| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K A Gary, B M Chronwal. The onset of dopaminergic innervation during ontogeny decreases melanotrope proliferation in the intermediate lobe of the rat pituitary. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 10. issue 2. 1992-08-18. PMID:1352934. |
dopamine, and its synthetic rate-limiting enzyme tyrosine hydroxylase, were first detected immunohistochemically on late post-natal day 3 or early postnatal day 4. |
1992-08-18 |
2023-08-11 |
rat |
| D L Rosin, W A Clark, M Goldstein, R H Roth, A Y Deutc. Effects of 6-hydroxydopamine lesions of the prefrontal cortex on tyrosine hydroxylase activity in mesolimbic and nigrostriatal dopamine systems. Neuroscience. vol 48. issue 4. 1992-08-14. PMID:1352864. |
effects of 6-hydroxydopamine lesions of the prefrontal cortex on tyrosine hydroxylase activity in mesolimbic and nigrostriatal dopamine systems. |
1992-08-14 |
2023-08-11 |
human |
| F Lisovoski, C Haby, E Borrelli, C Schleef, M O Revel, C Hindelang, J Zwille. Induction of D2 dopamine receptor mRNA synthesis in a 6-hydroxydopamine parkinsonian rat model. Brain research bulletin. vol 28. issue 5. 1992-08-05. PMID:1535533. |
the lesion has been characterized by several criteria: a rotational behavior in response to apomorphine, a complete loss of tyrosine hydroxylase immunoreactivity in the lesioned substantia nigra, a near total depletion of dopamine and metabolites in the striatum ipsilateral to the lesion, and a supersensitivity of the dopamine d2 receptors in the ipsilateral striatum. |
1992-08-05 |
2023-08-11 |
rat |
| F C Liu, A M Graybie. Heterogeneous development of calbindin-D28K expression in the striatal matrix. The Journal of comparative neurology. vol 320. issue 3. 1992-07-29. PMID:1351896. |
the localization of calbindin was documented in a series of developing rat brains, as was the compartmental location of these cells relative to tyrosine hydroxylase (th)-immunostained dopamine islands, sites of future striosomes. |
1992-07-29 |
2023-08-11 |
rat |
| S G Kohama, F Freesh, C L Bethe. Immunocytochemical colocalization of hypothalamic progestin receptors and tyrosine hydroxylase in steroid-treated monkeys. Endocrinology. vol 131. issue 1. 1992-07-27. PMID:1351839. |
to determine whether hypothalamic dopamine neurons are progestin target cells, the colocalization of pr and tyrosine hydroxylase (th), a phenotypic marker of dopaminergic neurons, was examined with double immunocytochemistry. |
1992-07-27 |
2023-08-11 |
monkey |
| M Niimi, J Takahara, M Sato, K Kawanish. Identification of dopamine and growth hormone-releasing factor-containing neurons projecting to the median eminence of the rat by combined retrograde tracing and immunohistochemistry. Neuroendocrinology. vol 55. issue 1. 1992-07-20. PMID:1608512. |
the topographical location of tyrosine hydroxylase (th) neurons, a marker for dopamine neurons in the hypothalamus, that project to the median eminence was identified with immunofluorescence staining in combination with retrograde transblue, indicating that they projected to the median eminence. |
1992-07-20 |
2023-08-11 |
rat |
| P Horellou, C Lundberg, B Le Bourdellès, K Wictorin, P Brundin, P Kalén, A Björklund, J Malle. Behavioural effects of genetically engineered cells releasing dopa and dopamine after intracerebral grafting in a rat model of Parkinson's disease. Journal de physiologie. vol 85. issue 3. 1992-07-15. PMID:1687823. |
in the present study we grafted cell lines, expressing the form i of human tyrosine hydroxylase after infection with a recombinant retrovirus and selection in tyrosine-free-medium, to the denervated striatum in order to analyse the extent to which extracellular dopamine levels can be restored and the effect of a diffuse release of dopamine on motor impairement in a rat model of parkinson's disease. |
1992-07-15 |
2023-08-11 |
human |
| R D Hartman, J J Liaw, J R He, C A Barracloug. Effects of reserpine on tyrosine hydroxylase mRNA levels in locus coeruleus and medullary A1 and A2 neurons analyzed by in situ hybridization histochemistry and quantitative image analysis methods. Brain research. Molecular brain research. vol 13. issue 3. 1992-06-29. PMID:1350653. |
these studies examined the effects of reserpine on concentrations of norepinephrine (ne), dopamine (da) and epinephrine (epi) and on levels of tyrosine hydroxylase (th) mrna in locus coeruleus (lc) and medullary a1 and a2 neurons. |
1992-06-29 |
2023-08-11 |
Not clear |
| D M Wallace, D J Magnuson, T S Gra. Organization of amygdaloid projections to brainstem dopaminergic, noradrenergic, and adrenergic cell groups in the rat. Brain research bulletin. vol 28. issue 3. 1992-06-29. PMID:1591601. |
this was accomplished by means of the phaseolus vulgaris leucoagglutinin lectin (pha-l) anterograde tracing technique combined with glucose-oxidase immunocytochemistry to catecholamine markers (i.e., tyrosine hydroxylase, dopamine beta hydroxylase, and phenylethanolamine n-methyltransferase). |
1992-06-29 |
2023-08-11 |
rat |
| J S Schneider, A Pope, K Simpson, J Taggart, M G Smith, L DiStefan. Recovery from experimental parkinsonism in primates with GM1 ganglioside treatment. Science (New York, N.Y.). vol 256. issue 5058. 1992-06-19. PMID:1350379. |
treatment with gm1 ganglioside also increased striatal dopamine and metabolite levels and enhanced the dopaminergic innervation of the striatum as demonstrated by tyrosine hydroxylase immunohistochemistry. |
1992-06-19 |
2023-08-11 |
Not clear |
| F Rodríguez de Fonseca, M L Hernández, R de Miguel, J J Fernández-Ruiz, J A Ramo. Early changes in the development of dopaminergic neurotransmission after maternal exposure to cannabinoids. Pharmacology, biochemistry, and behavior. vol 41. issue 3. 1992-06-18. PMID:1350099. |
we measured the endogenous content of dopamine and its intraneuronal metabolite, l-3,4-dihydroxyphenylacetic acid, and the activity of tyrosine hydroxylase as indices of dopaminergic activity. |
1992-06-18 |
2023-08-11 |
rat |
| F Rodríguez de Fonseca, M L Hernández, R de Miguel, J J Fernández-Ruiz, J A Ramo. Early changes in the development of dopaminergic neurotransmission after maternal exposure to cannabinoids. Pharmacology, biochemistry, and behavior. vol 41. issue 3. 1992-06-18. PMID:1350099. |
the only alteration in females occurred on the tenth day of development: an increase in dopamine content was observed with no changes in either the content of l-3,4-dihydroxyphenylacetic acid or tyrosine hydroxylase activity. |
1992-06-18 |
2023-08-11 |
rat |
| F Rodríguez de Fonseca, M L Hernández, R de Miguel, J J Fernández-Ruiz, J A Ramo. Early changes in the development of dopaminergic neurotransmission after maternal exposure to cannabinoids. Pharmacology, biochemistry, and behavior. vol 41. issue 3. 1992-06-18. PMID:1350099. |
although the reduction in its metabolite disappeared on the fifth day, the decrease in dopamine was maintained and it was correlated with a decrease in tyrosine hydroxylase activity. |
1992-06-18 |
2023-08-11 |
rat |
| M Goldstein, A Lieberma. The role of the regulatory enzymes of catecholamine synthesis in Parkinson's disease. Neurology. vol 42. issue 4 Suppl 4. 1992-06-16. PMID:1350074. |
the major neuropathology of parkinson's disease (pd) is the degeneration of nigrostriatal dopamine (da), resulting in a deficiency of da, and of the enzyme tyrosine hydroxylase (th), which catalyzes the synthesis of l-dopa. |
1992-06-16 |
2023-08-11 |
mouse |
| H Moukhles, A Nieoullon, A Daszut. Early and widespread normalization of dopamine-neuropeptide Y interactions in the rat striatum after transplantation of fetal mesencephalon cells. Neuroscience. vol 47. issue 4. 1992-06-05. PMID:1349734. |
as early as one month post-grafting, a complete reversal of the increase in the number of neuropeptide y-immunoreactive neurons occurring after 6-hydroxydopamine lesion was observed in dopamine-grafted animals, although a partial restoration of the tyrosine hydroxylase immunostaining and a recovery of 8% dopamine tissue level were observed in the striata of grafted as compared to normal rats. |
1992-06-05 |
2023-08-11 |
rat |
| K D Swanson, R Gangul. Characterization of a Drosophila melanogaster gene similar to the mammalian genes encoding the tyrosine/tryptophan hydroxylase activator and protein kinase C inhibitor proteins. Gene. vol 113. issue 2. 1992-06-04. PMID:1349290. |
dna sequencing showed that the cdna-encoded protein is similar to a family of mammalian proteins, called 14-3-3, which activate tyrosine hydroxylase (tyrohase) and tryptophan hydroxylase (trpohase), the two key enzymes regulating biosynthesis of biogenic monoamine neurotransmitters, such as dopamine and serotonin, in the brain. |
1992-06-04 |
2023-08-11 |
cattle |
| A McMahon, R Kvetnanský, K Fukuhara, V K Weise, I J Kopin, E L Sabba. Regulation of tyrosine hydroxylase and dopamine beta-hydroxylase mRNA levels in rat adrenals by a single and repeated immobilization stress. Journal of neurochemistry. vol 58. issue 6. 1992-06-04. PMID:1349344. |
regulation of tyrosine hydroxylase and dopamine beta-hydroxylase mrna levels in rat adrenals by a single and repeated immobilization stress. |
1992-06-04 |
2023-08-11 |
rat |
| A McMahon, R Kvetnanský, K Fukuhara, V K Weise, I J Kopin, E L Sabba. Regulation of tyrosine hydroxylase and dopamine beta-hydroxylase mRNA levels in rat adrenals by a single and repeated immobilization stress. Journal of neurochemistry. vol 58. issue 6. 1992-06-04. PMID:1349344. |
in this study the effects of a single and repeated immobilization stress on mrna levels of the adrenal catecholamine biosynthetic enzymes, tyrosine hydroxylase and dopamine beta-hydroxylase, were examined. |
1992-06-04 |
2023-08-11 |
rat |
| A McMahon, R Kvetnanský, K Fukuhara, V K Weise, I J Kopin, E L Sabba. Regulation of tyrosine hydroxylase and dopamine beta-hydroxylase mRNA levels in rat adrenals by a single and repeated immobilization stress. Journal of neurochemistry. vol 58. issue 6. 1992-06-04. PMID:1349344. |
a repeated 2-hr daily immobilization for 7 consecutive days markedly elevated both tyrosine hydroxylase and dopamine beta-hydroxylase mrna levels (about six- and fourfold, respectively). |
1992-06-04 |
2023-08-11 |
rat |
| A McMahon, R Kvetnanský, K Fukuhara, V K Weise, I J Kopin, E L Sabba. Regulation of tyrosine hydroxylase and dopamine beta-hydroxylase mRNA levels in rat adrenals by a single and repeated immobilization stress. Journal of neurochemistry. vol 58. issue 6. 1992-06-04. PMID:1349344. |
in contrast, tyrosine hydroxylase but not dopamine beta-hydroxylase mrna levels were elevated immediately following a single immobilization. |
1992-06-04 |
2023-08-11 |
rat |