| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sergio Mena, Allison Cruikshank, Janet Best, H F Nijhout, Michael C Reed, Parastoo Hashem. Modulation of serotonin transporter expression by escitalopram under inflammation. Communications biology. vol 7. issue 1. 2024-06-08. PMID:38851804. |
in this work, we create a theoretical hippocampal model incorporating escitalopram's pharmacokinetics, pharmacodynamics (competitive and non-competitive inhibition, and serotonin transporter (sert) internalization), inflammation, and receptor dynamics. |
2024-06-08 |
2024-06-11 |
mouse |
| Xiaoxian Xie, Lei Sun, Haoshen Xu, Mengya Zhang, Jiafeng Zhou, Shulin Du, Zhengwei Fu, Zezhi L. Exposure to hexafluoropropylene oxide trimer acid (HFPO-TA) impairs 5-HT metabolism by impacting the brain-gut axis in mice. Chemosphere. 2024-04-25. PMID:38663680. |
in keeping with this prediction, our findings confirmed that the levels of several neurotransmitters, including tryptophan (trp), 5-ht, 5-htp, and 5-hiaa, were all impaired by hfpo-ta exposure in the serum, colon, and hippocampus, as was the colonic and hippocampal expression of trp and 5-ht metabolism-related genes such as sert, mao-a, and ido. |
2024-04-25 |
2024-04-28 |
mouse |
| Amine Bah. Serotonin transporter knockdown relieves depression-like behavior and ethanol-induced CPP in mice after chronic social defeat stress. Behavioural brain research. 2024-04-13. PMID:38614210. |
to further investigate this hypothesis, we used a lentiviral-mediated knockdown approach to examine the role of hippocampal sert knockdown in social defeat stress-elicited depression like behavior and ethanol-induced place preference (cpp). |
2024-04-13 |
2024-04-16 |
mouse |
| Amine Bah. Serotonin transporter knockdown relieves depression-like behavior and ethanol-induced CPP in mice after chronic social defeat stress. Behavioural brain research. 2024-04-13. PMID:38614210. |
moreover, and most importantly, social stress-induced ethanol-cpp acquisition and reinstatement were significantly reduced following hippocampal sert knockdown using short hairpin rna shrna-expressing lentiviral vectors. |
2024-04-13 |
2024-04-16 |
mouse |
| Amine Bah. Serotonin transporter knockdown relieves depression-like behavior and ethanol-induced CPP in mice after chronic social defeat stress. Behavioural brain research. 2024-04-13. PMID:38614210. |
finally, we confirmed that sert hippocampal mrna expression correlated with measures of depression- and ethanol-related behaviors by pearson's correlation analysis. |
2024-04-13 |
2024-04-16 |
mouse |
| Jia-Ya Zheng, Xue-Xin Li, Xiao Liu, Chen-Chen Zhang, Ya-Xin Sun, Yu-Nu Ma, Hong-Li Wang, Yun-Ai Su, Tian-Mei Si, Ji-Tao L. Fluoxetine reverses early-life stress-induced depressive-like behaviors and region-specific alterations of monoamine transporters in female mice. Pharmacology, biochemistry, and behavior. 2024-02-09. PMID:38336220. |
at the molecular level, we largely replicated the es effects, such as reduced serotonin transporter (sert) expression in the amygdala and increased norepinephrine transporter (net) expression in the medial prefrontal cortex (mpfc) and hippocampus. |
2024-02-09 |
2024-02-12 |
mouse |
| Jia-Ya Zheng, Xue-Xin Li, Xiao Liu, Chen-Chen Zhang, Ya-Xin Sun, Yu-Nu Ma, Hong-Li Wang, Yun-Ai Su, Tian-Mei Si, Ji-Tao L. Fluoxetine reverses early-life stress-induced depressive-like behaviors and region-specific alterations of monoamine transporters in female mice. Pharmacology, biochemistry, and behavior. 2024-02-09. PMID:38336220. |
similar reversal effects of fluoxetine and vortioxetine were observed, including sert in the amygdala and net in the mpfc, whereas different reversal effects were observed for net in the hippocampus and vesicular monoamine transporters expression in the nucleus accumbens. |
2024-02-09 |
2024-02-12 |
mouse |
| Hatice Yildirim, Burcu Efe Daşkan, Elif Aksöz, Fazilet Şen, Murat Çeleb. Regional expression differences of SERT and TSPAN8 in hippocampus, cerebellum and cortex of wild-type young, adult and middle-aged rats. Gene. 2023-08-12. PMID:37572802. |
regional expression differences of sert and tspan8 in hippocampus, cerebellum and cortex of wild-type young, adult and middle-aged rats. |
2023-08-12 |
2023-08-16 |
rat |
| Hatice Yildirim, Burcu Efe Daşkan, Elif Aksöz, Fazilet Şen, Murat Çeleb. Regional expression differences of SERT and TSPAN8 in hippocampus, cerebellum and cortex of wild-type young, adult and middle-aged rats. Gene. 2023-08-12. PMID:37572802. |
our protein analysis revealed that aging mainly triggers sert gene expression in the cerebellum and hippocampus, showing that an increase in mrna expression correlates with protein expression. |
2023-08-12 |
2023-08-16 |
rat |
| Shufang Xia, Gusonghan Maitiniyazi, Yuan Liu, Yue Chen, Mengting Guo, Jianyun He, Wei Tao, Ziyuan L. Whey protein isolate attenuates depression-like behavior developed in a mouse model of breast tumor. Food research international (Ottawa, Ont.). vol 169. 2023-05-31. PMID:37254425. |
moreover, wpi promoted the hippocampal trp, 5-hydroxytryptophan (5-htp), 5-ht, 5-hydroxyindoleacetic acid (5-hiaa) levels and inhibited kynurenine (kyn) through up-regulating serotonin transporter (sert) and down-regulating indoleamine 2, 3-dioxygenase (ido). |
2023-05-31 |
2023-08-14 |
mouse |
| Amine Bahi, Jean-Luc Dreye. Anxiety and Ethanol Consumption in Socially Defeated Mice; Effect of Hippocampal Serotonin Transporter Knockdown. Behavioural brain research. 2023-05-27. PMID:37244437. |
therefore, the aim of this study was to determine whether reductions in sert expression in the hippocampus were sufficient to ameliorate anxiety- and ethanol-related behaviors in socially defeated mice. |
2023-05-27 |
2023-08-14 |
mouse |
| Amine Bahi, Jean-Luc Dreye. Anxiety and Ethanol Consumption in Socially Defeated Mice; Effect of Hippocampal Serotonin Transporter Knockdown. Behavioural brain research. 2023-05-27. PMID:37244437. |
results showed that hippocampal sert loss-of-function prevented stress-elicited anxiogenic-like effects with no differences in spontaneous locomotor activity. |
2023-05-27 |
2023-08-14 |
mouse |
| Amine Bahi, Jean-Luc Dreye. Anxiety and Ethanol Consumption in Socially Defeated Mice; Effect of Hippocampal Serotonin Transporter Knockdown. Behavioural brain research. 2023-05-27. PMID:37244437. |
interestingly, we confirmed that sert hippocampal mrna expression correlated with measures of anxiety- and ethanol-related behaviors by pearson correlation analysis. |
2023-05-27 |
2023-08-14 |
mouse |
| The people behind the papers - Roberto De Gregorio and Ji Sze. Development (Cambridge, England). vol 149. issue 21. 2022-10-31. PMID:36314568. |
now, a paper published in development finds that sert acts in a defined developmental time window in the hippocampus in a sex-biased fashion, and its absence from ca3 pyramid neurons leads to defects in neural circuit assembly, electrophysiology and behaviour. |
2022-10-31 |
2023-08-14 |
Not clear |
| Roberto De Gregorio, Galadu Subah, Jennifer C Chan, Luisa Speranza, Xiaolei Zhang, Aarthi Ramakrishnan, Li Shen, Ian Maze, Patric K Stanton, Ji Y Sz. Sex-biased effects on hippocampal circuit development by perinatal SERT expression in CA3 pyramidal neurons. Development (Cambridge, England). 2022-09-30. PMID:36178075. |
sex-biased effects on hippocampal circuit development by perinatal sert expression in ca3 pyramidal neurons. |
2022-09-30 |
2023-08-14 |
mouse |
| Roberto De Gregorio, Galadu Subah, Jennifer C Chan, Luisa Speranza, Xiaolei Zhang, Aarthi Ramakrishnan, Li Shen, Ian Maze, Patric K Stanton, Ji Y Sz. Sex-biased effects on hippocampal circuit development by perinatal SERT expression in CA3 pyramidal neurons. Development (Cambridge, England). 2022-09-30. PMID:36178075. |
here, we identify in mice that serotonin uptake transporter (sert) in non-serotonergic neurons - hippocampal and prefrontal pyramidal neurons - confers sex-biased effects specifically during neural circuit development. |
2022-09-30 |
2023-08-14 |
mouse |
| Roberto De Gregorio, Galadu Subah, Jennifer C Chan, Luisa Speranza, Xiaolei Zhang, Aarthi Ramakrishnan, Li Shen, Ian Maze, Patric K Stanton, Ji Y Sz. Sex-biased effects on hippocampal circuit development by perinatal SERT expression in CA3 pyramidal neurons. Development (Cambridge, England). 2022-09-30. PMID:36178075. |
a set of gradient patterned ca3 pyramidal neurons transiently express sert to clear extracellular serotonin, coinciding with hippocampal synaptic circuit establishment. |
2022-09-30 |
2023-08-14 |
mouse |
| Roberto De Gregorio, Galadu Subah, Jennifer C Chan, Luisa Speranza, Xiaolei Zhang, Aarthi Ramakrishnan, Li Shen, Ian Maze, Patric K Stanton, Ji Y Sz. Sex-biased effects on hippocampal circuit development by perinatal SERT expression in CA3 pyramidal neurons. Development (Cambridge, England). 2022-09-30. PMID:36178075. |
ablating pyramidal neuron sert (sertpyramidΔ) alters dendritic spine developmental trajectory in the hippocampus, and precipitates sex-biased impairments in long-term activity-dependent hippocampal synaptic plasticity and cognitive behaviors. |
2022-09-30 |
2023-08-14 |
mouse |
| Ping Tian, Wei Zhang, Kai-Yan Li, Hong-Wei Li, Kai Ma, De-En Ha. [Effect of Rehmanniae Radix on depression-like behavior and hippocampal monoamine neurotransmitters of chronic unpredictable mild stress model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164876. |
western blot was used to detect the protein expressions of tryptophan hydroxylase 2(tph2), serotonin transporter(sert), and monoamine oxidase a(mao-a) in the hippocampus of rats. |
2022-09-27 |
2023-08-14 |
rat |
| Bernardo Lopez-Torres, Irma Ares, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, María-Aránzazu Martíne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-20. PMID:36126889. |
this research study also showed in hippocampus and prefrontal cortex, that lambda-cyhalothrin modified the mrna levels of da transporter gene (dat1 up-regulation), 5-ht transporter gene (sert down-regulation), da receptor genes (drd1and drd2 down-regulation), 5-ht receptor genes (5-ht1a and 5-ht2a down-regulation/up-regulation), da synthesis gene (th down-regulation), 5-ht synthesis gene (tph2 down-regulation), da and 5-ht degradation genes (maoa and maob up-regulation). |
2022-09-20 |
2023-08-14 |
rat |