| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huijuan Guo, Xinxu Liu, Ti Chen, Xiaoping Wang, Xiaojie Zhan. Akkermansia muciniphila Improves Depressive-Like Symptoms by Modulating the Level of 5-HT Neurotransmitters in the Gut and Brain of Mice. Molecular neurobiology. 2023-09-05. PMID:37668965. |
in conclusion, our study demonstrated the antidepressant effect of akk in mice exposed to alcohol exposure and cums, with the potential mechanism that akk implantation might lead to an increased level of 5-ht and inhibited sert expression in the gut, and might alter the gut-to-brain signal through suppression of enteric nerves activation. |
2023-09-05 |
2023-09-07 |
mouse |
| Christopher R Brown, James D Foste. Palmitoylation Regulates Human Serotonin Transporter Activity, Trafficking, and Expression and Is Modulated by Escitalopram. ACS chemical neuroscience. 2023-08-30. PMID:37644775. |
during serotonergic transmission, the synaptic concentration of serotonin is tightly controlled in a spatial and temporal manner by the serotonin transporter (sert). |
2023-08-30 |
2023-09-07 |
human |
| Christopher R Brown, James D Foste. Palmitoylation Regulates Human Serotonin Transporter Activity, Trafficking, and Expression and Is Modulated by Escitalopram. ACS chemical neuroscience. 2023-08-30. PMID:37644775. |
dysregulation of this process is implicated in the pathogenesis of major-depressive, obsessive-compulsive, and autism-spectrum disorders, which makes sert a primary target for prescription therapeutics, most notably selective serotonin reuptake inhibitors (ssris). |
2023-08-30 |
2023-09-07 |
human |
| Jean-Louis Montastru. Drugs and bruxism: a study in the World Health Organization's pharmacovigilance database. British journal of clinical pharmacology. 2023-08-14. PMID:37574820. |
for antidepressants, a negative association was found between ror values and net (norepinephrine transporter) but not sert (serotonin transporter) pki values, suggesting this adr is more closely linked to norepinephrine than serotonin reuptake inhibition. |
2023-08-14 |
2023-08-16 |
Not clear |
| Karla J Suchacki, Lynne E Ramage, T'ng Choong Kwok, Alexandra Kelman, Ben T McNeill, Stewart Rodney, Matthew Keegan, Calum Gray, Gillian MacNaught, Dilip Patel, Alison M Fletcher, Joanna P Simpson, Roderick N Carter, Robert K Semple, Natalie Z M Homer, Nicholas M Morton, Edwin J R van Beek, Sonia J Wakelin, Roland H Stimso. The serotonin transporter sustains human brown adipose tissue thermogenesis. Nature metabolism. 2023-08-03. PMID:37537371. |
here we show that the serotonin transporter (sert), encoded by slc6a4, prevents serotonin-mediated suppression of human bat function. |
2023-08-03 |
2023-08-14 |
human |
| Florian Koban, Michael Freissmut. The cell cycle protein MAD2 facilitates endocytosis of the serotonin transporter in the neuronal soma. EMBO reports. 2023-08-02. PMID:37530743. |
monoamine transporters retrieve serotonin (sert), dopamine (dat), and norepinephrine (net) from the synaptic cleft. |
2023-08-02 |
2023-08-14 |
Not clear |
| Johannes Hoch, Niklas Burkhard, Shanshan Zhang, Marina Rieder, Timoteo Marchini, Vincent Geest, Krystin Krauel, Timm Zahn, Nicolas Schommer, Muataz Ali Hamad, Carolina Bauer, Nadine Gauchel, Daniela Stallmann, Claus Normann, Dennis Wolf, R\\xc3\\xbcdiger Eberhard Scharf, Daniel Duerschmied, Nancy Schanz. Serotonin transporter-deficient mice display enhanced adipose tissue inflammation after chronic high-fat diet feeding. Frontiers in immunology. vol 14. 2023-07-31. PMID:37520561. |
deficiency of the serotonin transporter (sert) is associated with metabolic changes in humans and mice. |
2023-07-31 |
2023-08-14 |
mouse |
| Nina M Alyoshina, Maria D Tkachenko, Yulia O Nikishina, Denis A Nikishi. Serotonin Transporter Activity in Mouse Oocytes Is a Positive Indicator of Follicular Growth and Oocyte Maturity. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511007. |
in maturing mammalian oocytes, the accumulation of exogenous, maternal serotonin occurs due to the activity of the membrane transporter sert. |
2023-07-29 |
2023-08-14 |
mouse |
| Mattias Persson, Svante Vikingsson, Robert Kronstrand, Henrik Gree. Characterization of neurotransmitter inhibition for seven cathinones by a proprietary fluorescent dye method. Drug testing and analysis. 2023-07-25. PMID:37489044. |
to start addressing this need, a method measuring the inhibition of the dopamine, serotonin, and norepinephrine transporters (dat, sert, and net) by stimulant drugs was developed. |
2023-07-25 |
2023-08-14 |
Not clear |
| Cecilia E Villanueva, Bruno Hagenbuc. Palmitoylation of Solute Carriers. Biochemical pharmacology. 2023-07-22. PMID:37481134. |
among the best-characterized transporters are the glucose transporters glut1 (slc2a1) and glut4 (slc2a4), the three monoamine transporters norepinephrine transporter (net; slc6a2), dopamine transporter (dat; slc6a3), and serotonin transporter (sert; slc6a4), and the sodium-calcium exchanger ncx1 (slc8a1). |
2023-07-22 |
2023-08-14 |
Not clear |
| Karina Bravo, Marcelo Gonz\\xc3\\xa1lez-Ortiz, Sebastian Beltr\\xc3\\xa1n-Castillo, Daniela C\\xc3\\xa1ceres, Jaime Eugen\\xc3\\xad. Development of the Placenta and Brain Are Affected by\\xc2\\xa0Selective Serotonin Reuptake Inhibitor Exposure During Critical Periods. Advances in experimental medicine and biology. vol 1428. 2023-07-19. PMID:37466774. |
ssris block the serotonin transporter (sert), which is required for 5-ht reuptake from the synaptic cleft into the presynaptic neuron. |
2023-07-19 |
2023-08-14 |
Not clear |
| Mirjam Bloemendaal, Ekaterina Veniaminova, Daniel C Anthony, Anna Gorlova, Priscilla Vlaming, Adel Khairetdinova, Raymond Cespuglio, Klaus Peter Lesch, Alejandro Arias Vasquez, Tatyana Strekalov. Serotonin Transporter (SERT) Expression Modulates the Composition of the Western-Diet-Induced Microbiota in Aged Female Mice. Nutrients. vol 15. issue 13. 2023-07-14. PMID:37447374. |
serotonin transporter (sert) expression modulates the composition of the western-diet-induced microbiota in aged female mice. |
2023-07-14 |
2023-08-14 |
mouse |
| Dongxue Yang, Zhiyu Zhao, Emad Tajkhorshid, Eric Gouau. Structures and membrane interactions of native serotonin transporter in complexes with psychostimulants. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 29. 2023-07-13. PMID:37436958. |
the serotonin transporter (sert) is a member of the slc6 neurotransmitter transporter family that mediates serotonin reuptake at presynaptic nerve terminals. |
2023-07-13 |
2023-08-14 |
Not clear |
| Dongxue Yang, Zhiyu Zhao, Emad Tajkhorshid, Eric Gouau. Structures and membrane interactions of native serotonin transporter in complexes with psychostimulants. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 29. 2023-07-13. PMID:37436958. |
sert is the target of both therapeutic antidepressant drugs and psychostimulant substances such as cocaine and methamphetamines, which are small molecules that perturb normal serotonergic transmission by interfering with serotonin transport. |
2023-07-13 |
2023-08-14 |
Not clear |
| Sofi da Cunha-Bang, Vibe G Frokjaer, Brenda Mc Mahon, Peter Steen Jensen, Claus Svarer, Gitte Moos Knudse. The association between brain serotonin transporter binding and impulsivity and aggression in healthy individuals. Journal of psychiatric research. vol 165. 2023-07-13. PMID:37441926. |
although serotonin transporters (sert) are key in modulating synaptic serotonin levels, few studies have investigated the role of sert levels in human impulsive aggression. |
2023-07-13 |
2023-08-14 |
human |
| Rachel A Davies, Vy T Nguyen, Jose M Eltit, Richard A Glenno. Structure-Activity Relationships for a Recently Controlled Synthetic Cathinone Dopamine Transporter Reuptake Inhibitor: \\xce\\xb1-Pyrrolidinohexiophenone (\\xce\\xb1-PHP). ACS chemical neuroscience. 2023-07-05. PMID:37406364. |
here, we examined a series of 4-substituted \xce\xb1-php analogues and found that, with one exception, all behaved as relatively (28- to >300-fold) selective dat versus serotonin transporter (sert) reuptake inhibitors with dat inhibition potencies of most falling within a very narrow (i.e., <3-fold) range. |
2023-07-05 |
2023-08-14 |
Not clear |
| Elena Missir, Patrick Begley, Maryam Jessop, Nitasha Singh, Mark Aplin, Helena McMeekin, Puja Parekh, Malgorzata Raczek, Sabina Dizdarevi. Quantitative [123]I-Ioflupane DaTSCAN single-photon computed tomography-computed tomography in Parkinsonism. Nuclear medicine communications. 2023-07-03. PMID:37395542. |
[123]i-ioflupane (datscan) binds to the presynaptic dopamine transporter (dat) and with a lower affinity to the serotonin transporter (sert). |
2023-07-03 |
2023-08-14 |
Not clear |
| N J Clauss, F P Mayer, W A Owens, M Vitela, K M Clarke, M A Bowman, R E Horton, D Gr\\xc3\\xbcndemann, D Schmid, M Holy, G G Gould, W Koek, H H Sitte, L C Daw. Ethanol inhibits dopamine uptake via organic cation transporter 3: Implications for ethanol and cocaine co-abuse. Molecular psychiatry. 2023-06-12. PMID:37308680. |
cocaine increases extracellular monoamines by blocking dopamine (da), norepinephrine (ne) and serotonin (5-ht) transporters (dat, net and sert, respectively). |
2023-06-12 |
2023-08-14 |
mouse |
| Dilpreet Singh, G D Gupt. A Complete Sojourn of Gene Therapy Along with its Targeting Approaches for the Treatment of the Major Depressive Disorder. Current gene therapy. 2023-06-02. PMID:37264624. |
depression has been linked to the malfunctioning of serotonin signaling genes, including p11, sert, etc, according to earlier research. |
2023-06-02 |
2023-08-14 |
Not clear |
| Shufang Xia, Gusonghan Maitiniyazi, Yuan Liu, Yue Chen, Mengting Guo, Jianyun He, Wei Tao, Ziyuan L. Whey protein isolate attenuates depression-like behavior developed in a mouse model of breast tumor. Food research international (Ottawa, Ont.). vol 169. 2023-05-31. PMID:37254425. |
moreover, wpi promoted the hippocampal trp, 5-hydroxytryptophan (5-htp), 5-ht, 5-hydroxyindoleacetic acid (5-hiaa) levels and inhibited kynurenine (kyn) through up-regulating serotonin transporter (sert) and down-regulating indoleamine 2, 3-dioxygenase (ido). |
2023-05-31 |
2023-08-14 |
mouse |