof. Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. Oncogene. vol 24. issue 6. 2005-03-02. PMID:15592504. |
vhl functions in the destruction of the alpha subunits of the heterodimeric transcription factor, hypoxia-inducible factor (hif-1 alpha and hif-2 alpha), in normoxic conditions. |
2005-03-02 |
2023-08-12 |
Not clear |