| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Tanganelli, A M Signorini, G Gragnol. Effects of somatostatin on the behavior of thromboxane B2 and B-thromboglobulin in type 1 diabetes. Bollettino della Societa italiana di biologia sperimentale. vol 60. issue 11. 1985-04-09. PMID:6084513. |
somatostatin, as an adjunct to insulin in the treatment of poorly controlled type 1 diabetes, has been recently suggested. |
1985-04-09 |
2023-08-12 |
human |
| A Hisatomi, H Maruyama, L Orci, M Vasko, R H Unge. Adrenergically mediated intrapancreatic control of the glucagon response to glucopenia in the isolated rat pancreas. The Journal of clinical investigation. vol 75. issue 2. 1985-04-03. PMID:2857731. |
the pattern of somatostatin secretion in these experiments resembled that of insulin. |
1985-04-03 |
2023-08-11 |
rat |
| J P Knochel, J D Blachley, J H Johnson, N W Carte. Muscle cell electrical hyperpolarization and reduced exercise hyperkalemia in physically conditioned dogs. The Journal of clinical investigation. vol 75. issue 2. 1985-04-03. PMID:2982919. |
although insulin might have played a role in the acquired electrical hyperpolarization, the reduced exercise-produced hyperkalemia after training was not reversed by blockade of insulin release with somatostatin. |
1985-04-03 |
2023-08-11 |
Not clear |
| P O Schwille, W Engelhardt, H Volkholz, C Gebhardt, H Zirngibl, M Stolt. Influence of pancreatic duct occlusion on islet hormones in peripheral and portal plasma and in the pancreas of the mini-pig. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. vol 17. issue 1. 1985-03-27. PMID:2578962. |
in a total of 18 'göttingen' mini-pigs we studied basal glucose in the peripheral plasma, and the hormones insulin, glucagon, and somatostatin in the peripheral and portal plasma, as well as in extracts of pancreatic tissue, both in animals subjected to pancreatic duct occlusion with prolamine (occ pigs) 9 months previously and in controls. |
1985-03-27 |
2023-08-11 |
Not clear |
| P O Schwille, W Engelhardt, H Volkholz, C Gebhardt, H Zirngibl, M Stolt. Influence of pancreatic duct occlusion on islet hormones in peripheral and portal plasma and in the pancreas of the mini-pig. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. vol 17. issue 1. 1985-03-27. PMID:2578962. |
in peripheral blood of occ pigs glucose, insulin, and somatostatin were unchanged, while glucagon was decreased. |
1985-03-27 |
2023-08-11 |
Not clear |
| P O Schwille, W Engelhardt, H Volkholz, C Gebhardt, H Zirngibl, M Stolt. Influence of pancreatic duct occlusion on islet hormones in peripheral and portal plasma and in the pancreas of the mini-pig. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. vol 17. issue 1. 1985-03-27. PMID:2578962. |
also after occlusion the portal plasma revealed an increase in insulin but unchanged glucagon and somatostatin, while in the pancreatic tissue insulin and glucagon were statistically unchanged, but somatostatin was reduced. |
1985-03-27 |
2023-08-11 |
Not clear |
| V Leclercq-Meyer, J Marchand, M C Woussen-Colle, M H Giroix, W J Malaiss. Multiple effects of leucine on glucagon, insulin, and somatostatin secretion from the perfused rat pancreas. Endocrinology. vol 116. issue 3. 1985-03-27. PMID:2857640. |
multiple effects of leucine on glucagon, insulin, and somatostatin secretion from the perfused rat pancreas. |
1985-03-27 |
2023-08-11 |
rat |
| V Leclercq-Meyer, J Marchand, M C Woussen-Colle, M H Giroix, W J Malaiss. Multiple effects of leucine on glucagon, insulin, and somatostatin secretion from the perfused rat pancreas. Endocrinology. vol 116. issue 3. 1985-03-27. PMID:2857640. |
concomitantly, leucine was always a positive stimulus for both insulin and somatostatin secretion. |
1985-03-27 |
2023-08-11 |
rat |
| N R Rosenthal, E J Barret. An assessment of insulin action in hyperosmolar hyperglycemic nonketotic diabetic patients. The Journal of clinical endocrinology and metabolism. vol 60. issue 3. 1985-03-25. PMID:2857727. |
the effect of insulin treatment on the rate of decline of plasma glucose concentration was determined in nine patients with hyperosmolar hyperglycemic nonketosis [hhnk; mean plasma glucose, 999 +/- 59 (+/- sem) mg/dl] and in six normal subjects rendered hyperglycemic by a combined infusion of somatostatin and glucose (mean plasma glucose, 653 +/- 28 mg/dl). |
1985-03-25 |
2023-08-11 |
human |
| G Szilágyi, G Irsy, M Góth, I Szabolcs, D H Coy, A M Comaru-Schally, A V Schall. Effect of a somatostatin analogue on trophic hormone levels in acromegalic patients with elevated hGH after adenomectomy and treatment with bromocriptine. Experimental and clinical endocrinology. vol 84. issue 2. 1985-03-25. PMID:6543182. |
somatostatin analogue caused a fall in serum insulin levels in all but one patient, who had diabetes mellitus and in whom serum insulin was undetectable. |
1985-03-25 |
2023-08-12 |
Not clear |
| P B Kristensen, S M Paulse. Simultaneous presentation of a small-cell carcinoma involving the ovary and the uterine endometrium. Journal of submicroscopic cytology. vol 17. issue 1. 1985-03-22. PMID:2983080. |
immunohistochemically, no content of polypeptide hormones (acth, calcitonin, gastrin, glucagon, insulin, somatostatin and vip) were encountered. |
1985-03-22 |
2023-08-11 |
Not clear |
| T Perrone, R K Sibley, J Rosa. Duodenal gangliocytic paraganglioma. An immunohistochemical and ultrastructural study and a hypothesis concerning its origin. The American journal of surgical pathology. vol 9. issue 1. 1985-03-14. PMID:2578747. |
the epithelial cells stained for neurofilament, neuron-specific enolase, pancreatic polypeptide, and somatostatin in three cases; leu-enkephalin, molluskan cardioexcitatory peptide, and vasoactive intestinal peptide in two; and glucagon and insulin in one case each. |
1985-03-14 |
2023-08-11 |
Not clear |
| C Bordi, O De Vita, C Ferrari, G Altavilla, A Corallini, G Barbanti-Brodan. Histologic, immunofluorescence, and ultrastructural study of malignant islet-cell tumors of the pancreas induced in hamsters by BK human papovavirus. The American journal of pathology. vol 118. issue 2. 1985-03-11. PMID:2982271. |
insulin cells were present in 16 cases, glucagon cells in 11, somatostatin cells in 7, pp cells in 6. |
1985-03-11 |
2023-08-11 |
human |
| R G Cutfield, K Polonsky, L Olson, G Kyriakides, J Miller, D H Mint. Long-term follow-up of canine segmental pancreatic autografts. Diabetes. vol 34. issue 2. 1985-03-05. PMID:2857144. |
immunoperoxidase stains confirmed the presence of insulin, glucagon, and somatostatin within nests of islet cells. |
1985-03-05 |
2023-08-11 |
Not clear |
| S J Bhathena, K I Timmers, H K Oie, N R Voyles, L Recan. Cytosolic insulin-degrading activity in islet-derived tumor cell lines and in normal rat islets. Diabetes. vol 34. issue 2. 1985-03-05. PMID:2981750. |
the enzyme is inactive at phs below 6.0, indicating that it is not lysosomal, is completely inhibited by n-ethylmaleimide, and exhibits apparent competitive inhibition constants (microm) for the following peptides: desoctapeptide insulin, 0.043; guinea pig insulin, 0.048; proinsulin, 0.64; insulin b-chain, 1.17; glucagon, 7.0; and cyclic somatostatin, 8.6. |
1985-03-05 |
2023-08-11 |
mouse |
| G Bestetti, G L Ross. Islet cell carcinomas in dogs. Virchows Archiv. A, Pathological anatomy and histopathology. vol 405. issue 2. 1985-03-01. PMID:2982230. |
antisera to insulin, pancreatic polypeptide, somatostatin and glucagon were used. |
1985-03-01 |
2023-08-11 |
dog |
| T Tomita, V Doull, J R Kimmel, H G Polloc. Pancreatic polypeptide and other hormones in pancreas of obese (ob/ob) mice. Diabetologia. vol 27. issue 4. 1985-02-21. PMID:6150871. |
the insulin, glucagon, somatostatin and pancreatic polypeptide content of acid-ethanol extracts of pancreas from lean and obese (ob/ob) mice of various ages was determined by radioimmunoassay. |
1985-02-21 |
2023-08-12 |
mouse |
| S Webb, I Levy, J A Wass, A Llorens, E Penman, R Casamitjana, P Wu, J Gaya, M J Martínez, F River. Studies on the mechanisms of somatostatin release after insulin induced hypoglycaemia in man. Clinical endocrinology. vol 21. issue 6. 1985-02-11. PMID:6150771. |
studies on the mechanisms of somatostatin release after insulin induced hypoglycaemia in man. |
1985-02-11 |
2023-08-12 |
human |
| S Webb, I Levy, J A Wass, A Llorens, E Penman, R Casamitjana, P Wu, J Gaya, M J Martínez, F River. Studies on the mechanisms of somatostatin release after insulin induced hypoglycaemia in man. Clinical endocrinology. vol 21. issue 6. 1985-02-11. PMID:6150771. |
insulin plus dextrose caused no significant changes in circulating somatostatin levels, whereas insulin plus saline was associated with a marked, sustained and significant rise in all subjects; insulin plus cimetidine also produced a rise but it was delayed; the area under the curve was significantly (p less than 0.05) greater with insulin plus saline than with insulin plus cimetidine. |
1985-02-11 |
2023-08-12 |
human |
| S Webb, I Levy, J A Wass, A Llorens, E Penman, R Casamitjana, P Wu, J Gaya, M J Martínez, F River. Studies on the mechanisms of somatostatin release after insulin induced hypoglycaemia in man. Clinical endocrinology. vol 21. issue 6. 1985-02-11. PMID:6150771. |
these results show that in man insulin itself does not stimulate somatostatin secretion directly, but indirectly via hypoglycaemia. |
1985-02-11 |
2023-08-12 |
human |