| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Märki, U M Bucher, J C Richte. Multiple subcutaneous injections of somatostatin induce tachyphylaxis of the suppression of plasma insulin, but not glucagon, in the rat. Regulatory peptides. vol 4. issue 6. 1983-02-25. PMID:6129682. |
during infusion of 10 and 30 micrograms/kg per min, somatostatin continuously suppressed plasma insulin and plasma glucagon. |
1983-02-25 |
2023-08-12 |
rat |
| T M Lin, D C Evans, C J Shaar, M A Roo. Action of somatostatin on stomach, pancreas, gastric mucosal blood flow, and hormones. The American journal of physiology. vol 244. issue 1. 1983-02-25. PMID:6129805. |
3) the low doses of somatostatin used in this study significantly inhibited gastric and pancreatic secretion without affecting the basal plasma concentrations of insulin, glucagon, growth hormone, gastrin, or secretin in the dogs, suggesting that the inhibitory action was not mediated by changes or reduction in plasma concentration of these hormones. |
1983-02-25 |
2023-08-12 |
Not clear |
| J A Parsons, M A Hartfel, O D Hegre, R C McEvo. Effect of MtTW15 mammosomatotropic tumors on pancreatic islet hormones. Diabetes. vol 32. issue 1. 1983-02-25. PMID:6336705. |
pancreatic content of insulin and glucagon was doubled, while that of somatostatin was constant. |
1983-02-25 |
2023-08-12 |
rat |
| R R Wolfe, J F Burk. Somatostatin infusion inhibits glucose production in burn patients. Circulatory shock. vol 9. issue 5. 1983-02-14. PMID:6129073. |
in all patients the somatostatin reduced both insulin and glucagon levels, and the glucagon was reduced to a greater extent (on a molar basis) than the insulin. |
1983-02-14 |
2023-08-12 |
Not clear |
| R R Wolfe, J F Burk. Somatostatin infusion inhibits glucose production in burn patients. Circulatory shock. vol 9. issue 5. 1983-02-14. PMID:6129073. |
glucose clearance was consistently depressed, and the magnitude of change in glucose clearance was directly correlated to the magnitude of the reduction in insulin concentration induced by the somatostatin infusion (p less than 0.01). |
1983-02-14 |
2023-08-12 |
Not clear |
| R R Wolfe, J F Burk. Somatostatin infusion inhibits glucose production in burn patients. Circulatory shock. vol 9. issue 5. 1983-02-14. PMID:6129073. |
in one additional study, insulin was infused during the somatostatin infusion in order to maintain the basal level of insulin throughout the infusion, thus creating a selective drop in glucagon concentration. |
1983-02-14 |
2023-08-12 |
Not clear |
| M O Thorner, J Rivier, J Spiess, J L Borges, M L Vance, S R Bloom, A D Rogol, M J Cronin, D L Kaiser, W S Evans, J D Webster, R M MacLeod, W Val. Human pancreatic growth-hormone-releasing factor selectively stimulates growth-hormone secretion in man. Lancet (London, England). vol 1. issue 8314-5. 1983-02-14. PMID:6129370. |
similarly, the concentrations of blood glucose, plasma insulin, glucagon, pancreatic polypeptide, cholecystokinin, gastrin, gastric inhibitory peptide, motilin, and somatostatin were unaffected by hpgrf-40. |
1983-02-14 |
2023-08-12 |
human |
| M Marre, E Bobbioni, M Sheppard, S Kronheim, J Miller, R Assa. The nervous control of rat somatostatin, glucagon and insulin secretions. Diabete & metabolisme. vol 8. issue 3. 1983-01-27. PMID:6128263. |
the nervous control of rat somatostatin, glucagon and insulin secretions. |
1983-01-27 |
2023-08-12 |
rat |
| B Ahrén, I Lundquis. Influence of glucagon, gastric inhibitory polypeptide, pancreatic polypeptide and somatostatin on beta-adrenergically induced insulin secretion in the mouse. Diabete & metabolisme. vol 8. issue 3. 1983-01-27. PMID:6128264. |
influence of glucagon, gastric inhibitory polypeptide, pancreatic polypeptide and somatostatin on beta-adrenergically induced insulin secretion in the mouse. |
1983-01-27 |
2023-08-12 |
mouse |
| B Ahrén, I Lundquis. Influence of glucagon, gastric inhibitory polypeptide, pancreatic polypeptide and somatostatin on beta-adrenergically induced insulin secretion in the mouse. Diabete & metabolisme. vol 8. issue 3. 1983-01-27. PMID:6128264. |
the effect of four polypeptides, glucagon, gastric inhibitory polypeptide (gip), pancreatic polypeptide (pp) and somatostatin on beta-adrenoceptor stimulated insulin secretion in vivo in the mouse was investigated. |
1983-01-27 |
2023-08-12 |
mouse |
| B Ahrén, I Lundquis. Influence of glucagon, gastric inhibitory polypeptide, pancreatic polypeptide and somatostatin on beta-adrenergically induced insulin secretion in the mouse. Diabete & metabolisme. vol 8. issue 3. 1983-01-27. PMID:6128264. |
insulin secretion induced by ipna was increased by glucagon and inhibited by somatostatin. |
1983-01-27 |
2023-08-12 |
mouse |
| B Ahrén, I Lundquis. Influence of glucagon, gastric inhibitory polypeptide, pancreatic polypeptide and somatostatin on beta-adrenergically induced insulin secretion in the mouse. Diabete & metabolisme. vol 8. issue 3. 1983-01-27. PMID:6128264. |
it is concluded from this and earlier published studies that glucagon, but not always gip, serves as a positive modulator of basal and stimulated insulin secretion, and that somatostatin is a general inhibitor of insulin release. |
1983-01-27 |
2023-08-12 |
mouse |
| B Ahrén, I Lundquis. Influence of glucagon, gastric inhibitory polypeptide, pancreatic polypeptide and somatostatin on beta-adrenergically induced insulin secretion in the mouse. Diabete & metabolisme. vol 8. issue 3. 1983-01-27. PMID:6128264. |
beta-adrenoceptor-induced insulin secretion however, seems to be less sensitive to somatostatin than insulin release induced by glucose. |
1983-01-27 |
2023-08-12 |
mouse |
| J B Hanks, W J Kortz, D K Andersen, R S Jone. Somatostatin suppression of canine fasting bile secretion. Gastroenterology. vol 84. issue 1. 1983-01-27. PMID:6128286. |
in addition, suppression of basal insulin concentration occurred at somatostatin infusion of 200 ng . |
1983-01-27 |
2023-08-12 |
Not clear |
| K V Axen, F X Pi-Sunye. Altered insulin and glucagon secretion in perfused ethionine-treated rat pancreases. The American journal of physiology. vol 243. issue 6. 1983-01-27. PMID:6756165. |
in isolated, perfused ethionine-treated pancreases secretin failed to stimulate insulin secretion, whereas basal insulin secretion and insulin responses to glucose, arginine, gastric inhibitory polypeptide, vasoactive intestinal peptide (vip), and somatostatin were similar to those of controls. |
1983-01-27 |
2023-08-12 |
rat |
| W Bauer, U Briner, W Doepfner, R Haller, R Huguenin, P Marbach, T J Petcher, Ples. SMS 201-995: a very potent and selective octapeptide analogue of somatostatin with prolonged action. Life sciences. vol 31. issue 11. 1983-01-19. PMID:6128648. |
stepwise modification of a conformationally stabilised analogue of the fragment of somatostatin which had been thought to be essential biologically active moiety has enabled us to synthesise the analogue h-(d) phe-cys-phe-(d) trp-lys-thr-cys-thr(ol) code-named sms 201-995, which in vitro is three times more potent than the native hormone in inhibiting the secretion of growth hormone, which is highly resistant to degradation by pure enzymes and by tissue homogenates, which in vivo in rat and rhesus monkey is (depending on test system) at least 20 times more active than somatostatin, which is much longer acting, and which moreover in both species is much more selective in inhibiting the secretion of growth hormone than that of insulin. |
1983-01-19 |
2023-08-12 |
rat |
| R G Long, N D Christofides, M L Fitzpatrick, D J O'Shaughnessy, S R Bloo. Effects of intravenous somatostatin and motilin on the blood glucose and hormonal response to oral glucose. European journal of clinical investigation. vol 12. issue 4. 1983-01-07. PMID:6128230. |
the somatostatin infusion reduced concentrations of motilin, insulin, gastric inhibitory polypeptide, gastrin and neurotensin whilst the motilin infusion was associated with an increased initial rise in insulin and gastric inhibitory polypeptide. |
1983-01-07 |
2023-08-12 |
human |
| E J Verspohl, H P Ammo. Insulin receptors on rat pancreatic islets: specificity of 125 I-insulin binding. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 14. issue 9. 1983-01-07. PMID:6128293. |
glucagon and somatostatin did not affect insulin binding. |
1983-01-07 |
2023-08-12 |
rat |
| P Masiello, C B Wollheim, D Janjic, A Gjinovci, B Blondel, G A Praz, A E Renol. Stimulation of insulin release by glucose in a transplantable rat islet cell tumor. Endocrinology. vol 111. issue 6. 1983-01-07. PMID:6183110. |
tumors grew rapidly after sc transplantation and were rich in insulin, but contained only small amounts of glucagon and somatostatin. |
1983-01-07 |
2023-08-12 |
rat |
| H Yamauchi, I Baca, U Mittmann, H P Geisen, M Salze. Postischemic liver damage in rats: effect of some therapeutic interventions on survival rate. The Tohoku journal of experimental medicine. vol 138. issue 1. 1983-01-07. PMID:6293117. |
the aim of this paper is to elucidate the cause of death after 90 min of normothermic partial (2/3) ischemia of the liver and to examine the effects of glucagon, somatostatin, insulin, prednisolone and oral administration of polymyxin b (pb). |
1983-01-07 |
2023-08-12 |
rat |