| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E C Griffiths, S L Jeffcoate, D T Hollan. Local degradation of growth hormone-release-inhibiting hormone (somatostatin) in the central nervous system. Neuroscience letters. vol 4. issue 1. 2012-10-02. PMID:19604916. |
somatostatin was also detected in significant quantities in fractions from the thalamus, hypothalamus, and cortex, after peptidase activity had been removed by heat denaturation. |
2012-10-02 |
2023-08-12 |
rat |
| Meinrad Drexel, Elke Kirchmair, Anna Wieselthaler-Hölzl, Adrian Patrick Preidt, Günther Sper. Somatostatin and neuropeptide Y neurons undergo different plasticity in parahippocampal regions in kainic acid-induced epilepsy. Journal of neuropathology and experimental neurology. vol 71. issue 4. 2012-05-07. PMID:22437342. |
somatostatin messenger rna (mrna) is rapidly but transiently expressed de novo in pyramidal neurons of the subiculum and entorhinal cortex 24 hours after ka. |
2012-05-07 |
2023-08-12 |
human |
| Nada Zecevic, Frances Hu, Igor Jakovcevsk. Interneurons in the developing human neocortex. Developmental neurobiology. vol 71. issue 1. 2011-11-29. PMID:21154907. |
neuropeptide y, somatostatin, or parvalbumin cells are sparse in mid-term cerebral cortex. |
2011-11-29 |
2023-08-12 |
human |
| Peter C Brunjes, Rachel B Kay, J P Arrivillag. The mouse olfactory peduncle. The Journal of comparative neurology. vol 519. issue 14. 2011-11-15. PMID:21618219. |
an immunohistochemical analysis demonstrated that all peduncular regions (pe, pp, the dorsal peduncular cortex, ventral tenia tecta, and anterior olfactory tubercle and piriform cortex) have cells that express either calbindin, calretinin, parvalbumin, somatostatin, vasoactive intestinal polypeptide, neuropeptide y, or cholecystokinin (antigens commonly co-expressed by subspecies of γ-aminobutyric acid [gaba]ergic neurons), although the relative numbers of each cell type differ between zones. |
2011-11-15 |
2023-08-12 |
mouse |
| Hanna Pisarek, Roman Krupiński, Robert Kubiak, Edyta Borkowska, Marek Pawlikowski, Katarzyna Winczy. Differential expression of somatostatin receptor subtype-related genes and proteins in non-functioning and functioning adrenal cortex adenomas. Molecular medicine reports. vol 4. issue 5. 2011-11-01. PMID:21720716. |
differential expression of somatostatin receptor subtype-related genes and proteins in non-functioning and functioning adrenal cortex adenomas. |
2011-11-01 |
2023-08-12 |
Not clear |
| Qing Xu, Lihua Guo, Holly Moore, Ronald R Waclaw, Kenneth Campbell, Stewart A Anderso. Sonic hedgehog signaling confers ventral telencephalic progenitors with distinct cortical interneuron fates. Neuron. vol 65. issue 3. 2010-03-15. PMID:20159447. |
interneurons in the cerebral cortex regulate cortical functions through the actions of distinct subgroups that express parvalbumin, somatostatin, or calretinin. |
2010-03-15 |
2023-08-12 |
Not clear |
| Manfred J Oswald, David N Palmer, Graham W Kay, Karen J Barwell, Jonathan D Coope. Location and connectivity determine GABAergic interneuron survival in the brains of South Hampshire sheep with CLN6 neuronal ceroid lipofuscinosis. Neurobiology of disease. vol 32. issue 1. 2009-05-21. PMID:18634879. |
loss of parvalbumin positive neurons from the affected cortex was apparent at four months and became profound by 19 months, as was somatostatin positive neuron loss to a lesser extent. |
2009-05-21 |
2023-08-12 |
Not clear |
| M Tejeda, D Gaal, L Hullán, O Csuka, R Schwab, O Szokoloczi, G Y Kér. Continuous administration of the somatostatin structural derivative /TT-232/ by subcutaneously implanted osmotic pump improves the efficacy and potency of antitumor therapy in different mouse and human tumor models. Anticancer research. vol 28. issue 5A. 2008-12-16. PMID:19035308. |
this somatostatin structural derivative has no gh release inhibitory or antisecretory activity and does not bind to rat pituitary or the cortex, where all the known somatostatin receptor subtypes are expressed. |
2008-12-16 |
2023-08-12 |
mouse |
| Alicia Rubio, Mar Pérez, Luis de Lecea, Jesús Avil. Effect of cortistatin on tau phosphorylation at Ser262 site. Journal of neuroscience research. vol 86. issue 11. 2008-09-30. PMID:18438934. |
both somatostatin and cortistatin induce tau phosphorylation at ser262, a site modified in alzheimer's disease, although with different kinetics in cortex. |
2008-09-30 |
2023-08-12 |
mouse |
| Stephen V Straub, Adrian D Bonev, M Keith Wilkerson, Mark T Nelso. Dynamic inositol trisphosphate-mediated calcium signals within astrocytic endfeet underlie vasodilation of cerebral arterioles. The Journal of general physiology. vol 128. issue 6. 2007-02-09. PMID:17130519. |
regenerative ca(2+) release processes within the endfeet were evident, as were localized regions of ca(2+) release, and treatment of slices with the vasoactive neuropeptides somatostatin and vasoactive intestinal peptide was capable of inducing endfoot [ca(2+)](i) increases, suggesting the potential for signaling between local interneurons and astrocytic endfeet in the cortex. |
2007-02-09 |
2023-08-12 |
Not clear |
| Anna Maria Lavezzi, Giulia Ottaviani, Maria Mauri, Luigi Matturr. Alterations of biological features of the cerebellum in sudden perinatal and infant death. Current molecular medicine. vol 6. issue 4. 2006-09-05. PMID:16900666. |
besides the ontogenesis of the cerebellar cortex in man, we reported alterations of biopathological features (neuronal immaturity, altered apoptotic programs, negative expression of somatostatin and en2 gene, intense c-fos expression positivity, astrogliosis) in the cortex and in the dentate nucleus of the 63% of sudden deaths, and only in 10% of the controls. |
2006-09-05 |
2023-08-12 |
Not clear |
| A J McDonald, F Mascagn. Differential expression of Kv3.1b and Kv3.2 potassium channel subunits in interneurons of the basolateral amygdala. Neuroscience. vol 138. issue 2. 2006-08-16. PMID:16413129. |
in the cortex these subunits are mainly associated with fast-firing gabaergic interneurons containing parvalbumin or somatostatin. |
2006-08-16 |
2023-08-12 |
rat |
| Qing Xu, Carl P Wonders, Stewart A Anderso. Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon. Development (Cambridge, England). vol 132. issue 22. 2006-01-17. PMID:16221724. |
these results are corroborated by the examination of nestincre:shh(fl/fl) cortex at postnatal day 12, in which there is a dramatic reduction in cell profiles that express somatostatin or parvalbumin. |
2006-01-17 |
2023-08-12 |
mouse |
| Rosa Maria Facciolo, Maria Madeo, Raffaella Alò, Marcello Canonaco, Francesco Dessì-Fulgher. Neurobiological effects of bisphenol A may be mediated by somatostatin subtype 3 receptors in some regions of the developing rat brain. Toxicological sciences : an official journal of the Society of Toxicology. vol 88. issue 2. 2006-01-10. PMID:16162846. |
one type of action, with respect to animals treated with vehicle alone, consisted of a very strong (p < 0.001) decrease of somatostatin receptor subtype 3 mrna levels in layer v of the frontoparietal cortex of adult rats (sprague-dawley) after transplacental and lactational exposure to bisphenol a (400 microg/kg/day). |
2006-01-10 |
2023-08-12 |
rat |
| U Kuma. Expression of somatostatin receptor subtypes (SSTR1-5) in Alzheimer's disease brain: an immunohistochemical analysis. Neuroscience. vol 134. issue 2. 2005-11-15. PMID:15961235. |
somatostatin levels are consistently decreased in the cortex of alzheimer's disease (ad) brain and in cerebrospinal fluid, and have become reproducible markers of this disease. |
2005-11-15 |
2023-08-12 |
human |
| Avron D Spier, Véronique Fabre, Luis de Lece. Cortistatin radioligand binding in wild-type and somatostatin receptor-deficient mouse brain. Regulatory peptides. vol 124. issue 1-3. 2005-10-06. PMID:15544857. |
in somatostatin receptor subtype-2 knock-out (ko) mice, autoradiographic iodinated somatostatin-14 binding was observed in the hippocampus and habenula but was removed in the cortex and amygdaloid nuclei, specific iodinated cortistatin-14 binding sites were found in the hippocampus, habenula and throughout the cortex. |
2005-10-06 |
2023-08-12 |
mouse |
| M I Ransome, A M Turnle. Analysis of neuronal subpopulations in mice over-expressing suppressor of cytokine signaling-2. Neuroscience. vol 132. issue 3. 2005-08-30. PMID:15837129. |
in the cortex, parvalbumin and somatostatin expressing neuron densities were unaffected, while calretinin and calbindin positive neuronal densities increased by 48% and 45% respectively. |
2005-08-30 |
2023-08-12 |
mouse |
| Vicente Barrios, Lilian Puebla-Jiménez, María del Carmen Boyano-Adánez, Manuel Sanz, Leandro Soriano-Guillén, Eduardo Arilla-Ferreir. Differential effects of ethanol ingestion on somatostatin content, somatostatin receptors and adenylyl cyclase activity in the frontoparietal cortex of virgin and parturient rats. Life sciences. vol 77. issue 10. 2005-08-02. PMID:15978264. |
differential effects of ethanol ingestion on somatostatin content, somatostatin receptors and adenylyl cyclase activity in the frontoparietal cortex of virgin and parturient rats. |
2005-08-02 |
2023-08-12 |
rat |
| Ralf K Stumm, Chun Zhou, Stefan Schulz, Matthias Endres, Golo Kronenberg, Jeremy P Allen, Giovanni Tulipano, Volker Höll. Somatostatin receptor 2 is activated in cortical neurons and contributes to neurodegeneration after focal ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 50. 2005-07-21. PMID:15601946. |
somatostatin receptor 2 (sstr2) mediates neuromodulatory signals of somatostatin and cortistatin in the cerebral cortex. |
2005-07-21 |
2023-08-12 |
mouse |
| Alena Savonenko, Guilian M Xu, Tatiana Melnikova, Johanna L Morton, Victoria Gonzales, Molly P F Wong, Donald L Price, Fai Tang, Alicja L Markowska, David R Borchel. Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities. Neurobiology of disease. vol 18. issue 3. 2005-05-17. PMID:15755686. |
in the 18-month-old cohorts, amyloid burdens were much higher in appswe/ps1de9 mice with statistically significant but mild decreases in cholinergic markers (cortex and hippocampus) and somatostatin levels (cortex). |
2005-05-17 |
2023-08-12 |
mouse |