| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianglin Tan, Weifeng He, Gaoxing Luo, Jun W. iTRAQ-based proteomic profiling reveals different protein expression between normal skin and hypertrophic scar tissue. Burns & trauma. vol 3. 2016-08-30. PMID:27574659. |
a hypertrophic scar is a unique fibrotic disease that only exists in humans. |
2016-08-30 |
2023-08-13 |
Not clear |
| Jianglin Tan, Weifeng He, Gaoxing Luo, Jun W. iTRAQ-based proteomic profiling reveals different protein expression between normal skin and hypertrophic scar tissue. Burns & trauma. vol 3. 2016-08-30. PMID:27574659. |
despite advances in burn care and rehabilitation, as well as progress in the management during these decades, the hypertrophic scar remains hard to cure following surgical methods and drugs for treatment. |
2016-08-30 |
2023-08-13 |
Not clear |
| Jianglin Tan, Weifeng He, Gaoxing Luo, Jun W. iTRAQ-based proteomic profiling reveals different protein expression between normal skin and hypertrophic scar tissue. Burns & trauma. vol 3. 2016-08-30. PMID:27574659. |
in this study, we are looking forward to finding the multitude of possible traumatic mechanisms and the underlying molecular signal ways in the formation of the hypertrophic scar. |
2016-08-30 |
2023-08-13 |
Not clear |
| Cecilia W P Li-Tsan. "Scarless world or scar-less world": expedition on new perspectives on management of post-burn hypertrophic scar. Burns & trauma. vol 4. 2016-08-30. PMID:27574691. |
"scarless world or scar-less world": expedition on new perspectives on management of post-burn hypertrophic scar. |
2016-08-30 |
2023-08-13 |
Not clear |
| Zhiliang Zhao, Mengyao Xu, Meng Wu, Kui Ma, Mengli Sun, Xiaocheng Tian, Cuiping Zhang, Xiaobing F. Direct reprogramming of human fibroblasts into sweat gland-like cells. Cell cycle (Georgetown, Tex.). vol 14. issue 21. 2016-08-29. PMID:26566868. |
the skin of patients with an extensive deep burn injury is repaired by a process that leaves a hypertrophic scar without sweat glands and therefore loses the function of perspiration. |
2016-08-29 |
2023-08-13 |
human |
| Shawn Tejiram, Jenny Zhang, Taryn E Travis, Bonnie C Carney, Abdulnaser Alkhalil, Lauren T Moffatt, Laura S Johnson, Jeffrey W Shup. Compression therapy affects collagen type balance in hypertrophic scar. The Journal of surgical research. vol 201. issue 2. 2016-08-22. PMID:27020811. |
compression therapy affects collagen type balance in hypertrophic scar. |
2016-08-22 |
2023-08-13 |
Not clear |
| Shawn Tejiram, Jenny Zhang, Taryn E Travis, Bonnie C Carney, Abdulnaser Alkhalil, Lauren T Moffatt, Laura S Johnson, Jeffrey W Shup. Compression therapy affects collagen type balance in hypertrophic scar. The Journal of surgical research. vol 201. issue 2. 2016-08-22. PMID:27020811. |
the effects of pressure on hypertrophic scar are poorly understood. |
2016-08-22 |
2023-08-13 |
Not clear |
| Shawn Tejiram, Jenny Zhang, Taryn E Travis, Bonnie C Carney, Abdulnaser Alkhalil, Lauren T Moffatt, Laura S Johnson, Jeffrey W Shup. Compression therapy affects collagen type balance in hypertrophic scar. The Journal of surgical research. vol 201. issue 2. 2016-08-22. PMID:27020811. |
to examine this further, collagen composition was analyzed in a model of pressure therapy in hypertrophic scar. |
2016-08-22 |
2023-08-13 |
Not clear |
| Gopu Sriram, Paul Lorenz Bigliardi, Mei Bigliardi-Q. Fibroblast heterogeneity and its implications for engineering organotypic skin models in vitro. European journal of cell biology. vol 94. issue 11. 2016-08-19. PMID:26344860. |
furthermore, the heterogeneity among the fibroblasts play a critical role in scarless wound healing and complete restoration of native tissue architecture in fetus and oral mucosa; and excessive scar formation in diseased states like keloids and hypertrophic scars. |
2016-08-19 |
2023-08-13 |
human |
| L Chokotho, E van Hassel. The use of tannins in the local treatment of burn wounds - a pilot study. Malawi medical journal : the journal of Medical Association of Malawi. vol 17. issue 1. 2016-08-18. PMID:27528993. |
the most important observations were that no adverse reactions were encountered and that in the tannin group only one patient developed a hypertrophic scar compared to 5 patients in the other group. |
2016-08-18 |
2023-08-13 |
Not clear |
| Emily C Lynam, Yan Xie, Rebecca Dawson, Jacqui Mcgovern, Zee Upton, XiQiao Wan. Severe hypoxia and malnutrition collectively contribute to scar fibroblast inhibition and cell apoptosis. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 23. issue 5. 2016-08-04. PMID:26174572. |
this study aims to investigate whether severe hypoxia and malnutrition in scar tissue play key roles to induce hypertrophic scar regression. |
2016-08-04 |
2023-08-13 |
Not clear |
| Layla Nabai, Ruhangiz T Kilani, Farzian Aminuddin, Yunyuan Li, Aziz Ghahar. Methotrexate modulates the expression of MMP-1 and type 1 collagen in dermal fibroblast. Molecular and cellular biochemistry. vol 409. issue 1-2. 2016-07-22. PMID:26298287. |
under the same experimental conditions, the level of secreted and intracellular type i collagen was markedly reduced and, conversely, the level of mmp-1 increased in treated neonatal, adult, and hypertrophic scar fibroblasts as compared with those of controls. |
2016-07-22 |
2023-08-13 |
human |
| Layla Nabai, Ruhangiz T Kilani, Farzian Aminuddin, Yunyuan Li, Aziz Ghahar. Methotrexate modulates the expression of MMP-1 and type 1 collagen in dermal fibroblast. Molecular and cellular biochemistry. vol 409. issue 1-2. 2016-07-22. PMID:26298287. |
in summary, the findings of this study revealed that mtx significantly reduced collagen production in different strains of fibroblasts derived from neonatal, adult, and hypertrophic scar tissues, while under the same experimental conditions, it increased the expression of mmp-1. |
2016-07-22 |
2023-08-13 |
human |
| Jianglin Tan, Weifeng He, Gaoxing Luo, Jun W. Involvement of impaired desmosome-related proteins in hypertrophic scar intraepidermal blister formation. Burns : journal of the International Society for Burn Injuries. vol 41. issue 7. 2016-07-15. PMID:25922301. |
involvement of impaired desmosome-related proteins in hypertrophic scar intraepidermal blister formation. |
2016-07-15 |
2023-08-13 |
human |
| Jianglin Tan, Weifeng He, Gaoxing Luo, Jun W. Involvement of impaired desmosome-related proteins in hypertrophic scar intraepidermal blister formation. Burns : journal of the International Society for Burn Injuries. vol 41. issue 7. 2016-07-15. PMID:25922301. |
hypertrophic scar is one of the unique fibrotic diseases in human. |
2016-07-15 |
2023-08-13 |
human |
| Jianglin Tan, Weifeng He, Gaoxing Luo, Jun W. Involvement of impaired desmosome-related proteins in hypertrophic scar intraepidermal blister formation. Burns : journal of the International Society for Burn Injuries. vol 41. issue 7. 2016-07-15. PMID:25922301. |
intraepidermal blister is a common clinical symptom following the hypertrophic scar formation. |
2016-07-15 |
2023-08-13 |
human |
| Jianglin Tan, Weifeng He, Gaoxing Luo, Jun W. Involvement of impaired desmosome-related proteins in hypertrophic scar intraepidermal blister formation. Burns : journal of the International Society for Burn Injuries. vol 41. issue 7. 2016-07-15. PMID:25922301. |
in this study, we selected three patients with hypertrophic scar as manifested by raised, erythematous, pruritic, blister and thickened appearance undergoing scar resection. |
2016-07-15 |
2023-08-13 |
human |
| Jianglin Tan, Weifeng He, Gaoxing Luo, Jun W. Involvement of impaired desmosome-related proteins in hypertrophic scar intraepidermal blister formation. Burns : journal of the International Society for Burn Injuries. vol 41. issue 7. 2016-07-15. PMID:25922301. |
in order to understand the molecular mechanism of blister formation, we screened the different protein expression between hypertrophic scar and normal skin tissue by means of isobaric tags for relative and absolute quantitation (itraq) labeling technology and high throughput 2d lc-ms/ms. |
2016-07-15 |
2023-08-13 |
human |
| Jianglin Tan, Weifeng He, Gaoxing Luo, Jun W. Involvement of impaired desmosome-related proteins in hypertrophic scar intraepidermal blister formation. Burns : journal of the International Society for Burn Injuries. vol 41. issue 7. 2016-07-15. PMID:25922301. |
there were 48 proteins found to be downregulated in hypertrophic scar. |
2016-07-15 |
2023-08-13 |
human |
| Jianglin Tan, Weifeng He, Gaoxing Luo, Jun W. Involvement of impaired desmosome-related proteins in hypertrophic scar intraepidermal blister formation. Burns : journal of the International Society for Burn Injuries. vol 41. issue 7. 2016-07-15. PMID:25922301. |
transmission electron microscopy further showed the considerably reduced size and intensity of hemidesmosome and desmosome in hypertrophic scar tissue, compared to control normal skin. |
2016-07-15 |
2023-08-13 |
human |