| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katherine J Susa, Gary A Bradshaw, Robyn J Eisert, Charlotte M Schilling, Marian Kalocsay, Stephen C Blacklow, Andrew C Krus. A spatiotemporal map of co-receptor signaling networks underlying B cell activation. Cell reports. vol 43. issue 6. 2024-06-08. PMID:38850533. |
we show that the glutamate transporter slc1a1 is responsible for mediating rapid metabolic reprogramming and for maintaining redox homeostasis during b cell activation. |
2024-06-08 |
2024-06-11 |
Not clear |
| Jun Liu, Jing Yan, Fei Qu, Weiming Mo, Hong Yu, Pingfang Hu, Zengyu Zhan. A pilot study on glutamate receptor and carrier gene variants and risk of childhood autism spectrum. Metabolic brain disease. 2023-08-14. PMID:37578654. |
this case-control study was to examine single nucleotide polymorphisms (snps) in glutamate receptor and carrier genes and determine their association with childhood asd in a chinese han population. a total of 12 snps in genes encoding glutamate receptors (grm7 and grm8) and carriers (slc1a1 and slc25a12) were examined in 249 autistic children and 353 healthy controls. |
2023-08-14 |
2023-08-16 |
Not clear |
| Zhou Yang, Wei Su, Xiyi Wei, Shuang Qu, Dan Zhao, Jingwan Zhou, Yunjun Wang, Qing Guan, Chao Qin, Jun Xiang, Ke Zen, Bing Ya. HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1. Cell reports. vol 42. issue 8. 2023-08-05. PMID:37542723. |
in addition, hif-1α also enhances transcription of slc1a1, an important glutamate transporter, and promotes cystine uptake to promote ferroptosis resistance. |
2023-08-05 |
2023-08-14 |
mouse |
| Katherine J Susa, Gary A Bradshaw, Robyn J Eisert, Charlotte M Schilling, Marian Kalocsay, Stephen C Blacklow, Andrew C Krus. A Spatiotemporal Map of Co-Receptor Signaling Networks Underlying B Cell Activation. bioRxiv : the preprint server for biology. 2023-03-30. PMID:36993395. |
in particular, we show that the glutamate transporter slc1a1 is responsible for mediating rapid metabolic reprogramming immediately downstream of bcr stimulation and for maintaining redox homeostasis during b cell activation. |
2023-03-30 |
2023-08-14 |
Not clear |
| Linlin Sheng, Qi Luo, Ligong Che. Amino Acid Solute Carrier Transporters in Inflammation and Autoimmunity. Drug metabolism and disposition: the biological fate of chemicals. 2022-02-13. PMID:35152203. |
in detail, the importance of glutamate transporters slc1a1, slc1a2, and slc1a3, mainly expressed in the brain where they help prevent glutamate excitotoxicity, is discussed in the context of central nervous system disorders such as multiple sclerosis. |
2022-02-13 |
2023-08-13 |
Not clear |
| Muhammad O Chohan, Jared M Kopelman, Hannah Yueh, Zeinab Fazlali, Natasha Greene, Alexander Z Harris, Peter D Balsam, E David Leonardo, Edgar R Kramer, Jeremy Veenstra-VanderWeele, Susanne E Ahmar. Developmental impact of glutamate transporter overexpression on dopaminergic neuron activity and stereotypic behavior. Molecular psychiatry. 2022-01-21. PMID:35058566. |
genetic studies in ocd have pointed to slc1a1, which encodes the neuronal glutamate transporter eaat3, with evidence suggesting that increased expression contributes to risk. |
2022-01-21 |
2023-08-13 |
mouse |
| Paul Daniel Arnold, Frank P Macmaster, Gregory L Hanna, Margaret A Richter, Tricia Sicard, Eliza Burroughs, Yousha Mirza, Phillip C Easter, Michelle Rose, James L Kennedy, David R Rosenber. Glutamate system genes associated with ventral prefrontal and thalamic volume in pediatric obsessive-compulsive disorder. Brain imaging and behavior. vol 3. issue 1. 2021-10-20. PMID:21031159. |
volumetric magnetic resonance imaging (mri) and genotyping of 7 polymorphisms in two genes, glutamate receptor, ionotropic, n-methyl-d-aspartate 2b (grin2b) and solute linked carrier, family 1, member 1 (slc1a1) were conducted in 31 psychotropic-naïve pediatric ocd patients. |
2021-10-20 |
2023-08-12 |
Not clear |
| Wenzheng Guo, Kaimi Li, Beibei Sun, Dongliang Xu, Lingfeng Tong, Huijing Yin, Yueling Liao, Hongyong Song, Tong Wang, Bo Jing, Min Hu, Shuli Liu, Yanbin Kuang, Jing Ling, Qi Li, Yadi Wu, Qi Wang, Feng Yao, Binhua P Zhou, Shu-Hai Lin, Jiong Den. Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc Cancer research. vol 81. issue 3. 2021-04-29. PMID:33229341. |
dysregulated glutamate transporter slc1a1 propels cystine uptake via xc cancer cells need to generate large amounts of glutathione (gsh) to buffer oxidative stress during tumor development. |
2021-04-29 |
2023-08-13 |
Not clear |
| Tulika Shukla, Ravi Kumar Nadella, Reshma Jabeen Taj M J, Suhas Ganesh, Gerald Nestadt, Meera Purushottam, Sanjeev Jain, Y C Janardhan Reddy, Biju Viswanat. Association of SLC1A1 gene polymorphism with obsessive compulsive disorder in a sample from southern India. Experimental and clinical psychopharmacology. vol 28. issue 6. 2021-03-12. PMID:31985241. |
the glutamate transporter gene slc1a1 has been shown to have an association with obsessive-compulsive disorder (ocd), and serotonin reuptake inhibitor (sri) treatment response. |
2021-03-12 |
2023-08-13 |
human |
| Claudia Delgado-Acevedo, Sebastián F Estay, Anna K Radke, Ayesha Sengupta, Angélica P Escobar, Francisca Henríquez-Belmar, Cristopher A Reyes, Valentina Haro-Acuña, Elías Utreras, Ramón Sotomayor-Zárate, Andrew Cho, Jens R Wendland, Ashok B Kulkarni, Andrew Holmes, Dennis L Murphy, Andrés E Chávez, Pablo R Moy. Behavioral and synaptic alterations relevant to obsessive-compulsive disorder in mice with increased EAAT3 expression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 6. 2019-12-20. PMID:30622300. |
the slc1a1 gene encoding the neuronal glutamate transporter eaat3 has been proposed as a candidate gene for this disorder. |
2019-12-20 |
2023-08-13 |
mouse |
| Chris Pickering, Johan Alsiö, Julia Morud, Mia Ericson, Trevor W Robbins, Bo Söderpal. Ethanol impairment of spontaneous alternation behaviour and associated changes in medial prefrontal glutamatergic gene expression precede putative markers of dependence. Pharmacology, biochemistry, and behavior. vol 132. 2019-11-20. PMID:25743187. |
in the medial prefrontal cortex, 2.5g/kg ethanol decreased mrna expression of brain-derived neurotrophic factor, nmda nr2a subunit, mglur8 receptor, homer1, the glutamate transporters slc1a1 and slc1a6 and srr. |
2019-11-20 |
2023-08-13 |
rat |
| Sercan Ergün, Sezgin Güneş, Recep Büyükalpelli, Oğuz Aydı. Glutamate transporter SLC1A1 is associated with clear cell renal cell carcinoma Turkish journal of medical sciences. vol 49. issue 2. 2019-09-11. PMID:30862152. |
glutamate transporter slc1a1 is associated with clear cell renal cell carcinoma this study aimed to comparatively analyze the expression levels of the slc1a1 gene in renal specimens from tumorsand adjacent healthy kidney tissues of patients with clear cell renal cell carcinoma (ccrcc). |
2019-09-11 |
2023-08-13 |
Not clear |
| Setareh Abdolhosseinzadeh, Marzie Sina, Abolhassan Ahmadiani, Sareh Asadi, Jamal Sham. Genetic and pharmacogenetic study of glutamate transporter (SLC1A1) in Iranian patients with obsessive-compulsive disorder. Journal of clinical pharmacy and therapeutics. vol 44. issue 1. 2019-03-13. PMID:30315580. |
genetic and pharmacogenetic study of glutamate transporter (slc1a1) in iranian patients with obsessive-compulsive disorder. |
2019-03-13 |
2023-08-13 |
Not clear |
| Nicoletta Potenza, Nicola Mosca, Paolo Mondola, Simona Damiano, Aniello Russo, Bruna De Felic. Human miR-26a-5p regulates the glutamate transporter SLC1A1 (EAAT3) expression. Relevance in multiple sclerosis. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 1. 2018-03-26. PMID:28962897. |
human mir-26a-5p regulates the glutamate transporter slc1a1 (eaat3) expression. |
2018-03-26 |
2023-08-13 |
human |
| Jin-Ling Ye, Chun-Qi Gao, Xiang-Guang Li, Cheng-Long Jin, Dan Wang, Gang Shu, Wen-Ce Wang, Xiang-Feng Kong, Kang Yao, Hui-Chao Yan, Xiu-Qi Wan. EAAT3 promotes amino acid transport and proliferation of porcine intestinal epithelial cells. Oncotarget. vol 7. issue 25. 2018-02-27. PMID:27231847. |
excitatory amino acid transporter 3 (eaat3, encoded by slc1a1) is an epithelial type high-affinity anionic amino acid transporter, and glutamate is the major oxidative fuel for intestinal epithelial cells. |
2018-02-27 |
2023-08-13 |
Not clear |
| Hae Won Kim, Jee In Kang, Eun Hee Hwang, Se Joo Ki. Association between glutamate transporter gene polymorphisms and obsessive-compulsive disorder/trait empathy in a Korean population. PloS one. vol 13. issue 1. 2018-02-15. PMID:29304071. |
particularly, genetic influence of glutamate transporter gene (slc1a1) on ocd has been frequently replicated in previous studies, but several studies did not replicate the result. |
2018-02-15 |
2023-08-13 |
Not clear |
| Timothy F Day, Rajshree R Mewani, Joshua Starr, Xin Li, Debyani Chakravarty, Habtom Ressom, Xiaojun Zou, Ofer Eidelman, Harvey B Pollard, Meera Srivastava, Usha N Kasi. Transcriptome and Proteome Analyses of TNFAIP8 Knockdown Cancer Cells Reveal New Insights into Molecular Determinants of Cell Survival and Tumor Progression. Methods in molecular biology (Clifton, N.J.). vol 1513. 2018-01-11. PMID:27807832. |
depending on the tumor cell type, knockdown of tnfaip8 was found to be associated with increased mrna expression of several antiproliferative and apoptotic genes (e.g., il-24, fat3, lphn2, epha3) and fatty acid oxidation gene acadl, and decreased mrna levels of oncogenes (e.g., nfat5, malat1, met, foxa1, kras, s100p, ostf1) and glutamate transporter gene slc1a1. |
2018-01-11 |
2023-08-13 |
human |
| Ya Bin Wei, Philippe A Melas, J Carlos Villaescusa, Jia Jia Liu, Ning Xu, Søren Hofman Christiansen, Heidi Elbrønd-Bek, David Paul Drucker Woldbye, Gregers Wegener, Aleksander A Mathé, Catharina Lavebrat. MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro. The international journal of neuropsychopharmacology. vol 19. issue 12. 2018-01-08. PMID:27507301. |
microrna 101b is downregulated in the prefrontal cortex of a genetic model of depression and targets the glutamate transporter slc1a1 (eaat3) in vitro. |
2018-01-08 |
2023-08-13 |
Not clear |
| Luis F González, Francisca Henríquez-Belmar, Claudia Delgado-Acevedo, Marisol Cisternas-Olmedo, Gloria Arriagada, Ramón Sotomayor-Zárate, Dennis L Murphy, Pablo R Moy. Neurochemical and behavioral characterization of neuronal glutamate transporter EAAT3 heterozygous mice. Biological research. vol 50. issue 1. 2017-12-06. PMID:28927446. |
ocd has a strong genetic component, and the slc1a1 gene that encodes neuronal glutamate transporter eaat3 is a strong candidate for this disorder. |
2017-12-06 |
2023-08-13 |
mouse |
| Mami Nishisako, Akira Meguro, Eiichi Nomura, Takahiro Yamane, Masaki Takeuchi, Masao Ota, Kenji Kashiwagi, Fumihiko Mabuchi, Hiroyuki Iijima, Kazuhide Kawase, Tetsuya Yamamoto, Makoto Nakamura, Akira Negi, Takeshi Sagara, Teruo Nishida, Masaru Inatani, Hidenobu Tanihara, Makoto Aihara, Makoto Araie, Takeo Fukuchi, Haruki Abe, Tomomi Higashide, Kazuhisa Sugiyama, Takashi Kanamoto, Yoshiaki Kiuchi, Aiko Iwase, Shinki Chin, Shigeaki Ohno, Hidetoshi Inoko, Nobuhisa Mizuk. SLC1A1 Gene Variants and Normal Tension Glaucoma: An Association Study. Ophthalmic genetics. vol 37. issue 2. 2017-11-06. PMID:26771863. |
it has been hypothesized that dysfunction of the solute carrier family 1, member1 gene (slc1a1), which encodes the glutamate aspartate transporter, may play a role in normal tension glaucoma. |
2017-11-06 |
2023-08-13 |
Not clear |