| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P M Radosevich, P E Williams, D B Lacy, J R McRae, K E Steiner, A D Cherrington, W W Lacy, N N Abumra. Effects of morphine on glucose homeostasis in the conscious dog. The Journal of clinical investigation. vol 74. issue 4. 1984-11-09. PMID:6148357. |
we also examined the effect of low dose morphine on glucose kinetics independent of changes in the endocrine pancreas by the use of somatostatin plus intraportal replacement of basal insulin and glucagon. |
1984-11-09 |
2023-08-12 |
dog |
| D J Evans, R Murray, A H Kisseba. Relationship between skeletal muscle insulin resistance, insulin-mediated glucose disposal, and insulin binding. Effects of obesity and body fat topography. The Journal of clinical investigation. vol 74. issue 4. 1984-11-09. PMID:6148358. |
the increase in percentage of synthase i in response to submaximal steady state plasma insulin (sspi) of approximately 100 microu/ml achieved by the infusion of somatostatin, insulin, and glucose, however, was significantly lower in obese than in nonobese subjects, and was inversely correlated with whr. |
1984-11-09 |
2023-08-12 |
human |
| N Lytras, A Grossman, L H Rees, A V Schally, S R Bloom, G M Besse. Corticotrophin releasing factor: effects on circulating gut and pancreatic peptides in man. Clinical endocrinology. vol 20. issue 6. 1984-10-25. PMID:6147213. |
there was a significant rise in pancreatic polypeptide compared to a control infusion, but no change in plasma insulin, pancreatic glucagon, gastrin, somatostatin, motilin, neurotensin, gastric inhibitory peptide, or cholecystokinin was seen. |
1984-10-25 |
2023-08-12 |
human |
| E J Barrett, R G Schwartz, C K Francis, B L Zare. Regulation by insulin of myocardial glucose and fatty acid metabolism in the conscious dog. The Journal of clinical investigation. vol 74. issue 3. 1984-10-24. PMID:6381537. |
to assess the effect of physiological elevations of plasma insulin upon myocardial glucose and ffa uptake in vivo independent of changes in plasma substrate concentration, we measured arterial and coronary sinus concentrations of glucose, lactate, and ffa, and coronary blood flow in conscious dogs during a 30 min basal and a 2 h experimental period employing three protocols: (a) euglycemic hyperinsulinemia (insulin clamp, n = 5), (b) euglycemic hyperinsulinemia with ffa replacement (n = 5), (c) hyperglycemic euinsulinemia (hyperglycemic clamp with somatostatin, n = 5). |
1984-10-24 |
2023-08-12 |
dog |
| E J Barrett, R G Schwartz, C K Francis, B L Zare. Regulation by insulin of myocardial glucose and fatty acid metabolism in the conscious dog. The Journal of clinical investigation. vol 74. issue 3. 1984-10-24. PMID:6381537. |
hyperglycemia (plasma glucose = 186 +/- 8 mg/100 ml) during somatostatin infusion resulted in only a small rise in plasma insulin (delta = 12 +/- 7 microu/ml), and although plasma ffa tended to decline, heart glucose uptake did not rise significantly (delta = 5.5 +/- 3.2 mumol/min, p = ns). |
1984-10-24 |
2023-08-12 |
dog |
| P G Burhol, I Lygren, T G Jenssen, J Florholmen, R Jord. Somatostatin release and plasma molecular somatostatin components in man. Acta physiologica Scandinavica. vol 121. issue 3. 1984-10-24. PMID:6433648. |
the present paper describes a sensitive, precise and specific radioimmunoassay method for measurements of plasma somatostatin; significant rises in plasma somatostatin following a test meal, intraduodenal infusion of fat and hcl, and intravenous injection of insulin; and separation of immunoreactive plasma somatostatin into two components probably representing bound and free molecular forms of somatostatin both in fasting and postprandial human plasmas. |
1984-10-24 |
2023-08-12 |
human |
| Y Yawata, K Yamatani, M Tominaga, I Ebitani, M Hara, H Sasak. Hyperglycemic effect of neurotensin. The Tohoku journal of experimental medicine. vol 143. issue 2. 1984-10-11. PMID:6147906. |
although blood levels of glucagon and insulin were greatly reduced and not elevated by neurotensin in the presence of somatostatin, the response of blood glucose to neurotensin was similar to that in the absence of somatostatin. |
1984-10-11 |
2023-08-12 |
Not clear |
| R W Schwize. Effects of dissociation and culture on the maintenance of insulin, glucagon and somatostatin release by neonatal rat islets of Langerhans. Life sciences. vol 35. issue 7. 1984-10-02. PMID:6147743. |
effects of dissociation and culture on the maintenance of insulin, glucagon and somatostatin release by neonatal rat islets of langerhans. |
1984-10-02 |
2023-08-12 |
rat |
| R W Schwize. Effects of dissociation and culture on the maintenance of insulin, glucagon and somatostatin release by neonatal rat islets of Langerhans. Life sciences. vol 35. issue 7. 1984-10-02. PMID:6147743. |
as estimated by the radioimmunoassay of insulin, glucagon and somatostatin in tissue extracts, the amount of islet tissue available for culture was reduced 50-70% following dissociation; an additional loss occurred after the first day in vitro. |
1984-10-02 |
2023-08-12 |
rat |
| R W Schwize. Effects of dissociation and culture on the maintenance of insulin, glucagon and somatostatin release by neonatal rat islets of Langerhans. Life sciences. vol 35. issue 7. 1984-10-02. PMID:6147743. |
the concentrations of insulin and glucagon in the medium approximately doubled and somatostatin increased 3-fold. |
1984-10-02 |
2023-08-12 |
rat |
| V E Eysselei. [Neurotensin--what is known about its role as a hormone in the gastrointestinal tract?]. Klinische Wochenschrift. vol 62. issue 11. 1984-10-01. PMID:6471777. |
potential actions of neurotensin include thermoregulation, regulation of hormone release from brain (pituitary hormones) and gut (glucagon, insulin, somatostatin, pancreatic polypeptide), increase of vascular permeability, vasodilatation, inhibition of gastric acid secretion, stimulation of pancreatic secretion and changes of gut motility from the fasting to the fed type. |
1984-10-01 |
2023-08-12 |
human |
| P O Schwille, W Engelhardt, E Gumbert, C Gebhardt, F P Gal. Long-term pancreatic duct occlusion impairs the entero-insular axis in the dog--failure of plasma VIP to respond as "incretin". Peptides. vol 5. issue 2. 1984-09-24. PMID:6147819. |
the two studies with glucose administration designed to demonstrate the release of insulin, vip, somatostatin into plasma as modified by enteric signals (represented by the difference of plasma peptide concentration during ogt minus peptide concentration during iv glucose) revealed the following: (1) basal plasma glucose, insulin, vip, somatostatin did not differ between sham and occ dogs; (2) after ogt in occ dogs the plasma glucose was elevated, whereas plasma insulin was markedly reduced, and vip, somatostatin were largely unchanged; (3) the integrated output of insulin only was impaired when considering the so-called entero-insulin axis, while integrated vip, somatostatin were unaltered. |
1984-09-24 |
2023-08-12 |
dog |
| P O Schwille, W Engelhardt, E Gumbert, C Gebhardt, F P Gal. Long-term pancreatic duct occlusion impairs the entero-insular axis in the dog--failure of plasma VIP to respond as "incretin". Peptides. vol 5. issue 2. 1984-09-24. PMID:6147819. |
it was concluded (a) the occ procedure in the dog has the capacity to subtotal destruction of the pancreatic acinar tissue, and of the entero-insular axis of insulin, the latter through yet unknown pathways, (b) the occ technique may be a useful tool for investigation of the nature of "incretin," (c) vip and somatostatin do not respond to elevated blood glucose and may have no role in the "incretin" concept of enteric modulation of the b-cell. |
1984-09-24 |
2023-08-12 |
dog |
| N Y Ip, C Baldwin, R E Zigmon. Acute stimulation of ganglionic tyrosine hydroxylase activity by secretin, VIP and PHI. Peptides. vol 5. issue 2. 1984-09-24. PMID:6147816. |
secretin and vasoactive intestinal peptide (vip) both increased th activity, whereas angiotensin ii, bombesin, bradykinin, cholecystokinin octapeptide, insulin, luteinizing hormone-releasing hormone, [d-ala2, met5]enkephalinamide, motilin, neurotensin, somatostatin, and substance p produced no effects. |
1984-09-24 |
2023-08-12 |
human |
| D Gonzalez-Barcena, F Mendoza, R Medina, D H Coy, W A Murphy, A V Schall. Effect of Ala-2-D-Trp-8-D-Cys-14-somatostatin on the arginine induced release of insulin, GH and glucagon in normal men. Endocrine research. vol 10. issue 1. 1984-09-19. PMID:6146518. |
somatostatin suppressed the release of insulin, glucagon and gh when administered in a dose of 100 micrograms/hr. |
1984-09-19 |
2023-08-12 |
human |
| D Gonzalez-Barcena, F Mendoza, R Medina, D H Coy, W A Murphy, A V Schall. Effect of Ala-2-D-Trp-8-D-Cys-14-somatostatin on the arginine induced release of insulin, GH and glucagon in normal men. Endocrine research. vol 10. issue 1. 1984-09-19. PMID:6146518. |
these results indicate that in humans this analog is a less potent inhibitor of insulin release than somatostatin. |
1984-09-19 |
2023-08-12 |
human |
| V Lance, J W Hamilton, J B Rouse, J R Kimmel, H G Polloc. Isolation and characterization of reptilian insulin, glucagon, and pancreatic polypeptide: complete amino acid sequence of alligator (Alligator mississippiensis) insulin and pancreatic polypeptide. General and comparative endocrinology. vol 55. issue 1. 1984-09-17. PMID:6146554. |
the insulin, glucagon, pancreatic polypeptide, and somatostatin contents of acid-alcohol extracts of alligator pancreas have been estimated by heterologous radioimmunoassay, and the insulin, glucagon, and pancreatic polypeptide have been isolated. |
1984-09-17 |
2023-08-12 |
chicken |
| M D Ruggere, Y C Pate. Somatostatin, glucagon, and insulin secretion from perfused pancreas of BB rats. The American journal of physiology. vol 247. issue 2 Pt 1. 1984-09-14. PMID:6147095. |
somatostatin, glucagon, and insulin secretion from perfused pancreas of bb rats. |
1984-09-14 |
2023-08-12 |
rat |
| M D Ruggere, Y C Pate. Somatostatin, glucagon, and insulin secretion from perfused pancreas of BB rats. The American journal of physiology. vol 247. issue 2 Pt 1. 1984-09-14. PMID:6147095. |
we reported previously that pancreatic somatostatin and glucagon content and d and a cells are reduced in spontaneously diabetic bb rats while portal plasma levels of these hormones are elevated but normalized by insulin therapy. |
1984-09-14 |
2023-08-12 |
rat |
| M D Ruggere, Y C Pate. Somatostatin, glucagon, and insulin secretion from perfused pancreas of BB rats. The American journal of physiology. vol 247. issue 2 Pt 1. 1984-09-14. PMID:6147095. |
a theophylline-induced paradoxical inhibition of somatostatin secretion that was normalized by insulin was found in insulin-openic diabetic rats. |
1984-09-14 |
2023-08-12 |
rat |