All Relations between tnf and hippocampus

Publication Sentence Publish Date Extraction Date Species
Kavitha Ukkirapandian, Kayalvizhi Elumalai, Karthika Priyadharshini Udaykumar, Sundaravadivel Vp, Muthulakshmi Rangasm. Behavioral and Biochemical Assays for Autism Models of Wistar Rats. Cureus. vol 16. issue 1. 2024-02-13. PMID:38344592. the estimation of antioxidant profile (malondialdehyde {mda}, glutathione {gsh}, catalase (cat), and superoxide dismutase {sod}), proinflammatory markers (tumor necrosis factor {tnf} alpha, transforming growth factor {tgf} beta, interleukin {il} 6, and il-1 beta), neurotransmitters (gamma-aminobutyric acid {gaba} and serotonin), and brain-derived neurotrophic factor (bdnf) in the hippocampal region was done. 2024-02-13 2024-02-15 rat
Dominic Osei, Eveline Baumgart-Vogt, Barbara Ahlemeyer, Christiane Herde. Tumor Necrosis Factor-α Receptor 1 Mediates Borna Disease Virus 1-Induced Changes in Peroxisomal and Mitochondrial Dynamics in Neurons. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339126. using different mouse lines-i.e., tumor necrosis factor-α transgenic (tnftg; to pro-inflammatory status), tnf receptor-1 knockout (tnfr1ko), and tnfr2ko mice in comparison to wild-type (wt) mice-we analyzed the abundances of both organelles and their main antioxidant enzymes, catalase and superoxide dismutase 2 (sod2), in neurons of the hippocampal, cerebral, and cerebellar cortices. 2024-02-10 2024-02-12 mouse
Hussain N Alhamami, Abdullah M Albogami, Mohammad M Algahtani, Mohammed Alqinyah, Wael A Alanazi, Fawaz Alasmari, Khalid Alhazzani, Ahmed Z Alanazi, Yasseen A Alassmrry, Abdullah S Alhame. The effect of inhibiting hindbrain A2 noradrenergic neurons by 6-Hydroxydopamine on lipopolysaccharide-treated male rats autistic animal model. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 32. issue 3. 2024-02-08. PMID:38328791. multiple studies have documented the presence of neuroinflammation and increased levels of inflammatory cytokines, specifically, il-6, tnf, and nf-κb, in various brain regions, including the prefrontal cortex (pfc) and hippocampus in individuals with asd. 2024-02-08 2024-02-10 rat
Ling Wang, Haoran Sha, Xiaoyi He, Yinyin Xie, Jiapeng Deng, Jiexuan Chen, Guoying Li, Junhua Yan. Neonatal IL-4 Over-Exposure is Accompanied by Macrophage Accumulation in Dura Mater After Instant Anti-inflammatory Cytokine Response in CSF. Cellular and molecular neurobiology. vol 44. issue 1. 2024-02-05. PMID:38315435. here, we found a delayed pro-inflammatory cytokines response (higher il-6, il-1β and, tnf levels) in both hippocampus and csf after an instant anti-inflammatory cytokine response in il-4 over-exposed rats. 2024-02-05 2024-02-09 rat
Natalia Surzenko, Johana Bastidas, Robert W Reid, Julien Curaba, Wei Zhang, Hamed Bostan, Mickey Wilson, Ashley Dominique, Julia Roberson, Glicerio Ignacio, Slavko Komarnytsky, Alexa Sanders, Kevin Lambirth, Cory R Brouwer, Bassem F El-Khodo. Functional recovery following traumatic brain injury in rats is enhanced by oral supplementation with bovine thymus extract. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 3. 2024-02-05. PMID:38315443. using rna-seq, we identified an array of signaling pathways that are modulated by tnf supplementation in rat hippocampus, including those involved in the process of autophagy. 2024-02-05 2024-02-09 rat
Victor H B de Andrade, Erick Y M Rodrigues, Nayara A F Dias, Gabriela F C Ferreira, Diego B de Carvalho, Amarith R das Neves, Paola M V Coronel, Murilo K A Yonekawa, Eduardo B Parisotto, Edson A Dos Santos, Albert S Souza, Edgar J Paredes-Gamero, Kamylla S de Sousa, Letícia L de Souza, Leonardo B M Resstel, Adriano C M Baroni, Davi C Lagatt. Neuroprotective Profile of Triazole Grandisin Analogue against Amyloid-Beta Oligomer-Induced Cognitive Impairment. ACS chemical neuroscience. 2023-12-04. PMID:38048522. additionally, tga reduced tumor necrosis factor (tnf) and interferon-γ (ifn-γ) levels in the hippocampus. 2023-12-04 2023-12-10 mouse
Victor H B de Andrade, Erick Y M Rodrigues, Nayara A F Dias, Gabriela F C Ferreira, Diego B de Carvalho, Amarith R das Neves, Paola M V Coronel, Murilo K A Yonekawa, Eduardo B Parisotto, Edson A Dos Santos, Albert S Souza, Edgar J Paredes-Gamero, Kamylla S de Sousa, Letícia L de Souza, Leonardo B M Resstel, Adriano C M Baroni, Davi C Lagatt. Neuroprotective Profile of Triazole Grandisin Analogue against Amyloid-Beta Oligomer-Induced Cognitive Impairment. ACS chemical neuroscience. 2023-12-04. PMID:38048522. by contrast, memantine failed to prevent cortex/hippocampus lipid peroxidation, recognition memory decline, and aβo-induced increases in tnf and ifn-γ levels in the hippocampus. 2023-12-04 2023-12-10 mouse
Vanessa Valéria Miron, Charles Elias Assmann, Vitor Bastianello Mostardeiro, Nathieli Bianchin Bottari, Jucimara Baldissarelli, Karine Paula Reichert, Aniélen Dutra da Silva, Milagros Fanny Vera Castro, Loren Borba de Jesus, Marcylene Vieira da Silveira, Tais Vidal Palma, Vera Maria Morsch, Andréia Machado Cardoso, Maria Rosa Chitolina Schetinge. Resistance physical exercise alleviates lipopolysaccharide-triggered neuroinflammation in cortex and hippocampus of rats via purinergic signaling. Neurotoxicology. vol 99. 2023-11-09. PMID:37890558. enzymes activities (ntpdase, 5'-nucleotidase, and adenosine deaminase), purinoceptors' density (p2x7r, a1, and a2a), and the levels of inflammatory indicators (pyrin domain-containing protein 3 (nlrp3), caspase-1, interleukin (il)- 6, il-1b, and tumor necrosis factor (tnf) -α) were measured in the cortex and hippocampus of the animals. 2023-11-09 2023-11-20 rat
João P Novo, Mariana Muga, Teresa Lourenço, Eliane S Sanches, Ricardo A Leitão, Ana Paula Silv. Dichotomous effect of methylphenidate on microglia and astrocytes: Insights from in vitro and animal studies. Toxicology letters. 2023-10-16. PMID:37844808. on the contrary, mph promotes astrogliosis, oxidative/nitrosative stress, and increases proinflammatory cytokine tnf levels by astrocytes, which was concordant with the results obtained in the hippocampus of wky rats. 2023-10-16 2023-11-08 human
Matthew I Hiskens, Katy M Li, Anthony G Schneiders, Andrew S Fennin. Repetitive mild traumatic brain injury-induced neurodegeneration and inflammation is attenuated by acetyl-L-carnitine in a preclinical model. Frontiers in pharmacology. vol 14. 2023-09-25. PMID:37745053. rt-pcr analysis of the cortex and hippocampus was undertaken for mapt, gfap, aif1, gria, ccl11, tdp43, and tnf genes. 2023-09-25 2023-10-07 mouse
Mandana Shekarchian, Maghsoud Peeri, Mohammad Ali Azarbayjan. Physical activity in a swimming pool attenuates memory impairment by reducing glutamate and inflammatory cytokines and increasing BDNF in the brain of mice with type 2 diabetes. Brain research bulletin. 2023-08-05. PMID:37543294. we also measured inflammatory cytokines (interleukin (il)-6, il-1β, and tumor-necrosis-factor (tnf)-α), an anti-inflammatory cytokine (il-10), and brain-derived-neurotrophic-factor (bdnf), and glutamate levels in the hippocampus or prefrontal cortex of mice. 2023-08-05 2023-08-14 mouse
Ali Barzegari, Hassan Amouzad Mahdirejei, Masoumeh Hanani, Mohammad Hossein Esmaeili, Ali-Akbar Salar. Adolescent swimming exercise following maternal valproic acid treatment improves cognition and reduces stress-related symptoms in offspring mice: Role of sex and brain cytokines. Physiology & behavior. 2023-06-09. PMID:37295664. we assessed neurobehavioral performances and inflammatory cytokines (interleukin-(il)6, tumor-necrosis-factor-(tnf)α, interferon-(ifn)γ, and il-17a) in the hippocampus and prefrontal cortex of offspring. 2023-06-09 2023-08-14 mouse
Zhijing Zhang, Lideng Guo, Fei Yang, Shanpan Peng, Di Wang, Xiawei Lai, Baiqin Su, Haihui Xi. Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats. ACS chemical neuroscience. 2023-05-04. PMID:37141577. further experiments indicated that apn could inhibit the toll-like receptor 4 (tlr4)/myeloid differentiation factor 88 (myd88)/nuclear factor kappa b (nf-κb) p65 pathway to decrease the degree of oxidative damage (malondialdehyde (mda) and superoxide dismutase (sod)), microglia-mediated neuroinflammation (ionized calcium binding adapter molecule 1 (iba1), caspase-1, tumor necrosis factor (tnf)-α, interleukin-1β (il-1β), and interleukin-6 (il-6)), and apoptosis (p53, bcl2, bax, and caspase 3) in hippocampus. 2023-05-04 2023-08-14 rat
b' Sinan Saral, Atilla Top\\xc3\\xa7u, Mehmet Alkanat, Tolga Mercantepe, Zafer \\xc5\\x9eahin, Kerimali Aky\\xc4\\xb1ld\\xc4\\xb1z, Kader Semra Karata\\xc5\\x9f, Lamiye Y\\xc4\\xb1ld\\xc4\\xb1z, Levent T\\xc3\\xbcmkaya, Zihni A\\xc3\\xa7ar Yaz\\xc4\\xb1c\\xc4\\xb. Agomelatine attenuates cisplatin-induced cognitive impairment via modulation of BDNF/TrkB signaling in rat hippocampus. Journal of chemical neuroanatomy. 2023-03-31. PMID:37001681.' after behavioral tests, rats were euthanized and bdnf, tnf, il-1β, mda and gsh levels were measured in hippocampal homegenates by elisa. 2023-03-31 2023-08-14 rat
Wenshu Zou, Kai Zhang, Zhengying Qiu, Ruihua Xin, Guibo Wang, Jingyan Zhang, Jianxi L. Asiatic acid and andrographolide reduce hippocampal injury through suppressing neuroinflammation caused by Salmonella typhimurium infection. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-12-29. PMID:36581090. the results showed that the neurons in the hippocampus of mice were damaged after s. typhimurium invaded cns in mice, and the inflammation was increased, which was manifested by the increased expression of inflammatory factors interleukin (il)-1β, tumor necrosis factor (tnf)-α, il-6, interferon (ifn)-γ and il-12b and the activation of nod-, lrr- and pyrin domain-containing protein 3 (nlrp3) inflammasomes. 2022-12-29 2023-08-14 mouse
Hongtao Shen, Tianzhen Zhang, Yao Ji, Yu Zhang, Yongxiang Wang, Yuling Jiang, Xiongjin Chen, Qiuhao Liang, Kefeng Wu, Yunfeng Li, Xingyu Lu, Lili Cui, Bin Zhao, Yan Wan. GRK5 Deficiency in the Hippocampus Leads to Cognitive Impairment via Abnormal Microglial Alterations. Molecular neurobiology. 2022-12-16. PMID:36525154. in addition, transcriptional analysis of hippocampal tissues revealed striking changes in neuroactive ligand‒receptor interactions and tnf signaling in grk5-deficient mice. 2022-12-16 2023-08-14 mouse
Fu-Sheng Wei, Mu-Wen Rao, Yuan-Lu Huang, Shi-Biao Chen, Yu-Qian Wu, Lei Yan. miR-182-5p Delivered by Plasma Exosomes Promotes Sevoflurane-Induced Neuroinflammation and Cognitive Dysfunction in Aged Rats with Postoperative Cognitive Dysfunction by Targeting Brain-Derived Neurotrophic Factor and Activating NF-κB Pathway. Neurotoxicity research. 2022-10-29. PMID:36308704. besides, the morris water maze (mwm) and fear conditioning test were used to evaluate the learning and memory ability of rats; western blot to detect the expression levels of neurotrophic factors (brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf)) as well as nf-κb pathway-related proteins (p65 and p-p65) in rat hippocampal tissues or pc-12 cells; qrt-pcr to assess the expression levels of mir-182-5p and bdnf in rat plasma, plasma exosomes, hippocampal tissues, and pc-12 cells; elisa to evaluate the levels of tumor necrosis factor (tnf)-α, interleukin (il)-6, and il-1β in rat hippocampal tissues; and dual-luciferase reporter assay to verify the targeting relationship between mir-182-5p and bdnf. 2022-10-29 2023-08-14 rat
Xiaoli Wu, Jingwen Gu, Zhicong Zou, Meng Yu, Chen Zhang, Qinghui Xiao, Xin Chen, Chuwen L. Suppressive Effects of Isofraxidin on Depressive-like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice. Brain sciences. vol 12. issue 10. 2022-10-27. PMID:36291310. also, isofraxidin suppresses tumor necrosis factor (tnf)-α, interleukin (il)-1β, and il-6 expression in the hippocampus of cums mice. 2022-10-27 2023-08-14 mouse
Gina M Kemp, Haider F Altimimi, Yoonmi Nho, Renu Heir, Adam Klyczek, David Stellwage. Sustained TNF signaling is required for the synaptic and anxiety-like behavioral response to acute stress. Molecular psychiatry. 2022-09-14. PMID:36104437. here we reveal that tumor necrosis factor α (tnf) is a required downstream mediator of the stress response in mice, necessary for stress-induced synaptic potentiation in the ventral hippocampus and for an increase in anxiety-like behaviour. 2022-09-14 2023-08-14 mouse
Gina M Kemp, Haider F Altimimi, Yoonmi Nho, Renu Heir, Adam Klyczek, David Stellwage. Sustained TNF signaling is required for the synaptic and anxiety-like behavioral response to acute stress. Molecular psychiatry. 2022-09-14. PMID:36104437. critically, on-going tnf signaling specifically in the ventral hippocampus is necessary to sustain both the stress-induced synaptic and behavioral changes, as these could be reversed hours after induction by antagonizing tnf signaling. 2022-09-14 2023-08-14 mouse