| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessandra Gentile, Marga Albu, Yanli Xu, Newsha Mortazavi, Agatha Ribeiro da Silva, Didier Y R Stainier, Felix Gunawa. Mechanical forces remodel the cardiac extracellular matrix during zebrafish development. Development (Cambridge, England). vol 151. issue 13. 2024-07-10. PMID:38984541. |
among the ecm remodelers highly expressed during cardiac morphogenesis, we found one that was upregulated in non-contractile hearts, namely tissue inhibitor of matrix metalloproteinase 2 (timp2). |
2024-07-10 |
2024-07-12 |
zebrafish |
| Sarah M Shoeib, Asmaa Hassan, Eman Habeeb, Rasha Abdallah Ragab, Sara Elakshar, Dalia Sherie. Urinary Insulin-Like Growth Factor-Binding Protein 7 (IGFBp7), Urinary Tissue Inhibitor of Matrix Metalloproteinase 2 (TIMP2), and Serum Transgelin as Novel Biomarkers of Kidney Injury in Multiple Myeloma. Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion. vol 40. issue 2. 2024-05-06. PMID:38708150. |
urinary insulin-like growth factor-binding protein 7 (igfbp7), urinary tissue inhibitor of matrix metalloproteinase 2 (timp2), and serum transgelin as novel biomarkers of kidney injury in multiple myeloma. |
2024-05-06 |
2024-05-08 |
Not clear |
| Linping Wang, Luyi Chen, Daniel Schlenk, Feixue Li, Jing Li. Parabens promotes invasive properties of multiple human cells: A potential cancer-associated adverse outcome pathway. The Science of the total environment. 2024-03-28. PMID:38547973. |
mp and pp up-regulated the expression levels and enzymatic activities of matrix metalloproteinase 2 and 9 (mmp2 and mmp9), as well as altered the expression of the tissue inhibitors of metalloproteinase 1 and 2 (timp1 and timp2) in four cell lines, suggesting mmps/timps as potential key events (kes) for paraben-induced cell invasion. |
2024-03-28 |
2024-03-31 |
human |
| Tong Chen, Shiquan Wu, Ling Feng, Siyu Long, Yu Liu, Caibin Zhang, Wenqian Lu, Yuli Shen, Shanshan Jiang, Wenya Chen, Guoai Hong, Li Zhou, Fang Wang, Yuechan Luo, Hequn Zo. The association between activation of the ERK1/2-NF-κB signaling pathway by TIMP2 expression and chronic renal allograft dysfunction in the CRAD rat model. Transplant immunology. 2024-01-06. PMID:38184210. |
the tissue inhibitor of metalloproteinase 2 (timp2), a natural inhibitor of matrix metalloproteinase (mmp), regulates inflammation, fibrosis, and cell proliferation. |
2024-01-06 |
2024-01-09 |
rat |
| Xin-Yi Fan, Xiao-Qi Wei, Yun-Yang Zhang, Hai-Yin Pu, Fang-He Li, Kuo Gao, Xue Yu, Shu-Zhen Gu. [Effect and mechanism of Jiming Powder on myocardial fibrosis in mice with myocardial infarction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114180. |
western blot analysis was performed to detect key proteins involved in ventricular remodeling, including transforming growth factor-β1(tgf-β1), α-smooth muscle actin(α-sma), wingless-type mmtv integration site family member 3a(wnt3a), β-catenin, matrix metallopeptidase 2(mmp2), matrix metallopeptidase 3(mmp3), timp metallopeptidase inhibitor 1(timp1), and timp metallopeptidase inhibitor 2(timp2). |
2023-12-19 |
2023-12-23 |
mouse |
| Xin-Yi Fan, Xiao-Qi Wei, Yun-Yang Zhang, Hai-Yin Pu, Fang-He Li, Kuo Gao, Xue Yu, Shu-Zhen Gu. [Effect and mechanism of Jiming Powder on myocardial fibrosis in mice with myocardial infarction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114180. |
western blot results showed that jiming powder reduced the expression of tgf-β1, α-sma, wnt3a, and β-catenin, decreased the levels of mmp2, mmp3, and timp2, and increased the level of timp1, suggesting its role in inhibiting cardiac fibroblast transformation, reducing extracellular matrix metabolism in myocardial cells, and lowering collagen Ⅰ and α-sma content, thus exerting an anti-myocardial fibrosis effect after myocardial infarction. |
2023-12-19 |
2023-12-23 |
mouse |
| Jingshu Tang, Yuying Kang, Yujun Zhou, Nianying Shang, Xinnan Li, Hongyue Wang, Jiaqi Lan, Shuai Wang, Lei Wu, Ying Pen. TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-Cadherin internalization. The Journal of clinical investigation. 2023-11-28. PMID:38015626. |
tissue inhibitor of metalloproteinase-2 (timp2), a molecule with dual functions of inhibiting matrix metalloproteinase (mmp) activity and displaying cytokine-like activity through receptor binding, has been reported to inhibit vegf-induced vascular hyperpermeability. |
2023-11-28 |
2023-12-07 |
mouse |
| Ana Catarina Ferreira, Brittany M Hemmer, Sarah M Philippi, Alejandro B Grau-Perales, Jacob L Rosenstadt, Hanxiao Liu, Jeffrey D Zhu, Tatyana Kareva, Tim Ahfeldt, Merina Varghese, Patrick R Hof, Joseph M Castellan. Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity. Molecular psychiatry. 2023-11-02. PMID:37914840. |
neuronal timp2 regulates hippocampus-dependent plasticity and extracellular matrix complexity. |
2023-11-02 |
2023-11-08 |
Not clear |
| Ana Catarina Ferreira, Brittany M Hemmer, Sarah M Philippi, Alejandro B Grau-Perales, Jacob L Rosenstadt, Hanxiao Liu, Jeffrey D Zhu, Tatyana Kareva, Tim Ahfeldt, Merina Varghese, Patrick R Hof, Joseph M Castellan. Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity. Molecular psychiatry. 2023-11-02. PMID:37914840. |
consistent with the accumulation of extracellular matrix (ecm) in the hippocampus we observe with aging, we find that timp2 acts to reduce accumulation of ecm around synapses in the hippocampus. |
2023-11-02 |
2023-11-08 |
Not clear |
| Rachel Britton, Tristan Wasley, Reema Harish, Charles Holz, John Hall, Dennis C Yee, Jody Melton Witt, Elizabeth A Booth, Steven Braithwaite, Eva Czirr, Meghan Kerrisk Campbel. Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging. eNeuro. vol 10. issue 6. 2023-06-15. PMID:37321845. |
peripheral administration of tissue inhibitor of metalloproteinases 2 (timp2), a protein inhibitor of matrix metalloproteinases (mmps), has previously been shown to have beneficial effects on cognition and neurons in aged mice. |
2023-06-15 |
2023-08-14 |
mouse |
| Lihong Shi, Qiangsheng Zhang, Shirui Zhu, Qing Tang, Xin Chen, Rui Lan, Ningyu Wang, Yongxia Zh. Pharmacological inhibition of EZH2 using a covalent inhibitor suppresses human ovarian cancer cell migration and invasion. Molecular and cellular biochemistry. 2023-05-18. PMID:37199893. |
enhancer of zeste homolog 2 (ezh2), a histone-lysine n-methyltransferase enzyme, promotes oc cell migration and invasion by regulating the expression of tissue inhibitor of metalloproteinase-2 (timp2) and matrix metalloproteinases-9 (mmp9). |
2023-05-18 |
2023-08-14 |
human |
| Huijun Zhao, Gregory Pond, Demetrios Simos, Zhou Wang, Susan Robertson, Gurmit Singh, Lisa Vandermeer, Mark Clemons, Christina Lynn Addiso. Doxycycline-Induced Changes in Circulating MMP or TIMP2 Levels Are Not Associated with Skeletal-Related Event-Free or Overall Survival in Patients with Bone Metastases from Breast Cancer. Cancers. vol 15. issue 3. 2023-02-11. PMID:36765529. |
exploratory analysis of the effects of doxycycline on circulating levels of mmp or tissue inhibitor of matrix metalloproteinase 2 (timp2) was performed in enrolled patients. |
2023-02-11 |
2023-08-14 |
Not clear |
| Dan-Dan Wang, Wen-Xiu Xu, Wen-Quan Chen, Lei Li, Su-Jin Yang, Jian Zhang, Jin-Hai Tan. Identification of TIMP2 as a Prognostic Biomarker and Its Correlation with Tumor Immune Microenvironment: A Comprehensive Pan-Cancer Analysis. Journal of oncology. vol 2022. 2022-10-28. PMID:36304987. |
tissue inhibitor of metalloproteinase-2 (timp2), an endogenous inhibitor of matrix metalloproteinases, has been disclosed to participate in the development and carcinogenesis of multiple malignancies. |
2022-10-28 |
2023-08-14 |
Not clear |
| Hang Yang, Zhen Xu, Sumei Tan, Chunyan Zhang, Xiaoqin Li, Xiangjun Len. In vitro effects of Eucommia ulmoides and its active components on the growth, lipid metabolism and collagen metabolism of grass carp (Ctenopharyngodon idellus) hepatocyte and intramuscular fibroblast. Journal of fish biology. 2022-06-06. PMID:35662011. |
in intramuscular fibroblasts, the ebe, ele, cga, qc and au supplementations significantly increased in vitro hydroxyproline concentrations, promoted the relative expressions of transforming growth factor-β1 (tgfβ1), connective tissue growth factor (ctgf), collagen type i alpha 1/2 chain (col1a1, col1a2), lysine oxidase (lox) and tissue inhibitor of matrix metalloproteinase-2 (timp2), and decreased matrix metalloproteinase-2 (mmp2) gene expression. |
2022-06-06 |
2023-08-14 |
drosophila_melanogaster |
| Peng Shi, Kai Liao, Jilin Xu, Yajun Wang, Shanliang Xu, Xiaojun Ya. Eicosapentaenoic acid mitigates palmitic acid-induced heat shock response, inflammation and repair processes in fish intestine. Fish & shellfish immunology. 2022-04-14. PMID:35421576. |
furthermore, pa reduced the expression of collagen type i (col1a1a and col1a1b) and extracellular matrix (ecm) degradation-related gene mmp2, while up-regulating timp2 mrna expression. |
2022-04-14 |
2023-08-13 |
zebrafish |
| Yang Li, Min Li, Caijie Qu, Yongxi Li, Zhanli Tang, Zhike Zhou, Zengzhao Yu, Xu Wang, Linlin Xin, Tongxin Sh. The Polygenic Map of Keloid Fibroblasts Reveals Fibrosis-Associated Gene Alterations in Inflammation and Immune Responses. Frontiers in immunology. vol 12. 2022-01-27. PMID:35082796. |
for example, il17ra is involved in il-17 signal transduction, timp2 and mmp14 activate extracellular matrix metalloproteinases, and tnc, itgb2, and itga4 interact with cell surface integrins. |
2022-01-27 |
2023-08-13 |
Not clear |
| Pradeepa, Voddu Suresh, Vivek Kumar Singh, Kasturi Bala Nayak, Shantibhusan Senapati, Soumen Chakrabort. EVI1 promotes metastasis by downregulating TIMP2 in metastatic colon and breast cancer cells. The international journal of biochemistry & cell biology. vol 142. 2021-12-10. PMID:34800694. |
differential gene expression analysis revealed significant downregulation of tissue inhibitor of matrix metalloproteinase-2 (timp2) in evi1 expressing cells. |
2021-12-10 |
2023-08-13 |
mouse |
| Wang Xin, Shi Qiang, Ding Jianing, Liang Jiaming, Lin Fangqi, Cai Bin, Chen Yuanyuan, Zhang Guowang, Xu Jianguang, Lian Xiaofen. Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Attenuate Blood-Spinal Cord Barrier Disruption via the TIMP2/MMP Pathway After Acute Spinal Cord Injury. Molecular neurobiology. vol 58. issue 12. 2021-12-03. PMID:34554399. |
next, we found that tissue inhibitors of matrix metalloproteinase 2 (timp2) have been shown to play an important role in the function of bmsc-exos by inhibiting the matrix metalloproteinase (mmp) pathway, thereby reducing the reduction of cell junction proteins. |
2021-12-03 |
2023-08-13 |
human |
| Yamin Oo, Justin Quiel Lasam Nealiga, Khanit Suwanborirux, Supakarn Chamni, Gea Abigail Uy Ecoy, Varisa Pongrakhananon, Pithi Chanvorachote, Chatchai Chaotha. 22-O-(N-Boc-L-glycine) ester of renieramycin M inhibits migratory activity and suppresses epithelial-mesenchymal transition in human lung cancer cells. Journal of natural medicines. vol 75. issue 4. 2021-11-25. PMID:34287745. |
the alteration of invasion-related proteins in 22-boc-gly-rm-treated h460 cells was indicated by the diminution of matrix metalloproteinases (mt1-mmp, mmp-2, mmp-7, and mmp-9), as well as the upregulation of tissue inhibitors of metalloproteinases (timp), timp2, and timp3. |
2021-11-25 |
2023-08-13 |
human |
| DongWei Liu, FengXun Liu, ZhengYong Li, ShaoKang Pan, JunWei Xie, ZiHao Zhao, ZhenJie Liu, JiaHui Zhang, ZhangSuo Li. HNRNPA1-mediated exosomal sorting of miR-483-5p out of renal tubular epithelial cells promotes the progression of diabetic nephropathy-induced renal interstitial fibrosis. Cell death & disease. vol 12. issue 3. 2021-09-14. PMID:33692334. |
our results expounded that hnrnpa1-mediated exosomal sorting transported cellular mir-483-5p out of tecs into the urine, thus lessening the restraint of cellular mir-483-5p on mapk1 and timp2 mrnas, and ultimately boosting extracellular matrix deposition and the progression of dn-induced renal interstitial fibrosis. |
2021-09-14 |
2023-08-13 |
mouse |