| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elodie Martin, William Cazenave, Anne-Emilie Allain, Daniel Cattaert, Pascal Brancherea. Implication of 5-HT in the Dysregulation of Chloride Homeostasis in Prenatal Spinal Motoneurons from the G93A Mouse Model of Amyotrophic Lateral Sclerosis. International journal of molecular sciences. vol 21. issue 3. 2020-11-18. PMID:32046135. |
we recently demonstrated that prenatal e17.5 lumbar spinal motoneurons (mns) from sod1 |
2020-11-18 |
2023-08-13 |
mouse |
| Eric J Granucci, Ana Griciuc, Kaly A Mueller, Alexandra N Mills, Hoang Le, Amanda M Dios, Danielle McGinty, Joao Pereira, David Elmaleh, James D Berry, Sabrina Paganoni, Merit E Cudkowicz, Rudolph E Tanzi, Ghazaleh Sadri-Vakil. Cromolyn sodium delays disease onset and is neuroprotective in the SOD1 Scientific reports. vol 9. issue 1. 2020-11-03. PMID:31776380. |
previous reports have demonstrated an increase in microgliosis and astrogliosis in the lumbar spinal cord of sod1 |
2020-11-03 |
2023-08-13 |
Not clear |
| Nathan Duval, Whitney A Sumner, Anna G Andrianakos, Josie J Gray, Ron J Bouchard, Heather M Wilkins, Daniel A Linsema. The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29440992. |
large alpha motor neurons in lumbar spinal cord sections of both wt and end-stage mutant sod1 mice stained positively for a number of bh3-only proteins; however, no discernible differences were observed in either the relative intensity of staining or number of bh3-immunoreactive motor neurons between wt and mutant sod1 mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Nathan Duval, Whitney A Sumner, Anna G Andrianakos, Josie J Gray, Ron J Bouchard, Heather M Wilkins, Daniel A Linsema. The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29440992. |
staining of additional end-stage g93a mutant sod1 tissues showed specific upregulation of dp5/hrk in lumbar spinal cord sections, but not in cerebellum or cortex. |
2020-10-01 |
2023-08-13 |
mouse |
| Nathan Duval, Whitney A Sumner, Anna G Andrianakos, Josie J Gray, Ron J Bouchard, Heather M Wilkins, Daniel A Linsema. The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29440992. |
finally, examination of protein expression using western blotting also revealed marked increases in dp5/hrk and bnip3l in g93a mutant sod1 lumbar spinal cord lysates compared to wt controls. |
2020-10-01 |
2023-08-13 |
mouse |
| Cristina Zalfa, Laura Rota Nodari, Elena Vacchi, Maurizio Gelati, Daniela Profico, Marina Boido, Elena Binda, Lidia De Filippis, Massimiliano Copetti, Valentina Garlatti, Paola Daniele, Jessica Rosati, Alessandro De Luca, Francesca Pinos, Laura Cajola, Alberto Visioli, Letizia Mazzini, Alessandro Vercelli, Maria Svelto, Angelo Luigi Vescovi, Daniela Ferrar. Transplantation of clinical-grade human neural stem cells reduces neuroinflammation, prolongs survival and delays disease progression in the SOD1 rats. Cell death & disease. vol 10. issue 5. 2020-05-19. PMID:31024007. |
the hnscs were transplanted bilaterally into the anterior horns of the lumbar spinal cord (four grafts each, segments l3-l4) of superoxide dismutase 1 g93a transgenic rats (sod1 rats) at the symptomatic stage. |
2020-05-19 |
2023-08-13 |
human |
| b' Monika \\xc5\\x98eho\\xc5\\x99ov\\xc3\\xa1, Ingrid Vargov\\xc3\\xa1, Serhiy Forostyak, Irena Vackov\\xc3\\xa1, Karol\\xc3\\xadna Turnovcov\\xc3\\xa1, Helena Kupcov\\xc3\\xa1 Skaln\\xc3\\xadkov\\xc3\\xa1, Petr Vodi\\xc4\\x8dka, \\xc5\\xa0\\xc3\\xa1rka Kubinov\\xc3\\xa1, Eva Sykov\\xc3\\xa1, Pavla Jendelov\\xc3\\xa. A Combination of Intrathecal and Intramuscular Application of Human Mesenchymal Stem Cells Partly Reduces the Activation of Necroptosis in the Spinal Cord of SOD1 Stem cells translational medicine. vol 8. issue 6. 2020-04-30. PMID:30802001.' |
we compared the effect of repeated intrathecal applications of hmsc or their conditioned medium (condm) using lumbar puncture or injection into the muscle (quadriceps femoris), or a combination of both applications in symptomatic sod1 |
2020-04-30 |
2023-08-13 |
human |
| Mariana Bravo-Hernandez, Takahiro Tadokoro, Michael R Navarro, Oleksandr Platoshyn, Yoshiomi Kobayashi, Silvia Marsala, Atsushi Miyanohara, Stefan Juhas, Jana Juhasova, Helena Skalnikova, Zoltan Tomori, Ivo Vanicky, Hana Studenovska, Vladimir Proks, PeiXi Chen, Noe Govea-Perez, Dara Ditsworth, Joseph D Ciacci, Shang Gao, Wenlian Zhu, Eric T Ahrens, Shawn P Driscoll, Thomas D Glenn, Melissa McAlonis-Downes, Sandrine Da Cruz, Samuel L Pfaff, Brian K Kaspar, Don W Cleveland, Martin Marsal. Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS. Nature medicine. vol 26. issue 1. 2020-04-13. PMID:31873312. |
one-time injection at cervical and lumbar levels just before disease onset in mice expressing a familial amyotrophic lateral sclerosis (als)-causing mutant sod1 produces long-term suppression of motoneuron disease, including near-complete preservation of spinal α-motoneurons and muscle innervation. |
2020-04-13 |
2023-08-13 |
mouse |
| Mariángeles Kovacs, Emiliano Trias, Valentina Varela, Sofia Ibarburu, Joseph S Beckman, Ivan C Moura, Olivier Hermine, Peter H King, Ying Si, Yuri Kwon, Luis Barbeit. CD34 Identifies a Subset of Proliferating Microglial Cells Associated with Degenerating Motor Neurons in ALS. International journal of molecular sciences. vol 20. issue 16. 2020-01-15. PMID:31395804. |
immunohistochemistry for cd34 and microglia markers was performed in lumbar spinal cords of als rats bearing the sod1 |
2020-01-15 |
2023-08-13 |
rat |
| Lorenzo Schiaffino, Roberta Bonafede, Ilaria Scambi, Edoardo Parrella, Marina Pizzi, Raffaella Mariott. Acetylation state of RelA modulated by epigenetic drugs prolongs survival and induces a neuroprotective effect on ALS murine model. Scientific reports. vol 8. issue 1. 2019-10-29. PMID:30150770. |
here we showed that the pro-apoptotic acetylation mode of rela, involving a general lysine deacetylation of the subunit with the exclusion of the lysine 310, is evident in the lumbar spinal cord of sod1(g93a) mice, a murine model of als. |
2019-10-29 |
2023-08-13 |
mouse |
| Lorenzo Schiaffino, Roberta Bonafede, Ilaria Scambi, Edoardo Parrella, Marina Pizzi, Raffaella Mariott. Acetylation state of RelA modulated by epigenetic drugs prolongs survival and induces a neuroprotective effect on ALS murine model. Scientific reports. vol 8. issue 1. 2019-10-29. PMID:30150770. |
the epigenetic treatment rescued the lumbar motor neurons affected in sod1(g93a) mice, accompanied by increased levels of protein products of nf-kb-target genes, bcl-xl and brain-derived neurotrophic factor. |
2019-10-29 |
2023-08-13 |
mouse |
| Elaheh Ekhtiari Bidhendi, Johan Bergh, Per Zetterström, Karin Forsberg, Bente Pakkenberg, Peter M Andersen, Stefan L Marklund, Thomas Brännströ. Mutant superoxide dismutase aggregates from human spinal cord transmit amyotrophic lateral sclerosis. Acta neuropathologica. vol 136. issue 6. 2019-10-09. PMID:30284034. |
we have previously reported that two strains of mutant human (h) sod1 aggregates (denoted a and b) can arise in hsod1-transgenic models for als and that inoculation of such aggregates into the lumbar spinal cord of mice results in rostrally spreading, templated hsod1 aggregation and premature fatal als-like disease. |
2019-10-09 |
2023-08-13 |
mouse |
| Thomas Gaj, David S Ojala, Freja K Ekman, Leah C Byrne, Prajit Limsirichai, David V Schaffe. In vivo genome editing improves motor function and extends survival in a mouse model of ALS. Science advances. vol 3. issue 12. 2019-07-02. PMID:29279867. |
genome editing reduced mutant sod1 protein by >2.5-fold in the lumbar and thoracic spinal cord, resulting in improved motor function and reduced muscle atrophy. |
2019-07-02 |
2023-08-13 |
mouse |
| Kathryn Volkening, Brian A Keller, Cheryl Leystra-Lantz, Michael J Stron. RNA and Protein Interactors with TDP-43 in Human Spinal-Cord Lysates in Amyotrophic Lateral Sclerosis. Journal of proteome research. vol 17. issue 4. 2019-06-03. PMID:29513014. |
in this study, we have characterized both protein and rna tdp-43 interactors from neuropathologically normal (control) and als-affected ventral lumbar spinal cord, including sporadic als (sals) and familial cases harboring either a a4t mutant sod1 or a 3' utr *c.41g>a mutant fus/tls or expressing pathological c9orf72 expanded repeats. |
2019-06-03 |
2023-08-13 |
human |
| Kallol Dutta, Priyanka Patel, Jean-Pierre Julie. Protective effects of Withania somnifera extract in SOD1 Experimental neurology. vol 309. 2019-03-04. PMID:30134145. |
our results show that administration of ws extracts by gavage to mice expressing g93a mutant form of superoxide dismutase (sod1) resulted in increased longevity, improved motor performance and increased number of motor neurons in lumbar spinal cord. |
2019-03-04 |
2023-08-13 |
mouse |
| Andrei B Belousov, Hiroshi Nishimune, Janna V Denisova, Joseph D Fonte. A potential role for neuronal connexin 36 in the pathogenesis of amyotrophic lateral sclerosis. Neuroscience letters. vol 666. 2018-12-11. PMID:29246791. |
we show here that the expression of cx36 is significantly decreased in lumbar segments of the spinal cord of both human als subjects and sod1 |
2018-12-11 |
2023-08-13 |
human |
| Tomohiro Ohgomori, Jun Yamada, Hideyuki Takeuchi, Kenji Kadomatsu, Shozo Jinn. Comparative morphometric analysis of microglia in the spinal cord of SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis. The European journal of neuroscience. vol 43. issue 10. 2017-11-16. PMID:26946061. |
to address this issue, here we morphometrically analysed three-dimensionally reconstructed ionized calcium binding adaptor molecule 1-immunoreactive (iba1(+) ) microglia in the ventral horn of the lumbar spinal cord of sod1(g93a) transgenic mice, a model of amyotrophic lateral sclerosis. |
2017-11-16 |
2023-08-13 |
mouse |
| Elaheh Ekhtiari Bidhendi, Johan Bergh, Per Zetterström, Peter M Andersen, Stefan L Marklund, Thomas Brännströ. Two superoxide dismutase prion strains transmit amyotrophic lateral sclerosis-like disease. The Journal of clinical investigation. vol 126. issue 6. 2017-09-13. PMID:27140399. |
here, minute amounts of strain a and b hsod1 aggregate seeds that were prepared by centrifugation through a density cushion were inoculated into lumbar spinal cords of 100-day-old mice carrying a human sod1 tg. |
2017-09-13 |
2023-08-13 |
mouse |
| Xiaoxing Ma, Patrick C Turnbull, Eli Prentice Crapper, Henan Wang, Anna Drannik, Fan Jiang, Sean Xia, John Turnbul. Cytosolic localization of Fox proteins in motor neurons of G93A SOD1 mice. Histochemistry and cell biology. vol 145. issue 5. 2016-12-13. PMID:26724814. |
since altered splicing may be important in the pathogenesis of als, we compared the localization (predominantly nuclear or cytosolic) of all three fox proteins in the lumbar spinal cord of wild-type and g93a sod1 mice before and after the development of clinical signs of disease. |
2016-12-13 |
2023-08-13 |
mouse |
| Takao Fujisawa, Motoo Takahashi, Yuka Tsukamoto, Namiko Yamaguchi, Masayoshi Nakoji, Megumi Endo, Hiroshi Kodaira, Yuki Hayashi, Hideki Nishitoh, Isao Naguro, Kengo Homma, Hidenori Ichij. The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis. Human molecular genetics. vol 25. issue 2. 2016-10-17. PMID:26604152. |
in parallel, immunohistochemical analysis revealed that k811 and k812 treatment inhibited glial activation in the lumbar spinal cord of sod1(g93a) transgenic mice. |
2016-10-17 |
2023-08-13 |
mouse |