| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dwight D Harris, Sharif A Sabe, Mark Broadwin, Chris Stone, Krishna Bellam, Akshay Malhotra, M Ruhul Abid, Frank W Sellk. Dipeptidyl peptidase 4 inhibitor sitagliptin decreases myocardial fibrosis and modulates myocardial insulin signaling in a swine model of chronic myocardial ischemia. PloS one. vol 19. issue 7. 2024-07-29. PMID:39074126. |
sit treatment was associated with increased expression of insulin receptor one and decreased expression of makers for insulin resistance, including phospho-pkc- alpha, rbp-4, sirt1, and pi3k (p<0.05). |
2024-07-29 |
2024-08-02 |
Not clear |
| Qi Gao, Yingying Jiang, Zhenqiang Song, Huizhu Ren, Yan Kong, Cong Wang, Miaoyan Zheng, Chunyan Shan, Yanhui Yan. Dapagliflozin improves skeletal muscle insulin sensitivity through SIRT1 activation induced by nutrient deprivation state. Scientific reports. vol 14. issue 1. 2024-07-23. PMID:39043740. |
dapagliflozin improves skeletal muscle insulin sensitivity through sirt1 activation induced by nutrient deprivation state. |
2024-07-23 |
2024-07-26 |
mouse |
| Qi Gao, Yingying Jiang, Zhenqiang Song, Huizhu Ren, Yan Kong, Cong Wang, Miaoyan Zheng, Chunyan Shan, Yanhui Yan. Dapagliflozin improves skeletal muscle insulin sensitivity through SIRT1 activation induced by nutrient deprivation state. Scientific reports. vol 14. issue 1. 2024-07-23. PMID:39043740. |
this study investigates whether dapa can trigger nutrient deprivation to activate sirt1 and enhance insulin sensitivity in skeletal muscle. |
2024-07-23 |
2024-07-26 |
mouse |
| Qi Gao, Yingying Jiang, Zhenqiang Song, Huizhu Ren, Yan Kong, Cong Wang, Miaoyan Zheng, Chunyan Shan, Yanhui Yan. Dapagliflozin improves skeletal muscle insulin sensitivity through SIRT1 activation induced by nutrient deprivation state. Scientific reports. vol 14. issue 1. 2024-07-23. PMID:39043740. |
thus, dapa promotes a nutrient deprivation state and enhances skeletal muscle insulin sensitivity via sirt1 activation. |
2024-07-23 |
2024-07-26 |
mouse |
| Luning Yang, Di Liu, Shide Jiang, Hengzhen Li, Lin Chen, Yuxiang Wu, Anko Elijah Essien, Michael Opoku, Shinen Naranmandakh, ShuGuang Liu, Qin Ru, Yusheng L. SIRT1 signaling pathways in sarcopenia: Novel mechanisms and potential therapeutic targets. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-22. PMID:38908209. |
sirt1 functioned as an important role in the occurrence and progression of sarcopenia through regulating key pathways related to protein homeostasis, apoptosis, mitochondrial dysfunction, insulin resistance and autophagy in skeletal muscle, including sirt1/forkhead box o (foxo), amp-activated protein kinase (ampk)/sirt1/nuclear factor κb (nf-κb), sirt1/p53, ampk/sirt1/peroxisome proliferator-activated receptor gamma coactivator-1α (pgc-1α), and sirt1/live kinase b1 (lkb1)/ampk pathways. |
2024-06-22 |
2024-06-25 |
human |
| Jaw Long Sun, Young Jin Kim, Wonjun Cho, Do Su Lim, Hyeon Ji Gwon, A M Abd El-Aty, Mehmet Akif Nas, Ji Hoon Jeong, Tae Woo Jun. Interleukin 38 improves insulin resistance in hyperlipidemic skeletal muscle cells via PPARδ/SIRT1-mediated suppression of STAT3 signaling and oxidative stress. Biochemical and biophysical research communications. vol 722. 2024-05-25. PMID:38795455. |
knockdown of pparδ or sirt1 using appropriate sirnas abrogated the effects of il-38 on insulin signaling, oxidative stress, and the stat3-dependent pathway. |
2024-05-25 |
2024-05-31 |
Not clear |
| Kaixuan Zhao, Haoyue Zhang, Dong Yan. SIRT1 exerts protective effects by inhibiting endoplasmic reticulum stress and NF-κB signaling pathways. Frontiers in cell and developmental biology. vol 12. 2024-05-16. PMID:38745862. |
through these mechanisms, sirt1 can ameliorate insulin resistance in metabolic diseases, exert cardioprotective effects in ischemia-reperfusion injury, and reduce neuronal damage in neurodegenerative diseases. |
2024-05-16 |
2024-05-27 |
Not clear |
| Davide Gnocchi, Dragana Nikolic, Rosa Rita Paparella, Carlo Sabbà, Antonio Mazzocc. Crithmum maritimum Extract Restores Lipid Homeostasis and Metabolic Profile of Liver Cancer Cells to a Normal Phenotype. Plant foods for human nutrition (Dordrecht, Netherlands). 2024-05-06. PMID:38710924. |
here, we aimed to further characterise the effects of c. maritimum on lipid metabolism and markers of cellular metabolic health, such as amp-activated protein kinase (ampk), sirtuin 1 (sirt1), and sirtuin 3 (sirt3), as well as the insulin signalling pathway. |
2024-05-06 |
2024-05-27 |
Not clear |
| Laia Bosch de Basea, Marina Boguñà, Alicia Sánchez, Montserrat Esteve, Mar Grasa, Maria Del Mar Romer. Sex-Dependent Metabolic Effects in Diet-Induced Obese Rats following Intermittent Fasting Compared with Continuous Food Restriction. Nutrients. vol 16. issue 7. 2024-04-13. PMID:38613042. |
both caloric restrictions improved insulin sensitivity, but more markedly in females, which showed a more pronounced decrease in homa-ir score and an upregulation of hepatic irs2 and sirt1 gene expression that was not observed in males. |
2024-04-13 |
2024-04-15 |
rat |
| Troy C Krzysiak, You-Jin Choi, Yong Joon Kim, Yunhan Yang, Christopher DeHaven, Lariah Thompson, Ryan Ponticelli, Mara M Mermigos, Laurel Thomas, Andrea Marquez, Ian Sipula, Jongsook Kim Kemper, Michael Jurczak, Gary Thomas, Angela M Gronenbor. Inhibitory protein-protein interactions of the SIRT1 deacetylase are choreographed by post-translational modification. Protein science : a publication of the Protein Society. vol 33. issue 4. 2024-03-27. PMID:38533551. |
we previously showed that insulin triggers the epigenetic regulator dbc1 to prime sirt1 for repression by the multifunctional trafficking protein pacs-2. |
2024-03-27 |
2024-03-29 |
human |
| Sanghee Park, Filip Jevtovic, Polina M Krassovskaia, Alec B Chaves, Donghai Zheng, Jonas T Treebak, Joseph A Houmar. Effect of resveratrol on insulin action in primary myotubes from lean individuals and individuals with severe obesity. American journal of physiology. Endocrinology and metabolism. vol 326. issue 3. 2024-03-05. PMID:38324260. |
primary skeletal muscle cells were derived from biopsies obtained from age-matched lean and insulin-resistant women with severe obesity and incubated with resveratrol (1 µm) for 24 h. insulin-stimulated glucose oxidation and incorporation into glycogen, insulin signal transduction, and energy-sensitive protein targets [amp-activated protein kinase (ampk), sirt1, and pgc1α] were analyzed. |
2024-03-05 |
2024-03-07 |
human |
| Gholamreza Taheripak, Niusha Sabeti, Naba Najar, Zahrasadat Razavi, Saber Saharkhiz, Iraj Alipourfar. SIRT1 activation attenuates palmitate induced apoptosis in C Molecular biology reports. vol 51. issue 1. 2024-02-24. PMID:38400872. |
sirt1 activation attenuates palmitate induced apoptosis in c type 2 diabetes is characterized by insulin resistance, which manifests mainly in skeletal muscles. |
2024-02-24 |
2024-02-27 |
Not clear |
| Gholamreza Taheripak, Niusha Sabeti, Naba Najar, Zahrasadat Razavi, Saber Saharkhiz, Iraj Alipourfar. SIRT1 activation attenuates palmitate induced apoptosis in C Molecular biology reports. vol 51. issue 1. 2024-02-24. PMID:38400872. |
sirt1 has been found to play a role in the insulin signaling pathway. |
2024-02-24 |
2024-02-27 |
Not clear |
| Rashmi Patil, Urmila Aswar, Nishant Vya. Pterostilbene alleviates cafeteria diet-induced obesity and underlying depression in adolescent male Swiss albino mice and affects insulin resistance, inflammation, HPA axis dysfunction and SIRT1 mediated leptin-ghrelin signaling. Hormones and behavior. vol 161. 2024-02-14. PMID:38354494. |
pterostilbene alleviates cafeteria diet-induced obesity and underlying depression in adolescent male swiss albino mice and affects insulin resistance, inflammation, hpa axis dysfunction and sirt1 mediated leptin-ghrelin signaling. |
2024-02-14 |
2024-02-17 |
mouse |
| Yahia A Kaabi, Ammar A Abdelmola, Siddig I Abdelwahab, Nahla A Alshaikh, Mustafa A Halawi, Hadi M Kurir. Common Genetic Variants in SIRT1 Gene Promoter and Type 2 Diabetes Mellitus in Saudi Arabia. Clinical laboratory. vol 70. issue 2. 2024-02-13. PMID:38345973. |
silent information regulator of transcription-1 (sirt1) positively influences insulin sensitivity and might contribute to the pathogenesis of t2dm. |
2024-02-13 |
2024-02-15 |
Not clear |
| Badr Qasem, Agnieszka Dąbrowska, Jarosław Króliczewski, Jacek Łyczko, Krzysztof Maryc. Trodusquemine (MSI-1436) Restores Metabolic Flexibility and Mitochondrial Dynamics in Insulin-Resistant Equine Hepatic Progenitor Cells (HPCs). Cells. vol 13. issue 2. 2024-01-22. PMID:38247843. |
furthermore, our findings suggest that msi-1436 enhances 2-nbdg uptake by increasing the expression of sirt1, which is associated with liver insulin sensitivity. |
2024-01-22 |
2024-01-24 |
Not clear |
| Valeria Melissa García-Cruz, Clorinda Aria. Palmitic Acid Induces Posttranslational Modifications of Tau Protein in Alzheimer's Disease-Related Epitopes and Increases Intraneuronal Tau Levels. Molecular neurobiology. 2024-01-03. PMID:38167971. |
among other effects, pa induces insulin resistance, increases intracellular calcium and reactive oxygen species (ros) production, and reduces the nad+/nadh ratio, resulting in decreased activity of the deacetylase sirtuin1 (sirt1) in neurons. |
2024-01-03 |
2024-01-06 |
human |
| Deepsikha Swargiary, Bhaswati Kashyap, Pranamika Sarma, Semim Akhtar Ahmed, Shalini Gurumayum, Sagar Ramrao Barge, Devi Basumatary, Jagat C Bora. Free radical scavenging polyphenols isolated from Phyllanthus niruri L. ameliorates hyperglycemia via SIRT1 induction and GLUT4 translocation in in vitro and in vivo models. Fitoterapia. 2024-01-03. PMID:38171388. |
pneaf treated ir c2c12 myotubes and stz induced wistar rats elevated sirt1, pgc1-α signaling cascade through phosphorylation of ampk and glut4 translocation resulting in insulin sensitization. |
2024-01-03 |
2024-01-06 |
rat |
| Jinxiao He, Fang Fan, Jingxian Li, Yi Han, Ye Song, Rong Zhang, Yang Xu, Huajie Wu, Rui Fa. SIRT1 alleviates insulin resistance and respiratory distress in late preterm rats by activating QKI5-mediated PPARγ/PI3K/AKT pathway. Cell cycle (Georgetown, Tex.). 2023-12-26. PMID:38146686. |
sirt1 alleviates insulin resistance and respiratory distress in late preterm rats by activating qki5-mediated pparγ/pi3k/akt pathway. |
2023-12-26 |
2023-12-28 |
rat |
| Decheng Meng, Fengxia Zhang, Wenfei Yu, Xin Zhang, Guoliang Yin, Pengpeng Liang, Yanan Feng, Suwen Chen, Hongshuai Li. Biological Role and Related Natural Products of SIRT1 in Nonalcoholic Fatty Liver. Diabetes, metabolic syndrome and obesity : targets and therapy. vol 16. 2023-12-13. PMID:38089432. |
sirt1 is a member of sirtuins, a group of highly conserved histone deacetylases regulated by nad+, and plays a vital role in regulating cholesterol and lipid metabolism, improving oxidative stress, inflammation, and insulin resistance through deacetylating some downstream transcription factors and thus improving nafld. |
2023-12-13 |
2023-12-17 |
Not clear |