| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongwei Li, Liu Yang, Yuebing Zhang, Zhigang Ga. Kaempferol inhibits fibroblast collagen synthesis, proliferation and activation in hypertrophic scar via targeting TGF-β receptor type I. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-02-07. PMID:27522259. |
kaempferol inhibits fibroblast collagen synthesis, proliferation and activation in hypertrophic scar via targeting tgf-β receptor type i. hypertrophic scar (hps) formation is a debilitating condition that results in pain, esthetic symptom and loss of tissue function. |
2017-02-07 |
2023-08-13 |
mouse |
| Shengzhi Mu, Bei Kang, Weihui Zeng, Yaowen Sun, Fan Yan. MicroRNA-143-3p inhibits hyperplastic scar formation by targeting connective tissue growth factor CTGF/CCN2 via the Akt/mTOR pathway. Molecular and cellular biochemistry. vol 416. issue 1-2. 2017-02-06. PMID:27075467. |
post-traumatic hypertrophic scar (hs) is a fibrotic disease with excessive extracellular matrix (ecm) production, which is a response to tissue injury by fibroblasts. |
2017-02-06 |
2023-08-13 |
human |
| Yan Li, Shan Shi, Jianxin Gao, Shichao Han, Xue Wu, Yanhui Jia, Linlin Su, Jihong Shi, Dahai H. Cryptotanshinone downregulates the profibrotic activities of hypertrophic scar fibroblasts and accelerates wound healing: A potential therapy for the reduction of skin scarring. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 80. 2017-01-31. PMID:27133042. |
cryptotanshinone downregulates the profibrotic activities of hypertrophic scar fibroblasts and accelerates wound healing: a potential therapy for the reduction of skin scarring. |
2017-01-31 |
2023-08-13 |
mouse |
| Yan Li, Shan Shi, Jianxin Gao, Shichao Han, Xue Wu, Yanhui Jia, Linlin Su, Jihong Shi, Dahai H. Cryptotanshinone downregulates the profibrotic activities of hypertrophic scar fibroblasts and accelerates wound healing: A potential therapy for the reduction of skin scarring. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 80. 2017-01-31. PMID:27133042. |
hypertrophic scar (hs) is a skin fibrotic disease that causes major clinically problematic symptoms. |
2017-01-31 |
2023-08-13 |
mouse |
| Shu-Chung Hsieh, Chun-Chi Wu, Shih-Lan Hsu, Chin-Hsing Feng, Jung-Hsing Ye. Gallic acid attenuates TGF-β1-stimulated collagen gel contraction via suppression of RhoA/Rho-kinase pathway in hypertrophic scar fibroblasts. Life sciences. vol 161. 2017-01-30. PMID:27457401. |
gallic acid attenuates tgf-β1-stimulated collagen gel contraction via suppression of rhoa/rho-kinase pathway in hypertrophic scar fibroblasts. |
2017-01-30 |
2023-08-13 |
Not clear |
| Shu-Chung Hsieh, Chun-Chi Wu, Shih-Lan Hsu, Chin-Hsing Feng, Jung-Hsing Ye. Gallic acid attenuates TGF-β1-stimulated collagen gel contraction via suppression of RhoA/Rho-kinase pathway in hypertrophic scar fibroblasts. Life sciences. vol 161. 2017-01-30. PMID:27457401. |
to examine the effect and molecular mechanism of gallic acid (ga) on transforming growth factor-β1 (tgf-β1)-stimulated hypertrophic scar fibroblast (hsf) contraction. |
2017-01-30 |
2023-08-13 |
Not clear |
| Bing Li, Chao Gao, Jian-Sheng Diao, Da-Lei Wang, Fei-Fei Chu, Yang Li, Gang Wang, Shu-Zhong Guo, Wei Xi. Aberrant Notch signalling contributes to hypertrophic scar formation by modulating the phenotype of keratinocytes. Experimental dermatology. vol 25. issue 2. 2017-01-10. PMID:26566963. |
aberrant notch signalling contributes to hypertrophic scar formation by modulating the phenotype of keratinocytes. |
2017-01-10 |
2023-08-13 |
rabbit |
| Bing Li, Chao Gao, Jian-Sheng Diao, Da-Lei Wang, Fei-Fei Chu, Yang Li, Gang Wang, Shu-Zhong Guo, Wei Xi. Aberrant Notch signalling contributes to hypertrophic scar formation by modulating the phenotype of keratinocytes. Experimental dermatology. vol 25. issue 2. 2017-01-10. PMID:26566963. |
hypertrophic scar (hs) is characterized by fibroblast hyperproliferation and excessive matrix deposition. |
2017-01-10 |
2023-08-13 |
rabbit |
| Li-Wu Qian, Andrea B Fourcaudot, Kazuyoshi Yamane, Tao You, Rodney K Chan, Kai P Leun. Exacerbated and prolonged inflammation impairs wound healing and increases scarring. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 24. issue 1. 2017-01-05. PMID:26562746. |
to bridge this gap, we used the established rabbit ear hypertrophic scar model for studying the causal effect of dysregulated inflammation. |
2017-01-05 |
2023-08-13 |
rabbit |
| Li-Wu Qian, Andrea B Fourcaudot, Kazuyoshi Yamane, Tao You, Rodney K Chan, Kai P Leun. Exacerbated and prolonged inflammation impairs wound healing and increases scarring. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 24. issue 1. 2017-01-05. PMID:26562746. |
moreover, treatment of these inflamed wounds with indomethacin (at concentrations of 0.01, 0.1, and 0.4%) reduced scar elevation but with adverse effects of delayed wound closure and increased cartilage hypertrophy. |
2017-01-05 |
2023-08-13 |
rabbit |
| Aubrey E Winn, Shayna C Rivard, Brian Gree. Lesions Arising in a Tattoo of an Active Duty US Marine Corps Woman. Journal of special operations medicine : a peer reviewed journal for SOF medical professionals. vol 16. issue 2. 2017-01-03. PMID:27450611. |
ultimately, a skin biopsy revealed early hypertrophic scar formation responsive to therapy with intralesional triamcinolone acetonide (kenalog® [ilk]). |
2017-01-03 |
2023-08-13 |
Not clear |
| Shaowei Yang, Yexiao Sun, Zhijun Geng, Kui Ma, Xiaoyan Sun, Xiaobing F. Abnormalities in the basement membrane structure promote basal keratinocytes in the epidermis of hypertrophic scars to adopt a proliferative phenotype. International journal of molecular medicine. vol 37. issue 5. 2016-12-26. PMID:26986690. |
for this purpose, in this study, we used normal, wound edge and hypertrophic scar tissue to examine the morphological changes which occur during epidermal regeneration as part of the wound healing process and found that the histological structure of hypertrophic scar tissues differed from that of normal skin, with a significant increase in epidermal thickness. |
2016-12-26 |
2023-08-13 |
Not clear |
| Shaowei Yang, Yexiao Sun, Zhijun Geng, Kui Ma, Xiaoyan Sun, Xiaobing F. Abnormalities in the basement membrane structure promote basal keratinocytes in the epidermis of hypertrophic scars to adopt a proliferative phenotype. International journal of molecular medicine. vol 37. issue 5. 2016-12-26. PMID:26986690. |
moreover, immunofluorescence staining for cytokeratin (ck)10, ck14, ck5, ck19 and integrin-β1 indicated the differential expression of cell markers in the epidermal keratinocytes among the normal, wound edge and hypertrophic scar tissues, which corresponded with the altered bm structures. |
2016-12-26 |
2023-08-13 |
Not clear |
| Maria G Onesti, Pasquale Fino, Paolo Fioramonti, Vittoria Amorosi, Nicolò Scuder. Reconstruction after skin cancer excision through a dermal induction template: our experience. International wound journal. vol 13. issue 2. 2016-12-22. PMID:24684743. |
by using a dermal induction template, it was possible to cover substantial loss of substances without the need of autologous tissue, with smoother and less apparent scar, minor occurrence of hypertrophic and retracted scars, better flexibility of healed skin and therefore a better result from an aesthetic point of view. |
2016-12-22 |
2023-08-12 |
human |
| Qing Chun, Wang ZhiYong, Song Fei, Wang XiQia. Dynamic biological changes in fibroblasts during hypertrophic scar formation and regression. International wound journal. vol 13. issue 2. 2016-12-22. PMID:24802644. |
dynamic biological changes in fibroblasts during hypertrophic scar formation and regression. |
2016-12-22 |
2023-08-13 |
human |
| Qing Chun, Wang ZhiYong, Song Fei, Wang XiQia. Dynamic biological changes in fibroblasts during hypertrophic scar formation and regression. International wound journal. vol 13. issue 2. 2016-12-22. PMID:24802644. |
the human hypertrophic scar undergoes hyperplasia and regression during progression. |
2016-12-22 |
2023-08-13 |
human |
| Qing Chun, Wang ZhiYong, Song Fei, Wang XiQia. Dynamic biological changes in fibroblasts during hypertrophic scar formation and regression. International wound journal. vol 13. issue 2. 2016-12-22. PMID:24802644. |
this study aimed to investigate whether fibroblasts in scar tissue undergo biological changes during the formation and regression of human hypertrophic scar. |
2016-12-22 |
2023-08-13 |
human |
| Qing Chun, Wang ZhiYong, Song Fei, Wang XiQia. Dynamic biological changes in fibroblasts during hypertrophic scar formation and regression. International wound journal. vol 13. issue 2. 2016-12-22. PMID:24802644. |
dynamic changes in fibroblast biology correlated with the formation and progression of hypertrophic scar. |
2016-12-22 |
2023-08-13 |
human |
| Ruixia Kuang, Zhiguo Wang, Quanchen Xu, Xia Cai, Tao Li. Exposure to Varying Strain Magnitudes Influences the Conversion of Normal Skin Fibroblasts Into Hypertrophic Scar Cells. Annals of plastic surgery. vol 76. issue 4. 2016-12-22. PMID:26545222. |
exposure to varying strain magnitudes influences the conversion of normal skin fibroblasts into hypertrophic scar cells. |
2016-12-22 |
2023-08-13 |
human |
| Ruixia Kuang, Zhiguo Wang, Quanchen Xu, Xia Cai, Tao Li. Exposure to Varying Strain Magnitudes Influences the Conversion of Normal Skin Fibroblasts Into Hypertrophic Scar Cells. Annals of plastic surgery. vol 76. issue 4. 2016-12-22. PMID:26545222. |
influence of varying cyclic strain magnitudes on cultured human normal skin fibroblasts and its transformation into hypertrophic scar fibroblast-like phenotype is investigated in this study. |
2016-12-22 |
2023-08-13 |
human |