| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melanie J Perc. Familial erythrocytosis arising from a gain-of-function mutation in the HIF2A gene of the oxygen sensing pathway. The Ulster medical journal. vol 77. issue 2. 2008-09-04. PMID:18711622. |
continued study of idiopathic cases of erythrocytosis with raised serum epo will reveal whether hif-2 alpha will be a major cause of erythrocytosis on par with vhl. |
2008-09-04 |
2023-08-12 |
Not clear |
| Qingzhou Ji, Robert D Bur. Downregulation of integrins by von Hippel-Lindau (VHL) tumor suppressor protein is independent of VHL-directed hypoxia-inducible factor alpha degradation. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 86. issue 3. 2008-08-07. PMID:18523483. |
downregulation of integrins by von hippel-lindau (vhl) tumor suppressor protein is independent of vhl-directed hypoxia-inducible factor alpha degradation. |
2008-08-07 |
2023-08-12 |
Not clear |
| Qingzhou Ji, Robert D Bur. Downregulation of integrins by von Hippel-Lindau (VHL) tumor suppressor protein is independent of VHL-directed hypoxia-inducible factor alpha degradation. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 86. issue 3. 2008-08-07. PMID:18523483. |
although vhl can target hypoxia-inducible factor alpha (hifalpha) subunits for degradation, vhl-dependent reduction of integrins was independent of o2 concentration and hifalpha levels. |
2008-08-07 |
2023-08-12 |
Not clear |
| Yutaka Maeda, Takuji Suzuki, Xiufang Pan, Gang Chen, Songqin Pan, Thomas Bartman, Jeffrey A Whitset. CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis. The Journal of biological chemistry. vol 283. issue 23. 2008-07-15. PMID:18372249. |
cullin 2 (cul2) is a component of the elonginb/c-cul2-rbx-1-von hippel-lindau (vhl) tumor suppressor complex that ubiquitinates and degrades hypoxia-inducible factor alpha (hifalpha). |
2008-07-15 |
2023-08-12 |
zebrafish |
| A Toschi, J Edelstein, P Rockwell, M Ohh, D A Foste. HIF alpha expression in VHL-deficient renal cancer cells is dependent on phospholipase D. Oncogene. vol 27. issue 19. 2008-05-19. PMID:17998935. |
hif alpha expression in vhl-deficient renal cancer cells is dependent on phospholipase d. loss of the von hippel-lindau (vhl) tumor suppressor gene contributes to proliferative disorders including renal cell carcinoma. |
2008-05-19 |
2023-08-12 |
Not clear |
| Olga Mikhaylova, Monika L Ignacak, Teresa J Barankiewicz, Svetlana V Harbaugh, Ying Yi, Patrick H Maxwell, Martin Schneider, Katie Van Geyte, Peter Carmeliet, Monica P Revelo, Michael Wyder, Kenneth D Greis, Jarek Meller, Maria F Czyzyk-Krzesk. The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress. Molecular and cellular biology. vol 28. issue 8. 2008-04-21. PMID:18285459. |
human renal clear cell carcinoma (rcc) is frequently associated with loss of the von hippel-lindau (vhl) tumor suppressor (pvhl), which inhibits ubiquitylation and degradation of the alpha subunits of hypoxia-inducible transcription factor. |
2008-04-21 |
2023-08-12 |
human |
| G Kurban, E Duplan, N Ramlal, V Hudon, Y Sado, Y Ninomiya, A Paus. Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2. Oncogene. vol 27. issue 7. 2008-03-04. PMID:17700531. |
we show that vhl directly binds to the collagen iv alpha 2 (col4a2) chain and that this interaction is necessary for its assembly into the ecm. |
2008-03-04 |
2023-08-12 |
Not clear |
| Andrew Doedens, Randall S Johnso. Transgenic models to understand hypoxia-inducible factor function. Methods in enzymology. vol 435. 2008-02-29. PMID:17998050. |
under normal oxygen tensions, the pathway is negatively regulated by posttranslational proteasomal degradation of hif-alpha (alpha) subunits in a pathway requiring prolyl-hydroxylase domain (phd) containing enzyme modification followed by von-hippel lindau (vhl) tumor suppressor polyubiquitination (pvhl). |
2008-02-29 |
2023-08-12 |
Not clear |
| Veronica A Carroll, Margaret Ashcrof. Regulation of angiogenic factors by HDM2 in renal cell carcinoma. Cancer research. vol 68. issue 2. 2008-02-14. PMID:18199551. |
we show in von hippel-lindau (vhl)-defective renal carcinoma cells that express constitutively high levels of hif-1 alpha and hif-2 alpha that down-regulation of hdm2 by sirna leads to decreased levels of both hif-1 alpha and hif-2 alpha protein levels. |
2008-02-14 |
2023-08-12 |
Not clear |
| W Kimryn Rathmell, Shufen Che. VHL inactivation in renal cell carcinoma: implications for diagnosis, prognosis and treatment. Expert review of anticancer therapy. vol 8. issue 1. 2008-01-17. PMID:18095884. |
pvhl, vhl gene product and a protein member of the e3 ubiquitin ligase family, acts in normal cells to direct the degradation and clearance of the hypoxia inducible factor (hif)alpha transcription factor family, such that in its absence, as in ccrcc, the hif proteins stabilize, accumulate to supraphysiologic levels and activate the transcription of genes such as vegf and pdgf, which contributes substantially to the physiology of the tumor, and has been assessed indirectly as a prognostic factor. |
2008-01-17 |
2023-08-12 |
Not clear |
| H Harada, S Kizaka-Kondoh, G Li, S Itasaka, K Shibuya, M Inoue, M Hiraok. Significance of HIF-1-active cells in angiogenesis and radioresistance. Oncogene. vol 26. issue 54. 2008-01-09. PMID:17563752. |
we have previously reported that procaspase-3 fused with a von hippel-lindau (vhl)-mediated protein destruction motif of alpha subunit of hif-1 (hif-1alpha) containing pro564, named tat-odd-procaspase-3 (top3), specifically induced cell death to hypoxic cells in vivo as well as in vitro. |
2008-01-09 |
2023-08-12 |
human |
| Melanie J Percy, Paul W Furlow, Philip A Beer, Terence R J Lappin, Mary Frances McMullin, Frank S Le. A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove. Blood. vol 110. issue 6. 2007-10-30. PMID:17579185. |
hif in turn is regulated through its alpha subunit, which under normoxic conditions is hydroxylated on specific prolines and targeted for degradation by the von hippel lindau (vhl) protein. |
2007-10-30 |
2023-08-12 |
Not clear |
| Sunyoung Lee, Elizabeth I O Garner, William R Welch, Ross S Berkowitz, Samuel C Mo. Over-expression of hypoxia-inducible factor 1 alpha in ovarian clear cell carcinoma. Gynecologic oncology. vol 106. issue 2. 2007-09-06. PMID:17532031. |
since tumor hypoxia has been shown to be strongly associated with poor prognosis, deregulation of the representative factor of tissue hypoxia; hypoxia-inducible factor 1 alpha (hif-1alpha) and related protein; von hippel-lindau (vhl) may be associated with poor prognosis of ovarian clear cell carcinoma. |
2007-09-06 |
2023-08-12 |
Not clear |
| Lianjie Li, Liang Zhang, Xiaoping Zhang, Qin Yan, Yoji Andrew Minamishima, Aria F Olumi, Mao Mao, Steven Bartz, William G Kaeli. Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations. Molecular and cellular biology. vol 27. issue 15. 2007-08-23. PMID:17526729. |
the vhl gene product, pvhl, is part of a ubiquitin ligase complex that targets the alpha subunits of the heterodimeric transcription factor hypoxia-inducible factor (hif) for destruction under well-oxygenated conditions. |
2007-08-23 |
2023-08-12 |
Not clear |
| Michael D Hughes, Erilda Kapllani, Ashlynn E Alexander, Robert D Burk, Alan R Schoenfel. HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation. Cancer cell international. vol 7. 2007-08-13. PMID:17598890. |
the product of the vhl gene, pvhl, acts to target hypoxia-inducible factor alpha (hif-alpha) subunits for ubiquitination and subsequent degradation. |
2007-08-13 |
2023-08-12 |
Not clear |
| Ying Wang, Chao Wan, Lianfu Deng, Ximeng Liu, Xuemei Cao, Shawn R Gilbert, Mary L Bouxsein, Marie-Claude Faugere, Robert E Guldberg, Louis C Gerstenfeld, Volker H Haase, Randall S Johnson, Ernestina Schipani, Thomas L Clemen. The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. The Journal of clinical investigation. vol 117. issue 6. 2007-07-10. PMID:17549257. |
mice overexpressing hif alpha in osteoblasts through selective deletion of the von hippel-lindau gene (vhl) expressed high levels of vegf and developed extremely dense, heavily vascularized long bones. |
2007-07-10 |
2023-08-12 |
mouse |
| Jian Fu, Keon Menzies, Robert S Freeman, Mark B Taubma. EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability. The Journal of biological chemistry. vol 282. issue 17. 2007-06-14. PMID:17344222. |
egln3, a member of the egln family of prolyl hydroxylases, has been shown to catalyze hydroxylation of the alpha subunit of hypoxia-inducible factor-alpha, which targets hypoxia-inducible factor-alpha for ubiquitination by a ubiquitin ligase complex containing the von hippel-lindau (vhl) tumor suppressor. |
2007-06-14 |
2023-08-12 |
Not clear |
| Karen Block, Yves Gorin, Paul Hoover, Paul Williams, Tomasz Chelmicki, Robert A Clark, Toshiyuki Yoneda, Hanna E Abbou. NAD(P)H oxidases regulate HIF-2alpha protein expression. The Journal of biological chemistry. vol 282. issue 11. 2007-04-24. PMID:17200123. |
in the absence of vhl, the alpha subunits of heterodimeric hypoxia-inducible transcription factors (hif-1alpha and hif-2alpha) are stabilized. |
2007-04-24 |
2023-08-12 |
mouse |
| Ryan C Russell, Michael Oh. The role of VHL in the regulation of E-cadherin: a new connection in an old pathway. Cell cycle (Georgetown, Tex.). vol 6. issue 1. 2007-04-09. PMID:17245122. |
vhl is a component of an e3 ubiquitin ligase that targets the alpha subunit of hypoxia-inducible factor (hifalpha) for ubiquitin-mediated destruction under normal oxygen tension. |
2007-04-09 |
2023-08-12 |
Not clear |
| Premal H Patel, Rajendrakumar S V Chadalavada, R S K Chaganti, Robert J Motze. Targeting von Hippel-Lindau pathway in renal cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 12. issue 24. 2007-03-15. PMID:17189392. |
in the absence of vhl, hypoxia-inducible factor alpha accumulates, leading to production of several growth factors, including vascular endothelial growth factor and platelet-derived growth factor. |
2007-03-15 |
2023-08-12 |
Not clear |