| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Timothy W Rhoads, Jared R Williams, Nathan I Lopez, Jeffrey T Morré, C Samuel Bradford, Joseph S Beckma. Using theoretical protein isotopic distributions to parse small-mass-difference post-translational modifications via mass spectrometry. Journal of the American Society for Mass Spectrometry. vol 24. issue 1. 2013-07-01. PMID:23247967. |
using these methods, we could resolve the relative contributions of copper and zinc binding, as well as disulfide reduction to intact sod1 protein present from <100 μg of the lumbar spinal cord of a transgenic, sod1 overexpressing mouse. |
2013-07-01 |
2023-08-12 |
mouse |
| Michael P Hefferan, Jan Galik, Osamu Kakinohana, Gabriela Sekerkova, Camila Santucci, Silvia Marsala, Roman Navarro, Marian Hruska-Plochan, Karl Johe, Eva Feldman, Don W Cleveland, Martin Marsal. Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation. PloS one. vol 7. issue 8. 2013-05-15. PMID:22916141. |
previous experimental studies have shown that spinal grafting of human fetal spinal neural stem cells (hnscs) into the lumbar spinal cord of sod1(g93a) rats leads to a moderate therapeutical effect as evidenced by local α-motoneuron sparing and extension of lifespan. |
2013-05-15 |
2023-08-12 |
human |
| Michael P Hefferan, Jan Galik, Osamu Kakinohana, Gabriela Sekerkova, Camila Santucci, Silvia Marsala, Roman Navarro, Marian Hruska-Plochan, Karl Johe, Eva Feldman, Don W Cleveland, Martin Marsal. Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation. PloS one. vol 7. issue 8. 2013-05-15. PMID:22916141. |
the aim of the present study was to analyze the degree of therapeutical effect of hnscs once grafted into the lumbar spinal ventral horn in presymptomatic immunosuppressed sod1(g93a) rats and to assess the presence and functional integrity of the descending motor system in symptomatic sod1(g93a) animals. |
2013-05-15 |
2023-08-12 |
human |
| Caty Casas, Mireia Herrando-Grabulosa, Raquel Manzano, Renzo Mancuso, Rosario Osta, Xavier Navarr. Early presymptomatic cholinergic dysfunction in a murine model of amyotrophic lateral sclerosis. Brain and behavior. vol 3. issue 2. 2013-03-28. PMID:23531559. |
the analysis showed an early reduction in chat content in soma and presynaptic boutons apposed onto mns (to 76%) as well as in cholinergic interneurons in the lumbar spinal cord of the 30-day-old sod1(g93a) mice. |
2013-03-28 |
2023-08-12 |
mouse |
| Ernesto Miquel, Adriana Cassina, Laura Martínez-Palma, Carmen Bolatto, Emiliano Trías, Mandi Gandelman, Rafael Radi, Luis Barbeito, Patricia Cassin. Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis. PloS one. vol 7. issue 4. 2012-08-07. PMID:22509356. |
systemic dca also normalized the reduced rcr value measured in lumbar spinal cord tissue of diseased sod1(g93a) mice. |
2012-08-07 |
2023-08-12 |
mouse |
| Jean-Nicolas Audet, Geneviève Gowing, Renée Paradis, Geneviève Soucy, Jean-Pierre Julie. Ablation of proliferating cells in the CNS exacerbates motor neuron disease caused by mutant superoxide dismutase. PloS one. vol 7. issue 4. 2012-08-03. PMID:22523565. |
ara-c treatment caused substantial decreases in the number of microglia, ng2+ progenitors, olig2+ cells and cd3+ t cells in the lumbar spinal cord of symptomatic sod1(g93a) transgenic mice. |
2012-08-03 |
2023-08-12 |
mouse |
| A A Filipchuk, J Duran. Postnatal dendritic development in lumbar motoneurons in mutant superoxide dismutase 1 mouse model of amyotrophic lateral sclerosis. Neuroscience. vol 209. 2012-07-30. PMID:22387111. |
in the present study, we examined the morphology of lumbar mns in wild-type (wt) and sod1(g85r) mice at two postnatal ages (p3-p4 and p8-p9) when differences in size and excitability were reported. |
2012-07-30 |
2023-08-12 |
mouse |
| Simona Jurkovic Mlakar, Josko Osredkar, Janez Prezelj, Janja Mar. Antioxidant enzymes GSR, SOD1, SOD2, and CAT gene variants and bone mineral density values in postmenopausal women: a genetic association analysis. Menopause (New York, N.Y.). vol 19. issue 3. 2012-07-11. PMID:22089180. |
furthermore, antioxidant enzymes have been observed to have low protective activity in women with osteoporosis.the aim of the present study was to examine any association of selected gene polymorphisms of the glutathione s-reductase (gsr), superoxide dismutase (sod1 and sod2), and catalase (cat) genes, alone or in combination, with the bone mineral density (bmd) values of femoral neck (fn), lumbar spine (ls), and total hip (th) in slovenian postmenopausal women. |
2012-07-11 |
2023-08-12 |
cat |
| Xiaoxing Ma, Randy Peterson, John Turnbul. Adenylyl cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in G93A SOD1 mice. BMC neuroscience. vol 12. 2012-03-20. PMID:21767396. |
adenylyl cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in g93a sod1 mice. |
2012-03-20 |
2023-08-12 |
mouse |
| Xiaoxing Ma, Randy Peterson, John Turnbul. Adenylyl cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in G93A SOD1 mice. BMC neuroscience. vol 12. 2012-03-20. PMID:21767396. |
we hypothesized that primary cilial dysfunction might play a role in the pathogenesis of amyotrophic lateral sclerosis (als), and as a first step, report on the prevalence of primary cilial markers on cultured motor neurons from the lumbar spinal cord of embryonic wildtype (wt) and transgenic g93a sod1 mice, and on motor neurons in situ in the lumbar spinal cord. |
2012-03-20 |
2023-08-12 |
mouse |
| Michael P Hefferan, Karl Johe, Thomas Hazel, Eva L Feldman, J Simon Lunn, Martin Marsal. Optimization of immunosuppressive therapy for spinal grafting of human spinal stem cells in a rat model of ALS. Cell transplantation. vol 20. issue 8. 2012-03-08. PMID:21669047. |
in the present study we characterized the survival of human spinal stem cells when grafted into the lumbar spinal cords of a rodent model of als, sod1 (g93a) male and female rats (60-67 days old). |
2012-03-08 |
2023-08-12 |
human |
| Hidetoshi Nojiri, Yoshitomo Saita, Daichi Morikawa, Keiji Kobayashi, Chizuru Tsuda, Tsuyoshi Miyazaki, Mitsuru Saito, Keishi Marumo, Ikuho Yonezawa, Kazuo Kaneko, Takuji Shirasawa, Takahiko Shimiz. Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 26. issue 11. 2012-02-08. PMID:22025246. |
we also showed that the surface areas of osteoblasts and osteoclasts were decreased significantly in the lumbar vertebrae of sod1(-/-) mice, indicating the occurrence of low-turnover osteopenia. |
2012-02-08 |
2023-08-12 |
mouse |
| Gary J Cowin, Tim J Butler, Nyoman D Kurniawan, Charles Watson, Robyn H Wallac. Magnetic resonance microimaging of the spinal cord in the SOD1 mouse model of amyotrophic lateral sclerosis detects motor nerve root degeneration. NeuroImage. vol 58. issue 1. 2011-11-23. PMID:21689764. |
mrm at 15μm in plane resolution enabled the axons of pure populations of sensory and motor neurons to be measured in the lumbar region of the sod1 mouse model of als. |
2011-11-23 |
2023-08-12 |
mouse |
| Gary J Cowin, Tim J Butler, Nyoman D Kurniawan, Charles Watson, Robyn H Wallac. Magnetic resonance microimaging of the spinal cord in the SOD1 mouse model of amyotrophic lateral sclerosis detects motor nerve root degeneration. NeuroImage. vol 58. issue 1. 2011-11-23. PMID:21689764. |
mrm signal intensity increased by 38.3% (p<0.05) exclusively in the ventral motor nerve roots of the lumbar spinal cord of als-affected sod1 mice compared to wildtype littermates. |
2011-11-23 |
2023-08-12 |
mouse |
| Ji Hyeon Ahn, Jung Hoon Choi, Jin Sang Kim, Hyun Joo Lee, Choong Hyun Lee, Ki-Yeon Yoo, In Koo Hwang, Yun Lyul Lee, Hyung-Cheul Shin, Moo-Ho Wo. Comparison of immunoreactivities in 4-HNE and superoxide dismutases in the cervical and the lumbar spinal cord between adult and aged dogs. Experimental gerontology. vol 46. issue 8. 2011-10-14. PMID:21396438. |
in the present study, we compared the neuronal distribution and immunoreactivities of 4-hydroxy-2e-nonenal (4-hne, end product of lipid peroxidation), and superoxide dismutase 1 (sod1) and sod2 in the cervical and lumbar spinal cord between adult (2-3 years) and aged (10-12 years) dogs. |
2011-10-14 |
2023-08-12 |
dog |
| Leyan Xu, Peilin Shen, Thomas Hazel, Karl Johe, Vassilis E Koliatso. Dual transplantation of human neural stem cells into cervical and lumbar cord ameliorates motor neuron disease in SOD1 transgenic rats. Neuroscience letters. vol 494. issue 3. 2011-08-17. PMID:21402124. |
dual transplantation of human neural stem cells into cervical and lumbar cord ameliorates motor neuron disease in sod1 transgenic rats. |
2011-08-17 |
2023-08-12 |
human |
| Leyan Xu, Peilin Shen, Thomas Hazel, Karl Johe, Vassilis E Koliatso. Dual transplantation of human neural stem cells into cervical and lumbar cord ameliorates motor neuron disease in SOD1 transgenic rats. Neuroscience letters. vol 494. issue 3. 2011-08-17. PMID:21402124. |
in the present study, we transplanted human neural stem cells (nscs) into the ventral horn of both the lumbar (l4-l5) and cervical (c4-c5) protuberance of sod1 g93a rats, in an effort to test the feasibility and general efficacy of a dual grafting paradigm addressing several muscle groups in the front limbs, hind limbs and the respiratory apparatus. |
2011-08-17 |
2023-08-12 |
human |
| Clare K Underwood, Nyoman D Kurniawan, Tim J Butler, Gary J Cowin, Robyn H Wallac. Non-invasive diffusion tensor imaging detects white matter degeneration in the spinal cord of a mouse model of amyotrophic lateral sclerosis. NeuroImage. vol 55. issue 2. 2011-06-10. PMID:21185943. |
here we examine the ability of magnetic resonance imaging (mri) to measure axonal degeneration in the lumbar spinal cord of the sod1 mouse model of als. |
2011-06-10 |
2023-08-12 |
mouse |
| Clare K Underwood, Nyoman D Kurniawan, Tim J Butler, Gary J Cowin, Robyn H Wallac. Non-invasive diffusion tensor imaging detects white matter degeneration in the spinal cord of a mouse model of amyotrophic lateral sclerosis. NeuroImage. vol 55. issue 2. 2011-06-10. PMID:21185943. |
fractional anisotropy (fa) values were reduced exclusively in the ventral white matter tracts of the lumbar spinal cord of als-affected sod1 mice compared to wild-type littermates, with this effect becoming more pronounced with disease progression. |
2011-06-10 |
2023-08-12 |
mouse |
| Tomomi Sanagi, Shigeki Yuasa, Yasuko Nakamura, Eri Suzuki, Masashi Aoki, Hitoshi Warita, Yasuto Itoyama, Shigeo Uchino, Shinichi Kohsaka, Keiko Ohsaw. Appearance of phagocytic microglia adjacent to motoneurons in spinal cord tissue from a presymptomatic transgenic rat model of amyotrophic lateral sclerosis. Journal of neuroscience research. vol 88. issue 12. 2011-03-11. PMID:20648658. |
in this study, we revealed that activated microglia aggregated in the lumbar spinal cord of presymptomatic mutant sod1(h46r) transgenic rats, an animal model of familial als. |
2011-03-11 |
2023-08-12 |
rat |