| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H S Kruger, C S Venter, H H Vorste. Obesity in African women in the North West Province, South Africa is associated with an increased risk of non-communicable diseases: the THUSA study. Transition and Health during Urbanisation of South Africans. The British journal of nutrition. vol 86. issue 6. 2002-01-17. PMID:11749683. |
after adjustment for age and smoking status, bmi correlated significantly with diastolic blood pressure (r 0.21, p=0.037), serum triacylglycerols (tg) (r 0.30, p=0.003), fasting glucose (r 0.29, p=0.005) and log fasting insulin (r 0.24, p=0.02). |
2002-01-17 |
2023-08-12 |
human |
| G T Ko, C S Cockram, J Woo, J C Cha. Obesity, insulin resistance and isolated low high-density-lipoprotein cholesterol in Chinese subjects. Diabetic medicine : a journal of the British Diabetic Association. vol 18. issue 8. 2001-12-28. PMID:11553205. |
we examined the prevalence of isolated low hdl-c in hong kong chinese and its relationship with insulin resistance and triglyceride (tg) level. |
2001-12-28 |
2023-08-12 |
human |
| T Yamauchi, J Kamon, H Waki, K Murakami, K Motojima, K Komeda, T Ide, N Kubota, Y Terauchi, K Tobe, H Miki, A Tsuchida, Y Akanuma, R Nagai, S Kimura, T Kadowak. The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. The Journal of biological chemistry. vol 276. issue 44. 2001-12-07. PMID:11533050. |
we show here that supraphysiological activation of ppargamma by ppargamma agonist thiazolidinediones (tzd) markedly increases triglyceride (tg) content of white adipose tissue (wat), thereby decreasing tg content of liver and muscle, leading to amelioration of insulin resistance at the expense of obesity. |
2001-12-07 |
2023-08-12 |
Not clear |
| T Yamauchi, J Kamon, H Waki, K Murakami, K Motojima, K Komeda, T Ide, N Kubota, Y Terauchi, K Tobe, H Miki, A Tsuchida, Y Akanuma, R Nagai, S Kimura, T Kadowak. The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. The Journal of biological chemistry. vol 276. issue 44. 2001-12-07. PMID:11533050. |
moderate reduction of ppargamma activity by heterozygous ppargamma deficiency decreases tg content of wat, skeletal muscle, and liver due to increased leptin expression and increase in fatty acid combustion and decrease in lipogenesis, thereby ameliorating high fat diet-induced obesity and insulin resistance. |
2001-12-07 |
2023-08-12 |
Not clear |
| T Yamauchi, J Kamon, H Waki, K Murakami, K Motojima, K Komeda, T Ide, N Kubota, Y Terauchi, K Tobe, H Miki, A Tsuchida, Y Akanuma, R Nagai, S Kimura, T Kadowak. The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. The Journal of biological chemistry. vol 276. issue 44. 2001-12-07. PMID:11533050. |
we conclude that, although by different mechanisms, both heterozygous ppargamma deficiency and ppargamma agonist improve insulin resistance, which is associated with decreased tg content of muscle/liver and prevention of adipocyte hypertrophy. |
2001-12-07 |
2023-08-12 |
Not clear |
| P J Voshol, M C Jong, V E Dahlmans, D Kratky, S Levak-Frank, R Zechner, J A Romijn, L M Haveke. In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake. Diabetes. vol 50. issue 11. 2001-12-07. PMID:11679438. |
the aim of the present study was to determine whether there is a causal relation between intramuscular tg accumulation and insulin sensitivity. |
2001-12-07 |
2023-08-12 |
mouse |
| P J Voshol, M C Jong, V E Dahlmans, D Kratky, S Levak-Frank, R Zechner, J A Romijn, L M Haveke. In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake. Diabetes. vol 50. issue 11. 2001-12-07. PMID:11679438. |
in conclusion, overexpression of human lpl in muscle increases intramuscular tg accumulation, but does not affect whole-body or muscle-specific insulin-mediated uptake, findings that argue against a simple causal relation between intramuscular tg content and insulin resistance. |
2001-12-07 |
2023-08-12 |
mouse |
| T Yamauchi, H Waki, J Kamon, K Murakami, K Motojima, K Komeda, H Miki, N Kubota, Y Terauchi, A Tsuchida, N Tsuboyama-Kasaoka, N Yamauchi, T Ide, W Hori, S Kato, M Fukayama, Y Akanuma, O Ezaki, A Itai, R Nagai, S Kimura, K Tobe, H Kagechika, K Shudo, T Kadowak. Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. The Journal of clinical investigation. vol 108. issue 7. 2001-12-04. PMID:11581301. |
paradoxically, treatment of heterozygous ppargamma-deficient mice with an rxr antagonist or a ppargamma antagonist depletes white adipose tissue and markedly decreases leptin levels and energy dissipation, which increases tg content in skeletal muscle and the liver, thereby leading to the re-emergence of insulin resistance. |
2001-12-04 |
2023-08-12 |
mouse |
| K L Edwards, P J Talmud, B Newman, R M Krauss, M A Austi. Lipoprotein candidate genes for multivariate factors of the insulin resistance syndrome: a sib-pair linkage analysis in women twins. Twin research : the official journal of the International Society for Twin Studies. vol 4. issue 1. 2001-12-04. PMID:11665324. |
the insulin resistance syndrome (irs) is characterized by a combination of interrelated coronary heart disease risk factors, including low high-density lipoprotein cholesterol (hdlc) levels, obesity and increases in triglyceride (tg), systolic and diastolic blood pressure (bp), small low-density lipoprotein particles (ldl-size), and fasting and postload plasma insulin and glucose. |
2001-12-04 |
2023-08-12 |
Not clear |
| F Pulzer, U Haase, M Knüpfer, J Kratzsch, V Richter, F Rassoul, W Kiess, E Kelle. Serum leptin in formerly small-for-gestational-age children during adolescence: relationship to gender, puberty, body composition, insulin sensitivity, creatinine, and serum uric acid. Metabolism: clinical and experimental. vol 50. issue 10. 2001-11-01. PMID:11586484. |
we therefore aimed to evaluate the interrelationship between leptin and markers of the metabolic syndrome by studying serum leptin concentration, body mass index (bmi), percent body fat (fat%), total fat mass (fm), sum of skinfolds (ss), triglycerides (tg), total cholesterol (chol), high-density lipoprotein cholesterol (hdl-c), low-density lipoprotein cholesterol (ldl-c), glucose, insulin, calculated insulin resistance (homa), creatinine (cr), and uric acid (ua) concentration in 50 former small-for-gestational-age (sga) children and 21 infants born adequate for gestational age (aga) at the time of mid-puberty. |
2001-11-01 |
2023-08-12 |
human |
| N F Chu, D Spiegelman, G S Hotamisligil, N Rifai, M Stampfer, E B Rim. Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. Atherosclerosis. vol 157. issue 2. 2001-10-25. PMID:11472752. |
men in the highest quintile of body mass index (bmi, mean=30.5 kg/m(2)) were less physically active and had a more adverse cardiovascular lipid and homeostatic profile, as indicated by levels of insulin, triglyceride (tg), tissue plasminogen activator (t-pa) antigen levels, and apolipoprotein a1 (apo-a1). |
2001-10-25 |
2023-08-12 |
Not clear |
| D R Bremmer, S L Trower, S J Bertics, S A Besong, U Bernabucci, R R Grumme. Etiology of fatty liver in dairy cattle: effects of nutritional and hormonal status on hepatic microsomal triglyceride transfer protein. Journal of dairy science. vol 83. issue 10. 2001-10-04. PMID:11049064. |
in experiment 3, bovine hepatocytes isolated from the caudate process of five preruminating holstein bull calves were incubated with 2 mm [1-14c]oleate for 24 h to accumulate tg, followed by a 36-h period of tg depletion, during which hepatocytes were incubated with no hormone, 10 nm insulin, or 10 nm glucagon. |
2001-10-04 |
2023-08-12 |
cattle |
| D R Bremmer, S L Trower, S J Bertics, S A Besong, U Bernabucci, R R Grumme. Etiology of fatty liver in dairy cattle: effects of nutritional and hormonal status on hepatic microsomal triglyceride transfer protein. Journal of dairy science. vol 83. issue 10. 2001-10-04. PMID:11049064. |
there was no effect of insulin or glucagon on intracellular tg, mtp activity or mass. |
2001-10-04 |
2023-08-12 |
cattle |
| D R Bremmer, S L Trower, S J Bertics, S A Besong, U Bernabucci, R R Grumme. Etiology of fatty liver in dairy cattle: effects of nutritional and hormonal status on hepatic microsomal triglyceride transfer protein. Journal of dairy science. vol 83. issue 10. 2001-10-04. PMID:11049064. |
results suggest that hepatic mtp mrna may be affected by tg accumulation, insulin, and glucagon in vitro. |
2001-10-04 |
2023-08-12 |
cattle |
| D R Bremmer, S L Trower, S J Bertics, S A Besong, U Bernabucci, R R Grumme. Etiology of fatty liver in dairy cattle: effects of nutritional and hormonal status on hepatic microsomal triglyceride transfer protein. Journal of dairy science. vol 83. issue 10. 2001-10-04. PMID:11049064. |
however, hepatic mtp activity and mass are not affected by nutritional status of nonlactating dairy cows, tg accumulation in vitro, or insulin and glucagon in vitro. |
2001-10-04 |
2023-08-12 |
cattle |
| D J Dyck, G Steinberg, A Bone. Insulin increases FA uptake and esterification but reduces lipid utilization in isolated contracting muscle. American journal of physiology. Endocrinology and metabolism. vol 281. issue 3. 2001-09-06. PMID:11500316. |
we examined the effect of insulin on the synthesis and degradation of muscle lipid pools [phospholipid (pl), diacylglycerol (dg), triacylglycerol (tg)] and palmitate oxidation in isolated resting and contracting (20 tetani/min) soleus muscles. |
2001-09-06 |
2023-08-12 |
Not clear |
| D J Dyck, G Steinberg, A Bone. Insulin increases FA uptake and esterification but reduces lipid utilization in isolated contracting muscle. American journal of physiology. Endocrinology and metabolism. vol 281. issue 3. 2001-09-06. PMID:11500316. |
at rest, insulin significantly increased total palmitate uptake into soleus muscle (+49%, p < 0.05), corresponding to enhanced dg (+60%, p < 0.05) and tg (+61%, p < 0.05) esterification, but blunted palmitate oxidation (-38%, p < 0.05) and tg hydrolysis (-34%, p < 0.05). |
2001-09-06 |
2023-08-12 |
Not clear |
| D J Dyck, G Steinberg, A Bone. Insulin increases FA uptake and esterification but reduces lipid utilization in isolated contracting muscle. American journal of physiology. Endocrinology and metabolism. vol 281. issue 3. 2001-09-06. PMID:11500316. |
during muscle contraction, when total palmitate uptake was increased, insulin further enhanced uptake (+21%, p < 0.05) and esterification of fatty acids (fa) to pl (+73%, p < 0.05), dg (+19%, p < 0.05), and tg (+161%, p < 0.01). |
2001-09-06 |
2023-08-12 |
Not clear |
| D J Dyck, G Steinberg, A Bone. Insulin increases FA uptake and esterification but reduces lipid utilization in isolated contracting muscle. American journal of physiology. Endocrinology and metabolism. vol 281. issue 3. 2001-09-06. PMID:11500316. |
despite a profound shift in the relative partitioning of fa away from esterification and toward oxidation during contraction, the increase in palmitate oxidation and tg hydrolysis was significantly blunted by insulin [oxidation, -24% (p = 0.05); hydrolysis, -83% (p < 0.01)]. |
2001-09-06 |
2023-08-12 |
Not clear |
| D J Dyck, G Steinberg, A Bone. Insulin increases FA uptake and esterification but reduces lipid utilization in isolated contracting muscle. American journal of physiology. Endocrinology and metabolism. vol 281. issue 3. 2001-09-06. PMID:11500316. |
in summary, the effects of insulin and contraction on palmitate uptake and esterification are additive, while insulin opposes the stimulatory effect of contraction on fa oxidation and tg hydrolysis. |
2001-09-06 |
2023-08-12 |
Not clear |