| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ralf Kirchei. In Silico Analyses Indicate a Lower Potency for Dimerization of TLR4/MD-2 as the Reason for the Lower Pathogenicity of Omicron Compared to Wild-Type Virus and Earlier SARS-CoV-2 Variants. International journal of molecular sciences. vol 25. issue 10. 2024-05-25. PMID:38791489. |
further analyses indicate a clear tendency for decreasing tlr4 dimerization potential during sars-cov-2 evolution via alpha to gamma to delta to omicron variants. |
2024-05-25 |
2024-05-27 |
Not clear |
| Jiangang Zheng, Abdul Haseeb, Ziyang Wang, Hejie Wan. Network pharmacology, computational biology integrated surface plasmon resonance technology reveals the mechanism of ellagic acid against rotavirus. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555283. |
the results of network pharmacological analysis showed that there were 35 intersection proteins, among which interleukin-1β (il-1β), albumin (alb), nuclear factor kappa-b1 (nf-κb1), toll-like receptor 4 (tlr4), tumor necrosis factor alpha (tnf-α), tumor protein p53 (tp53), recombinant smad family member 3 (samd3), epidermal growth factor (egf) and interleukin-4 (il-4) were potential core targets of ea anti-rv. |
2024-03-30 |
2024-04-02 |
Not clear |
| Joon Ha Park, Tae-Kyeong Lee, Dae Won Kim, Ji Hyeon Ahn, Myoung Cheol Shin, Jun Hwi Cho, Moo-Ho Won, Il Jun Kan. Neuroprotective Effects of Aucubin against Cerebral Ischemia and Ischemia Injury through the Inhibition of the TLR4/NF-κB Inflammatory Signaling Pathway in Gerbils. International journal of molecular sciences. vol 25. issue 6. 2024-03-28. PMID:38542434. |
changes in toll-like receptor 4 (tlr4)/nuclear factor-κb (nf-κb) signaling pathway were assessed by measuring levels of tlr4, inhibitor of nf-κb alpha (iκbα), and nf-κb p65 using western blot. |
2024-03-28 |
2024-03-30 |
Not clear |
| Chiranjib Chakraborty, Bidyut Mallick, Manojit Bhattacharya, Siddappa N Byraredd. SARS-CoV-2 Omicron Spike shows strong binding affinity and favourable interaction landscape with the TLR4/MD2 compared to other variants. Journal, genetic engineering & biotechnology. vol 22. issue 1. 2024-03-17. PMID:38494253. |
similarly, the alpha variants' spike with the tlr4 has illustrated that 14 hydrogen bonds participated in the interaction. |
2024-03-17 |
2024-03-20 |
Not clear |
| Chiranjib Chakraborty, Bidyut Mallick, Manojit Bhattacharya, Siddappa N Byraredd. SARS-CoV-2 Omicron Spike shows strong binding affinity and favourable interaction landscape with the TLR4/MD2 compared to other variants. Journal, genetic engineering & biotechnology. vol 22. issue 1. 2024-03-17. PMID:38494253. |
similarly, the alpha spike shows higher binding affinity with tlr4 than the wild type and delta variant. |
2024-03-17 |
2024-03-20 |
Not clear |
| Bristy Basak, Sachiko Akashi-Takamur. IRF3 function and immunological gaps in sepsis. Frontiers in immunology. vol 15. 2024-02-20. PMID:38375470. |
tlr4 signaling is diverted to the classical acute innate immune, inflammation-driving pathway in conjunction with the classical nf-κb pivot of myd88, leading to epigenetic linkage shifts in nuclear pro-inflammatory transcription and chromatin structure-function; in addition, tlr4 signaling to the tir domain-containing adapter-induced ifn-β (trif) apparatus and to nuclear pivots that signal the association of interferons alpha and beta (ifn-α and ifn-β) with acute inflammation, often coupled with oxidants favor inhibition or resistance to tissue injury. |
2024-02-20 |
2024-02-22 |
Not clear |
| Lei Yang, Zhao-Yong Li, Lu Ma, Yan-Tao Guo, Shao-Feng Yang, Hui Xiong, Bo-Yu Wu, Jia-Hao Duan, En-Xu Liu, Chao Zhang, Ying Nie, Long Chen, Lin-Quan Li. [Aucubin combined with ADSCs-exos protects TBHP-induced nucleus pulposus cells via TLR4/NF-κB pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 19. 2023-12-19. PMID:38114119. |
real-time fluorescence quantitative pcr and western blot were employed to determine the mrna and protein levels of aggregated proteoglycan(aggrecan), type Ⅱ collagen alpha 1(col2a1), toll-like receptor 4(tlr4), and nuclear factor-kappa b(nf-κb). |
2023-12-19 |
2023-12-23 |
Not clear |
| Chao Zhang, Yanlang Yan. Targeting Toll-like receptor 4 and the NLRP3 inflammasome: Novel and emerging therapeutic targets for hyperuricaemia nephropathy. Biomolecules & biomedicine. 2023-12-02. PMID:38041694. |
toll-like receptor 4 (tlr4), a subclass of innate immune receptors, detects both pathogen-associated molecular patterns (pamps) and damage-associated molecular patterns (damps), initiating inflammatory and immune responses that lead to the release of pro-inflammatory cytokines interleukin (il) 1β and tumor necrosis factor alpha (tnf-α). |
2023-12-02 |
2023-12-10 |
Not clear |
| Huaiyong Zhang, Herinda Pertiwi, Maryam Majdeddin, Joris Michiel. Mucosa-associated lymphoid tissue lymphoma translocation protein 1 inhibition alleviates intestinal impairment induced by chronic heat stress in finisher broilers. Poultry science. vol 103. issue 1. 2023-11-19. PMID:37980762. |
meanwhile, the gene expression levels of toll-like receptor 4 (tlr4), malt1, nf-κb, interleukin-6 (il-6), and tumor necrosis factor alpha (tnf-α) in the jejunum were significantly downregulated by mepazine administration (p < 0.05). |
2023-11-19 |
2023-11-29 |
Not clear |
| Qian Wu, Junya Li, Shengyu Hao, Yuyang Guo, Zongze Li, Zhengxin Liu, Hongzhuan Xua. Caffeic acid phenethyl ester inhibits MDA-MB-231 cell proliferation in inflammatory microenvironment by suppressing glycolysis and lipid metabolism. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-10-21. PMID:37864895. |
compared with the lps group, pro-inflammatory mediators, including toll-like receptor 4 (tlr4), tumor necrosis factor alpha (tnf-α), nf-kappa-b inhibitor alpha (iκbα), interleukin (il)-1β, and il-6, as well as interleukin-1 receptor-associated kinase 4 (irak4), declined after the cape treatment. |
2023-10-21 |
2023-11-08 |
Not clear |
| Wan-Yu Li, Qing-Yin Long, Xin-Ying Fu, Lu Ma, Wei Tan, Yan-Ling Li, Shun-Zhou Xu, Wei Zhang, Chang-Qing Den. [Effects of Buyang Huanwu Decoction and Astragali Radix-Angelicae Sinensis Radix combination on inflammatory responses in atherosclerotic mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 15. 2023-10-06. PMID:37802785. |
moreover, the model group showed increased expression of vascular cell adhesion molecule-1(vcam-1) and inducible nitric oxide synthase(inos)(p<0.01), inhibited expression of endothelial nitric oxide synthase(enos) and cluster of differentiation 206(cd206)(p<0.01), and up-regulated mrna and protein levels of tlr4, myd88, nf-κb inhibitor alpha(iκbα), and nf-κb in the vessel wall(p<0.05). |
2023-10-06 |
2023-10-15 |
mouse |
| Shereen E Elkholy, Shymaa Ahmad Maher, Noura R Abd El-Hamid, Heba A Elsayed, Wael Abdou Hassan, Asmaa K K Abdelmaogood, Samar M Hussein, Mariusz Jaremko, Samar Zuhair Alshawwa, Hanan M Alharbi, Samar Imbab. The immunomodulatory effects of probiotics and azithromycin in dextran sodium sulfate-induced ulcerative colitis in rats via TLR4-NF-κB and p38-MAPK pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-06-16. PMID:37327586. |
in the present rats-established uc, the therapeutic roles of oral probiotics (60 billion probiotic bacteria per kg per day) and azithromycin (40 mg per kg per day) regimens were evaluated by measuring changes in disease activity index, macroscopic damage index, oxidative stress markers, tlr4, p-38 mapk, nf-κb signaling pathway in addition to their molecular downstream; tumor necrosis factor alpha (tnfα), interleukin (il)1β, il6, il10 and inducible nitric oxide synthase (inos). |
2023-06-16 |
2023-08-14 |
rat |
| Márk Kozsurek, Kornél Király, Klára Gyimesi, Erika Lukácsi, Csaba Fekete, Balázs Gereben, Petra Mohácsik, Zsuzsanna Helyes, Kata Bölcskei, Valéria Tékus, Károly Pap, Edina Szűcs, Sándor Benyhe, Tímea Imre, Pál Szabó, Andrea Gajtkó, Krisztina Holló, Zita Puská. Unique, Specific CART Receptor-Independent Regulatory Mechanism of CART(55-102) Peptide in Spinal Nociceptive Transmission and Its Relation to Dipeptidyl-Peptidase 4 (DDP4). International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36674439. |
dpp4 interacts with toll-like receptor 4 (tlr4) signalling in spinal astrocytes and enhances the tlr4-induced expression of interleukin-6 and tumour necrosis factor alpha contributing to inflammatory pain. |
2023-01-21 |
2023-08-14 |
rat |
| Xiaofen Tan, Yifan Wen, Zhijun Han, Xuyang Su, Jing Peng, Feng Chen, Yadong Wang, Tianming Wang, Changzhong Wang, Kelong M. Cinnamaldehyde ameliorates dextran sulfate sodium-induced colitis in mice by modulating TLR4/NF-κB signaling pathway and NLRP3 inflammasome activation. Chemistry & biodiversity. 2023-01-18. PMID:36653304. |
seven intersection targets shared by cin and uc were obtained, and four hub targets, i.e., toll-like receptor 4 (tlr4), transcription factor p65 (nf-κb), nf-kappa-b inhibitor alpha (iκbα), prostaglandin g/h synthase 2 (cox2) were acquired, which were mainly involved in nf-κb, tumour necrosis factor (tnf), toll-like receptor and nod-like receptor signaling pathways. |
2023-01-18 |
2023-08-14 |
mouse |
| Ya-Ting Wang, Amy Sansone, Asya Smirnov, Christina L Stallings, Anthony Orvedah. Myeloid autophagy genes protect mice against fatal TNF- and LPS-induced cytokine storm syndromes. Autophagy. 2022-09-03. PMID:36056542. |
atg5: autophagy related 5; atg7: autophagy related 7; atg14: autophagy related 14; atg16l1: autophagy related 16-like 1 (s. cerevisiae); becn1: beclin 1, autophagy related; casp1: caspase 1; casp4/casp11: caspase 4, apoptosis-related cysteine peptidase; cim: conditionally immortalized macrophage; clp: cecal ligation and puncture; css: cytokine storm syndrome; dc: dendritic cell; ifng/ifnγ: interferon gamma; ifngr1: interferon gamma receptor 1; ip: intraperitoneal; iv: intravenous; il12/p70: interleukin 12, p70 heterodimer; il18: interleukin 18; itgax/cd11c: integrin alpha x; lap: lc3-associated phagocytosis; lps: lipopolysaccharide; lyz2/lysm: lysozyme 2; map1lc3a/lc3: microtubule-associated protein 1 light chain 3 alpha; rb1cc1/fip200: rb1-inducible coiled-coil 1; s100a8/mrp8: s100 calcium binding protein a8 (calgranulin a); ticam1/trif: tir domain containing adaptor molecule 1; tlr4: toll-like receptor 4; tnf: tumor necrosis factor. |
2022-09-03 |
2023-08-14 |
mouse |
| Wenqiang Jiang, Yan Lin, Linjie Qian, Linghong Miao, Bo Liu, Xianping Ge, Huaishun She. Mulberry leaf meal: A potential feed supplement for juvenile Megalobrama amblycephala "Huahai No. 1". Fish & shellfish immunology. 2022-07-23. PMID:35870747. |
compare to the control group, fml2 diet significantly increased the expression of i-kappa-b alpha (ikbα) genes in liver, and decreased the expression of foxo1α, toll-like receptors 4 (tlr4) and nuclear factor-kappa b (nf-κb) genes (p < 0.05). |
2022-07-23 |
2023-08-14 |
cat |
| Honglong Zhu, Yongxin Yang, Tao Wu, Yunxia Qi, Dongwei Huang, Rongwei Han, Sheng Chen, Jishun Tang, Man Ren, Xiaowei Zha. Bovine colostrum promoted ileal health in newborn lambs at 24 h after birth: insight from intestinal morphology and innate immunity. Animal : an international journal of animal bioscience. vol 16. issue 8. 2022-07-16. PMID:35841825. |
messenger rna (mrna) abundance of toll-like receptor (tlr)-2, tlr3, tlr4, tlr6, tlr7, tlr8 and tumour necrosis factor alpha in the ileum was lower in c24h than that in n24h lambs (p < 0.05). |
2022-07-16 |
2023-08-14 |
cattle |
| Honglong Zhu, Yongxin Yang, Tao Wu, Yunxia Qi, Dongwei Huang, Rongwei Han, Sheng Chen, Jishun Tang, Man Ren, Xiaowei Zha. Bovine colostrum promoted ileal health in newborn lambs at 24 h after birth: insight from intestinal morphology and innate immunity. Animal : an international journal of animal bioscience. vol 16. issue 8. 2022-07-16. PMID:35841825. |
we also observed strong positive correlations of tumour necrosis factor alpha expression with that of tlr2 (r = 0.71; p < 0.001), tlr4 (r = 0.88; p < 0.001) and tlr8 (r = 0.83; p < 0.001). |
2022-07-16 |
2023-08-14 |
cattle |
| Noha A T Abbas, Heba A Hassa. The protective and therapeutic effects of 5-androstene3β, 17β-diol (ADIOL) in abdominal post-operative adhesions in rat: Suppressing TLR4/NFκB/HMGB1/TGF1 β/α SMA pathway. International immunopharmacology. vol 109. 2022-05-03. PMID:35504204. |
interestingly, per administration of adiol before apa induction leads to inhibit oxidative stress by increasing superoxide dismutase (sod) and decreasing malondialdehyde (mad) levels to a similar level to the sham group, in addition inhibiting inflammatory pathway by decreasing toll-like receptor 4 (tlr4), nuclear factor kappa-b (nfκb), and high mobility group box 1 (hmgb1) to a similar level to the sham group, furthermore decreasing transforming growth factor beta 1 (tgfβ1) and alpha smooth muscle -actin (α sma) levels to similar levels in the sham group. |
2022-05-03 |
2023-08-13 |
rat |
| Man Kit Cheung, Grace Gar-Lee Yue, Adele Joyce Gomes, Eric Chun-Wai Wong, Julia Kin-Ming Lee, Frankie Hin-Fai Kwok, Philip Wai-Yan Chiu, Clara Bik-San La. Network pharmacology reveals potential functional components and underlying molecular mechanisms of Andrographis paniculata in esophageal cancer treatment. Phytotherapy research : PTR. 2022-02-17. PMID:35174914. |
epidermal growth factor receptor (egfr), signal transducer and activator of transcription 3 (stat3), rac-alpha serine/threonine-protein kinase (akt1), prostaglandin-endoperoxide synthase 2 (ptgs2), chemokine (c-x-c motif) ligand 8 (cxcl8), phosphatidylinositol 4,5-bisphosphate 3-kinase subunit alpha (pik3ca), and toll-like receptor 4 (tlr4) were most highly ranked among the predicted targets of ap in ec treatment and may play important roles in the anti-ec effects of ap. |
2022-02-17 |
2023-08-13 |
human |