| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mardi M Algandaby, Ali M El-Halawany, Hossam M Abdallah, Abdulrahman M Alahdal, Ayman A Nagy, Osama M Ashour, Ashraf B Abdel-Nai. Gingerol protects against experimental liver fibrosis in rats via suppression of pro-inflammatory and profibrogenic mediators. Naunyn-Schmiedeberg's archives of pharmacology. vol 389. issue 4. 2016-12-13. PMID:26809353. |
gin significantly ameliorated the increase in serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) activities, albumin, total cholesterol (tc) and triglyceride (tg) concentrations, and liver index. |
2016-12-13 |
2023-08-13 |
rat |
| Qingpu Liu, Xuan Li, Cunyu Li, Yunfeng Zheng, Fang Wang, Hongyang Li, Guoping Pen. 1-Deoxynojirimycin Alleviates Liver Injury and Improves Hepatic Glucose Metabolism in db/db Mice. Molecules (Basel, Switzerland). vol 21. issue 3. 2016-11-08. PMID:26927057. |
dnj was observed to significantly reduce the levels of serum triglyceride (tg), total cholesterol (tc), low density lipoprotein cholesterol (ldl-c) and liver tg, as well as activities of serum alanine aminotransferase (alt), and aspartate transaminase (ast); dnj also alleviated macrovesicular steatosis and decreased tumor necrosis factor α (tnf-α), interleukin-1 (il-1), interleukin-6 (il-6) levels in liver tissue. |
2016-11-08 |
2023-08-13 |
mouse |
| C Zou, Q Qiu, H Chen, L Dou, J Lian. Hepatoprotective effects of selenium during diabetes in rats. Human & experimental toxicology. vol 35. issue 2. 2016-10-14. PMID:25820154. |
the effects of different treatments were studied on various parameters in rat liver, which included serum glucose levels, serum insulin levels, alkaline phosphatase (alp), aspartate aminotransferase (ast), alanine aminotransferase (alt), lipid peroxidation (lpo), glutathione reduced (gsh), oxidized glutathione (gssg), total glutathione (tg), superoxide dismutase (sod), catalase (cat), glutathione reductase, glutathione peroxidase, metallothionein (mt), and histoarchitecture. |
2016-10-14 |
2023-08-13 |
rat |
| Kathamuthu Gokul Raj, Ranganathan Chidambaram, Krishnamoorthy Varunkumar, Vilwanathan Ravikumar, Mohan Pand. Chemopreventive potential of fungal taxol against 7, 12-dimethylbenz[a]anthracene induced mammary gland carcinogenesis in Sprague Dawley rats. European journal of pharmacology. vol 767. 2016-10-05. PMID:26460148. |
infrared thermal imaging analysis, serum biochemical parameters such as lipid peroxidase (lpo), creatinine, enzymic and non enzymic antioxidants, liver markers tests such as alanine transaminase (alt), aspartate aminotransferase (ast), total cholesterol (tc), triglycerides (tg) and lipoproteins was analysed. |
2016-10-05 |
2023-08-13 |
rat |
| Yuanyuan Hu, Yan Zhao, Daoyuan Ren, Jianjun Guo, Yiyang Luo, Xingbin Yan. Hypoglycemic and hepatoprotective effects of D-chiro-inositol-enriched tartary buckwheat extract in high fructose-fed mice. Food & function. vol 6. issue 12. 2016-09-22. PMID:26412138. |
continuous administration of dtbe in hf-fed mice dose-dependently reduced the hf-induced elevation of body weight, serum glucose, insulin, total cholesterol (tc), total triglycerides (tg) and low density lipoprotein cholesterol (ldl-c) levels, as well as serum alanine aminotransferase (alt), aspartate aminotransferase (ast), c-reactive protein (crp) and lactate dehydrogenase (ldh) activities, while the hf-induced decline of serum high density lipoprotein-cholesterol (hdl-c) levels could be markedly elevated in the mice. |
2016-09-22 |
2023-08-13 |
mouse |
| Junming Wang, Mingsan Miao, Lingbo Qu, Ying Cui, Yueyue Zhan. Protective effects of geniposide against Tripterygium glycosides (TG)-induced liver injury and its mechanisms. The Journal of toxicological sciences. vol 41. issue 1. 2016-09-22. PMID:26763404. |
oral administration of tg (270 mg/kg) induced significant elevation in the levels of serum alanine / aspartate transaminase (alt/ast), hepatic malondialdehyde (mda) and pro-inflammatory cytokine tumor necrosis factor-alpha (tnf-α) (all p < 0.01). |
2016-09-22 |
2023-08-13 |
mouse |
| Wenxia Lu, Sainan Li, Jingjing Li, Jianrong Wang, Rong Zhang, Yuqing Zhou, Qin Yin, Yuanyuan Zheng, Fan Wang, Yujing Xia, Kan Chen, Tong Liu, Jie Lu, Yingqun Zhou, Chuanyong Gu. Effects of Omega-3 Fatty Acid in Nonalcoholic Fatty Liver Disease: A Meta-Analysis. Gastroenterology research and practice. vol 2016. 2016-09-21. PMID:27651787. |
a meta-analysis was conducted to assess the effect of omega-3 fatty acid supplementation (n-3 pufas) in lowering liver fat, liver enzyme (alanine aminotransferase (alt), aspartate aminotransferase (ast), and gamma-glutamyltransferase (ggt) levels), and blood lipids (triglyceride (tg), total cholesterol (tc), high density lipoprotein (hdl), and low density lipoprotein (ldl)) in patients with nonalcoholic fatty liver disease (nafld) or nonalcoholic steatohepatitis (nash). |
2016-09-21 |
2023-08-13 |
Not clear |
| Jinghua Wang, Chengfu Xu, Yunhao Xun, Zhenya Lu, Junping Shi, Chaohui Yu, Youming L. ZJU index: a novel model for predicting nonalcoholic fatty liver disease in a Chinese population. Scientific reports. vol 5. 2016-09-14. PMID:26568423. |
the model, named the zju index, was developed based on body mass index (bmi), fasting plasma glucose (fpg), triglycerides (tg), and the serum alanine aminotransferase (alt) to serum aspartate transaminase (ast) ratio. |
2016-09-14 |
2023-08-13 |
human |
| Linqiang Zhang, Zhiguo Zhang, Yunhai Li, Shasha Liao, Xiaoyun Wu, Qing Chang, Bin Lian. Cholesterol induces lipoprotein lipase expression in a tree shrew (Tupaia belangeri chinensis) model of non-alcoholic fatty liver disease. Scientific reports. vol 5. 2016-09-13. PMID:26522240. |
here, using high fat, cholesterol and cholate diet (hfhc), we generated a novel tree shrew (tupaia belangeri chinensis) model of nafld, which displayed dyslipidemia with increased levels of plasma alanine aminotransferase (alt) and aspartate aminotransferase (ast), total cholesterol (tc), low density lipoprotein-cholesterol (ldl-c) and high density lipoprotein-cholesterol (hdl-c), but decreased level of triglycerides (tg). |
2016-09-13 |
2023-08-13 |
Not clear |
| Babatunji Emmanuel Oyinloye, Abiola Fatimah Adenowo, Foluso Oluwagbemiga Osunsanmi, Bolajoko Idiat Ogunyinka, Sarah Onyenibe Nwozo, Abidemi Paul Kapp. Aqueous extract of Monodora myristica ameliorates cadmium-induced hepatotoxicity in male rats. SpringerPlus. vol 5. 2016-06-22. PMID:27330907. |
at the end of the experiment, levels of serum enzyme biomarkers (alanine transaminase, alkaline phosphatase and aspartate transaminase) as well as total cholesterol (tc), triacylglyceride (tg) and malondialdehyde were significantly raised in the cadmium treated groups. |
2016-06-22 |
2023-08-13 |
rat |
| Abidemi J Akindele, Edafe Otuguor, Dhirendra Singh, Duncan Ota, Adokiye S Beneb. Hypoglycemic, antilipidemic and antioxidant effects of valproic acid in alloxan-induced diabetic rats. European journal of pharmacology. vol 762. 2016-05-24. PMID:26015307. |
on day 21, blood samples were collected for assay of serum biochemical parameters (total protein, creatinine, urea, alanine transaminase (alt), aspartate transaminase (ast), alkaline phosphatase (alp), triglycerides (tg), total cholesterol (tc), high density lipoprotein (hdl), and low density lipoprotein (ldl)). |
2016-05-24 |
2023-08-13 |
rat |
| Bhesh Raj Sharma, Jin Oh, Hyeon-A Kim, Yong Jae Kim, Kyu-Shik Jeong, Dong Young Rhy. Anti-Obesity Effects of the Mixture of Eriobotrya japonica and Nelumbo nucifera in Adipocytes and High-Fat Diet-Induced Obese Mice. The American journal of Chinese medicine. vol 43. issue 4. 2016-04-19. PMID:26133751. |
in our results, the administration of ej, nn, and mix significantly decreased body weight (bw), fat weight, liver weight, hepatic triglyceride (tg) and total cholesterol (tc), lipid droplets in the liver, food efficacy ratio, and the plasma tg, tc, glucose, insulin, alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels in a dose-dependent manner, and mix treatment showed stronger effect than their individual treatments. |
2016-04-19 |
2023-08-13 |
mouse |
| Huijie Xing, Kun Jia, Jun He, Changzheng Shi, Meixia Fang, Linliang Song, Pu Zhang, Yue Zhao, Jiangnan Fu, Shoujun L. Establishment of the tree shrew as an alcohol-induced Fatty liver model for the study of alcoholic liver diseases. PloS one. vol 10. issue 6. 2016-04-12. PMID:26030870. |
compared with the normal group, the levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), gamma-glutamyl transpeptidase (ggt), total cholesterol (tc), triglyceride (tg), reactive oxygen species (ros), and malondialdehyde (mda) were significantly enhanced in alcohol-treated tree shrews. |
2016-04-12 |
2023-08-13 |
Not clear |
| Md Ibrahim Khalil, E M Tanvir, Rizwana Afroz, Siti Amrah Sulaiman, Siew Hua Ga. Cardioprotective Effects of Tualang Honey: Amelioration of Cholesterol and Cardiac Enzymes Levels. BioMed research international. vol 2015. 2016-03-10. PMID:26064893. |
subcutaneous injection of iso (85 mg/kg in saline) for two consecutive days caused a significant increase in serum cardiac marker enzymes (creatine kinase-mb (ck-mb), lactate dehydrogenase (ldh), and aspartate transaminase (ast)), ctni, serum tc, and tg levels. |
2016-03-10 |
2023-08-13 |
rat |
| Tong Chen, Jin Gao, Pengjun Xiang, Yongde Chen, Jing Ji, Peng Xie, Hui Wu, Wei Xiao, Yidan Wei, Shumin Wang, Li Lan, Hui Ji, Tianhua Ya. Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th17 balance. International immunopharmacology. vol 26. issue 2. 2016-02-29. PMID:25887267. |
pld effectively downregulated aspartate transaminase (ast), alanine aminotransferase (alt), total cholesterol (tc), and triglycerides (tg) in liver. |
2016-02-29 |
2023-08-13 |
mouse |
| Jianjun Guo, Yonghong Meng, Yan Zhao, Yuanyuan Hu, Daoyuan Ren, Xingbin Yan. Myricetin derived from Hovenia dulcis Thunb. ameliorates vascular endothelial dysfunction and liver injury in high choline-fed mice. Food & function. vol 6. issue 5. 2016-02-05. PMID:25881982. |
furthermore, continuous administration of myr at 400 and 800 mg per kg bw in choline-fed mice could significantly decrease the high choline diet-induced elevation of serum total cholesterol (tc), total triglyceride (tg), low density lipoprotein-cholesterol (ldl-c), endothelin 1 (et-1) and thromboxane a2 (txa2) levels as well as alanine aminotransferase (alt) and aspartate aminotransferase (ast) activities, while the choline-induced decline of serum high density lipoprotein-cholesterol (hdl-c), endothelin nitric oxide synthase (enos), nitric oxide (no) and prostaglandin i2 (pgi2) levels could be markedly elevated in mice (p < 0.05, p < 0.01). |
2016-02-05 |
2023-08-13 |
mouse |
| Shuang Xu, Jin-Feng Hu, Shi-Feng Chu, Ning Han, Jing-Wei Li, Yue-Ting Li, Nai-Hong Che. [Oil of Piper longum unsaponifiable matter prevents cholesterol gallstone formation]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 48. issue 7. 2016-02-02. PMID:24133988. |
the results showed that serum tc, tg (triglycerides) and ast (aspartate transaminase) contents, gallbladder cholesterol crystallization and csi increased significantly (p < 0.05). |
2016-02-02 |
2023-08-12 |
mouse |
| Meng Wang, Jianguo Sun, Zhihui Jiang, Wenyan Xie, Xiaoying Zhan. Hepatoprotective effect of kaempferol against alcoholic liver injury in mice. The American journal of Chinese medicine. vol 43. issue 2. 2016-01-14. PMID:25787296. |
the liver functions were observed by monitoring the following parameters: aspartate aminotransferase (ast/got) and alanine aminotransferase (alt/gpt) levels in serum; histopathological studies of liver tissue; oxidative stress by hydrogen peroxide (h2o2), superoxide dismutase (sod) and glutathione (gsh); the lipid peroxidation status by malondialdehyde (mda) and lipid accumulation by triglyceride (tg) level in serum; and the expression levels and activities of a key microsomal enzyme cytochrome 2e1 (cyp2e1), by both in vitro and in vivo methods. |
2016-01-14 |
2023-08-13 |
mouse |
| Jai-Jen Tsai, Hsing-Chun Kuo, Kam-Fai Lee, Tung-Hu Tsa. Glycyrrhizin represses total parenteral nutrition-associated acute liver injury in rats by suppressing endoplasmic reticulum stress. International journal of molecular sciences. vol 14. issue 6. 2015-10-15. PMID:23771023. |
we found that aspartate aminotransferase (ast), alanine aminotransferase (alt), total bilirubin (tb) and triglyceride (tg) levels were significantly increased in the tpn group without glycyrrhizin pretreatment and decreased in the glycyrrhizin-pretreated tpn group in a dose-dependent manner. |
2015-10-15 |
2023-08-12 |
rat |
| b' Okan K\\xc4\\xb1z\\xc4\\xb1lyel, Mahmut S Metin, \\xc3\\x96mer F Elmas, Yasemin \\xc3\\x87ay\\xc4\\xb1r, Ak\\xc4\\xb1n Akta\\xc5\\x9. Effects of oral isotretinoin on lipids and liver enzymes in acne patients. Cutis. vol 94. issue 5. 2015-09-28. PMID:25474452.' |
each patient's medical records were evaluated to determine baseline triglyceride (tg), low-density lipoprotein (ldl), high-density lipoprotein (hdl), aspartate aminotransferase (ast), and alanine aminotransferase (alt) levels compared to levels recorded at 3 and 6 months following initiation of treatment with oral isotretinoin. |
2015-09-28 |
2023-08-13 |
Not clear |