| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Theodosia Maina, Berthold Nock, Anastasia Nikolopoulou, Petros Sotiriou, George Loudos, Dimitrios Maintas, Paul Cordopatis, Efstratios Chiotelli. [99mTc]Demotate, a new 99mTc-based [Tyr3]octreotate analogue for the detection of somatostatin receptor-positive tumours: synthesis and preclinical results. European journal of nuclear medicine and molecular imaging. vol 29. issue 6. 2003-01-07. PMID:12029547. |
the affinity of the unlabelled peptide for somatostatin receptors is high (ic(50)=0.13 n m) and comparable to that of [tyr3]octreotate or [tyr3]octreotide, as demonstrated by competition binding experiments in rat brain cortex or ar42j cell membrane preparations. |
2003-01-07 |
2023-08-12 |
mouse |
| F Tang, S Nag, S Y W Shiu, S F Pan. The effects of melatonin and Ginkgo biloba extract on memory loss and choline acetyltransferase activities in the brain of rats infused intracerebroventricularly with beta-amyloid 1-40. Life sciences. vol 71. issue 22. 2002-12-03. PMID:12354581. |
intraventricular infusion of rats with beta-amyloid for 14 days resulted in memory deficit in the water maze as well as decreases in choline acetyltransferase activities and somatostatin levels in the cerebral cortex and hippocampus. |
2002-12-03 |
2023-08-12 |
rat |
| Domenico Rubello, Chuong Bui, Dario Casara, Milton D Gross, Lorraine M Fig, Brahm Shapir. Functional scintigraphy of the adrenal gland. European journal of endocrinology. vol 147. issue 1. 2002-08-26. PMID:12088915. |
agents widely used in clinical practice include: (a) uptake and storage of radiolabelled cholesterol analogues via the low density lipoprotein (ldl) receptor and cholesterol ester storage pool in the adrenal cortex ((131)i-6-beta-iodomethyl-norcholesterol, (75)se-selenomethyl-norcholesterol); (b) catecholamine type i, presynaptic, uptake mechanism and intracellular granule uptake and storage mechanism in the adrenal medulla and extra-adrenal paraganglia ((131)i-, (123)i- and (124)i-meta-iodo-benzyl-guanidine (mibg), (18)f-metafluoro-benzyl-guanidine); (c) cell surface receptor binding of peptides/neurotransmitters/modulators such as for the family of five subtypes of somatostatin receptors ((123)i-tyr-octreotide, (111)in-dtpa-octreotide, (111)in-dota-octreotide and many others); (d) although not specific for the adrenal gland, increased glycolysis by tumours, particularly the most malignant varieties, (18)f-2-fluoro-d-deoxyglucose can thus be expected to depict certain malignant lesions such as malignant pheochromocytomas (particularly the minority which are not detected by mibg) and adrenal incidentalomas (particularly when they occur in patients with known extra-adrenal malignancies). |
2002-08-26 |
2023-08-12 |
Not clear |
| P Cervera, C Videau, C Viollet, C Petrucci, J Lacombe, R Winsky-Sommerer, Z Csaba, L Helboe, C Daumas-Duport, J C Reubi, J Epelbau. Comparison of somatostatin receptor expression in human gliomas and medulloblastomas. Journal of neuroendocrinology. vol 14. issue 6. 2002-07-18. PMID:12047721. |
the expression of the five somatostatin receptor subtypes, sst1-5 was compared on tissue containing glial tumours (glioblastomas or oligodendrogliomas), medulloblastomas, and on normal human cortex. |
2002-07-18 |
2023-08-12 |
human |
| R M Izquierdo-Claros, M C Boyano-Adánez, G Torrecillas, M Rodríguez-Puyol, E Arilla-Ferreir. Acute modulation of somatostatin receptor function by melatonin in the rat frontoparietal cortex. Journal of pineal research. vol 31. issue 1. 2002-01-22. PMID:11485004. |
acute modulation of somatostatin receptor function by melatonin in the rat frontoparietal cortex. |
2002-01-22 |
2023-08-12 |
rat |
| A D Spier, L de Lece. Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain research. Brain research reviews. vol 33. issue 2-3. 2001-01-08. PMID:11011067. |
however, cortistatin also has many properties distinct from somatostatin including induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. |
2001-01-08 |
2023-08-12 |
mouse |
| T C Kang, S K Park, S G Do, J G Suh, S M Jo, Y S Oh, Y G Jeong, M H Wo. The over-expression of somatostatin in the gerbil entorhinal cortex induced by seizure. Brain research. vol 882. issue 1-2. 2000-12-28. PMID:11056184. |
the over-expression of somatostatin in the gerbil entorhinal cortex induced by seizure. |
2000-12-28 |
2023-08-12 |
Not clear |
| R M Izquierdo-Claros, M del Boyano-Adánez, E Arilla-Ferreir. Activation of D1 and D2 dopamine receptors increases the activity of the somatostatin receptor-effector system in the rat frontoparietal cortex. Journal of neuroscience research. vol 62. issue 1. 2000-11-30. PMID:11002291. |
activation of d1 and d2 dopamine receptors increases the activity of the somatostatin receptor-effector system in the rat frontoparietal cortex. |
2000-11-30 |
2023-08-12 |
rat |
| A Martínez-Ferrer, M C Boyano-Adánez, R M Izquierdo-Claros, E Arilla-Ferreir. Diazepam attenuation of somatostatin binding and effect of somatostatin on accumulation of inositol 1,4,5-trisphosphate in the rat frontoparietal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 2. 2000-09-06. PMID:10882844. |
diazepam attenuation of somatostatin binding and effect of somatostatin on accumulation of inositol 1,4,5-trisphosphate in the rat frontoparietal cortex. |
2000-09-06 |
2023-08-12 |
rat |
| P T Schwartz, B Perez-Villamil, A Rivera, R Moratalla, M Vallej. Pancreatic homeodomain transcription factor IDX1/IPF1 expressed in developing brain regulates somatostatin gene transcription in embryonic neural cells. The Journal of biological chemistry. vol 275. issue 25. 2000-08-16. PMID:10751390. |
cellular colocalization of idx1/ipf1 and somatostatin was found in several areas of the developing brain, including cortex, ganglionic eminence, hypothalamus, and inferior colliculus. |
2000-08-16 |
2023-08-12 |
rat |
| J F Smiley, J P McGinnis, D C Javit. Nitric oxide synthase interneurons in the monkey cerebral cortex are subsets of the somatostatin, neuropeptide Y, and calbindin cells. Brain research. vol 863. issue 1-2. 2000-07-14. PMID:10773208. |
nitric oxide synthase interneurons in the monkey cerebral cortex are subsets of the somatostatin, neuropeptide y, and calbindin cells. |
2000-07-14 |
2023-08-12 |
monkey |
| E Bologna, P Lerou. Identification of multiple somatostatin receptors in the rat somatosensory cortex during development. The Journal of comparative neurology. vol 420. issue 4. 2000-05-31. PMID:10805921. |
identification of multiple somatostatin receptors in the rat somatosensory cortex during development. |
2000-05-31 |
2023-08-12 |
rat |
| E Bologna, P Lerou. Identification of multiple somatostatin receptors in the rat somatosensory cortex during development. The Journal of comparative neurology. vol 420. issue 4. 2000-05-31. PMID:10805921. |
the present study was aimed at identifying somatostatin receptor subtypes on the basis of their ligand-binding properties in the rat somatosensory cortex during fetal and postnatal development. |
2000-05-31 |
2023-08-12 |
rat |
| S Nag, B K Yee, F Tan. Reduction in somatostatin and substance P levels and choline acetyltransferase activity in the cortex and hippocampus of the rat after chronic intracerebroventricular infusion of beta-amyloid (1-40). Brain research bulletin. vol 50. issue 4. 1999-12-28. PMID:10582523. |
reduction in somatostatin and substance p levels and choline acetyltransferase activity in the cortex and hippocampus of the rat after chronic intracerebroventricular infusion of beta-amyloid (1-40). |
1999-12-28 |
2023-08-12 |
rat |
| A Barnea, J Robert. An improved method for dissociation and aggregate culture of human fetal brain cells in serum-free medium. Brain research. Brain research protocols. vol 4. issue 2. 1999-10-12. PMID:10446410. |
50 (1997) 605-617; a. barnea, j. roberts, r.h. ho, evidence for a synergistic effect of the hiv-1 envelope protein gp120 and brain-derived neurotrophic factor (bdnf) leading to enhanced expression of somatostatin neurons in aggregate cultures derived from the human fetal cortex, brain res. |
1999-10-12 |
2023-08-12 |
human |
| J G Sutcliffe, L de Lece. Novel neurotransmitters for sleep and energy homeostasis. Results and problems in cell differentiation. vol 26. 1999-10-06. PMID:10453467. |
one postnatal-onset mrna, restricted to sparse gabaergic interneurons of the cerebral cortex and hippocampus, encodes preprocortistatin, the precursor of a 14-residue peptide that shares 11 amino acids with somatostatin. |
1999-10-06 |
2023-08-12 |
Not clear |
| M Händel, S Schulz, A Stanarius, M Schreff, M Erdtmann-Vourliotis, H Schmidt, G Wolf, V Höll. Selective targeting of somatostatin receptor 3 to neuronal cilia. Neuroscience. vol 89. issue 3. 1999-07-07. PMID:10199624. |
using specific anti-peptide antisera, we observed somatostatin receptor 3-like immunoreactivity in many brain regions, including the cerebral cortex, hippocampus, hypothalamus, amygdala and cerebellum. |
1999-07-07 |
2023-08-12 |
Not clear |
| P Liniger, J M Burgunder, T Lauterburg, G Kaise. Expression of cholecystokinin and somatostatin in the cortex of hydrocephalic and normal HTx rats. European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie. vol 8 Suppl 1. 1999-04-07. PMID:9926335. |
expression of cholecystokinin and somatostatin in the cortex of hydrocephalic and normal htx rats. |
1999-04-07 |
2023-08-12 |
rat |
| X Kong, R Ren, L Li. [Effects of zinc deficiency in fodder on brain development, learning and memory in rats]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. vol 31. issue 5. 1999-02-26. PMID:9812610. |
results showed that 1. brain weight, hippocampal weight, and serum and hippocampal zinc concentrations were significantly lower in zd group than those in controls; 2. proportion of induced long-term potentiation (ltp) was zero in zd group and proportion of active avoidance response decreased profoundly in zd group, significantly lower than that in normal controls whose ltp proportion was 100%; 3. concentrations of excitatory and inhibitory amino acids, glutamic acid, gamma-aminobutyric acid in cerebral cortex and hippocampus and nitrous oxide in hippocampus were significantly higher in zd group than those in normal one, and content of somatostatin in hippocampus and dna in pyramidocytes were significantly lower in zd group than those in normal one; and 4. number of synaptic vesicles in pyramidocytes of hippocampus decreased obviously in zd group. |
1999-02-26 |
2023-08-12 |
rat |
| A Barnea, J Roberts, R H H. Evidence for a synergistic effect of the HIV-1 envelope protein gp120 and brain-derived neurotrophic factor (BDNF) leading to enhanced expression of somatostatin neurons in aggregate cultures derived from the human fetal cortex. Brain research. vol 815. issue 2. 1999-02-26. PMID:9878821. |
evidence for a synergistic effect of the hiv-1 envelope protein gp120 and brain-derived neurotrophic factor (bdnf) leading to enhanced expression of somatostatin neurons in aggregate cultures derived from the human fetal cortex. |
1999-02-26 |
2023-08-12 |
human |