| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Elizabeth De Sousa Rodrigues, MacKenzie L Bolen, Lisa Blackmer-Raynolds, Noah Schwartz, Jianjun Chang, Malú Gámez Tansey, Timothy Robert Sampso. Diet-induced metabolic and immune impairments are sex-specifically modulated by soluble TNF signaling in the 5xFAD mouse model of Alzheimer's disease. Neurobiology of disease. 2024-04-26. PMID:38670277. |
targeted transcriptomics of cns regions revealed that inhibition of soluble tnf was sufficient to alter expression of hippocampal and cortical genes associated with beneficial immune and metabolic responses. |
2024-04-26 |
2024-04-29 |
mouse |
| Mehmet Öz, Hüseyin Erda. A TNF-α inhibitor abolishes sepsis-induced cognitive impairment in mice by modulating acetylcholine and nitric oxide homeostasis, BDNF release, and neuroinflammation. Behavioural brain research. 2024-04-10. PMID:38599251. |
blood and hippocampal tnf α and nitric oxide (no) levels, hippocampal bdnf, creb, and ach levels, and ache activity were measured by elisa. |
2024-04-10 |
2024-04-13 |
mouse |
| Maria Elizabeth De Sousa Rodrigues, MacKenzie L Bolen, Lisa Blackmer-Raynolds, Noah Schwartz, Jianjun Chang, Malú Gámez Tansey, Timothy Robert Sampso. Diet-induced metabolic and immune impairments are sex-specifically modulated by soluble TNF signaling in the 5xFAD mouse model of Alzheimer's disease. bioRxiv : the preprint server for biology. 2024-03-11. PMID:38464096. |
targeted transcriptomics of cns regions revealed that inhibition of soluble tnf was sufficient to alter expression of hippocampal and cortical genes associated with beneficial immune and metabolic responses. |
2024-03-11 |
2024-03-14 |
mouse |
| Züleyha Doğanyiğit, Aslı Okan, Seher Yılmaz, A Cihangir Uğuz, Enes Akyü. Gender-related variation expressions of neuroplastin TRAF6, GluA1, GABA(A) receptor, and PMCA in cortex, hippocampus, and brainstem in an experimental epilepsy model. Synapse (New York, N.Y.). vol 78. issue 2. 2024-03-04. PMID:38436644. |
it was observed that neuroplastin and related proteins tnf receptor-associated factor 6 (traf6), gamma amino butyric acid type a receptors [(gaba(a)], and plasma membrane ca2+ atpase (pmca) protein immunoreactivity levels increased especially in the male hippocampus, and only ampa receptor subunit type 1 (glua1) immunoreactivity decreased, unlike other proteins. |
2024-03-04 |
2024-03-06 |
rat |
| Xiaoyang Ma, Jeon-Kyung Kim, Yoon-Jung Shin, Hee-Seo Park, Dong-Yun Lee, Sung-Vin Yim, Dong-Hyun Ki. Lipopolysaccharide-producing Veillonella infantium and Escherichia fergusonii cause vagus nerve-mediated cognitive impairment in mice. Brain, behavior, and immunity. 2024-03-01. PMID:38428648. |
fmci transplantation increased cognitive impairment-like behavior, hippocampal tumor necrosis factor (tnf)-α expression, and the size of toll-like receptor (tlr)4 |
2024-03-01 |
2024-03-04 |
mouse |
| Mengjun Geng, Qiujing Shao, Jiacheng Fu, Jingyang Gu, Laipeng Feng, Liqin Zhao, Cong Liu, Junlin Mu, Xiaoli Zhang, Mingjun Zhao, Xinsheng Guo, Cai Song, Yan Li, Huiying Wang, Changhong Wan. Down-regulation of MKP-1 in hippocampus protects against stress-induced depression-like behaviors and neuroinflammation. Translational psychiatry. vol 14. issue 1. 2024-02-29. PMID:38424085. |
rats exposed to cums exhibited mkp-1 overexpression, greater numbers of activated microglia, and enhanced expressions of neuroinflammatory markers (interleukin [il]-6, [il]-1β, tumor necrosis factor [tnf]-ɑ, and decreased phosphorylation levels of erk and p38 in the hippocampus as well as anhedonia in the sucrose preference test, motor retardation in the open field, and greater immobility (despair) in the forced swimming tests. |
2024-02-29 |
2024-03-03 |
rat |
| Renu Heir, Zahra Abbasi, Pragya Komal, Haider F Altimimi, Marie Franquin, Dionysia Moschou, Julien Chambon, David Stellwage. Astrocytes are the source of TNF mediating homeostatic synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-02-23. PMID:38395613. |
hippocampal cultures from rats of both sexes depleted of microglia still will increase tnf levels following activity deprivation, and still express ttx-driven hsp. |
2024-02-23 |
2024-02-26 |
mouse |
| Kavitha Ukkirapandian, Kayalvizhi Elumalai, Karthika Priyadharshini Udaykumar, Sundaravadivel Vp, Muthulakshmi Rangasm. Behavioral and Biochemical Assays for Autism Models of Wistar Rats. Cureus. vol 16. issue 1. 2024-02-13. PMID:38344592. |
the estimation of antioxidant profile (malondialdehyde {mda}, glutathione {gsh}, catalase (cat), and superoxide dismutase {sod}), proinflammatory markers (tumor necrosis factor {tnf} alpha, transforming growth factor {tgf} beta, interleukin {il} 6, and il-1 beta), neurotransmitters (gamma-aminobutyric acid {gaba} and serotonin), and brain-derived neurotrophic factor (bdnf) in the hippocampal region was done. |
2024-02-13 |
2024-02-15 |
rat |
| Dominic Osei, Eveline Baumgart-Vogt, Barbara Ahlemeyer, Christiane Herde. Tumor Necrosis Factor-α Receptor 1 Mediates Borna Disease Virus 1-Induced Changes in Peroxisomal and Mitochondrial Dynamics in Neurons. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339126. |
using different mouse lines-i.e., tumor necrosis factor-α transgenic (tnftg; to pro-inflammatory status), tnf receptor-1 knockout (tnfr1ko), and tnfr2ko mice in comparison to wild-type (wt) mice-we analyzed the abundances of both organelles and their main antioxidant enzymes, catalase and superoxide dismutase 2 (sod2), in neurons of the hippocampal, cerebral, and cerebellar cortices. |
2024-02-10 |
2024-02-12 |
mouse |
| Hussain N Alhamami, Abdullah M Albogami, Mohammad M Algahtani, Mohammed Alqinyah, Wael A Alanazi, Fawaz Alasmari, Khalid Alhazzani, Ahmed Z Alanazi, Yasseen A Alassmrry, Abdullah S Alhame. The effect of inhibiting hindbrain A2 noradrenergic neurons by 6-Hydroxydopamine on lipopolysaccharide-treated male rats autistic animal model. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 32. issue 3. 2024-02-08. PMID:38328791. |
multiple studies have documented the presence of neuroinflammation and increased levels of inflammatory cytokines, specifically, il-6, tnf, and nf-κb, in various brain regions, including the prefrontal cortex (pfc) and hippocampus in individuals with asd. |
2024-02-08 |
2024-02-10 |
rat |
| Ling Wang, Haoran Sha, Xiaoyi He, Yinyin Xie, Jiapeng Deng, Jiexuan Chen, Guoying Li, Junhua Yan. Neonatal IL-4 Over-Exposure is Accompanied by Macrophage Accumulation in Dura Mater After Instant Anti-inflammatory Cytokine Response in CSF. Cellular and molecular neurobiology. vol 44. issue 1. 2024-02-05. PMID:38315435. |
here, we found a delayed pro-inflammatory cytokines response (higher il-6, il-1β and, tnf levels) in both hippocampus and csf after an instant anti-inflammatory cytokine response in il-4 over-exposed rats. |
2024-02-05 |
2024-02-09 |
rat |
| Natalia Surzenko, Johana Bastidas, Robert W Reid, Julien Curaba, Wei Zhang, Hamed Bostan, Mickey Wilson, Ashley Dominique, Julia Roberson, Glicerio Ignacio, Slavko Komarnytsky, Alexa Sanders, Kevin Lambirth, Cory R Brouwer, Bassem F El-Khodo. Functional recovery following traumatic brain injury in rats is enhanced by oral supplementation with bovine thymus extract. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 3. 2024-02-05. PMID:38315443. |
using rna-seq, we identified an array of signaling pathways that are modulated by tnf supplementation in rat hippocampus, including those involved in the process of autophagy. |
2024-02-05 |
2024-02-09 |
rat |
| Victor H B de Andrade, Erick Y M Rodrigues, Nayara A F Dias, Gabriela F C Ferreira, Diego B de Carvalho, Amarith R das Neves, Paola M V Coronel, Murilo K A Yonekawa, Eduardo B Parisotto, Edson A Dos Santos, Albert S Souza, Edgar J Paredes-Gamero, Kamylla S de Sousa, Letícia L de Souza, Leonardo B M Resstel, Adriano C M Baroni, Davi C Lagatt. Neuroprotective Profile of Triazole Grandisin Analogue against Amyloid-Beta Oligomer-Induced Cognitive Impairment. ACS chemical neuroscience. 2023-12-04. PMID:38048522. |
additionally, tga reduced tumor necrosis factor (tnf) and interferon-γ (ifn-γ) levels in the hippocampus. |
2023-12-04 |
2023-12-10 |
mouse |
| Victor H B de Andrade, Erick Y M Rodrigues, Nayara A F Dias, Gabriela F C Ferreira, Diego B de Carvalho, Amarith R das Neves, Paola M V Coronel, Murilo K A Yonekawa, Eduardo B Parisotto, Edson A Dos Santos, Albert S Souza, Edgar J Paredes-Gamero, Kamylla S de Sousa, Letícia L de Souza, Leonardo B M Resstel, Adriano C M Baroni, Davi C Lagatt. Neuroprotective Profile of Triazole Grandisin Analogue against Amyloid-Beta Oligomer-Induced Cognitive Impairment. ACS chemical neuroscience. 2023-12-04. PMID:38048522. |
by contrast, memantine failed to prevent cortex/hippocampus lipid peroxidation, recognition memory decline, and aβo-induced increases in tnf and ifn-γ levels in the hippocampus. |
2023-12-04 |
2023-12-10 |
mouse |
| Vanessa Valéria Miron, Charles Elias Assmann, Vitor Bastianello Mostardeiro, Nathieli Bianchin Bottari, Jucimara Baldissarelli, Karine Paula Reichert, Aniélen Dutra da Silva, Milagros Fanny Vera Castro, Loren Borba de Jesus, Marcylene Vieira da Silveira, Tais Vidal Palma, Vera Maria Morsch, Andréia Machado Cardoso, Maria Rosa Chitolina Schetinge. Resistance physical exercise alleviates lipopolysaccharide-triggered neuroinflammation in cortex and hippocampus of rats via purinergic signaling. Neurotoxicology. vol 99. 2023-11-09. PMID:37890558. |
enzymes activities (ntpdase, 5'-nucleotidase, and adenosine deaminase), purinoceptors' density (p2x7r, a1, and a2a), and the levels of inflammatory indicators (pyrin domain-containing protein 3 (nlrp3), caspase-1, interleukin (il)- 6, il-1b, and tumor necrosis factor (tnf) -α) were measured in the cortex and hippocampus of the animals. |
2023-11-09 |
2023-11-20 |
rat |
| João P Novo, Mariana Muga, Teresa Lourenço, Eliane S Sanches, Ricardo A Leitão, Ana Paula Silv. Dichotomous effect of methylphenidate on microglia and astrocytes: Insights from in vitro and animal studies. Toxicology letters. 2023-10-16. PMID:37844808. |
on the contrary, mph promotes astrogliosis, oxidative/nitrosative stress, and increases proinflammatory cytokine tnf levels by astrocytes, which was concordant with the results obtained in the hippocampus of wky rats. |
2023-10-16 |
2023-11-08 |
human |
| Matthew I Hiskens, Katy M Li, Anthony G Schneiders, Andrew S Fennin. Repetitive mild traumatic brain injury-induced neurodegeneration and inflammation is attenuated by acetyl-L-carnitine in a preclinical model. Frontiers in pharmacology. vol 14. 2023-09-25. PMID:37745053. |
rt-pcr analysis of the cortex and hippocampus was undertaken for mapt, gfap, aif1, gria, ccl11, tdp43, and tnf genes. |
2023-09-25 |
2023-10-07 |
mouse |
| Mandana Shekarchian, Maghsoud Peeri, Mohammad Ali Azarbayjan. Physical activity in a swimming pool attenuates memory impairment by reducing glutamate and inflammatory cytokines and increasing BDNF in the brain of mice with type 2 diabetes. Brain research bulletin. 2023-08-05. PMID:37543294. |
we also measured inflammatory cytokines (interleukin (il)-6, il-1β, and tumor-necrosis-factor (tnf)-α), an anti-inflammatory cytokine (il-10), and brain-derived-neurotrophic-factor (bdnf), and glutamate levels in the hippocampus or prefrontal cortex of mice. |
2023-08-05 |
2023-08-14 |
mouse |
| Ali Barzegari, Hassan Amouzad Mahdirejei, Masoumeh Hanani, Mohammad Hossein Esmaeili, Ali-Akbar Salar. Adolescent swimming exercise following maternal valproic acid treatment improves cognition and reduces stress-related symptoms in offspring mice: Role of sex and brain cytokines. Physiology & behavior. 2023-06-09. PMID:37295664. |
we assessed neurobehavioral performances and inflammatory cytokines (interleukin-(il)6, tumor-necrosis-factor-(tnf)α, interferon-(ifn)γ, and il-17a) in the hippocampus and prefrontal cortex of offspring. |
2023-06-09 |
2023-08-14 |
mouse |
| Zhijing Zhang, Lideng Guo, Fei Yang, Shanpan Peng, Di Wang, Xiawei Lai, Baiqin Su, Haihui Xi. Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats. ACS chemical neuroscience. 2023-05-04. PMID:37141577. |
further experiments indicated that apn could inhibit the toll-like receptor 4 (tlr4)/myeloid differentiation factor 88 (myd88)/nuclear factor kappa b (nf-κb) p65 pathway to decrease the degree of oxidative damage (malondialdehyde (mda) and superoxide dismutase (sod)), microglia-mediated neuroinflammation (ionized calcium binding adapter molecule 1 (iba1), caspase-1, tumor necrosis factor (tnf)-α, interleukin-1β (il-1β), and interleukin-6 (il-6)), and apoptosis (p53, bcl2, bax, and caspase 3) in hippocampus. |
2023-05-04 |
2023-08-14 |
rat |