| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin-Feng Su, Jian Wei, Pei-Shan Li, Hong-Hua Miao, Yong-Chao Ma, Yu-Xiu Qu, Jie Xu, Jie Qin, Bo-Liang Li, Bao-Liang Song, Zheng-Ping Xu, Jie Lu. Numb directs the subcellular localization of EAAT3 through binding the YxNxxF motif. Journal of cell science. vol 129. issue 16. 2017-07-31. PMID:27358480. |
excitatory amino acid transporter type 3 (eaat3, also known as slc1a1) is a high-affinity, na(+)-dependent glutamate carrier that localizes primarily within the cell and at the apical plasma membrane. |
2017-07-31 |
2023-08-13 |
rat |
| Kalpita Rashimi Karan, P Satishchandra, Sanjib Sinha, Anuranjan Anan. Rare SLC1A1 variants in hot water epilepsy. Human genetics. vol 136. issue 6. 2017-06-22. PMID:28324217. |
slc1a1 is a neuronal glutamate transporter which limits excitotoxicity and its loss-of-function leads to age-dependent neurodegeneration. |
2017-06-22 |
2023-08-13 |
Not clear |
| Kalpita Rashimi Karan, P Satishchandra, Sanjib Sinha, Anuranjan Anan. Rare SLC1A1 variants in hot water epilepsy. Human genetics. vol 136. issue 6. 2017-06-22. PMID:28324217. |
all three non-synonymous variants affected glutamate uptake, exhibited altered glutamate kinetics and anion conductance properties of slc1a1. |
2017-06-22 |
2023-08-13 |
Not clear |
| Sarah Beaudin, JoEllen Wels. 1,25-Dihydroxyvitamin D induces the glutamate transporter SLC1A1 and alters glutamate handling in non-transformed mammary cells. Molecular and cellular endocrinology. vol 424. 2016-12-13. PMID:26774511. |
1,25-dihydroxyvitamin d induces the glutamate transporter slc1a1 and alters glutamate handling in non-transformed mammary cells. |
2016-12-13 |
2023-08-13 |
human |
| Sarah Beaudin, JoEllen Wels. 1,25-Dihydroxyvitamin D induces the glutamate transporter SLC1A1 and alters glutamate handling in non-transformed mammary cells. Molecular and cellular endocrinology. vol 424. 2016-12-13. PMID:26774511. |
genomic profiling of immortalized human mammary epithelial (htert-hme1) cells identified several metabolic genes, including the membrane glutamate transporter, slc1a1, as 1,25-dihydroxyvitamin d3 (1,25d) regulated. |
2016-12-13 |
2023-08-13 |
human |
| Parisa Afshari, Marina Myles-Worsley, Ori S Cohen, Josepha Tiobech, Stephen V Faraone, William Byerley, Frank A Middleto. Characterization of a Novel Mutation in SLC1A1 Associated with Schizophrenia. Molecular neuropsychiatry. vol 1. issue 3. 2016-09-14. PMID:26380821. |
however, confocal microscopy and electrophysiological recordings demonstrate that the 5'-truncated slc1a1 lacks normal membrane localization and glutamate transport ability. |
2016-09-14 |
2023-08-13 |
Not clear |
| Hongxia Hu, Naoharu Takano, Lisha Xiang, Daniele M Gilkes, Weibo Luo, Gregg L Semenz. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget. vol 5. issue 19. 2015-08-07. PMID:25326682. |
we report that in hepatocellular carcinoma and clear cell renal carcinoma cells, increased activity of hypoxia-inducible factors (hifs) due to hypoxia or vhl loss-of-function, respectively, augmented release of glutamate, which was mediated by hif-dependent expression of the slc1a1 and slc1a3 genes encoding glutamate transporters. |
2015-08-07 |
2023-08-13 |
human |
| Jie Yin, Wenkai Ren, Jielin Duan, Li Wu, Shuai Chen, Tiejun Li, Yulong Yin, Guoyao W. Dietary arginine supplementation enhances intestinal expression of SLC7A7 and SLC7A1 and ameliorates growth depression in mycotoxin-challenged pigs. Amino acids. vol 46. issue 4. 2015-05-26. PMID:24368521. |
the measured variables included: (1) the average daily weight gain and feed:gain ratio; (2) activities of total superoxide dismutase, glutathione peroxidase, diamine oxidase, as well as amino acid and d-lactate concentrations in serum; (3) intestinal morphology; (4) expression of the genes for slc7a7 (amino acid transporter light chain, y(+l) system, family 7, member 7), slc7a1 (cationic amino acid transporter, y(+) system, family 7, member 1), slc1a1 (neuronal/epithelial high affinity glutamate transporter, system xag, member 1), slc5a1 (sodium/glucose cotransporter, family 5, member 1) in the ileum and jejunum. |
2015-05-26 |
2023-08-12 |
Not clear |
| Jingmei Zhang, Christina Sheerin, Howard Mandel, Anne N Banducci, Hugh Myrick, Ronald Acierno, Ananda B Amstadter, Zhewu Wan. Variation in SLC1A1 is related to combat-related posttraumatic stress disorder. Journal of anxiety disorders. vol 28. issue 8. 2015-02-09. PMID:25445080. |
we investigated 13 snps in the glutamate transporter gene (slc1a1) in relation to ptsd among combat-exposed veterans. |
2015-02-09 |
2023-08-13 |
human |
| Elliott Rees, James T R Walters, Kimberly D Chambert, Colm O'Dushlaine, Jin Szatkiewicz, Alexander L Richards, Lyudmila Georgieva, Gerwyn Mahoney-Davies, Sophie E Legge, Jennifer L Moran, Giulio Genovese, Douglas Levinson, Derek W Morris, Paul Cormican, Kenneth S Kendler, Francis A O'Neill, Brien Riley, Michael Gill, Aiden Corvin, Pamela Sklar, Christina Hultman, Carlos Pato, Michele Pato, Patrick F Sullivan, Pablo V Gejman, Steven A McCarroll, Michael C O'Donovan, Michael J Owen, George Kiro. CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1. Human molecular genetics. vol 23. issue 6. 2014-10-31. PMID:24163246. |
other plausible candidates include non-recurrent deletions at the glutamate transporter gene slc1a1, a cnv locus recently suggested to be involved in schizophrenia through linkage analysis, and duplications at 1p36.33 and cgnl1. |
2014-10-31 |
2023-08-12 |
Not clear |
| Jun Cai, Wen Zhang, Zhenghui Yi, Weihong Lu, Zhiguo Wu, Jun Chen, Shunying Yu, Yiru Fang, Chen Zhan. Influence of polymorphisms in genes SLC1A1, GRIN2B, and GRIK2 on clozapine-induced obsessive-compulsive symptoms. Psychopharmacology. vol 230. issue 1. 2014-06-10. PMID:23660601. |
recent data from neuroimaging and clinical trials suggest a role for altered glutamate neurotransmission in the etiology of oc disorder (ocd), and slc1a1, grin2b, and grik2 have all been reported to regulate glutamate transmission and affect ocd pathophysiology. |
2014-06-10 |
2023-08-12 |
Not clear |
| E Real, M Gratacòs, J Labad, P Alonso, G Escaramís, C Segalàs, M Subirà, C López-Solà, X Estivill, J M Menchó. Interaction of SLC1A1 gene variants and life stress on pharmacological resistance in obsessive-compulsive disorder. The pharmacogenomics journal. vol 13. issue 5. 2014-05-01. PMID:22776887. |
genetic and environmental factors seem to interact and influence both the onset and the course of obsessive-compulsive disorder (ocd), but the role of glutamate transporter variants (slc1a1) in pharmacological resistance is not known. |
2014-05-01 |
2023-08-12 |
Not clear |
| Martina Von Wilmsdorff, Carolin Blaich, Mathias Zink, Jens Treutlein, Manfred Bauer, Thomas Schulze, Thomas Schneider-Axmann, Oliver Gruber, Marcella Rietschel, Andrea Schmitt, Peter Falka. Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 14. issue 7. 2014-04-23. PMID:22424243. |
gene expression of glutamate transporters slc1a1, slc1a3 and slc1a6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment. |
2014-04-23 |
2023-08-12 |
Not clear |
| B Porton, B D Greenberg, K Askland, L M Serra, J Gesmonde, G Rudnick, S A Rasmussen, H-T Ka. Isoforms of the neuronal glutamate transporter gene, SLC1A1/EAAC1, negatively modulate glutamate uptake: relevance to obsessive-compulsive disorder. Translational psychiatry. vol 3. 2013-12-23. PMID:23695234. |
the slc1a1 gene, which encodes the neuronal glutamate transporter, eaac1, has consistently been implicated in obsessive-compulsive disorder (ocd) in genetic studies. |
2013-12-23 |
2023-08-12 |
mouse |
| Yun Zhou, Niels Christian Danbol. GABA and Glutamate Transporters in Brain. Frontiers in endocrinology. vol 4. 2013-11-25. PMID:24273530. |
the mammalian genome contains four genes encoding gaba transporters (gat1, slc6a1; gat2, slc6a13; gat3, slc6a11; bgt1, slc6a12) and five glutamate transporter genes (eaat1, slc1a3; eaat2, slc1a2; eaat3, slc1a1; eaat4, slc1a6; eaat5, slc1a7). |
2013-11-25 |
2023-08-12 |
mouse |
| S E Stewart, C Mayerfeld, P D Arnold, J R Crane, C O'Dushlaine, J A Fagerness, D Yu, J M Scharf, E Chan, F Kassam, P R Moya, J R Wendland, R Delorme, M A Richter, J L Kennedy, J Veenstra-VanderWeele, J Samuels, B D Greenberg, J T McCracken, J A Knowles, A J Fyer, S L Rauch, M A Riddle, M A Grados, O J Bienvenu, B Cullen, Y Wang, Y Y Shugart, J Piacentini, S Rasmussen, G Nestadt, D L Murphy, M A Jenike, E H Cook, D L Pauls, G L Hanna, C A Mathew. Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 162B. issue 4. 2013-10-17. PMID:23606572. |
meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene slc1a1. |
2013-10-17 |
2023-08-12 |
Not clear |
| S E Stewart, C Mayerfeld, P D Arnold, J R Crane, C O'Dushlaine, J A Fagerness, D Yu, J M Scharf, E Chan, F Kassam, P R Moya, J R Wendland, R Delorme, M A Richter, J L Kennedy, J Veenstra-VanderWeele, J Samuels, B D Greenberg, J T McCracken, J A Knowles, A J Fyer, S L Rauch, M A Riddle, M A Grados, O J Bienvenu, B Cullen, Y Wang, Y Y Shugart, J Piacentini, S Rasmussen, G Nestadt, D L Murphy, M A Jenike, E H Cook, D L Pauls, G L Hanna, C A Mathew. Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 162B. issue 4. 2013-10-17. PMID:23606572. |
the neuronal glutamate transporter gene slc1a1 is a candidate gene for obsessive-compulsive disorder (ocd) based on linkage studies and convergent evidence implicating glutamate in ocd etiology. |
2013-10-17 |
2023-08-12 |
Not clear |
| Marina Myles-Worsley, Josepha Tiobech, Sharon R Browning, Jeremy Korn, Sarah Goodman, Karen Gentile, Nadine Melhem, William Byerley, Stephen V Faraone, Frank A Middleto. Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 162B. issue 2. 2013-09-18. PMID:23341099. |
deletion at the slc1a1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family. |
2013-09-18 |
2023-08-12 |
Not clear |
| Marina Myles-Worsley, Josepha Tiobech, Sharon R Browning, Jeremy Korn, Sarah Goodman, Karen Gentile, Nadine Melhem, William Byerley, Stephen V Faraone, Frank A Middleto. Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 162B. issue 2. 2013-09-18. PMID:23341099. |
we investigated a deletion at the slc1a1 glutamate transporter gene originally identified as a copy number variant exclusively carried by members of a 5-generation palauan family. |
2013-09-18 |
2023-08-12 |
Not clear |
| Yoshikatsu Kanai, Benjamin Clémençon, Alexandre Simonin, Michele Leuenberger, Martin Lochner, Martin Weisstanner, Matthias A Hedige. The SLC1 high-affinity glutamate and neutral amino acid transporter family. Molecular aspects of medicine. vol 34. issue 2-3. 2013-09-09. PMID:23506861. |
the high-affinity glutamate transporters eaac1 (slc1a1), glt1 (slc1a2), glast (slc1a3), eaat4 (slc1a6), and eaat5 (slc1a7) mediate the cellular uptake of glutamate by the co-transport of three sodium ions (na(+)) and one proton (h(+)), with the counter-transport of one potassium ion (k(+)). |
2013-09-09 |
2023-08-12 |
Not clear |