| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
here we conducted a nine-week hfd protocol in male rats, followed by an analysis of the gut microbiome diversity and community composition, brainstem serotonergic gene expression (tph2, htr1a, and slc6a4), and anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Hailong Zhang, Deborah R Leitner, Yuko Hasegawa, Matthew K Waldo. Peripheral serotonergic neurons regulate gut motility and anxiety-like behavior. Current biology : CB. vol 34. issue 4. 2024-02-27. PMID:38412819. |
in contrast to mice lacking tph2 in all neurons, mice lacking tph2 in peripheral serotonergic neurons did not exhibit increased territorial aggression. |
2024-02-27 |
2024-03-01 |
mouse |
| Jennyfer M Payet, Laura Stevens, Adrian M Russo, Emily Jaehne, Maarten van den Buuse, Stephen Kent, Christopher A Lowry, Michael V Baratta, Matthew W Hal. The Role of Dorsal Raphe Nucleus Serotonergic Systems in Emotional Learning and Memory in Male BALB/c Mice. Neuroscience. 2023-10-23. PMID:37852412. |
activation of dr serotonergic neurons during fear conditioning (experiment 1) or fear memory recall (experiment 2), was measured using dual-label immunohistochemistry for tph2 and c-fos. |
2023-10-23 |
2023-11-08 |
mouse |
| Atae Akhrif, Marcel Romanos, Katharina Peters, Ann-Kathrin Furtmann, Julian Caspers, Klaus-Peter Lesch, Eva M Meisenzahl-Lechner, Susanne Neufan. Serotonergic modulation of normal and abnormal brain dynamics: The genetic influence of the TPH2 G-703T genotype and DNA methylation on wavelet variance in children and adolescents with and without ADHD. PloS one. vol 18. issue 4. 2023-04-27. PMID:37104367. |
serotonergic modulation of normal and abnormal brain dynamics: the genetic influence of the tph2 g-703t genotype and dna methylation on wavelet variance in children and adolescents with and without adhd. |
2023-04-27 |
2023-08-14 |
Not clear |
| Yan Liu, Liang Shan, Tiane Liu, Juan Li, Yongchang Chen, Changhong Sun, Chaojuan Yang, Xiling Bian, Yuyu Niu, Chen Zhang, Jianzhong Xi, Yi Ra. Molecular and cellular mechanisms of the first social relationship: A conserved role of 5-HT from mice to monkeys, upstream of oxytocin. Neuron. 2023-03-03. PMID:36868221. |
tph2 elimination from rn serotonergic neurons innervating pvn reduced maternal preference. |
2023-03-03 |
2023-08-14 |
mouse |
| Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research. 2022-10-22. PMID:36272053. |
the shh ligand activates two main transcriptional factors known as foxa2 and nkx2.2, which again activates another transcriptional factor, gata (gata2 and gata3), in post mitotic precursor cells of serotonergic neurons-following increased expression of pet-1 and lmx1b after gata regulates the expression of many serotonergic enzymes such as tph2, sert, vmat, slc6a4, htr1a, htr1b (serotonin receptor enzymes), and mao that regulate and control the release of serotonin and maintain their neuronal identity after their maturation. |
2022-10-22 |
2023-08-14 |
Not clear |
| Giulia Braccagni, Simona Scheggi, Marco Bortolat. Elevated levels of serotonin 5-HT European archives of psychiatry and clinical neuroscience. 2022-09-12. PMID:36094569. |
tissues were processed for immunoblotting analyses on eight key serotonergic targets: tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme of brain serotonin synthesis; serotonin transporter (sert), the primary carrier for serotonin uptake; monoamine oxidase a (maoa), the primary enzyme for serotonin catabolism; and five serotonin receptors previously shown to influence social behavior: 5-ht |
2022-09-12 |
2023-08-14 |
human |
| Tianle Zhu, Pan Gao, Jingjing Gao, Xi Liu, Hui Jiang, Xiansheng Zhan. The upregulation of tryptophan hydroxylase-2 expression is important for premature ejaculation treatment with the selective serotonin reuptake inhibitor. Andrology. 2021-12-07. PMID:34874128. |
although there was some evidence to suggest that the serotonergic system in the brain played an important role in premature ejaculation (pe), tryptophan hydroxylase-2 (tph2) is considered to be the key enzyme for the synthesis of 5-hydroxytryptamine (5-ht) and few studies have reported that brain tph2 is involved in the regulation of ejaculation. |
2021-12-07 |
2023-08-13 |
Not clear |
| Bhavana Talluri, Faith Hoelzel, Bidyut K Medda, Maia Terashvili, Patrick Sanvanson, Reza Shaker, Anjishnu Banerjee, Jyoti N Sengupta, Banani Banerje. Identification and characterization of rostral ventromedial medulla neurons synaptically connected to the urinary bladder afferents in female rats with or without neonatal cystitis. The Journal of comparative neurology. 2021-11-09. PMID:34628661. |
the results revealed that > 50% of rvm neurons that are synaptically connected to the bladder (i.e., prv-152+) were gabaergic, 40% enkephalinergic, and about 14% expressing serotonergic marker tryptophan hydroxylase 2 (tph2). |
2021-11-09 |
2023-08-13 |
rat |
| Chunyan Yao, Zhiyuan Wang, Huiyong Jiang, Ren Yan, Qianfei Huang, Yin Wang, Hui Xie, Ying Zou, Ying Yu, Longxian L. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34211003. |
glaa administration increased the levels of the sleep-promoting neurotransmitter 5-hydroxytryptamine and the tph2, iptr3 and gng13 transcripts in the sleep-regulating serotonergic synapse pathway in the hypothalamus during this process. |
2021-11-08 |
2023-08-13 |
mouse |
| Congcong Liu, Lei Xu, Jialin Li, Feng Zhou, Xi Yang, Xiaoxiao Zheng, Meina Fu, Keshuang Li, Cornelia Sindermann, Christian Montag, Yina Ma, Dirk Scheele, Richard P Ebstein, Shuxia Yao, Keith M Kendrick, Benjamin Becke. Serotonin and early life stress interact to shape brain architecture and anxious avoidant behavior - a TPH2 imaging genetics approach. Psychological medicine. vol 51. issue 14. 2021-10-12. PMID:32981537. |
central serotonergic biosynthesis rates are regulated by tryptophan hydroxylase 2 (tph2) and transgenic animal models suggest that tph2-gene associated differences in serotonergic signaling mediate the impact of aversive early life experiences on a phenotype characterized by anxious avoidance. |
2021-10-12 |
2023-08-13 |
Not clear |
| Jennyfer M Payet, Kira-Elise Wilson, Adrian M Russo, Anthony Angiolino, William Kavanagh-Ryan, Stephen Kent, Christopher A Lowry, Matthew W Hal. Involvement of dorsal raphe nucleus serotonergic systems in social approach-avoidance behaviour and in the response to fluoxetine treatment in peri-adolescent female BALB/c mice. Behavioural brain research. vol 408. 2021-09-02. PMID:33811952. |
activation of serotonergic neurons across subregions of the dr were subsequently measured, using dual-label immunohistochemistry for tph2 and c-fos. |
2021-09-02 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
this study aims to evaluate maternal hfd effects, during pregnancy and lactation, upon dams/mice offspring nutritional status, protein and gene expression of inflammatory pathway (jnk, pjnk and tnf-α), serotonin system molecules (tryptophan hydroxylase 2 (tph2), key-enzyme of serotonin synthesis, serotonin transporter (sert); 5-ht1a serotonergic receptor (5-ht1a)) and brain derived neurotrophic factor (bdnf) on recently weaned mice offspring hippocampus. |
2021-08-11 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
thus, our findings show that maternal hfd during gestation and lactation increased pjnk and tnf-α expression in their offspring hippocampus indicating a pro-inflammatory state, with increased bdnf expression and alterations in its serotonergic system reflected by increased tph2 expression. |
2021-08-11 |
2023-08-13 |
mouse |
| Nina C Donner, Sofia M Davies, Stephanie D Fitz, Drake M Kienzle, Anantha Shekhar, Christopher A Lowr. Crh receptor priming in the bed nucleus of the stria terminalis (BNST) induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety. Progress in neuro-psychopharmacology & biological psychiatry. vol 96. 2021-01-04. PMID:31415826. |
since the bnst projects heavily to the dorsal raphe nucleus (dr), the main source of brain serotonin, we here tested the hypothesis that such repeated, anxiety-inducing activation of crh receptors in the bnst alters the expression of serotonergic genes in the dr, including tph2, the gene encoding the rate-limiting enzyme for brain serotonin synthesis, and slc6a4, the gene encoding the serotonin transporter (sert). |
2021-01-04 |
2023-08-13 |
rat |
| Justin K Siemann, Piper Williams, Turnee N Malik, Chad R Jackson, Noah H Green, Ronald B Emeson, Pat Levitt, Douglas G McMaho. Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems. Scientific reports. vol 10. issue 1. 2020-12-15. PMID:32963273. |
hence, we evaluated, at multiple stages of postnatal development, the expression of key dopaminergic (th) and serotonergic (tph2, sert, and pet-1) genes, and midbrain monoamine content in mice raised under control equinox (ld 12:12), short winter-like (ld 8:16), or long summer-like (ld 16:8) photoperiods. |
2020-12-15 |
2023-08-13 |
mouse |
| Meiju Zhu, Hongzhu Zhu, Xiaomin Ding, Shaosheng Liu, Yuanhua Zo. Analysis of the anti-fatigue activity of polysaccharides from Spirulina platensis: role of central 5-hydroxytryptamine mechanisms. Food & function. vol 11. issue 2. 2020-10-19. PMID:32057057. |
this study evaluated the effects of polysaccharides from spirulina platensis (psp) on endurance during treadmill exercise; levels of some biochemical indicators including hemoglobin (hb), lactic acid (la), creatine kinase (ck), and blood urea nitrogen (bun); concentrations of 5-hydroxytryptamine (5-ht); and expressions of second isoforms of tryptophan hydroxylase (tph2) and serotonergic type 1b inhibitory autoreceptor (5-ht1b) in the caudate putamen of exercising rats. |
2020-10-19 |
2023-08-13 |
rat |
| Yoko Ikoma, Ikue Kusumoto-Yoshida, Akihiro Yamanaka, Youichirou Ootsuka, Tomoyuki Kuwak. Inactivation of Serotonergic Neurons in the Rostral Medullary Raphé Attenuates Stress-Induced Tachypnea and Tachycardia in Mice. Frontiers in physiology. vol 9. 2020-10-01. PMID:30050449. |
we used genetically modified mice [tryptophan hydroxylase 2 (tph2); archaerhodopsin-t (archt) mice] in which archt, a green light-driven neuronal silencer, was selectively expressed in serotonergic neurons under the regulation of tph2 promoters. |
2020-10-01 |
2023-08-13 |
mouse |
| Aleksei G Menzorov, Konstantin E Orishchenko, Veniamin S Fishman, Anastasia A Shevtsova, Roman V Mungalov, Inna E Pristyazhnyuk, Elena A Kizilova, Natalia M Matveeva, Natalia Alenina, Michael Bader, Nikolai B Rubtsov, Oleg L Sero. Targeted genomic integration of EGFP under tubulin beta 3 class III promoter and mEos2 under tryptophan hydroxylase 2 promoter does not produce sufficient levels of reporter gene expression. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-17. PMID:31106442. |
here we describe the generation of two fluorescent reporter systems: enhanced green fluorescent protein (egfp) under pan-neural marker class iii β-tubulin (tubb3) promoter and meos2 under serotonergic neuron-specific tryptophan hydroxylase 2 (tph2) promoter. |
2020-09-17 |
2023-08-13 |
Not clear |
| Margaret W Lieb, Magdalena Weidner, Mathew R Arnold, Kelsey M Loupy, Kadi T Nguyen, James E Hassell, K'Loni S Schnabel, Raphael Kern, Heidi E W Day, Klaus-Peter Lesch, Jonas Waider, Christopher A Lowr. Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice. Behavioural brain research. vol 373. 2020-09-14. PMID:31319134. |
serotonergic genes studied included tph2, the high-affinity, low-capacity, sodium-dependent serotonin transporter (slc6a4), the serotonin type 1a receptor (htr1a), and the corticosterone-sensitive, low-affinity, high-capacity sodium-independent serotonin transporter, organic cation transporter 3 (slc22a3). |
2020-09-14 |
2023-08-13 |
mouse |