| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arnav Paul, Diwakar Shukl. Oligomerization of Monoamine Transporters. Sub-cellular biochemistry. vol 104. 2024-07-04. PMID:38963486. |
the mat family functions using the electrochemical gradient of ions across the membrane and comprises three transporters, dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net). |
2024-07-04 |
2024-07-10 |
Not clear |
| Xiang Li, Xuankai Liang, Shenglu Ma, Shulei Zhao, Wenyao Wang, Mingxing Li, Dan Feng, Man Tan. SERT and OCT mediate 5-HT Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-25. PMID:38917762. |
sert and oct mediate 5-ht 5-ht clearance, commonly mediated by transporters in the uptake-1 and uptake-2 families, has been linked to 5-ht |
2024-06-25 |
2024-06-29 |
Not clear |
| Rémi Janet, Edmund Derrington, Jean-Claude Drehe. Relationships between Serotonin Transporter Availability and the Global Efficiency of the Executive Control Brain Network. International journal of molecular sciences. vol 25. issue 11. 2024-06-19. PMID:38891901. |
here, we used a simultaneous pet-fmri scanner combined with graph theory analyses to investigate the modulation of network properties by the serotonin transporter (sert) availability measured in the dorsal raphe nucleus (drn). |
2024-06-19 |
2024-06-21 |
Not clear |
| Sergio Mena, Allison Cruikshank, Janet Best, H F Nijhout, Michael C Reed, Parastoo Hashem. Modulation of serotonin transporter expression by escitalopram under inflammation. Communications biology. vol 7. issue 1. 2024-06-08. PMID:38851804. |
in this work, we create a theoretical hippocampal model incorporating escitalopram's pharmacokinetics, pharmacodynamics (competitive and non-competitive inhibition, and serotonin transporter (sert) internalization), inflammation, and receptor dynamics. |
2024-06-08 |
2024-06-11 |
mouse |
| Hoang Nguyen, Mary Hongying Cheng, Ji Young Lee, Shaili Aggarwal, Ole Valente Mortensen, Ivet Baha. Allosteric modulation of serotonin and dopamine transporters: New insights from computations and experiments. Current research in physiology. vol 7. 2024-06-05. PMID:38836245. |
we present here a comparative study of the structural dynamics and ligand-binding properties of two mats, dopamine transporter (dat) and serotonin transporter (sert), with focus on the allosteric modulation of their transport function by drugs or substrates that consistently bind a secondary site s2, proposed to serve as an allosteric site. |
2024-06-05 |
2024-06-07 |
human |
| Gianfabio Giorgioni, Alessandro Bonifazi, Luca Botticelli, Carlo Cifani, Federica Matteucci, Emanuela Micioni Di Bonaventura, Maria Vittoria Micioni Di Bonaventura, Mario Giannella, Alessandro Piergentili, Alessia Piergentili, Wilma Quaglia, Fabio Del Bell. Advances in drug design and therapeutic potential of selective or multitarget 5-HT1A receptor ligands. Medicinal research reviews. 2024-05-29. PMID:38808959. |
the structure-activity relationship studies (sar) performed over the last years have been devoted to three main goals: (i) design and synthesis of 5-ht1a-r selective/preferential ligands; (ii) identification of 5-ht1a-r biased agonists, differentiating pre- versus post-synaptic agonism and signaling cellular mechanisms; (iii) development of multitarget compounds endowed with well-defined poly-pharmacological profiles targeting 5-ht1a-r along with other serotonin receptors, serotonin transporter (sert), d2-like receptors and/or enzymes, such as acetylcholinesterase and phosphodiesterase, as a promising strategy for the management of complex psychiatric and neurodegenerative disorders. |
2024-05-29 |
2024-06-03 |
Not clear |
| Hayet Kouchi, Jonathon Smith, Béatrice Georges, Freya Cracknell, Laurent Bezin, Sylvain Rheim. Serotonin 2C receptor in a rat model of temporal lobe epilepsy: From brainstem expression to pharmacological blockade in relation to ventilatory function. Epilepsia. 2024-05-13. PMID:38738911. |
in a rat model of temporal lobe epilepsy (epi rats), in which we previously reported interictal respiratory dysfunctions and a reduction of brainstem 5-ht tone, quantitative reverse transcriptase polymerase chain reaction showed overexpression of tph2 (5-ht synthesis enzyme), sert (5-ht reuptake transporter), and 5-ht2c transcript levels in the brainstem of epi rats, and of rna-specific adenosine deaminase (adar1, adar2) involved in the production of 5-ht2c isoforms. |
2024-05-13 |
2024-05-27 |
rat |
| Rongpei Gou, Jingyi Yang, Menghan Guo, Yingjun Chen, Weiwei Xu. CNSMolGen: A Bidirectional Recurrent Neural Network-Based Generative Model for De Novo Central Nervous System Drug Design. Journal of chemical information and modeling. 2024-05-13. PMID:38739718. |
here, we used drugs against the classical cns disease target serotonin transporter (sert) as a fine-tuned data set and generated a focused database against the target protein. |
2024-05-13 |
2024-05-27 |
Not clear |
| Daiana Anne-Marie Dimcea, Răzvan-Cosmin Petca, Mihai Cristian Dumitrașcu, Florica Șandru, Claudia Mehedințu, Aida Petc. Postpartum Depression: Etiology, Treatment, and Consequences for Maternal Care. Diagnostics (Basel, Switzerland). vol 14. issue 9. 2024-05-11. PMID:38732283. |
the most frequently studied candidate gene was the serotonin transporter gene (sert) associated with ppd. |
2024-05-11 |
2024-05-27 |
Not clear |
| Mark S Yeoman, Sara Fidalgo, Gianluca Marcelli, Bhavik Anil Pate. Amperometry approach curve profiling to understand the regulatory mechanisms governing the concentration of intestinal extracellular serotonin. Scientific reports. vol 14. issue 1. 2024-05-07. PMID:38714793. |
this difference was due to a greater degree of activity of the 5-ht transporter (sert) and a reduced amount of 5-ht released from colonic ec cells. |
2024-05-07 |
2024-05-27 |
Not clear |
| Nathan Calzadilla, Dulari Jayawardena, Aisha Qazi, Anchal Sharma, Kai Mongan, Shane Comiskey, Abhijith Eathara, Seema Saksena, Pradeep K Dudeja, Waddah A Alrefai, Ravinder K Gil. Serotonin Transporter Deficiency Induces Metabolic Alterations in the Ileal Mucosa. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674044. |
serotonin transporter (sert) deficiency has been implicated in metabolic syndrome, intestinal inflammation, and microbial dysbiosis. |
2024-04-27 |
2024-04-29 |
Not clear |
| Xiaoxian Xie, Lei Sun, Haoshen Xu, Mengya Zhang, Jiafeng Zhou, Shulin Du, Zhengwei Fu, Zezhi L. Exposure to hexafluoropropylene oxide trimer acid (HFPO-TA) impairs 5-HT metabolism by impacting the brain-gut axis in mice. Chemosphere. 2024-04-25. PMID:38663680. |
in keeping with this prediction, our findings confirmed that the levels of several neurotransmitters, including tryptophan (trp), 5-ht, 5-htp, and 5-hiaa, were all impaired by hfpo-ta exposure in the serum, colon, and hippocampus, as was the colonic and hippocampal expression of trp and 5-ht metabolism-related genes such as sert, mao-a, and ido. |
2024-04-25 |
2024-04-28 |
mouse |
| Eva Hellsberg, Danila Boytsov, Qingyang Chen, Marco Niello, Michael Freissmuth, Gary Rudnick, Yuan-Wei Zhang, Walter Sandtner, Lucy R Forres. Identification of the potassium-binding site in serotonin transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 18. 2024-04-23. PMID:38652746. |
clearance of serotonin (5-hydroxytryptamine, 5-ht) from the synaptic cleft after neuronal signaling is mediated by serotonin transporter (sert), which couples this process to the movement of a na |
2024-04-23 |
2024-04-26 |
Not clear |
| Amine Bah. Serotonin transporter knockdown relieves depression-like behavior and ethanol-induced CPP in mice after chronic social defeat stress. Behavioural brain research. 2024-04-13. PMID:38614210. |
although, the specific mechanisms involved in stress-triggered alcohol dependence and mdd comorbidities are not well understood, a large body of literature suggests that the serotonin transporter (sert) plays a critical role in these abnormalities. |
2024-04-13 |
2024-04-16 |
mouse |
| Sixiang Chen, Xingyu Huang, Xintong Zhang, Chan Li, Yuan-Wei Zhan. A Conserved Intramolecular Ion-Pair Plays a Critical but Divergent Role in Regulation of Dimerization and Transport Function among the Monoamine Transporters. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612840. |
the monoamine transporters, including the serotonin transporter (sert), dopamine transporter (dat), and norepinephrine transporter (net), are the therapeutic targets for the treatment of many neuropsychiatric disorders. |
2024-04-13 |
2024-04-15 |
Not clear |
| Chuang-Hsin Chiu, Kuo-Hsing Ma, Eagle Yi-Kung Huang, Hsien-Wen Chang, Shao-Ju Weng, Tsung-Hsun Yu, Shiou-Shiow Farn, Yu-Yeh Kuo, Wen-Sheng Huang, Cheng-Yi Cheng, Pao-Luh Tao, Skye Hsin-Hsien Ye. Dextromethorphan moderates reward deficiency associated with central serotonin transporter availability in 3,4-methylenedioxy-methamphetamine-treated animals. Journal of the Chinese Medical Association : JCMA. 2024-04-08. PMID:38587377. |
dextromethorphan (dm), an antitussive drug, decreased morphine- or methamphetamine (ma)-induced reward in rats and may prevent mdma-induced serotonergic deficiency in primates, as indicated by increased serotonin transporter (sert) availability. |
2024-04-08 |
2024-04-10 |
rat |
| Xin Ye, Shubhamoy Ghosh, Bo-Chul Shin, Amit Ganguly, Liesbeth Maggiotto, Jonathan P Jacobs, Sherin U Devaska. Brain serotonin and serotonin transporter expression in male and female postnatal rat offspring in response to perturbed early life dietary exposures. Frontiers in neuroscience. vol 18. 2024-04-05. PMID:38576870. |
serotonin (5-ht) is critical for neurodevelopment and the serotonin transporter (sert) modulates serotonin levels. |
2024-04-05 |
2024-04-07 |
rat |
| Lina Bukowski, Markus Emanuel Strøm, Jens Lindengren Andersen, Jannick Bang Maesen, Lin Tian, Steffen Sinnin. 5-HT_FAsTR: a versatile, label-free, high-throughput, fluorescence-based microplate assay to quantify serotonin transport and release. Scientific reports. vol 14. issue 1. 2024-03-20. PMID:38504103. |
we demonstrate the applicability of the method for the study of a neuronal, high-affinity, low-capacity serotonin transporter (sert) as well as an extraneuronal low-affinity, high-capacity organic cation transporter and mutants thereof. |
2024-03-20 |
2024-03-23 |
Not clear |
| Kyung Oh Jeon, Oc-Hee Kim, Soo Yeon Seo, Jaesuk Yun, Choon-Gon Jang, Ri-Na Lim, Tae Wan Kim, Chae Ha Yang, Seong Shoon Yoon, Eun Young Jan. The psychomotor, reinforcing, and discriminative stimulus effects of synthetic cathinone mexedrone in male mice and rats. European journal of pharmacology. 2024-03-02. PMID:38431243. |
in addition, serotonin transporter (sert) levels were measured in the synaptosome of the dorsal striatum, and serotonin (5-ht) levels were measured in the dorsal striatum of acute mexedreone (50 mg/kg)-treated mice. |
2024-03-02 |
2024-03-06 |
mouse |
| Kyung Oh Jeon, Oc-Hee Kim, Soo Yeon Seo, Jaesuk Yun, Choon-Gon Jang, Ri-Na Lim, Tae Wan Kim, Chae Ha Yang, Seong Shoon Yoon, Eun Young Jan. The psychomotor, reinforcing, and discriminative stimulus effects of synthetic cathinone mexedrone in male mice and rats. European journal of pharmacology. 2024-03-02. PMID:38431243. |
acute mexedrone significantly increased c-fos expression in the dorsal striatum and decreased sert levels in the synaptosome of the dorsal striatum of mice, resulting in elevation of 5-ht levels. |
2024-03-02 |
2024-03-06 |
mouse |