| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Amendola, J P Gueritaud, B Lamotte d'Incamps, C Bories, S Liabeuf, C Allene, A Pambo-Pambo, J Duran. Postnatal electrical and morphological abnormalities in lumbar motoneurons from transgenic mouse models of amyotrophic lateral sclerosis. Archives italiennes de biologie. vol 145. issue 3-4. 2008-02-01. PMID:18075124. |
antidromically identified lumbar motoneurons intracellularly recorded in the entire brainstem/spinal cord preparation isolated from sod1(g85r) postnatal mice (p3-p10) were labelled with neurobiotin and fully reconstructed in 3d from serial sections in order to analyse their morphology. |
2008-02-01 |
2023-08-12 |
mouse |
| J Amendola, J P Gueritaud, B Lamotte d'Incamps, C Bories, S Liabeuf, C Allene, A Pambo-Pambo, J Duran. Postnatal electrical and morphological abnormalities in lumbar motoneurons from transgenic mouse models of amyotrophic lateral sclerosis. Archives italiennes de biologie. vol 145. issue 3-4. 2008-02-01. PMID:18075124. |
these results show that the sod1 mutations linked to familial als alter the development of the electrical and morphological properties of lumbar motoneurons. |
2008-02-01 |
2023-08-12 |
mouse |
| Jianhua Zhang, Hidefumi Ito, Reika Wate, Shizuo Ohnishi, Satoshi Nakano, Hirofumi Kusak. Altered distributions of nucleocytoplasmic transport-related proteins in the spinal cord of a mouse model of amyotrophic lateral sclerosis. Acta neuropathologica. vol 112. issue 6. 2007-09-12. PMID:16957927. |
to investigate the involvement of this system in the pathomechanisms of amyotrophic lateral sclerosis (als), we examined the immunohistochemical localization of proteins associated with nucleocytoplasmic transport in the lumbar spinal cord in a mutant sod1 (g93a) transgenic mouse model of als. |
2007-09-12 |
2023-08-12 |
mouse |
| Cyril Bories, Julien Amendola, Boris Lamotte d'Incamps, Jacques Duran. Early electrophysiological abnormalities in lumbar motoneurons in a transgenic mouse model of amyotrophic lateral sclerosis. The European journal of neuroscience. vol 25. issue 2. 2007-04-05. PMID:17284186. |
therefore, we investigated the electrical properties of lumbar motoneurons in an in-vitro neonatal spinal cord preparation isolated from sod1(g85r) mice, which is a transgenic model of amyotrophic lateral sclerosis. |
2007-04-05 |
2023-08-12 |
mouse |
| Edor Kabashi, Heather D Durha. Failure of protein quality control in amyotrophic lateral sclerosis. Biochimica et biophysica acta. vol 1762. issue 11-12. 2007-01-17. PMID:16876390. |
indeed, lumbar spinal cord of mutant sod1 transgenic mice show early reduction in their capacity for protein chaperoning and proteasome-mediated hydrolysis of substrates, and motor neurons are particularly vulnerable to aggregation of mutant sod1. |
2007-01-17 |
2023-08-12 |
mouse |
| Manuela Basso, Tania Massignan, Giuseppina Samengo, Cristina Cheroni, Silvia De Biasi, Mario Salmona, Caterina Bendotti, Valentina Bonett. Insoluble mutant SOD1 is partly oligoubiquitinated in amyotrophic lateral sclerosis mice. The Journal of biological chemistry. vol 281. issue 44. 2006-12-11. PMID:16943203. |
partial ubiquitination of sod1-rich inclusions was also confirmed by immunohistochemical and electron microscopy analysis of lumbar spinal cord sections from symptomatic g93a sod1 mice. |
2006-12-11 |
2023-08-12 |
mouse |
| Julie D Atkin, Manal A Farg, Bradley J Turner, Doris Tomas, Judith A Lysaght, Janelle Nunan, Alan Rembach, Phillip Nagley, Philip M Beart, Surindar S Cheema, Malcolm K Horn. Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1. The Journal of biological chemistry. vol 281. issue 40. 2006-11-30. PMID:16847061. |
proteomic analysis of the transgenic sod1(g93a) als rat model revealed significant up-regulation of endoplasmic reticulum (er)-resident protein-disulfide isomerase (pdi) family members in lumbar spinal cords. |
2006-11-30 |
2023-08-12 |
mouse |
| Yasuyuki Ohta, Makiko Nagai, Tetsuya Nagata, Tetsuro Murakami, Isao Nagano, Hisashi Narai, Tomoko Kurata, Mito Shiote, Mikio Shoji, Koji Ab. Intrathecal injection of epidermal growth factor and fibroblast growth factor 2 promotes proliferation of neural precursor cells in the spinal cords of mice with mutant human SOD1 gene. Journal of neuroscience research. vol 84. issue 5. 2006-11-28. PMID:16902995. |
we investigated three steps of neural precursor cell activation--proliferation, migration, and differentiation--in amyotrophic lateral sclerosis spinal cord treated with intrathecal infusion of epidermal growth factor (egf) and fibroblast growth factor 2 (fgf2) into the lumbar spinal cord region of normal and symptomatic transgenic (tg) mice with a mutant human cu/zn superoxide dismutase (sod1) gene. |
2006-11-28 |
2023-08-12 |
mouse |
| Andrea C Pardo, Victor Wong, Leah M Benson, Margaret Dykes, Kohichi Tanaka, Jeffrey D Rothstein, Nicholas J Maragaki. Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice. Experimental neurology. vol 201. issue 1. 2006-11-14. PMID:16753145. |
dramatic losses of the glt1 protein and reduced glutamate transport in the lumbar spinal cords of the sod1(g93a)/glt1+/- animals were also observed. |
2006-11-14 |
2023-08-12 |
mouse |
| Jacques Durand, Julien Amendola, Cyril Bories, Boris Lamotte d'Incamp. Early abnormalities in transgenic mouse models of amyotrophic lateral sclerosis. Journal of physiology, Paris. vol 99. issue 2-3. 2006-06-28. PMID:16448809. |
moreover, electrical properties of sod1 lumbar motoneurons are altered as early as the second postnatal week when mice begin to walk. |
2006-06-28 |
2023-08-12 |
mouse |
| Marco Virgili, Christophe Crochemore, Emiliano Peña-Altamira, Antonio Contestabil. Regional and temporal alterations of ODC/polyamine system during ALS-like neurodegenerative motor syndrome in G93A transgenic mice. Neurochemistry international. vol 48. issue 3. 2006-06-19. PMID:16290266. |
in parallel with the increase of odc activity putrescine levels were several times increased in both cervical and lumbar spinal cord and in the brain stem of 125-day-old sod1 g39a mice. |
2006-06-19 |
2023-08-12 |
mouse |
| Reika Wate, Hidefumi Ito, Jian Hua Zhang, Shizuo Ohnishi, Satoshi Nakano, Hirofumi Kusak. Expression of an endoplasmic reticulum-resident chaperone, glucose-regulated stress protein 78, in the spinal cord of a mouse model of amyotrophic lateral sclerosis. Acta neuropathologica. vol 110. issue 6. 2006-05-05. PMID:16231159. |
the immunohistochemical localization of glucose-regulated protein 78/bip (grp78), a chaperone protein that primarily resides within the lumen of the endoplasmic reticulum, was investigated in the lumbar spinal cord of mutant copper/zinc superoxide dismutase (sod1) transgenic mice. |
2006-05-05 |
2023-08-12 |
mouse |
| Mahmoud Kiaei, Susanne Petri, Khatuna Kipiani, Gabrielle Gardian, Dong-Kug Choi, Junyu Chen, Noel Y Calingasan, Peter Schafer, George W Muller, Charles Stewart, Kenneth Hensley, M Flint Bea. Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 9. 2006-04-11. PMID:16510725. |
both increased tnf-alpha and fasl immunostaining in the lumbar spinal cord of the g93a sod1 transgenic mice occurred at 40-60 d, well before the onset of symptoms and loss of motor neurons. |
2006-04-11 |
2023-08-12 |
mouse |
| Susanna C Benn, Ilknur Ay, Elena Bastia, Ru-Ju Chian, Samuel A Celia, R Blake Pepinsky, Paul S Fishman, Robert H Brown, Jonathan W Franci. Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice. Journal of neurochemistry. vol 95. issue 4. 2006-01-20. PMID:16271047. |
the percentage of neun+ ventral horn cells that were co-labeled with hsod1 antibody was greater in mice treated with sod1:ttc (cervical cord = 73 +/- 8.5%; lumbar cord = 62 +/- 7.7%) than in mice treated with hsod1 alone (cervical cord = 15 +/- 3.9%; lumbar cord = 27 +/-4.7%). |
2006-01-20 |
2023-08-12 |
mouse |
| Burkhard Schüt. Imbalanced excitatory to inhibitory synaptic input precedes motor neuron degeneration in an animal model of amyotrophic lateral sclerosis. Neurobiology of disease. vol 20. issue 1. 2005-12-19. PMID:16137574. |
the present study aimed in determining the composition and abundance of neurochemically defined input on lumbar spinal cord motor neurons in the sod1 mouse model of als by employing immunoreactivity (ir) for vesicular neurotransmitter transporter proteins. |
2005-12-19 |
2023-08-12 |
mouse |
| Isao Nagano, Hristelina Ilieva, Mito Shiote, Tetsuro Murakami, Masataka Yokoyama, Mikio Shoji, Koji Ab. Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of Amyotrophic Lateral Sclerosis. Journal of the neurological sciences. vol 235. issue 1-2. 2005-10-19. PMID:15990113. |
to examine the possible effectiveness of igf-1 in a mouse model of familial als, transgenic mice expressing human cu/zn superoxide dismutase (sod1) with a g93a mutation were treated by continuous igf-1 delivery into the intrathecal space of the lumbar spinal cord. |
2005-10-19 |
2023-08-12 |
mouse |
| Sandra M Klein, Soshana Behrstock, Jacalyn McHugh, Kristin Hoffmann, Kyle Wallace, Masatoshi Suzuki, Patrick Aebischer, Clive N Svendse. GDNF delivery using human neural progenitor cells in a rat model of ALS. Human gene therapy. vol 16. issue 4. 2005-08-23. PMID:15871682. |
these cells survived up to 11 weeks following transplantation into the lumbar spinal cord of rats overexpressing the g93a sod1 mutation (sod1 (g93a)). |
2005-08-23 |
2023-08-12 |
human |
| Marcelo R Vargas, Mariana Pehar, Patricia Cassina, Laura Martínez-Palma, John A Thompson, Joseph S Beckman, Luis Barbeit. Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: consequences for motor neuron survival. The Journal of biological chemistry. vol 280. issue 27. 2005-08-16. PMID:15870071. |
both nrf2 and ho-1 levels were increased and co-localized with reactive astrocytes in the degenerating lumbar spinal cord of rats expressing the amyotrophic lateral sclerosis-linked sod1 g93a mutation. |
2005-08-16 |
2023-08-12 |
rat |
| Mahmoud Kiaei, Khatuna Kipiani, Susanne Petri, Dong-Kug Choi, Junyu Chen, Noel Y Calingasan, M Flint Bea. Integrative role of cPLA with COX-2 and the effect of non-steriodal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis. Journal of neurochemistry. vol 93. issue 2. 2005-05-20. PMID:15816863. |
immunohistochemistry and real-time rt-pcr revealed elevated cpla2 protein and its mrna levels in the lumbar spinal cord of mutant sod1 mice. |
2005-05-20 |
2023-08-12 |
mouse |
| Hristelina Ilieva, Isao Nagano, Tetsuro Murakami, Mito Shiote, Mikio Shoji, Koji Ab. Sustained induction of survival p-AKT and p-ERK signals after transient hypoxia in mice spinal cord with G93A mutant human SOD1 protein. Journal of the neurological sciences. vol 215. issue 1-2. 2004-01-20. PMID:14568129. |
expression of survival p-akt and p-erk signals was examined by immunohistochemistry and western blotting in the lumbar spinal cord of 12-week-old presymptomatic mice with human mutant g93a sod1 gene (transgenic, tg) and their wild-type (wt) littermates during normoxia, and 0 and 6 h after 2 h of 9% hypoxia. |
2004-01-20 |
2023-08-12 |
mouse |