| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xue Wang, Lili Su, Silu Liu, Zhongmei He, Jianming Li, Ying Zong, Weijia Chen, Rui D. Paeoniflorin Inhibits the Activation of Microglia and Alleviates Depressive Behavior by Regulating SIRT1-NF-kB-NLRP3/Pyroptosis Pathway. International journal of molecular sciences. vol 25. issue 23. 2024-12-17. PMID:39684254. |
moreover, the expression level of sirt1 in the hippocampus was augmented, while the protein levels of nf-κb, p65, nlrp3, caspase-1, il-1β and gsdmd-n were diminished after pf treatment. |
2024-12-17 |
2024-12-21 |
mouse |
| Huijie Yang, Fangyu Wang, Peijun Zhao, Saif Ullah, Yan Ma, Guangshan Zhao, Yongxia Cheng, Qian Li, Tiange Li, Mingwu Qiao, Lianjun Song, Lei Zhang, Gianni Galaverna, Xianqing Huang, Ning L. Black soybean peptide mediates the AMPK/SIRT1/NF-κB signaling pathway to alleviate Alzheimer's-related neuroinflammation in lead-exposed HT22 cells. International journal of biological macromolecules. 2024-12-06. PMID:39643189. |
pb exposure was given to mouse hippocampus ht22 cells in the presence or absence of bsp1, positive control resveratrol (rsv), or the sirt1 inhibitor ex-527. |
2024-12-06 |
2024-12-10 |
mouse |
| Nonibala Gurumayum, M Bidyarani Devi, Puspanjali Khound, Anupam Bhattacharya, Himangshu Sarma, Mojibur R Khan, Rajlakshmi Dev. Bioactive fraction of Musa balbisiana seed mitigates D-galactose-induced brain aging via SIRT1/PGC-1α/FoxO3a activation and intestinal barrier dysfunction by modulating gut microbiota and core metabolites. Free radical biology & medicine. 2024-11-14. PMID:39542187. |
bf significantly induced the phosphorylation of foxo3a proteins and upregulated the gene expression of sirt1, pgc-1α, and tfam in the hippocampus. |
2024-11-14 |
2024-11-17 |
rat |
| Fernando Gabriel Altamirano, Ivanna Castro-Pascual, Ivana Tamara Ponce, Cinthia Daiana Coria-Lucero, Ethelina Cargnelutti, Mariana Lucila Ferramola, Marcela Silvia Delgado, Ana Cecilia Anzulovich, María Gabriela Lacost. Late-onset caloric restriction improves cognitive performance and restores circadian patterns of neurotrophic, clock and epigenetic factors in the hippocampus of male old rats. The journals of gerontology. Series A, Biological sciences and medical sciences. 2024-10-24. PMID:39447038. |
our results evidenced the existence of a highly coordinated temporal organization of bmal1, clock, bdnf, trkb, dnmts, sirt1, and pgc-1α in the hippocampus of young adult rats. |
2024-10-24 |
2024-10-28 |
rat |
| Defne Engur, Serap Cilaker Micili, Sila Soy, Gökcen Bilici, Kemal Ugur Tufekci, Cagla Kiser, İlkcan Ercan, Abdullah Kumral, Sermin Gen. Supplemental Oxygen Alters the Pentose Phosphate Pathway in the Developing Mouse Brain Through SIRT Signaling. Neurochemistry international. 2024-10-22. PMID:39437895. |
sirt1, glucose-6-phosphate dehydrogenase (g6pd) and transaldolase (taldo) proteins were examined immunohistochemically and molecularly in the prefrontal and hippocampus regions of the brain. |
2024-10-22 |
2024-10-25 |
mouse |
| Nevine Fathy, Merna A Labib, Reham M Essam, Noha A El-Boghdad. The Interplay between MiR-134/BDNF and LKB1/AMPK/SIRT1 Accentuates the Antidepressant Efficacy of Empagliflozin in Ovariectomized Rats. ACS chemical neuroscience. 2024-10-01. PMID:39350330. |
empa also dwindled ovx-induced changes of hippocampal p-lkb1/lkb1, p-ampk/ampk, sirt1, and inflammatory markers (nuclear factor-kappa-b, interleukin-1 beta, interleukin-6, and tumor necrosis factor alpha). |
2024-10-01 |
2024-10-03 |
rat |
| Shan Xing, Shuyi Xu, Linjiao Wang, Liyuan Guo, Xin Zhou, Haoxin Wu, Wei Wang, Lanying Li. Salidroside exerts antidepressant-like action by promoting adult hippocampal neurogenesis through SIRT1/PGC-1α signalling. Acta neuropsychiatrica. 2024-09-30. PMID:39344773. |
sal treatment also restored the expression of sirt1, pgc-1α, brain-derived neurotrophic factor (bdnf) and other proteins in the hippocampus. |
2024-09-30 |
2024-10-02 |
mouse |
| Shan Xing, Shuyi Xu, Linjiao Wang, Liyuan Guo, Xin Zhou, Haoxin Wu, Wei Wang, Lanying Li. Salidroside exerts antidepressant-like action by promoting adult hippocampal neurogenesis through SIRT1/PGC-1α signalling. Acta neuropsychiatrica. 2024-09-30. PMID:39344773. |
in addition, after blocking sirt1 signalling with ex527, we found that the treatment with sal failed to reduce the immobility time in tst and fst, the level of sirt1 and pgc-1α activity were correspondingly downregulated, and the expression of dcx and ki-67 in the hippocampus failed to be activated. |
2024-09-30 |
2024-10-02 |
mouse |
| Yuhang Liu, Yingfeng Li, Jingqi Li, Hui Rao, Jianfei Sun, Jiangfan Xiu, Ning W. Gypenosides alleviate oxidative stress in the hippocampus, promote mitophagy, and mitigate depressive-like behaviors induced by CUMS via SIRT1. Journal of ethnopharmacology. 2024-09-29. PMID:39343109. |
gypenosides alleviate oxidative stress in the hippocampus, promote mitophagy, and mitigate depressive-like behaviors induced by cums via sirt1. |
2024-09-29 |
2024-10-02 |
Not clear |
| Hatem I Mokhtar, Noha M Abd El-Fadeal, Rehab M El-Sayed, Ann Hegazy, Mohamed K El-Kherbetawy, Ahmed G Hamad, Mohamed H ElSayed, Sawsan A Zaiton. Computational Analysis and Experimental Data Exploring the Role of Hesperetin in Ameliorating ADHD and SIRT1/Nrf2/Keap1/OH-1 Signaling. International journal of molecular sciences. vol 25. issue 17. 2024-09-14. PMID:39273230. |
the present study aimed to test hesperetin efficacy in alleviating experimental adhd in mice and its influence on hippocampal neuron integrity and sirtuin 1 (sirt1) signaling. |
2024-09-14 |
2024-09-16 |
mouse |
| Mengyao Li, Xiangxiu Xu, Yifan Jia, Yuan Yuan, Guo Na, Ling Zhu, Xiaowei Xiao, Yamin Zhang, Haiqing Y. Transformation of mulberry polyphenols by Lactobacillus plantarum SC-5: Increasing phenolic acids and enhancement of anti-aging effect. Food research international (Ottawa, Ont.). vol 192. 2024-08-15. PMID:39147466. |
meanwhile, the expression of sirtuin 1 (sirt1) and brain-derived neurotrophic factor (bdnf) increased, which protected the integrity of hippocampal tissue. |
2024-08-15 |
2024-08-18 |
mouse |
| Limin Chen, Shuying Chen, Yanjie Bai, Yongchuang Zhang, Xiaoxiao Li, Yan Wang, Yuqian Xiao, Jun Wan, Kexin Su. Electroacupuncture improves cognitive impairment after ischemic stroke based on regulation of mitochondrial dynamics through SIRT1/PGC-1α pathway. Brain research. 2024-08-07. PMID:39111521. |
investigating the effects of ea on the expression of sirtuin1 (sirt1), peroxisome proliferator-activated receptor γ coactivator-1α (pgc-1α), optic atrophy 1r + (opa1) and dynamin-related protein 1 (drp1) in hippocampal neurons and on the morphology and function of hippocampal neurons and mitochondria. |
2024-08-07 |
2024-08-10 |
rat |
| Limin Chen, Shuying Chen, Yanjie Bai, Yongchuang Zhang, Xiaoxiao Li, Yan Wang, Yuqian Xiao, Jun Wan, Kexin Su. Electroacupuncture improves cognitive impairment after ischemic stroke based on regulation of mitochondrial dynamics through SIRT1/PGC-1α pathway. Brain research. 2024-08-07. PMID:39111521. |
moreover, ea increased the expression of sirt1, pgc-1α, and opa1 in hippocampal tissues, inhibited the expression of drp1, attenuated neuronal and mitochondrial damage, and reduced mitochondrial fragmentation. |
2024-08-07 |
2024-08-10 |
rat |
| Li-Hao Cheng, Chien-Chen Wu, Yu-Hsuan Wei, Pei-Jun Wen, Chih-Chieh Hsu, Ying-Chieh Tsai, Sabrina Wan. Anti-aging effects of Lacticaseibacillus paracasei PS117 on cognitive and intestinal health in naturally-aged mice: A focus on senescence-related proteins and microbiota composition. Experimental gerontology. 2024-07-30. PMID:39079652. |
furthermore, the level of senescence-related protein p16ink4a (p16) were reduced, while anti-senescence protein sirtuin 1 (sirt1) were increased in the hippocampus. |
2024-07-30 |
2024-08-02 |
mouse |
| Reham L Younis, Rehab M El-Gohary, Asmaa A Ghalwash, Islam Ibrahim Hegab, Maram M Ghabrial, Azza M Aboshanady, Raghad A Mostafa, Alaa H Abd El-Azeem, Eman E Farghal, Asmaa A E Belal, Haidy Khatta. Luteolin Mitigates D-Galactose-Induced Brain Ageing in Rats: SIRT1-Mediated Neuroprotection. Neurochemical research. 2024-07-10. PMID:38987448. |
additionally, luteolin treatment considerably attenuated neuronal apoptosis and upregulated hippocampal sirt1 mrna expression. |
2024-07-10 |
2024-07-13 |
rat |
| Reham L Younis, Rehab M El-Gohary, Asmaa A Ghalwash, Islam Ibrahim Hegab, Maram M Ghabrial, Azza M Aboshanady, Raghad A Mostafa, Alaa H Abd El-Azeem, Eman E Farghal, Asmaa A E Belal, Haidy Khatta. Luteolin Mitigates D-Galactose-Induced Brain Ageing in Rats: SIRT1-Mediated Neuroprotection. Neurochemical research. 2024-07-10. PMID:38987448. |
in conclusion, our findings revealed that luteolin administration attenuated d-gal-evoked brain senescence, improving mitochondrial function and enhancing hippocampal neuroregeneration in an ageing rat model through its antioxidant, senolytic, anti-inflammatory, and anti-apoptotic impacts, possibly due to upregulation of sirt1. |
2024-07-10 |
2024-07-13 |
rat |
| Yadong Wen, Weihua Zhang, Dingran Wang, Meijing L. Propofol ameliorates cognitive deficits following splenectomy in aged rats by inhibiting ferroptosis via the SIRT1/Nrf2/GPX4 pathway. Neuroreport. 2024-07-05. PMID:38968575. |
utilizing the western blotting to assess the expression of sirtuin-1 (sirt1) in the hippocampus. |
2024-07-05 |
2024-07-08 |
rat |
| Miriam Rebekka Rühling, Hans Hartmann, Anibh Martin Da. Simplification of Dietary Treatment in Pharmacoresistant Epilepsy: Impact of C8 and C10 Fatty Acids on Sirtuins of Neuronal Cells In Vitro. Nutrients. vol 16. issue 11. 2024-06-19. PMID:38892612. |
the aim of the present study was to investigate whether ß-hydroxybutyrate (ßhb), c8 fatty acids, c10 fatty acids, or a combination of c8 and c10 (250/250 µm) fatty acids, which all increase under a kd, could up-regulate sirt1, -3, -4, and -5 in ht22 hippocampal murine neurons in vitro. |
2024-06-19 |
2024-06-21 |
Not clear |
| Xi Liu, Jia Gu, Cheng Wang, Min Peng, Jilin Zhou, Xiyun Fei, Zhijun Zhong, Bo L. Ginsenoside Rg3 attenuates neuroinflammation and hippocampal neuronal damage after traumatic brain injury in mice by inactivating the NF-kB pathway via SIRT1 activation. Cell cycle (Georgetown, Tex.). 2024-05-26. PMID:38796716. |
ginsenoside rg3 attenuates neuroinflammation and hippocampal neuronal damage after traumatic brain injury in mice by inactivating the nf-kb pathway via sirt1 activation. |
2024-05-26 |
2024-05-31 |
mouse |
| Xi Liu, Jia Gu, Cheng Wang, Min Peng, Jilin Zhou, Xiyun Fei, Zhijun Zhong, Bo L. Ginsenoside Rg3 attenuates neuroinflammation and hippocampal neuronal damage after traumatic brain injury in mice by inactivating the NF-kB pathway via SIRT1 activation. Cell cycle (Georgetown, Tex.). 2024-05-26. PMID:38796716. |
as a result, ginsenoside rg3 enhanced neurological and motor functions in mice post-tbi, reduced brain water content, alleviated hippocampal neuronal neuroinflammation and damage, activated sirt1, and deactivated the nf-kb pathway. |
2024-05-26 |
2024-05-31 |
mouse |